KEGG   ENZYME: 1.14.14.26
Entry
EC 1.14.14.26               Enzyme                                 
Name
24-hydroxycholesterol 7alpha-hydroxylase;
24-hydroxycholesterol 7alpha-monooxygenase;
CYP39A1;
CYP39A1 oxysterol 7alpha-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
(24S)-cholest-5-ene-3beta,24-diol,NADPH---hemoprotein reductase:oxygen oxidoreductase (7alpha-hydroxylating)
Reaction(IUBMB)
(24S)-cholest-5-ene-3beta,24-diol + [reduced NADPH---hemoprotein reductase] + O2 = (24S)-cholest-5-ene-3beta,7alpha,24-triol + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R07208]
Reaction(KEGG)
R07208
Substrate
(24S)-cholest-5-ene-3beta,24-diol [CPD:C13550];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
(24S)-cholest-5-ene-3beta,7alpha,24-triol [CPD:C15518];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A P-450 heme-thiolate protein that is found in liver microsomes and in ciliary non-pigmented epithelium [2]. The enzyme is specific for (24S)-cholest-5-ene-3beta,24-diol, which is formed mostly in the brain by EC 1.14.14.25, cholesterol 24-hydroxylase. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.
History
EC 1.14.14.26 created 2005 as EC 1.14.13.99, transferred 2016 to EC 1.14.14.26
Pathway
ec00120  Primary bile acid biosynthesis
Orthology
K07439  24-hydroxycholesterol 7alpha-hydroxylase
Genes
HSA51302(CYP39A1)
PTR462743(CYP39A1)
PPS100994949(CYP39A1)
GGO101153001
PON100458771
NLE100604697
MCC704242(CYP39A1)
MCF102145162(CYP39A1)
CSAB103221412(CYP39A1)
CATY105590835
PANU101009400
TGE112623818
RRO104656795
RBB108533423
TFN117087312
PTEH111543188
CJC100414008(CYP39A1)
SBQ101047750
CSYR103253843 103259544
MMUR105860259
LCAT123632914
OGA100964357
MMU56050(Cyp39a1)
MCAL110283986
MPAH110336040
RNO301264(Cyp39a1)
MCOC116074246
MUN110552112
CGE100759356
MAUA101823549
PLEU114707856
MORG121450734
AAMP119823934
NGI103744879
HGL101717854
CPOC100733616
CCAN109698382
DORD105987725
DSP122101567
NCAR124988759
OCU100345427
OPI101527574
TUP102475202
CFA481825(CYP39A1)
CLUD112641685
VVP112914049
VLG121474005
AML100466240
UMR103664036
UAH113261234
UAR123795184
ELK111147739
LLV125103191
MPUF101676932
ORO101375591
EJU114204373
ZCA113926683
MLX118000690
FCA101100564
PYU121029540
PBG122489590
PTG102970914
PPAD109271703
AJU106973997
HHV120231229
BTA511195(CYP39A1)
BIU109577323
BBUB102405714
CHX102183469
OAS101120701
ODA120870051
CCAD122429346
SSC100113410(CYP39A1)
CFR102520068
CBAI105083840
CDK105101205
VPC102530862
BACU103015178
LVE103076430
OOR101274663
DLE111178887
PCAD102982999
PSIU116762874
ECB100068322
EPZ103565893
EAI106828769
MYB102256355
MYD102753466
MMYO118659779
MLF102428309
MNA107536895
PKL118705039
HAI109396002
DRO112302411
SHON118992370
AJM119047185
PDIC114494322
PHAS123821656
MMF118621602
RFQ117020570
PALE102885315
PGIG120596085
PVP105288516
RAY107517800
MJV108390890
TOD119252536
SARA101538881
LAV100658257
TMU101347682
DNM101425314
MDO100014394
GAS123246433
SHR100919523
PCW110213567
OAA100080779
GGA422058(CYP39A1)
PCOC116236334
MGP104910041
CJO107312474
NMEL110397081
APLA101805427
ACYG106038153
AFUL116488095
TGU100225542
LSR110470248
SCAN103821075
PMOA120495994
OTC121347505
PRUF121360840
GFR102042330
FAB101819354
PHI102113584
PMAJ107202268
CCAE111927420
CCW104685383
CBRC103622821
ETL114058828
ZAB102062785
FPG101916882
FCH102053587
CLV102093880
EGZ104126998
NNI104014664
PLET104614486
PCRI104024424
ACUN113478761
TALA104356978
PADL103913205
ACHC115351226
HALD104310387
CCRI104169301
CSTI104553876
EHS104516859
CMAC104485991
FGA104080550
GSTE104250738
LDI104340228
MNB103767855
OHA104336016
AAM106495198
AROW112962870
NPD112947833
DNE112979550
ASN102388360
AMJ102560263(CYP39A1)
CPOO109311477
GGN109300287
PSS102457950 102458362
CMY102943639 102943860
CPIC101934897 101942552
TST117875371 117875539
CABI116823201 116823202
MRV120400208 120401078
ACS100555389
PVT110083224
SUND121919149
VKO123030899
PMUA114593476
ZVI118082595
GJA107124890
XLA733346(cyp39a1.L)
XTR100486848(cyp39a1)
NPR108795524
RTEM120936240 120936244
BBUF120997277
BGAR122934953
DRE564475(cyp39a1)
SRX107727679
SANH107676273
SGH107602202
CCAR109070979 109084500
CAUA113037875 113076005
PPRM120494211
MAMB125278368
AMEX103046432
EEE113571629
SASA106607853
OTW112261912
OMY110522269
OGO123995131
ONE115139368
SALP111972540
SNH120019764
CCLU121548878
SFM108925172
PKI111854036
AANG118229747
LOC102682481
PSPA121317496
ARUT117411140
LCM102362076
CMK103184994
RTP109928868
BFO118422536
BBEL109485165
BGT106070044
GAE121370221
HRF124116332
HRJ124276705 124282671
CRG105348418
PMAX117328028
MMER123551075
 » show all
Reference
1  [PMID:10748047]
  Authors
Li-Hawkins J, Lund EG, Bronson AD, Russell DW
  Title
Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol.
  Journal
J Biol Chem 275:16543-9 (2000)
DOI:10.1074/jbc.M001810200
  Sequence
[hsa:51302] [mmu:56050]
Reference
2  [PMID:12649335]
  Authors
Ikeda H, Ueda M, Ikeda M, Kobayashi H, Honda Y
  Title
Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eye.
  Journal
Lab Invest 83:349-55 (2003)
DOI:10.1097/01.LAB.0000059933.35157.40
Reference
3  [PMID:12543708]
  Authors
Russell DW
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.26
IUBMB Enzyme Nomenclature: 1.14.14.26
ExPASy - ENZYME nomenclature database: 1.14.14.26
BRENDA, the Enzyme Database: 1.14.14.26
CAS: 288309-90-0

DBGET integrated database retrieval system