KEGG ENZYME: 1.14.14.137

ENZYME: 1.14.14.137

Entry

EC 1.14.14.137              Enzyme

Name

(+)-abscisic acid 8'-hydroxylase;
(+)-ABA 8'-hydroxylase;
ABA 8'-hydroxylase;
CYP707A1 (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

abscisate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (8'-hydroxylating)

Reaction(IUBMB)

(+)-abscisate + [reduced NADPH---hemoprotein reductase] + O2 = 8'-hydroxyabscisate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R07202]

Reaction(KEGG)

R07202

Substrate

(+)-abscisate;
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

8'-hydroxyabscisate [CPD:C15514];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

A cytochrome P-450 (heme-thiolate) protein found in plants. Catalyses the first step in the oxidative degradation of abscisic acid and is considered to be the pivotal enzyme in controlling the rate of degradation of this plant hormone [1]. CO inhibits the reaction, but its effects can be reversed by the presence of blue light [1]. The 8'-hydroxyabscisate formed can be converted into (-)-phaseic acid, most probably spontaneously.

History

EC 1.14.14.137 created 2005 as EC 1.14.13.93, transferred 2018 EC 1.14.14.137

Pathway

ec00906

Carotenoid biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K09843

(+)-abscisic acid 8'-hydroxylase

Genes

AJM:

119052980

ATH:	AT2G29090(CYP707A2) AT3G19270(CYP707A4) AT4G19230(CYP707A1) AT5G45340(CYP707A3)

ALY:	9301326 9304019 9317095 9321370

CRB:	17874776 17880652 17887641 17892766

CSAT:

104700603 104718390 104723117 104724884 104733490 104746312 104749974 104760380 104765790 104771755 104784217 104786786

EUS:	EUTSA_v10000876mg EUTSA_v10016581mg EUTSA_v10020656mg EUTSA_v10025059mg

BRP:	103827806 103839129 103849374 103853629 103857276 103859803 103861043 103869474

BNA:	106361235 106374933 106379426 106386394 106391221 106395068 106416491 106416608 106419785 106425473 106427439 106428338 106444094 106446905 111204767 111208232 111209689 125585432 125598879 125600415

BOE:	106292604 106301431 106304342 106319075 106322586 106332542 106336684 106337621 106344046

RSZ:	108807352 108813882 108823402 108835695 108840164 108850120 108851625 108857841 130494998 130512407

THJ:	104798530 104798797 104800678 104806199 104811149 104819469

CPAP:

110810226 110810237 110812139 110813756 110814346 110815190

CIT:	102608755 102611561(CYP707A4) 102613470(CYP707A1) 102616423(CYP707A3) 102627021(CYP707A2)

CIC:	CICLE_v10001043mg CICLE_v10011655mg CICLE_v10027226mg CICLE_v10028346mg CICLE_v10028355mg

PVY:	116112994 116118485 116125636 116130343 116140873

MINC:

123197285 123202735 123208058 123213458 123225235 123227356 123228553

TCC:	18590658 18591195 18606915 18607939

GRA:	105764928 105769218 105783663 105788803 105791455 105791826 105795249

GHI:	107885978 107894265 107900693 107905568 107908906 107929452 107933465 107935002 107937468 107946838 107950138 107954095 107958119 121212207

GAB:	108451979 108463088 108474845 108475552 108478478 108481002 108483651

HSYR:

120116330 120129407 120134508 120142074 120145666 120164253 120167915 120168265 120183035 120187077 120198826 120199190 120211208 120214865 120216651

DZI:	111275534 111282262 111285473 111290894 111296235 111302149 111303652 111308934 111314846

EGR:	104432702 104444184 104447893 104453198

GMX:	100170674 100779810 100779978 100780737(CYP707A1A) 100782541 100786428 100793868 100798525 100806350 100807446 100815135

GSJ:	114384273 114388565 114389666 114390295 114392176 114392178 114418680 114419691 114424983 114425369

PVU:	PHAVU_001G022100g PHAVU_002G122200g PHAVU_003G004800g PHAVU_003G278400g PHAVU_003G292200g

VRA:	106753610 106755472 106764057 106765605 106767139 106777777

VAR:	108333502 108334748 108335963 108338691 108342297

VUN:	114173137 114173713 114175921 114177395 114193627

VUM:	124827454 124834212 124834378 124837100

CCAJ:

109787837 109790974 109795845 109807873 109812312

APRC:

113846735 113857590 113858011 113868441 113868568

MTR:	11414529 11415565 11440521 11444685 11445728 25482830

TPRA:

123881458 123882496 123883530 123897786 123907479 123916736 123921486

CAM:	101490679 101499787 101500873 101501203 101505927 101506315 101507107

PSAT:

127074819 127092743 127097034 127106695 127106697 127119909

VVO:	131594155 131595258 131595722 131602592 131602593 131641545 131646698

LJA:	130710215 130712537 130717107 130740294 130747693

ADU:	107469732 107472024 107475501 107487353 107495798 127743947

AIP:	107605673 107623345 107624180 107624341 107642454

AHF:	112697839 112715576 112717164 112747584 112756137 112783178 112785166 112785268 112797741 112800189

LANG:

109330843 109331424 109332353 109332941 109340108 109343213 109348957 109349438 109350897

PCIN:

129285125 129293660 129295510 129303271 129311945 129312910 129321470

QSA:	O6P43_000185 O6P43_011717 O6P43_016067 O6P43_024635 O6P43_025016 O6P43_028210 O6P43_033458

FVE:	101294153 101299092 101304444 101309436

RCN:	112165278 112172477 112174832 112176036

PPER:

18768553 18771933 18776649 18793892

PMUM:

103320438 103322169 103335270 103343203 107881722

PAVI:

110757091 110761971 110766069 110768049 110771684

PDUL:

117628432 117631366 117635422 117636232 117637122

MDM:	103403019 103409417 103420642(CYP707A) 103436490(CYP707A) 103439226 103444865 103455974

MSYL:

126584913 126601417 126606407 126616844 126624819 126624976 126633116

PXB:	103931125 103941040 103950115 103954279 103955532 103957649

ZJU:	107410991 107419950 107423995 107424777 107427062

MNT:	112095132 21389777 21392134 21407981 21410144

CSAV:

115705748 115705785 115706850 115709153 115718499

CSV:	101212508(CYP707A1) 101213916 101216531 101219389 101220320

CMO:	103487890 103493031(CYP707A1) 103493539 103495236 103497144

BHJ:	120066976 120075099 120077498 120083169 120085429

MCHA:

111007825 111008490 111012581 111013891 111022241

CMAX:

111471004 111479973 111481123 111483101 111486079 111492434 111492574

CMOS:

111434488 111437516 111445975 111446961 111452117 111455363 111462760

CPEP:

111787110 111788762 111790974 111792754 111805623 111810919 111811273

RCU:	8262889 8275301 8275341 8278867 8280805

MEAN:

126654940 126659743 126661126 126676805 126686178

JCU:	105629862 105629943 105633644 105639703 105647970

HBR:	110636999 110638661 110643563 110643639 110646845 110654303 110655841 110660365

MESC:

110605978 110607493 110608009 110619124 110619719 110622027 110624210 110624640 110629292 122724855

POP:	18097786 18098425 18104892 7457533 7462884 7465099 7468629

PEU:	105108041 105112090 105120629 105128488 105129581 105131141 105133136

PALZ:

118028035 118028932 118035767 118050094 118050806 118053699 118059219 118062636

PNZ:	133679486 133680623 133681947 133687391 133692398 133699004 133699680

JRE:	108979551 108982942 108983082 108984444 108984621 108987785 109013006

CILL:

122280487 122289091 122291240 122297815 122299247 122313805

CAVE:

132164773 132173303 132175150 132175588 132175710 132178633 132185947

QSU:	111985954 111993076 111998892 112011065 112024981 136067322

QLO:	115967648 115972489 115977863 115986600

TWL:	119996142 119999604 120003120 120005772 120009958 120015865

VVI:	100245540 100246968 100257861(HYD3) 100260462 100264783(HYD2)

VRI:	117907283 117907359 117908802 117916798 117917254

SLY:	100136887(CYP707A1) 101249565 101254720 101266767

SPEN:

107010117 107016113 107026984 107027299

SOT:	102577541 102577723 102597402 102605008

SSTN:

125841241 125842022 125847935 125856479

SDUL:

129885546 129888448 129888823 129904425

CANN:

107840293 107850059 107867833 107870293

LBB:	132599055 132609623 132627860 132635471

NTA:	107760423 107776450 107776975 107781531(didiG2) 107791402 107804348 107804502 107820622 107830097

NSY:	104218760 104221448 104225411 104233010 104237354

NTO:	104090891 104098186 104103201 104105791

NAU:	109213242 109215578 109223421 109224982 109236785

INI:	109149139 109149809 109152675 109153083 109156303 109161629 109165388 109177228(CYP707A1) 109193208

ITR:	116002648 116016714 116020755 116021721 116023243 116024854 116026779 116028057 116031598

SIND:

105157462 105159170 105165006 105166246 105169543 105170431

OEU:	111367428 111367437 111381076 111384023 111384024 111393533 111397271 111397273 111398610 111401342 111404289 111409085 111410611 111410612

EGT:	105957559 105957940 105967270 105971434

SSPL:

121743511 121751269 121756425 121756829 121762805 121763341 121767311 121771112 121778141 121782436 121785506

SMIL:

130987139 130987154 131000786 131004796 131010837 131014912

SHIS:

125187622 125207547 125211295 125215547 125216868 125219729

APAN:

127239438 127243494 127247024 127250215 127251989 127255844 127262442 127264343 127265732

HAN:	110865034 110865515 110868510 110885657 110916009 110920974 110930333 110940077 110941392

ECAD:

122578162 122579841 122592593 122599888 122606492

LSV:	111877664 111880314 111898519 111902236 111908842 111919208

CCAV:

112506680 112514492 112516517 112518219 112527381 112529250

DCR:	108200176 108201942 108207471 108208135 108210231 108213545 108224693

CSIN:

114269053 114270314 114277042 114292338 114323824

RVL:	131307672 131308449 131314694 131326245 131331201 131333174 131334037

AEW:	130756824 130758562 130764974 130767355 130770771 130774152 130780152

BVG:	104883761 104892458 104900082

SOE:	110776184 110788345 110806004

CQI:	110682301 110684025 110688388 110710716 110718184 110719340

ATRI:

130804710 130814109 130824248 130826760

MOF:	131147644 131155763 131156293 131162943 131165249

NNU:	104597161 104601056 104601783 104604090 104606421 104610297

MING:

122058404 122063941 122064726 122065890 122087385

TSS:	122641522 122645562 122653211 122657352 122663370

PSOM:

113289510 113292705 113297768 113302842 113314237 113344559 113352916 113356837

OSA:	4345810(ABA8OX2) 4347261(ABA8OX3) 9269675(ABA8OX1)

OBR:	102708964 102712386 102720625

OGL:	127764476 127782517 127783664

BDI:	100833286 100837492

ATS:	109739218 109763237

TDC:	119301823 119310075 119317565 119323008

TAES:

100682449 123103964 123112199 123128115 123137905 123145207

TUA:	125509553 125514257

LPER:

127301838 127306522 127318450

LRD:	124653203 124681675 124682415 124692940 124696580

SBI:	8073163 8083090 8083537

ZMA:	100191697 100274595 100383693 103647484 103653298

MFLO:

136467536 136467551 136473186 136500395 136546360 136551914

SITA:

101760218 101777633 101782596

SVS:	117834664 117842728 117860191

PVIR:

120649354 120656938 120660878 120677234 120681104 120712626

PHAI:

112879339 112897089 112901462

PDA:	103698268 103712508 103713001 120107288

EGU:	105033850 105053512 105058241 105060896

MUS:	103977534 103981920 103983051 103990398 103995476 103997992

ZOF:	121967229 121967304 121989515 121998442 122020926 122024711 122042550 122047064 122052432 122052519

DCT:	110092529 110097017 110110599 110112069 110113154

PEQ:	110021788 110026332 110030934 110037185 110039063

AOF:	109822751 109825502 109837794 109845256

MSIN:

131233284 131236399 131236401 131242487 131244276 131247846 131252863

NCOL:

116253418 116254585 116258598 116265126

ATR:	18422678 18428701 18436176

SMO:	SELMODRAFT_104642 SELMODRAFT_89153(CYP707A20) SELMODRAFT_96503(CYP707A43) SELMODRAFT_97760

» show all

Reference

Authors

Cutler AJ, Squires TM, Loewen MK, Balsevich JJ.

Title

Induction of (+)-abscisic acid 8' hydroxylase by (+)-abscisic acid in cultured maize cells.

Journal

J Exp Bot 48:1787-1795 (1997)

Reference

2 [PMID:9808729]

Authors

Krochko JE, Abrams GD, Loewen MK, Abrams SR, Cutler AJ.

Title

(+)-Abscisic acid 8'-hydroxylase is a cytochrome P450 monooxygenase

Journal

Plant Physiol 118:849-60 (1998)
DOI:10.1104/pp.118.3.849

Reference

3 [PMID:15064374]

Authors

Saito S, Hirai N, Matsumoto C, Ohigashi H, Ohta D, Sakata K, Mizutani M

Title

Arabidopsis CYP707As encode (+)-abscisic acid 8'-hydroxylase, a key enzyme in the oxidative catabolism of abscisic acid.

Journal

Plant Physiol 134:1439-49 (2004)
DOI:10.1104/pp.103.037614

Sequence

[ath:AT4G19230 AT5G45340]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.14.137

IUBMB Enzyme Nomenclature:

1.14.14.137

ExPASy - ENZYME nomenclature database:

1.14.14.137

BRENDA, the Enzyme Database:

1.14.14.137

CAS:	153190-37-5

DBGET integrated database retrieval system