KEGG   ENZYME: 1.14.14.148
Entry
EC 1.14.14.148              Enzyme                                 
Name
angelicin synthase;
CYP71AJ4 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
(+)-columbianetin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
(+)-columbianetin + [reduced NADPH---hemoprotein reductase] + O2 = angelicin + [oxidized NADPH---hemoprotein reductase] + acetone + 2 H2O [RN:R09002]
Reaction(KEGG)
R09002
Substrate
(+)-columbianetin [CPD:C19707];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
angelicin [CPD:C09060];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
acetone [CPD:C00207];
H2O [CPD:C00001]
Comment
This cytochrome P-450 (heme-thiolate) enzyme from wild parsnip is involved in the formation of angular furanocoumarins. Attacks its substrate by syn-elimination of hydrogen from C-3'.
History
EC 1.14.14.148 created 2010 as EC 1.14.13.115, transferred 2018 to EC 1.14.14.148
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01110  Biosynthesis of secondary metabolites
Orthology
K21715  angelicin synthase
Reference
1  [PMID:19098286]
  Authors
Larbat R, Hehn A, Hans J, Schneider S, Jugde H, Schneider B, Matern U, Bourgaud F
  Title
Isolation and functional characterization of CYP71AJ4 encoding for the first P450 monooxygenase of angular furanocoumarin biosynthesis.
  Journal
J Biol Chem 284:4776-85 (2009)
DOI:10.1074/jbc.M807351200
  Sequence
[ag:ABO84854]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.148
IUBMB Enzyme Nomenclature: 1.14.14.148
ExPASy - ENZYME nomenclature database: 1.14.14.148
BRENDA, the Enzyme Database: 1.14.14.148

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (6)   
   UniProt (5)   
   SWISS-PROT (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (4)   
   InterPro (4)   
All databases (27)   

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