KEGG   ENZYME: 1.14.14.148
Entry
EC 1.14.14.148              Enzyme                                 

Name
angelicin synthase;
CYP71AJ4 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
(+)-columbianetin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
(+)-columbianetin + [reduced NADPH---hemoprotein reductase] + O2 = angelicin + [oxidized NADPH---hemoprotein reductase] + acetone + 2 H2O [RN:R09002]
Reaction(KEGG)
R09002
Substrate
(+)-columbianetin [CPD:C19707];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
angelicin [CPD:C09060];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
acetone [CPD:C00207];
H2O [CPD:C00001]
Comment
This cytochrome P-450 (heme-thiolate) enzyme from wild parsnip is involved in the formation of angular furanocoumarins. Attacks its substrate by syn-elimination of hydrogen from C-3'.
History
EC 1.14.14.148 created 2010 as EC 1.14.13.115, transferred 2018 to EC 1.14.14.148
Orthology
K21715  angelicin synthase
Reference
1  [PMID:19098286]
  Authors
Larbat R, Hehn A, Hans J, Schneider S, Jugde H, Schneider B, Matern U, Bourgaud F
  Title
Isolation and functional characterization of CYP71AJ4 encoding for the first P450 monooxygenase of angular furanocoumarin biosynthesis.
  Journal
J Biol Chem 284:4776-85 (2009)
DOI:10.1074/jbc.M807351200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.148
IUBMB Enzyme Nomenclature: 1.14.14.148
ExPASy - ENZYME nomenclature database: 1.14.14.148
BRENDA, the Enzyme Database: 1.14.14.148

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