KEGG   ENZYME: 1.14.14.157
Entry
EC 1.14.14.157              Enzyme                                 

Name
indolin-2-one monooxygenase;
BX3 (gene name);
CYP71C2 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
indolin-2-one,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
indolin-2-one + [reduced NADPH---hemoprotein reductase] + O2 = 3-hydroxyindolin-2-one + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R07421]
Reaction(KEGG)
R07421
Substrate
indolin-2-one [CPD:C12312];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
3-hydroxyindolin-2-one [CPD:C11130];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses).
History
EC 1.14.14.157 created 2012 as EC 1.14.13.138, transferred 2018 to EC 1.14.14.157
Pathway
ec00402  Benzoxazinoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K13224  indolin-2-one monooxygenase
Genes
ATS: 109753201(LOC109753201)
ZMA: 103652724
Reference
1  [PMID:9235894]
  Authors
Frey M, Chomet P, Glawischnig E, Stettner C, Grun S, Winklmair A, Eisenreich W, Bacher A, Meeley RB, Briggs SP, Simcox K, Gierl A.
  Title
Analysis of a chemical plant defense mechanism in grasses.
  Journal
Science 277:696-9 (1997)
DOI:10.1126/science.277.5326.696
  Sequence
Reference
2  [PMID:10385992]
  Authors
Glawischnig E, Grun S, Frey M, Gierl A.
  Title
Cytochrome P450 monooxygenases of DIBOA biosynthesis: specificity and conservation among grasses.
  Journal
Phytochemistry 50:925-30 (1999)
DOI:10.1016/S0031-9422(98)00318-5
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.157
IUBMB Enzyme Nomenclature: 1.14.14.157
ExPASy - ENZYME nomenclature database: 1.14.14.157
BRENDA, the Enzyme Database: 1.14.14.157

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