KEGG   ENZYME: 1.14.14.164
Entry
EC 1.14.14.164              Enzyme                                 

Name
fraxetin 5-hydroxylase;
CYP82C4;
fraxetin 5-monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
fraxetin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (5-hydroxylating)
Reaction(IUBMB)
fraxetin + [reduced NADPH---hemoprotein reductase] + O2 = sideretin (reduced form) + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R12223]
Reaction(KEGG)
R12223
Substrate
fraxetin [CPD:C09265];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
sideretin [CPD:C22007];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein involved in biosynthesis of iron(III)-chelating coumarins in higher plants.
History
EC 1.14.14.164 created 2018
Orthology
K23136  fraxetin 5-hydroxylase
Genes
ATH: AT4G31940(CYP82C4)
ALY: 9303340
CRB: 17879967
CSAT: 104716994 104720023 104721639 104727626 104730082 104733184
BRP: 103835488
BNA: 106390013 106449600
BOE: 106333001
RSZ: 108821793
THJ: 104803692 104819460 104819461
CPAP: 110813494
CIT: 102608597
TCC: 18591293
GRA: 105769156
GAB: 108471489
GMX: 100811993
GSJ: 114408673
VRA: 106760470
VAR: 108342698
VUN: 114162602
CCAJ: 109802833
LJA: Lj1g3v1615300.1(Lj1g3v1615300.1)
ADU: 107460456
AIP: 107610187
LANG: 109343928
FVE: 105350002
PPER: 18789706
PMUM: 103320922
PAVI: 110762562
MDM: 103441505
PXB: 103954079
PEU: 105130198
JRE: 109010345
QSU: 112004233
VVI: 100247206
SLY: 101267593
SPEN: 107007174
SOT: 102581162
NSY: 104246870
NTO: 104094857
NAU: 109215771
INI: 109169781
OEU: 111381794
CCAV: 112511847
 » show all
Reference
1  [PMID:29581584]
  Authors
Rajniak J, Giehl RFH, Chang E, Murgia I, von Wiren N, Sattely ES
  Title
Biosynthesis of redox-active metabolites in response to iron deficiency in plants.
  Journal
Nat Chem Biol 14:442-450 (2018)
DOI:10.1038/s41589-018-0019-2
  Sequence
[ath:AT4G31940]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.164
IUBMB Enzyme Nomenclature: 1.14.14.164
ExPASy - ENZYME nomenclature database: 1.14.14.164
BRENDA, the Enzyme Database: 1.14.14.164

DBGET integrated database retrieval system