EC               Enzyme                                 

heme oxygenase (biliverdin-producing);
ORP33 proteins;
haem oxygenase (ambiguous);
heme oxygenase (decyclizing) (ambiguous);
heme oxidase (ambiguous);
haem oxidase (ambiguous);
heme oxygenase (ambiguous);
heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
protoheme,NADPH---hemoprotein reductase:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
protoheme + 3 [reduced NADPH---hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH---hemoprotein reductase] + 3 H2O [RN:R00311]
protoheme [CPD:C00032];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
biliverdin [CPD:C00500];
Fe2+ [CPD:C14818];
CO [CPD:C00237];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
This mammalian enzyme participates in the degradation of heme. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules [4]. The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. The enzyme requires NAD(P)H and EC, NADPH---hemoprotein reductase. cf. EC, heme oxygenase (biliverdin-producing, ferredoxin).
EC created 1972 as EC, modified 2006, transferred 2015 to EC, modified 2016
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
K00510  heme oxygenase 1
K21418  heme oxygenase 2
HSA: 3162(HMOX1) 3163(HMOX2)
PTR: 453880(HMOX2) 470195(HMOX1)
PPS: 100977821(HMOX1) 100995961(HMOX2)
GGO: 101149599(HMOX2) 101152785(HMOX1)
PON: 100173339(HMOX1) 100451286(HMOX2)
NLE: 100587046(HMOX1) 100599593(HMOX2)
MCC: 705461(HMOX2) 719266(HMOX1)
MCF: 101926565(HMOX1) 102143766(HMOX2)
CSAB: 103223230(HMOX1) 103227650(HMOX2)
RRO: 104654687(HMOX2) 104682468(HMOX1)
RBB: 108538293(HMOX2) 108540867(HMOX1)
CJC: 100395145(HMOX2) 100405992 100414343(HMOX1)
SBQ: 101039608(HMOX1) 101053852(HMOX2)
MMU: 15368(Hmox1) 15369(Hmox2)
RNO: 24451(Hmox1) 79239(Hmox2)
CGE: 100756872(Hmox1) 100773727(Hmox2)
NGI: 103742105(Hmox1) 103744546(Hmox2)
HGL: 101708868(Hmox1) 101718879(Hmox2)
CCAN: 109692950(Hmox1) 109694248(Hmox2)
OCU: 100008919(HMOX1) 100009523(HMOX2)
TUP: 102472031(HMOX2) 102485781(HMOX1)
CFA: 442987(HMOX1) 479864(HMOX2)
AML: 100472787(HMOX2) 100479189(HMOX1)
UMR: 103668554(HMOX2) 103676557(HMOX1)
ORO: 101364369(HMOX1) 101367073(HMOX2)
FCA: 101092621(HMOX1) 101093823(HMOX2)
PTG: 102948800(HMOX1) 102960470(HMOX2)
AJU: 106978811(HMOX2) 106981079(HMOX1)
BTA: 510243(HMOX2) 513221(HMOX1)
BOM: 102274047(HMOX2) 102281265(HMOX1)
BIU: 109559493(HMOX1) 109578491(HMOX2)
PHD: 102322748(HMOX2) 102333615(HMOX1)
CHX: 100860951(HMOX1) 102189453(HMOX2)
OAS: 101102279(HMOX2) 101120910(HMOX1)
SSC: 396622(HMOX2) 445512(HMOX1)
CFR: 102503731(HMOX2) 102505023(HMOX1)
CDK: 105097386(HMOX1) 105099820(HMOX2)
BACU: 103012514(HMOX2) 103018426(HMOX1)
LVE: 103077914(HMOX1) 103090745(HMOX2)
OOR: 101279301(HMOX2) 101282134(HMOX1)
ECB: 100066114(HMOX2) 100069058(HMOX1)
EPZ: 103543240(HMOX1) 103553961(HMOX2)
EAI: 106825719(HMOX1) 106826005(HMOX2)
MYB: 102248030(HMOX1) 102253515(HMOX2)
MYD: 102764042(HMOX2) 102767690(HMOX1)
HAI: 109377639(HMOX1) 109392113(HMOX2)
RSS: 109445766(HMOX1) 109460746(HMOX2)
PALE: 102880347(HMOX1) 102882902(HMOX2)
LAV: 100662132(HMOX2) 100673521(HMOX1)
MDO: 100019502(HMOX2) 100024355(HMOX1) 100030714
SHR: 100925365(HMOX1) 100928954(HMOX2)
OAA: 100078850(HMOX2) 107547784(HMOX1)
GGA: 396287(HMOX1) 416663(HMOX2)
MGP: 100541778(HMOX2) 100551243(HMOX1)
CJO: 107314345(HMOX1) 107320929(HMOX2)
APLA: 101801310(HMOX2) 101805057(HMOX1)
ACYG: 106033412(HMOX2) 106035937(HMOX1)
TGU: 100190323(HMOX2) 100226348(HMOX1)
GFR: 102032618(HMOX2) 102043181(HMOX1)
FAB: 101817237(HMOX2) 101817317(HMOX1)
PHI: 102101610(HMOX1) 102104458(HMOX2)
PMAJ: 107205203(HMOX1) 107211143(HMOX2)
CCW: 104684958(HMOX2) 104696269(HMOX1)
FPG: 101915244(HMOX1) 101921302(HMOX2)
FCH: 102047339(HMOX2) 102055466(HMOX1)
CLV: 102084894(HMOX1) 106145636(HMOX2)
EGZ: 104121977(HMOX2) 104134285(HMOX1)
AAM: 106482411(HMOX2) 106488415(HMOX1)
ASN: 102368811(HMOX2) 102373399(HMOX1)
AMJ: 102573866(HMOX1) 102575746(HMOX2)
PSS: 102446230(HMOX2) 102462727(HMOX1)
CMY: 102940527(HMOX1) 102942411(HMOX2)
CPIC: 101931937(HMOX2) 101950994(HMOX1)
ACS: 100555210(hmox1)
PVT: 110075944(HMOX1) 110089101(HMOX2)
PBI: 103054508(HMOX2) 103065892(HMOX1)
GJA: 107109317(HMOX2) 107109423(HMOX1)
XLA: 398965(hmox1.S) 444101(hmox2.L) 734976(hmox1.L)
XTR: 100488303(hmox1) 780096(hmox2)
NPR: 108793696(HMOX1) 108796525(HMOX2)
DRE: 100002875(hmox2a) 100329531(hmox2b) 402970(hmox1b) 791518(hmox1a)
IPU: 100528875(hmox) 108272923 108272926 108276515(hmox2) 108278324(hmox1)
AMEX: 103022889 103032679(hmox2) 103044464(hmox1)
TRU: 101070079(hmox1) 101074254(hmox2)
NFU: 107376240(hmox1) 107376482(hmox2) 107382233
CSEM: 103393059(hmox2) 103393699(hmox1)
BPEC: 110167460(hmox2) 110172090(hmox1) 110172617
ELS: 105006006 105012149(hmox) 105013172(hmox1)
SFM: 108928847(hmox2) 108939753
LCM: 102354266(HMOX1) 102360501(HMOX2)
CMK: 103178752(hmox2) 103189669
CIN: 100185311
DME: Dmel_CG14716(Ho)
DSI: Dsimw501_GD18775(Dsim_GD18775)
MDE: 101894027
AAG: 5570153
AME: 494506(Ho)
BIM: 100743864
BTER: 100651999
SOC: 105203060
AEC: 105154734
ACEP: 105626739
CFO: 105251022
LHU: 105671105
PGC: 109860607
NVI: 100115195(Ho)
BMOR: 732895
PMAC: 106711006
PRAP: 110995109
API: 100162545
DNX: 107163196
ZNE: 110831500
OBI: 106879648
ADF: 107331736
 » show all
1  [PMID:18477]
Maines MD, Ibrahim NG, Kappas A.
Solubilization and partial purification of heme oxygenase from rat liver.
J Biol Chem 252:5900-3 (1977)
2  [PMID:6897023]
Sunderman FW Jr, Downs JR, Reid MC, Bibeau LM.
Gas-chromatographic assay for heme oxygenase activity.
Clin Chem 28:2026-32 (1982)
3  [PMID:4370250]
Yoshida T, Takahashi S, Kikuchi G.
Partial purification and reconstitution of the heme oxygenase system from pig spleen microsomes.
J Biochem (Tokyo) 75:1187-91 (1974)
4  [PMID:105935]
Noguchi M, Yoshida T, Kikuchi G.
Specific requirement of NADPH-cytochrome c reductase for the microsomal heme oxygenase reaction yielding biliverdin IX alpha.
FEBS Lett 98:281-4 (1979)
5  [PMID:12500973]
Lad L, Schuller DJ, Shimizu H, Friedman J, Li H, Ortiz de Montellano PR, Poulos TL.
Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1.
J Biol Chem 278:7834-43 (2003)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 9059-22-7

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