EC               Enzyme                                 

heme oxygenase (biliverdin-producing);
ORP33 proteins;
haem oxygenase (ambiguous);
heme oxygenase (decyclizing) (ambiguous);
heme oxidase (ambiguous);
haem oxidase (ambiguous);
heme oxygenase (ambiguous);
heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
protoheme,NADPH---hemoprotein reductase:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
protoheme + 3 [reduced NADPH---hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH---hemoprotein reductase] + 3 H2O [RN:R00311]
protoheme [CPD:C00032];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
biliverdin [CPD:C00500];
Fe2+ [CPD:C14818];
CO [CPD:C00237];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
This mammalian enzyme participates in the degradation of heme. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules [4]. The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. The enzyme requires NAD(P)H and EC, NADPH---hemoprotein reductase. cf. EC, heme oxygenase (biliverdin-producing, ferredoxin).
EC created 1972 as EC, modified 2006, transferred 2015 to EC, modified 2016
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
K00510  heme oxygenase 1
K21418  heme oxygenase 2
HSA: 3162(HMOX1) 3163(HMOX2)
PTR: 453880(HMOX2) 470195(HMOX1)
PPS: 100977821(HMOX1) 100995961(HMOX2)
GGO: 101149599(HMOX2) 101152785(HMOX1)
PON: 100173339(HMOX1) 100451286(HMOX2)
NLE: 100587046(HMOX1) 100599593(HMOX2)
MCC: 705461(HMOX2) 719266(HMOX1)
MCF: 101926565(HMOX1) 102143766(HMOX2)
CSAB: 103223230(HMOX1) 103227650(HMOX2)
CATY: 105572109(HMOX2) 105575783(HMOX1)
PANU: 100999853(HMOX1) 101007549(HMOX2)
RRO: 104654687(HMOX2) 104682468(HMOX1) 115895303
RBB: 108538293(HMOX2) 108540867(HMOX1)
TFN: 117095936(HMOX1) 117097713(HMOX2)
PTEH: 111549064(HMOX1) 111551702(HMOX2)
CJC: 100395145(HMOX2) 100405992 100414343(HMOX1)
SBQ: 101039608(HMOX1) 101053852(HMOX2)
MMUR: 105859706(HMOX2) 105883699(HMOX1)
MMU: 15368(Hmox1) 15369(Hmox2)
MCAL: 110300233(Hmox1) 110311757(Hmox2)
MPAH: 110329550(Hmox2) 110336229(Hmox1)
RNO: 24451(Hmox1) 79239(Hmox2)
MCOC: 116069585(Hmox1) 116084296(Hmox2)
MUN: 110545942(Hmox2) 110560720(Hmox1)
CGE: 100756872(Hmox1) 100773727(Hmox2)
PLEU: 114681400(Hmox1) 114710646(Hmox2)
NGI: 103742105(Hmox1) 103744546(Hmox2)
HGL: 101708868(Hmox1) 101718879(Hmox2)
CCAN: 109692950(Hmox1) 109694248(Hmox2)
OCU: 100008919(HMOX1) 100009523(HMOX2)
TUP: 102472031(HMOX2) 102485781(HMOX1)
CFA: 442987(HMOX1) 479864(HMOX2)
VVP: 112923276(HMOX2) 112929075(HMOX1)
VLG: 121486510(HMOX2) 121492112(HMOX1)
AML: 100472787(HMOX2) 100479189(HMOX1)
UMR: 103668554(HMOX2) 103676557(HMOX1)
UAH: 113256008(HMOX1) 113270845(HMOX2)
ORO: 101364369(HMOX1) 101367073(HMOX2)
MPUF: 101674208(HMOX2) 101685452(HMOX1)
EJU: 114197513(HMOX1) 114219917(HMOX2)
MLX: 117998752(HMOX1) 118021788(HMOX2)
FCA: 101092621(HMOX1) 101093823(HMOX2)
PTG: 102948800(HMOX1) 102960470(HMOX2)
PPAD: 109265494(HMOX1) 109278264(HMOX2)
AJU: 106978811(HMOX2) 106981079(HMOX1)
HHV: 120230746(HMOX1) 120236449(HMOX2)
BTA: 510243(HMOX2) 513221(HMOX1)
BOM: 102274047(HMOX2) 102281265(HMOX1)
BIU: 109559493(HMOX1) 109578491(HMOX2)
BBUB: 102408288(HMOX2) 102414425(HMOX1)
CHX: 100860951(HMOX1) 102189453(HMOX2)
OAS: 101102279(HMOX2) 101120910(HMOX1)
ODA: 120858594(HMOX1) 120874472(HMOX2)
SSC: 396622(HMOX2) 445512(HMOX1)
CFR: 102503731(HMOX2) 102505023(HMOX1)
CDK: 105097386(HMOX1) 105099820(HMOX2)
BACU: 103012514(HMOX2) 103018426(HMOX1)
LVE: 103077914(HMOX1) 103090745(HMOX2)
OOR: 101279301(HMOX2) 101282134(HMOX1)
DLE: 111185258(HMOX2) 111187883(HMOX1)
PCAD: 102976084(HMOX1) 102987384(HMOX2)
ECB: 100066114(HMOX2) 100069058(HMOX1)
EPZ: 103543240(HMOX1) 103553961(HMOX2)
EAI: 106825719(HMOX1) 106826005(HMOX2)
MYB: 102248030(HMOX1) 102253515(HMOX2)
MYD: 102764042(HMOX2) 102767690(HMOX1)
MMYO: 118650992(HMOX1) 118655950(HMOX2)
MNA: 107538275(HMOX2) 107545379(HMOX1)
HAI: 109377639(HMOX1) 109392113(HMOX2)
DRO: 112298373(HMOX2) 112321737(HMOX1)
SHON: 118975814(HMOX2) 119002348(HMOX1)
MMF: 118624557(HMOX1) 118641450(HMOX2)
PALE: 102880347(HMOX1) 102882902(HMOX2)
RAY: 107519297(HMOX1) 107521676(HMOX2)
MJV: 108399932(HMOX2) 108401565(HMOX1)
LAV: 100662132(HMOX2) 100673521(HMOX1)
MDO: 100019502(HMOX2) 100024355(HMOX1) 100030714
SHR: 100925365(HMOX1) 100928954(HMOX2)
PCW: 110202456(HMOX2) 110205714(HMOX1)
OAA: 100078850(HMOX2) 107547784(HMOX1)
GGA: 396287(HMOX1) 416663(HMOX2)
PCOC: 116230244(HMOX2) 116233287(HMOX1)
MGP: 100541778(HMOX2) 100551243(HMOX1)
CJO: 107314345(HMOX1) 107320929(HMOX2)
NMEL: 110393409(HMOX1) 110405969(HMOX2)
APLA: 101805057(HMOX1)
ACYG: 106033412(HMOX2) 106035937(HMOX1)
TGU: 100190323(HMOX2) 100226348(HMOX1)
LSR: 110476111(HMOX2) 110483841(HMOX1)
SCAN: 103813211(HMOX1) 103817760(HMOX2)
PMOA: 120510044(HMOX1) 120513305(HMOX2)
GFR: 102032618(HMOX2) 102043181(HMOX1)
FAB: 101817237(HMOX2) 101817317(HMOX1)
PHI: 102101610(HMOX1) 102104458(HMOX2)
PMAJ: 107205203(HMOX1) 107211143(HMOX2)
CCAE: 111935629(HMOX1) 111935886(HMOX2)
CCW: 104684958(HMOX2) 104696269(HMOX1)
ETL: 114055441(HMOX1) 114057016(HMOX2)
FPG: 101915244(HMOX1) 101921302(HMOX2)
FCH: 102047339(HMOX2) 102055466(HMOX1)
CLV: 102084894(HMOX1) 106145636(HMOX2)
EGZ: 104121977(HMOX2) 104134285(HMOX1)
NNI: 104021567(HMOX1) 104023461(HMOX2)
ACUN: 113485489(HMOX2) 113491611(HMOX1)
PADL: 103917531(HMOX2) 103924129(HMOX1)
AAM: 106482411(HMOX2) 106488415(HMOX1)
ASN: 102368811(HMOX2) 102373399(HMOX1)
AMJ: 102573866(HMOX1) 102575746(HMOX2)
CPOO: 109313453(HMOX2) 109316609(HMOX1)
GGN: 109290779(HMOX2) 109296079(HMOX1)
PSS: 102446230(HMOX2) 102462727(HMOX1)
CMY: 102940527(HMOX1) 102942411(HMOX2)
CPIC: 101931937(HMOX2) 101950994(HMOX1)
TST: 117881059(HMOX1) 117883718(HMOX2)
CABI: 116821576(HMOX1) 116825526(HMOX2)
ACS: 100555210(hmox1)
PVT: 110075944(HMOX1) 110089101(HMOX2)
PBI: 103054508(HMOX2) 103065892(HMOX1)
PMUR: 107283999(HMOX2) 107302627(HMOX1)
TSR: 106538506(HMOX1) 106556179(HMOX2)
PGUT: 117655382(HMOX1) 117679461(HMOX2)
PMUA: 114584030(HMOX2) 114605138(HMOX1)
ZVI: 118091347(HMOX1) 118093247(HMOX2)
GJA: 107109317(HMOX2) 107109423(HMOX1)
XLA: 398965(hmox1.S) 444101(hmox2.S) 734976(hmox1.L)
XTR: 100488303(hmox1) 780096(hmox2)
NPR: 108793696(HMOX1) 108796525(HMOX2)
DRE: 100002875(hmox2a) 100329531(hmox2b) 402970(hmox1b) 791518(hmox1a)
IPU: 100528875(hmox) 108272923 108272926 108276515(hmox2) 108278324(hmox1)
AMEX: 103022889 103032679(hmox2) 103044464(hmox1) 107197269
TRU: 101070079(hmox1) 101074254(hmox2)
ELY: 117254792(hmox2a) 117254844 117268891(hmox1a) 117268981(hmox2b)
PLEP: 121942196 121942351(hmox2a) 121956113(hmox1a) 121956313(hmox2b)
SLUC: 116040474 116059383(hmox2b) 116065467(hmox1a)
ECRA: 117936833 117957948(hmox1a) 117958131(hmox2b)
GAT: 120825069 120827581(hmox2b) 120828368(hmox1a)
CUD: 121503487(hmox2b) 121507955(hmox2a) 121508506 121529147(hmox1a)
OAU: 116310603(hmox2a) 116321400 116321440(hmox2b) 116326933(hmox1a)
OML: 112137078(hmox2a) 112146201(hmox2b) 112146994(hmox1a) 112157371
NFU: 107376240(hmox1) 107376482(hmox2) 107382233
KMR: 108236044(hmox1a) 108241505(hmox2a) 108244335 108247647(hmox2b)
CSEM: 103393059(hmox2) 103393699(hmox1)
XGL: 120788210(hmox1a) 120788230(hmox2b) 120799982(hmox2a) 120800607
BPEC: 110167460(hmox2) 110172090(hmox1) 110172617
ELS: 105006006 105012149(hmox) 105013172(hmox1)
SFM: 108928847(hmox2) 108939753
PKI: 111833488 111843261(hmox2)
LOC: 102694370(hmox2)
ARUT: 117418388(hmox2b) 117973711
LCM: 102354266(HMOX1) 102360501(HMOX2)
CMK: 103178752(hmox2) 103189669
RTP: 109926307 109928649(hmox2)
CIN: 100185311
DME: Dmel_CG14716(Ho)
DER: 6553971
DSE: 6606790
DSI: Dsimw501_GD18775(Dsim_GD18775)
DAN: 6501165
DSR: 110186867
DPE: 6594156
DWI: 6647136
DAZ: 108621706
DNV: 108659698
DHE: 111592007
DVI: 6632771
MDE: 101894027
LCQ: 111689597
ACOZ: 120961725
AARA: 120901430
AAG: 5570153
AME: 494506(Ho)
ACER: 107998426
BIM: 100743864
BTER: 100651999
CCAL: 108631636
MGEN: 117224328
NMEA: 116426858
CGIG: 122396484
SOC: 105203060
MPHA: 105833395
AEC: 105154734
ACEP: 105626739
PBAR: 105430072
VEM: 105564337
HST: 105185077
CFO: 105251022
LHU: 105671105
PGC: 109860607
OBO: 105281038
PCF: 106792852
NVI: 100115195(Ho)
CSOL: 105363178
MDL: 106694308
BMOR: 732895
BMAN: 114243382
MSEX: 115453211
BANY: 112046875
PMAC: 106711006
PPOT: 106103216
PXU: 106118624
PRAP: 110995109
ZCE: 119836687
HAW: 110382722
TNL: 113499275
API: 100162545
DNX: 107163196
AGS: 114130339
RMD: 113555527
BTAB: 109032218
CLEC: 106666447
ZNE: 110831500
CSEC: 111863330
FCD: 110851554
PVM: 113823598
HAME: 121870245
EAF: 111704909
OBI: 106879648
ATEN: 116298139
 » show all
1  [PMID:18477]
Maines MD, Ibrahim NG, Kappas A.
Solubilization and partial purification of heme oxygenase from rat liver.
J Biol Chem 252:5900-3 (1977)
2  [PMID:6897023]
Sunderman FW Jr, Downs JR, Reid MC, Bibeau LM.
Gas-chromatographic assay for heme oxygenase activity.
Clin Chem 28:2026-32 (1982)
3  [PMID:4370250]
Yoshida T, Takahashi S, Kikuchi G.
Partial purification and reconstitution of the heme oxygenase system from pig spleen microsomes.
J Biochem (Tokyo) 75:1187-91 (1974)
4  [PMID:105935]
Noguchi M, Yoshida T, Kikuchi G.
Specific requirement of NADPH-cytochrome c reductase for the microsomal heme oxygenase reaction yielding biliverdin IX alpha.
FEBS Lett 98:281-4 (1979)
5  [PMID:12500973]
Lad L, Schuller DJ, Shimizu H, Friedman J, Li H, Ortiz de Montellano PR, Poulos TL.
Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1.
J Biol Chem 278:7834-43 (2003)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 9059-22-7

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