CYP71AJ4 (gene name)
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
(+)-columbianetin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
(+)-columbianetin + [reduced NADPH---hemoprotein reductase] + O2 = angelicin + [oxidized NADPH---hemoprotein reductase] + acetone + 2 H2O [RN:
[reduced NADPH---hemoprotein reductase] [CPD:
This cytochrome P-450 (heme-thiolate) enzyme from wild parsnip is involved in the formation of angular furanocoumarins. Attacks its substrate by syn-elimination of hydrogen from C-3'.
EC 184.108.40.206 created 2010 as EC 220.127.116.11, transferred 2018 to EC 18.104.22.168
ec00999 Biosynthesis of various plant secondary metabolites
ec01110 Biosynthesis of secondary metabolites
Larbat R, Hehn A, Hans J, Schneider S, Jugde H, Schneider B, Matern U, Bourgaud F
Isolation and functional characterization of CYP71AJ4 encoding for the first P450 monooxygenase of angular furanocoumarin biosynthesis.