KEGG   ENZYME: 1.14.14.177
Entry
EC 1.14.14.177              Enzyme                                 
Name
ultra-long-chain fatty acid omega-hydroxylase;
CYP4F22 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
ultra-long-chain fatty acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating)
Reaction(IUBMB)
an ultra-long-chain fatty acid + [reduced NADPH---hemoprotein reductase] + O2 = an ultra-long-chain omega-hydroxy fatty acid + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R12714]
Reaction(KEGG)
R12714;
(other) R01348
Substrate
ultra-long-chain fatty acid [CPD:C22352];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
ultra-long-chain omega-hydroxy fatty acid [CPD:C22353];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
The enzyme, which is expressed in the epidermis of mammals, catalyses the omega-hydroxylation of ultra-long-chain fatty acids (C28 to C36). The products are incorporated into acylceramides, epidermis-specific ceramide species that are very important for skin barrier formation.
History
EC 1.14.14.177 created 2021
Orthology
K17731  ultra-long-chain fatty acid omega-hydroxylase
Genes
HSA126410(CYP4F22)
PTR455798(CYP4F22)
PPS100971205(CYP4F22)
GGO101151556
PON100459609
NLE100592034
MCC718303(CYP4F22)
MCF102129679(CYP4F22)
CSAB103234076
CATY105601613
PANU101005596
TGE112612736
RRO104661016
RBB108543269
TFN117075340
PTEH111554313
CJC100410072(CYP4F22)
SBQ101041845
CSYR103250603
MMUR105867974
OGA100941590
MMU320997(Cyp4f39)
MCAL110312353
MPAH110335465
RNO299566(Cyp4f39)
MCOC116076274
MUN110548891
CGE100772743
PLEU114680858 114686145
NGI103731636
HGL101706763
CPOC100733171
CCAN109687417
DORD105994652
DSP122100278
NCAR124968484
OCU100348443
OPI101531617
TUP102498037
CFA484868(CYP4F22)
VVP112913282
VLG121496111
AML100482288
UMR103677197
UAH113248705
UAR123779899
ELK111143780
LLV125083162
MPUF101694333
ORO101376749
EJU114202205
ZCA113917645
MLX118004974
FCA101089989
PYU121010936
PBG122487039
PTG102972493
PPAD109247522
AJU106982933
HHV120239207
BTA100301224
BOM102288122
BBUB102415308
CHX102187582
OAS101119041
ODA120864160
CCAD122440649
SSC100620265
CFR102520014
CBAI105074543
CDK105105134
VPC102526262
BACU103020472
LVE103078959
OOR101284429
DLE111166611
PCAD102976561
PSIU116751305
ECB100063353
EPZ103542411
EAI106839062
MYB102257128
MYD102765481
MMYO118652610
MLF102435462
MNA107534292
PKL118706552
HAI109376059
DRO112305113
SHON118975149
AJM119046766
PDIC114502747
PHAS123828480
MMF118615230
RFQ117038124
PALE102897561
PGIG120606480
PVP105308241
RAY107517207
MJV108408760
TOD119240021
SARA101546491
LAV100671951
TMU101357406
MDO100013319
GAS123232180
SHR100929206
PCW110196136
OAA100074551
GGA100859277(CYP4F22)
PCOC116238967
MGP100550430
CJO107307280
NMEL110391136
ACYG106049439
AFUL116500076
TGU100231824
LSR110482554
SCAN103825099
PMOA120504857
OTC121339056 121341065
PRUF121357893 121357895
GFR102031757
FAB101806213
PHI102108727
ZAB102067691
FPG101922134
EGZ104124658
NNI104014974
ACUN113490898
TALA116963276
ACHC115348254
AROW112960551
NPD112955235
DNE112993054
ASN102374771 112547994
AMJ102576428(CYP4F22) 102577349
PSS102458909
CMY102938515
CPIC101933864 101935523
CABI116828865
MRV120371021 120394703
ACS100554731 100561551 103282723
PVT110078023
SUND121920602
PBI103054301
PMUR107287120
TSR106539655
PGUT117677548
VKO123019428
PMUA114587741
ZVI118097784
GJA107105430
STOW125429351
XLA100037244(cyp4f22.S) 100337565(cyp4f2.L) 108708312
XTR548527(cyp4f22) 548774(cyp4f2)
NPR108800222
RTEM120926886
BBUF120995350
BGAR122932433
AANG118220863
LOC102682840
PSPA121304609
ARUT117409832 117966872
BBEL109470784
HRF124110794
HRJ124265616 124266010
PMAX117332832
 » show all
Reference
1  [PMID:26056268]
  Authors
Ohno Y, Nakamichi S, Ohkuni A, Kamiyama N, Naoe A, Tsujimura H, Yokose U, Sugiura K, Ishikawa J, Akiyama M, Kihara A.
  Title
Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation.
  Journal
Proc Natl Acad Sci U S A 112:7707-12 (2015)
DOI:10.1073/pnas.1503491112
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.177
IUBMB Enzyme Nomenclature: 1.14.14.177
ExPASy - ENZYME nomenclature database: 1.14.14.177
BRENDA, the Enzyme Database: 1.14.14.177

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