| Entry |
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| Name |
(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase;
SgcC
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
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| Sysname |
(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2],FADH2:oxygen oxidoreductase (5-hydroxylating)
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| Reaction(IUBMB) |
(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] + FADH2 + O2 = (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] + FAD + H2O
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| Reaction(KEGG) |
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| Substrate |
(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2];
FADH2 [CPD: C01352];
O2 [CPD: C00007]
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| Product |
(3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2];
FAD [CPD: C00016];
H2O [CPD: C00001]
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| Comment |
The enzyme from the bacterium Streptomyces globisporus is involved in the biosynthesis of the (S)-3-chloro-5-hydroxy-beta-tyrosine moiety prior to incorporation into the chromoprotein antitumor antibiotic C-1027.
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| History |
EC 1.14.14.15 created 2014
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| Pathway |
| ec01059 | Biosynthesis of enediyne antibiotics |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K21184 | two-component FAD-dependent monooxygenase |
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| Genes |
» show all
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| Reference |
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| Authors |
Lin S, Van Lanen SG, Shen B |
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| Title |
Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027. |
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| Journal |
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| Other DBs |
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