Entry |
|
Name |
(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase;
SgcC
|
Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
|
Sysname |
(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2],FADH2:oxygen oxidoreductase (5-hydroxylating)
|
Reaction(IUBMB) |
(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] + FADH2 + O2 = (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] + FAD + H2O
|
Reaction(KEGG) |
|
Substrate |
(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2];
FADH2 [CPD: C01352];
O2 [CPD: C00007]
|
Product |
(3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2];
FAD [CPD: C00016];
H2O [CPD: C00001]
|
Comment |
The enzyme from the bacterium Streptomyces globisporus is involved in the biosynthesis of the (S)-3-chloro-5-hydroxy-beta-tyrosine moiety prior to incorporation into the chromoprotein antitumor antibiotic C-1027.
|
History |
EC 1.14.14.15 created 2014
|
Pathway |
ec01059 | Biosynthesis of enediyne antibiotics |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K21184 | two-component FAD-dependent monooxygenase |
|
Genes |
» show all
|
Reference |
|
Authors |
Lin S, Van Lanen SG, Shen B |
Title |
Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027. |
Journal |
|
Other DBs |
|