KEGG ENZYME: 1.14.14.177

ENZYME: 1.14.14.177

Entry

EC 1.14.14.177 Enzyme

Name

ultra-long-chain fatty acid omega-hydroxylase;
CYP4F22 (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

ultra-long-chain fatty acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating)

Reaction(IUBMB)

an ultra-long-chain fatty acid + [reduced NADPH---hemoprotein reductase] + O2 = an ultra-long-chain omega-hydroxy fatty acid + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R12714]

Reaction(KEGG)

R12714;
(other) R01348

Substrate

ultra-long-chain fatty acid [CPD:C22352];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

ultra-long-chain omega-hydroxy fatty acid [CPD:C22353];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

The enzyme, which is expressed in the epidermis of mammals, catalyses the omega-hydroxylation of ultra-long-chain fatty acids (C28 to C36). The products are incorporated into acylceramides, epidermis-specific ceramide species that are very important for skin barrier formation.

History

EC 1.14.14.177 created 2021

Orthology

K17731

ultra-long-chain fatty acid omega-hydroxylase

Genes

HSA:	126410(CYP4F22)

PTR:	455798(CYP4F22)

PPS:

GGO:

PON:

NLE:

MCC:	718303(CYP4F22)

MCF:

CSAB:

CATY:

RRO:

RBB:

TFN:

CJC:	100410072(CYP4F22)

SBQ:

101041845

MMUR:

105867974

MMU:	320997(Cyp4f39)

MCAL:

110312353

MPAH:

110335465

RNO:	299566(Cyp4f39)

MCOC:

MUN:

CGE:

PLEU:

NGI:

HGL:

CCAN:

OCU:

TUP:

CFA:	484868(CYP4F22)

VVP:

AML:

UMR:

UAH:

ORO:

ELK:

MPUF:

EJU:

FCA:

PTG:

PPAD:

AJU:

BTA:

BOM:

BBUB:

CHX:

OAS:

SSC:

CFR:

CDK:

BACU:

LVE:

OOR:

DLE:

PCAD:

ECB:

EPZ:

EAI:

MYB:

MYD:

MMYO:

MNA:

HAI:

DRO:

SHON:

AJM:

MMF:

PALE:

RAY:

MJV:

LAV:

TMU:

MDO:

SHR:

PCW:

OAA:

GGA:	100859277(CYP4F22)

MGP:

CJO:

NMEL:

ACYG:

TGU:

LSR:

SCAN:

FAB:

PHI:

FPG:

EGZ:

NNI:

ACUN:

ASN:	102374771 112547994

AMJ:	102576428(CYP4F22) 102577349

PSS:

102458909

CMY:

102938515

CPIC:

101933864 101935523

ACS:	100554731 100561551 103282723

PVT:

PBI:

PMUR:

TSR:

PMUA:

GJA:

XLA:	100037244(cyp4f22.S) 100337565(cyp4f2.L) 108708312

XTR:	548527(cyp4f22) 548774(cyp4f2)

NPR:

108800222

» show all

Reference

1 [PMID:26056268]

Authors

Ohno Y, Nakamichi S, Ohkuni A, Kamiyama N, Naoe A, Tsujimura H, Yokose U, Sugiura K, Ishikawa J, Akiyama M, Kihara A.

Title

Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation.

Journal

Proc Natl Acad Sci U S A 112:7707-12 (2015)
DOI:10.1073/pnas.1503491112

Other DBs

ExplorEnz - The Enzyme Database:

1.14.14.177

IUBMB Enzyme Nomenclature:

1.14.14.177

ExPASy - ENZYME nomenclature database:

1.14.14.177

BRENDA, the Enzyme Database:

1.14.14.177

All links

Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (2)   
   KEGG REACTION (2)   
Gene (105)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (104)   
All databases (115)   

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