KEGG   ENZYME: 1.14.14.137Help
Entry
EC 1.14.14.137              Enzyme                                 

Name
(+)-abscisic acid 8'-hydroxylase;
(+)-ABA 8'-hydroxylase;
ABA 8'-hydroxylase;
CYP707A1 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
abscisate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (8'-hydroxylating)
Reaction(IUBMB)
(+)-abscisate + [reduced NADPH---hemoprotein reductase] + O2 = 8'-hydroxyabscisate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R07202]
Reaction(KEGG)
Substrate
(+)-abscisate;
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
8'-hydroxyabscisate [CPD:C15514];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein found in plants. Catalyses the first step in the oxidative degradation of abscisic acid and is considered to be the pivotal enzyme in controlling the rate of degradation of this plant hormone [1]. CO inhibits the reaction, but its effects can be reversed by the presence of blue light [1]. The 8'-hydroxyabscisate formed can be converted into (-)-phaseic acid, most probably spontaneously.
History
EC 1.14.14.137 created 2005 as EC 1.14.13.93, transferred 2018 EC 1.14.14.137
Pathway
ec00906  Carotenoid biosynthesis
Orthology
K09843  (+)-abscisic acid 8'-hydroxylase
Genes
ATH: AT2G29090(CYP707A2) AT3G19270(CYP707A4) AT4G19230(CYP707A1) AT5G45340(CYP707A3)
ALY: ARALYDRAFT_479442 ARALYDRAFT_481828 ARALYDRAFT_492925 ARALYDRAFT_683506
CRB: 17874776 17880652 17887641 17892766
CSAT: 104700603 104718390 104723117 104724884 104733490 104746312 104749974 104760380 104765790 104771755 104784217 104786786
EUS: EUTSA_v10000876mg EUTSA_v10016581mg EUTSA_v10020656mg EUTSA_v10025059mg
BRP: 103827806 103839129 103849374 103857276 103859803 103861043 103869474
BNA: 106361235 106373335 106374933 106379426 106386394 106391221 106391222 106395068 106416491 106416608 106419785 106425473 106427439 106428338 106444094 106446905 111197871 111204767 111206585 111208232 111209689 111215074
BOE: 106292604 106301431 106304342 106319075 106322586 106332542 106336684 106337621 106344046
RSZ: 108807352 108813882 108823402 108835695 108840164 108850120 108851625 108857841 108858885
THJ: 104798530 104798797 104800678 104806199 104811149 104819469
CIT: 102611561(CYP707A4) 102613470(CYP707A1) 102616423(CYP707A3) 102627021(CYP707A2)
LJA: Lj0g3v0285509.1(Lj0g3v0285509.1) Lj0g3v0332329.1(Lj0g3v0332329.1) Lj0g3v0340109.1(Lj0g3v0340109.1) Lj2g3v1550580.1(Lj2g3v1550580.1) Lj5g3v0290410.1(Lj5g3v0290410.1)
DOSA: Os02t0703600-01(Os02g0703600) Os08t0472800-01(Os08g0472800) Os09t0457100-01(Os09g0457100)
ATS: 109739218(LOC109739218) 109763237(LOC109763237)
PPP: 112276337
MNG: MNEG_7206
 » show all
Taxonomy
Reference
1
  Authors
Cutler, A.J., Squires, T.M., Loewen, M.K. and Balsevich, J.J.
  Title
Induction of (+)-abscisic acid 8' hydroxylase by (+)-abscisic acid in cultured maize cells.
  Journal
J Exp Bot 48:1787-1795 (1997)
Reference
2  [PMID:9808729]
  Authors
Krochko JE, Abrams GD, Loewen MK, Abrams SR, Cutler AJ.
  Title
(+)-Abscisic acid 8'-hydroxylase is a cytochrome P450 monooxygenase
  Journal
Plant Physiol 118:849-60 (1998)
DOI:10.1104/pp.118.3.849
Reference
3  [PMID:15064374]
  Authors
Saito S, Hirai N, Matsumoto C, Ohigashi H, Ohta D, Sakata K, Mizutani M
  Title
Arabidopsis CYP707As encode (+)-abscisic acid 8'-hydroxylase, a key enzyme in the oxidative catabolism of abscisic acid.
  Journal
Plant Physiol 134:1439-49 (2004)
DOI:10.1104/pp.103.037614
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.137
IUBMB Enzyme Nomenclature: 1.14.14.137
ExPASy - ENZYME nomenclature database: 1.14.14.137
BRENDA, the Enzyme Database: 1.14.14.137
CAS: 153190-37-5

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