| Entry |
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| Name |
angelicin synthase;
CYP71AJ4 (gene name)
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
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| Sysname |
(+)-columbianetin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
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| Reaction(IUBMB) |
(+)-columbianetin + [reduced NADPH---hemoprotein reductase] + O2 = angelicin + [oxidized NADPH---hemoprotein reductase] + acetone + 2 H2O [RN: R09002]
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| Reaction(KEGG) |
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| Substrate |
(+)-columbianetin [CPD: C19707];
[reduced NADPH---hemoprotein reductase] [CPD: C03024];
O2 [CPD: C00007]
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| Product |
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| Comment |
This cytochrome P-450 (heme-thiolate) enzyme from wild parsnip is involved in the formation of angular furanocoumarins. Attacks its substrate by syn-elimination of hydrogen from C-3'.
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| History |
EC 1.14.14.148 created 2010 as EC 1.14.13.115, transferred 2018 to EC 1.14.14.148
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| Orthology |
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| Reference |
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| Authors |
Larbat R, Hehn A, Hans J, Schneider S, Jugde H, Schneider B, Matern U, Bourgaud F. |
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| Title |
Isolation and functional characterization of CYP71AJ4 encoding for the first P450 monooxygenase of angular furanocoumarin biosynthesis. |
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| Journal |
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| Sequence |
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| Other DBs |
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