KEGG   ENZYME: 1.14.14.136Help
Entry
EC 1.14.14.136              Enzyme                                 

Name
deoxysarpagine hydroxylase;
DOSH
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
10-deoxysarpagine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (10-hydroxylating)
Reaction(IUBMB)
10-deoxysarpagine + [reduced NADPH---hemoprotein reductase] + O2 = sarpagine + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R05828]
Reaction(KEGG)
Substrate
10-deoxysarpagine [CPD:C11635];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
sarpagine [CPD:C09239];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytohrome P-450 (heme-thiolate) protein isolated from the plant Rauvolfia serpentina.
History
EC 1.14.14.136 created 2005 as EC 1.14.13.91, transferred 2018 to EC 1.14.14.136
Pathway
ec00901  Indole alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Reference
1  [PMID:12057637]
  Authors
Yu B, Ruppert M, Stockigt J.
  Title
Deoxysarpagine hydroxylase--a novel enzyme closing a short side pathway of alkaloid biosynthesis in Rauvolfia.
  Journal
Bioorg Med Chem 10:2479-83 (2002)
DOI:10.1016/S0968-0896(02)00126-8
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.136
IUBMB Enzyme Nomenclature: 1.14.14.136
ExPASy - ENZYME nomenclature database: 1.14.14.136
BRENDA, the Enzyme Database: 1.14.14.136

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