KEGG   ENZYME: 1.14.14.189
Entry
EC 1.14.14.189              Enzyme                                 
Name
strychnine 10-hydroxylase;
CYP82D36
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
strychnine,[NADPH---hemoprotein reductase]:oxygen oxidoreductase (10-hydroxylating)
Reaction(IUBMB)
strychnine + [reduced NADPH---hemoprotein reductase] + O2 = 10-hydroxystrychnine + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R13338]
Reaction(KEGG)
R13338
Substrate
strychnine [CPD:C06522];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
10-hydroxystrychnine [CPD:C22929];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. The enzyme, isolated from the tree Strychnos nux-vomica, participates in the biosynthesis of brucine.
History
EC 1.14.14.189 created 2024
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K27786  strychnine 10-hydroxylase
Reference
1  [PMID:35794473]
  Authors
Hong B, Grzech D, Caputi L, Sonawane P, Lopez CER, Kamileen MO, Hernandez Lozada NJ, Grabe V, O'Connor SE
  Title
Biosynthesis of strychnine.
  Journal
Nature 607:617-622 (2022)
DOI:10.1038/s41586-022-04950-4
  Sequence
[ag:UQZ09627]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.189
IUBMB Enzyme Nomenclature: 1.14.14.189
ExPASy - ENZYME nomenclature database: 1.14.14.189
BRENDA, the Enzyme Database: 1.14.14.189

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