KEGG   ENZYME: 1.14.14.177
Entry
EC 1.14.14.177              Enzyme                                 

Name
ultra-long-chain fatty acid omega-hydroxylase;
CYP4F22 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
ultra-long-chain fatty acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating)
Reaction(IUBMB)
an ultra-long-chain fatty acid + [reduced NADPH---hemoprotein reductase] + O2 = an ultra-long-chain omega-hydroxy fatty acid + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R12714]
Reaction(KEGG)
R12714;
(other) R01348
Substrate
ultra-long-chain fatty acid [CPD:C22352];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
ultra-long-chain omega-hydroxy fatty acid [CPD:C22353];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
The enzyme, which is expressed in the epidermis of mammals, catalyses the omega-hydroxylation of ultra-long-chain fatty acids (C28 to C36). The products are incorporated into acylceramides, epidermis-specific ceramide species that are very important for skin barrier formation.
History
EC 1.14.14.177 created 2021
Orthology
K17731  ultra-long-chain fatty acid omega-hydroxylase
Genes
HSA: 126410(CYP4F22)
PTR: 455798(CYP4F22)
PPS: 100971205
GGO: 101151556
PON: 100459609
NLE: 100592034
MCC: 718303(CYP4F22)
MCF: 102129679
CSAB: 103234076
CATY: 105601613
RRO: 104661016
RBB: 108543269
TFN: 117075340
CJC: 100410072(CYP4F22)
SBQ: 101041845
MMUR: 105867974
MMU: 320997(Cyp4f39)
MCAL: 110312353
MPAH: 110335465
RNO: 299566(Cyp4f39)
MCOC: 116076274
MUN: 110548891
CGE: 100772743
NGI: 103731636
HGL: 101706763
CCAN: 109687417
OCU: 100348443
TUP: 102498037
CFA: 484868(CYP4F22)
VVP: 112913282
AML: 100482288
UMR: 103677197
UAH: 113248705
ORO: 101376749
ELK: 111143780
MPUF: 101694333
EJU: 114202205
FCA: 101089989
PTG: 102972493
PPAD: 109247522
AJU: 106982933
BTA: 100301224
BOM: 102288122
BBUB: 102415308
CHX: 102187582
OAS: 101119041
SSC: 100620265
CFR: 102520014
CDK: 105105134
BACU: 103020472
LVE: 103078959
OOR: 101284429
DLE: 111166611
PCAD: 102976561
ECB: 100063353
EPZ: 103542411
EAI: 106839062
MYB: 102257128
MYD: 102765481
MMYO: 118652610
MNA: 107534292
HAI: 109376059
DRO: 112305113
SHON: 118975149
AJM: 119046766
MMF: 118615230
PALE: 102897561
RAY: 107517207
MJV: 108408760
LAV: 100671951
TMU: 101357406
MDO: 100013319
SHR: 100929206
PCW: 110196136
OAA: 100074551
GGA: 100859277(CYP4F22)
MGP: 100550430
CJO: 107307280
NMEL: 110391136
ACYG: 106049439
TGU: 100231824
LSR: 110482554
SCAN: 103825099
FAB: 101806213
PHI: 102108727
FPG: 101922134
EGZ: 104124658
NNI: 104014974
ACUN: 113490898
AMJ: 102576428(CYP4F22) 102577349
PSS: 102458909
CMY: 102938515
PVT: 110078023
PBI: 103054301
PMUR: 107287120
TSR: 106539655
PMUA: 114587741
GJA: 107105430
XLA: 100037244(cyp4f22.S) 100337565(cyp4f2.L) 108708312
XTR: 548527(cyp4f22) 548774(cyp4f2)
NPR: 108800222
 » show all
Reference
1  [PMID:26056268]
  Authors
Ohno Y, Nakamichi S, Ohkuni A, Kamiyama N, Naoe A, Tsujimura H, Yokose U, Sugiura K, Ishikawa J, Akiyama M, Kihara A.
  Title
Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation.
  Journal
Proc Natl Acad Sci U S A 112:7707-12 (2015)
DOI:10.1073/pnas.1503491112
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.177
IUBMB Enzyme Nomenclature: 1.14.14.177
ExPASy - ENZYME nomenclature database: 1.14.14.177
BRENDA, the Enzyme Database: 1.14.14.177

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