KEGG ENZYME: 1.14.14.177

ENZYME: 1.14.14.177

Entry

EC 1.14.14.177              Enzyme

Name

ultra-long-chain fatty acid omega-hydroxylase;
CYP4F22 (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

ultra-long-chain fatty acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating)

Reaction(IUBMB)

an ultra-long-chain fatty acid + [reduced NADPH---hemoprotein reductase] + O2 = an ultra-long-chain omega-hydroxy fatty acid + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R12714]

Reaction(KEGG)

R12714;
(other) R01348

Substrate

ultra-long-chain fatty acid [CPD:C22352];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

ultra-long-chain omega-hydroxy fatty acid [CPD:C22353];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

The enzyme, which is expressed in the epidermis of mammals, catalyses the omega-hydroxylation of ultra-long-chain fatty acids (C28 to C36). The products are incorporated into acylceramides, epidermis-specific ceramide species that are very important for skin barrier formation.

History

EC 1.14.14.177 created 2021

Orthology

K17731

ultra-long-chain fatty acid omega-hydroxylase

Genes

HSA:	126410(CYP4F22)

PTR:	455798(CYP4F22)

PPS:	100971205(CYP4F22)

GGO:

101151556

PON:

129047245

PPYG:

129020905

NLE:

100592034

HMH:

116479441

SSYN:

129460819

MCC:	718303(CYP4F22)

MCF:	102129679(CYP4F22)

MTHB:

126942250

MNI:

105494927

CSAB:

103234076

CATY:

105601613

PANU:

101005596

TGE:

112612736

MLEU:

105540093

RRO:

104661016

RBB:

108543269

TFN:

117075340

PTEH:

111554313

CANG:

105519769

CJC:	100410072(CYP4F22)

SBQ:

101041845

CIMI:

108296611(CYP4F22)

ANAN:

105720955(CYP4F22)

CSYR:

103250603

MMUR:

105867974

LCAT:

123636949

PCOQ:

105825070

OGA:

100941590

MMU:	320997(Cyp4f39)

MCAL:

110312353

MPAH:

110335465

RNO:	299566(Cyp4f39)

MCOC:

116076274

ANU:

117696585

ASYL:

127671098

MUN:

110548891

CGE:

100772743

MAUA:

101829834

PROB:

127216703

PLEU:

114680858 114686145

MORG:

121432418

MFOT:

126504037

AAMP:

119806238

NGI:

103731636

HGL:

101706763

CPOC:

100733171

CCAN:

109687417

DORD:

105994652

DSP:

122100278

PLOP:

125347709

NCAR:

124968484

MMMA:

107145299

ITI:

101977389

OCU:

100348443

OPI:

101531617

TUP:

102498037

GVR:

103593426

CFA:	484868(CYP4F22)

CLUD:

112666666

VVP:

112913282

VLG:

121496111

NPO:

129521795

AML:

100482288

UMR:

103677197

UAH:

113248705

UAR:

123779899

ELK:

111143780

LLV:

125083162

MPUF:

101694333

MNP:

132011114

MLK:

131823684

NVS:

122909645

ORO:

101376749

EJU:

114202205

ZCA:

113917645

MLX:

118004974

NSU:

110574475

LWW:

102736577

FCA:	101089989(CYP4F22)

PYU:

121010936

PCOO:

112852352

PBG:

122487039

PVIV:

125161112

LRUF:

124523008

LGF:

123605455

AJU:

106982933

PTG:

102972493

PPAD:

109247522

PUC:

125929160

PLEZ:

122214102

HHV:

120239207

BTA:	100301224(CYP4F22)

BOM:	102288122(CYP4F22)

BBUB:

102415308

BBIS:

104984324

CHX:

102187582

OAS:

101119041

BTAX:

128050613

CSUM:

138085374(CYP4F22)

ODA:

120864160

CCAD:

122440649

MREE:

136165589(CYP4F22)

OVR:	110129437(CYP4F22)

MBEZ:

129559305

SSC:

100620265

CFR:

102520014

CBAI:

105074543

CDK:

105105134

VPC:

102526262

BACU:

103020472

BMUS:

118892708

LVE:

103078959

OOR:

101284429

LALB:

132518639

DLE:

111166611

PCAD:

102976561

PSIU:

116751305

PPHC:

136120364(CYP4F22)

NASI:

112414746

ECB:

100063353

EPZ:

103542411

EAI:

106839062

MYB:

102257128

MYD:

102765481

MMYO:

118652610

MLF:

102435462

MDT:

132234885

MYUM:

139011070(CYP4F22)

PKL:

118706552

EFUS:

103300904

MNA:

107534292

DRO:

112305113

SHON:

118975149

AJM:

119046766

PDIC:

114502747

PHAS:

123828480

MMF:

118615230

PPAM:

129074804

HAI:

109376059

RFQ:

117038124

PALE:

102897561

PGIG:

120606480

PVP:

105308241

RAY:

107517207

MJV:

108408760

TOD:

119240021

SARA:

101546491

SFUM:

130028565

SETR:

126029431

LAV:

100671951

TMU:

101357406

ETF:

101639375

MDO:

100013319

GAS:

123232180

SHR:

100929206

AFZ:

127545029

PCW:

110196136

TVP:

118850704

PBRV:

138160315

OAA:

100074551

TACU:

119950323 119950536

GGA:	100859277(CYP4F22)

PCOC:

116238967

MGP:

100550430

CJO:

107307280

TPAI:

128079429

NMEL:

110391136

APLA:

119714246 119714247

ACYG:

106049439

CATA:

118261179

AFUL:

116500076

TGU:

100231824

LSR:

110482554

SCAN:

103825099

PMOA:

120504857

OTC:	121339056 121341065

PRUF:

121357893 121357895

GFR:

102031757

FAB:

101806213

OMA:

130262736

PHI:

102108727

CBRC:

103620402

ACOE:

138102163

ZAB:

102067691

ZLE:

135455287

HRT:

120764779

SATI:

136373142

CCIC:

134055738

FPG:

101922134

SHAB:

115603556

ACUN:

113490898

TALA:

116963276

ACHC:

115348254

HLE:

104832620

AGEN:

126043039

HHAR:

128147411

EGZ:

104124658

NNI:

104014974

CBOY:

140645137(CYP4F22)

CNIC:

136000931

CUCA:

104054259

OHA:

104334150

CVF:

104286919

RTD:

128901510

CRID:

134507983

AROW:

112960551

NPD:

112955235

TGT:

104565302

DNE:

112993054

SCAM:

104141227

ASN:	102374771 112547994

AMJ:	102576428(CYP4F22) 102577349

PSS:

102458909

CMY:

102938515

CCAY:

125629728

DCC:

119846113

CPIC:

101933864 101935523

CABI:

116828865

MRV:	120371021 120394703

ACS:	100554731 100561551 103282723

ASAO:

132768002 132768003

PVT:

110078023

SUND:

121920602

PBI:

103054301

PMUR:

107287120

CTIG:

120305080

TSR:

106539655

PGUT:

117677548

PCAE:

139313004(CYP4F22)

APRI:

131193242

VKO:

123019428

PMUA:

114587741

PRAF:

128405126

ZVI:

118097784

HCG:	128344529 128346015

GJA:

107105430

STOW:

125429351

EMC:

129345951

XLA:	100037244(cyp4f22.S) 100337565(cyp4f2.L) 108708312

XTR:	548527(cyp4f22) 548774(cyp4f2)

NPR:

108800222

RTEM:

120926886

ACAT:

141128280

BBUF:

120995350

BGAR:

122932433

DTC:

141086501

PWL:	138292020 138292023(CYP4F22)

MUO:

115466370

GSH:

117346462

LOC:

102682840

PSPA:

121304609

ARUT:

117409832 117966872

PSEX:

120541129

RTP:

109919110

CPLA:

122552154

HOC:

132836060

LERI:

129714465

HAKA:

140740187

PMRN:

116951902

LRJ:	133350370 133350979

BBEL:

109470784

ARUN:

117291864

AAMU:

139939897 139954209

AFIL:

140148136 140152295 140152296 140158149 140160512 140161836

PMAX:

117332832

AIRR:

138304922 138317630

RPHI:

132750777

MAEA:

128202792 128238713 128245687

RIE:	OCT59_000089

» show all

Reference

1 [PMID:26056268]

Authors

Ohno Y, Nakamichi S, Ohkuni A, Kamiyama N, Naoe A, Tsujimura H, Yokose U, Sugiura K, Ishikawa J, Akiyama M, Kihara A.

Title

Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation.

Journal

Proc Natl Acad Sci U S A 112:7707-12 (2015)
DOI:10.1073/pnas.1503491112

Other DBs

ExplorEnz - The Enzyme Database:

1.14.14.177

IUBMB Enzyme Nomenclature:

1.14.14.177

ExPASy - ENZYME nomenclature database:

1.14.14.177

BRENDA, the Enzyme Database:

1.14.14.177

All links

Gene (81)   
   MGENES (81)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (5)   
   InterPro (5)   
All databases (91)   

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