KEGG   ENZYME: 1.14.14.164
Entry
EC 1.14.14.164              Enzyme                                 
Name
fraxetin 5-hydroxylase;
CYP82C4;
fraxetin 5-monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
fraxetin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (5-hydroxylating)
Reaction(IUBMB)
fraxetin + [reduced NADPH---hemoprotein reductase] + O2 = sideretin (reduced form) + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R12223]
Reaction(KEGG)
R12223
Substrate
fraxetin [CPD:C09265];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
sideretin [CPD:C22007];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein involved in biosynthesis of iron(III)-chelating coumarins in higher plants.
History
EC 1.14.14.164 created 2018
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01110  Biosynthesis of secondary metabolites
Orthology
K23136  fraxetin 5-hydroxylase
Genes
ATHAT4G31940(CYP82C4)
ALY9303340
CRB17879967
CSAT104716994 104720023 104721639 104727626 104730082 104733184
BRP103835488
BNA106390013 106449600
BOE106333001
RSZ108821793
THJ104803692 104819460 104819461
CPAP110813494
CIT102608597
CICCICLE_v10003803mg
PVY116137768 116140031
MINC123228524
TCC18591293
GRA105769156
GHI107888141 107942681
GAB108471489
DZI111311379 111314823
GMX100811993
GSJ114408673
PVUPHAVU_009G061600g
VRA106760470
VAR108342698
VUN114162602
CCAJ109802833
APRC113865890
LJALj1g3v1615300.1(Lj1g3v1615300.1)
ADU107460456
AIP107610187
AHF112705794 112762412
LANG109343928
FVE105350002
PPER18789706
PMUM103320922
PAVI110762562
PDUL117615155
MDM103441505
PXB103954079
MNT112091840 21404129
RCU8260896 8260897 8260900
JCU105633709 105633710 105633711
HBR110661464 110661466
MESC110604432 110614589 110615124 110616234
POP112324075 18104964
PEU105130198
PALZ118034182 118034206 118036573
JRE109010345
QSU112004233
QLO115957904
TWL120000202
VVI100247206
VRI117907345
SLY101267593
SPEN107007174
SOT102581162
NTA107782393 107790829
NSY104246870
NTO104094857
NAU109215771
INI109169781
ITR116013393
OEU111381794
HAN110868438 110914130
ECAD122609547
LSV111876237 111876238 111893788
CCAV112511847
CSIN114289226 114302463 114311935 114311955
NNU104594945 104602643
MING122057355 122057456 122062028 122064336 122064730 122064731 122066479 122069348 122070247 122072865 122072912 122073149 122073602 122074394 122074395 122074740 122074750 122075296 122075812 122075964 122076219 122076251 122077292 122079511 122086196 122086257 122093030
TSS122638622 122643304 122643712 122645181 122645182 122645310 122645792 122645793 122645796 122645799 122645805 122646692 122648499 122648500 122648503 122650927 122654093 122654104 122654105 122655608 122665079 122665816 122669424 122669804 122669805 122669806 122672531 122672552
NCOL116245782 116245832 116245835 116245851 116245854 116245899 116245912 116248524 116249848 116249858 116249984 116249996 116250038 116250385 116252370 116252483 116253042 116253119 116253192 116253473 116253742
 » show all
Reference
1  [PMID:29581584]
  Authors
Rajniak J, Giehl RFH, Chang E, Murgia I, von Wiren N, Sattely ES
  Title
Biosynthesis of redox-active metabolites in response to iron deficiency in plants.
  Journal
Nat Chem Biol 14:442-450 (2018)
DOI:10.1038/s41589-018-0019-2
  Sequence
[ath:AT4G31940]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.164
IUBMB Enzyme Nomenclature: 1.14.14.164
ExPASy - ENZYME nomenclature database: 1.14.14.164
BRENDA, the Enzyme Database: 1.14.14.164

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