KEGG   ENZYME: 1.14.14.26Help
Entry
EC 1.14.14.26               Enzyme                                 

Name
24-hydroxycholesterol 7alpha-hydroxylase;
24-hydroxycholesterol 7alpha-monooxygenase;
CYP39A1;
CYP39A1 oxysterol 7alpha-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
(24S)-cholest-5-ene-3beta,24-diol,NADPH---hemoprotein reductase:oxygen oxidoreductase (7alpha-hydroxylating)
Reaction(IUBMB)
(24S)-cholest-5-ene-3beta,24-diol + [reduced NADPH---hemoprotein reductase] + O2 = (24S)-cholest-5-ene-3beta,7alpha,24-triol + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R07208]
Reaction(KEGG)
Substrate
(24S)-cholest-5-ene-3beta,24-diol [CPD:C13550];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
(24S)-cholest-5-ene-3beta,7alpha,24-triol [CPD:C15518];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A P-450 heme-thiolate protein that is found in liver microsomes and in ciliary non-pigmented epithelium [2]. The enzyme is specific for (24S)-cholest-5-ene-3beta,24-diol, which is formed mostly in the brain by EC 1.14.14.25, cholesterol 24-hydroxylase. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.
History
EC 1.14.14.26 created 2005 as EC 1.14.13.99, transferred 2016 to EC 1.14.14.26
Pathway
ec00120  Primary bile acid biosynthesis
Orthology
K07439  24-hydroxycholesterol 7alpha-hydroxylase
Genes
HSA: 51302(CYP39A1)
PTR: 462743(CYP39A1)
PPS: 100994949
GGO: 101153001
PON: 100458771
NLE: 100604697
MCC: 704242(CYP39A1)
MCF: 102145162
CSAB: 103221412(CYP39A1)
RRO: 104656795
RBB: 108533423
CJC: 100414008(CYP39A1)
SBQ: 101047750
MMU: 56050(Cyp39a1)
MCAL: 110283986
MPAH: 110336040
RNO: 301264(Cyp39a1)
MUN: 110552112
CGE: 100759356
NGI: 103744879
HGL: 101717854
CCAN: 109698382
OCU: 100345427
TUP: 102475202
CFA: 481825(CYP39A1)
VVP: 112914049
AML: 100466240
UMR: 103664036
UAH: 113261234
ORO: 101375591
FCA: 101100564
PTG: 102970914
PPAD: 109271703
AJU: 106973997
BTA: 511195(CYP39A1)
BIU: 109577323
BBUB: 102405714
CHX: 102183469
OAS: 101120701
SSC: 100113410(CYP39A1)
CFR: 102520068
CDK: 105101205
BACU: 103015178
LVE: 103076430
OOR: 101274663
DLE: 111178887
PCAD: 102982999
ECB: 100068322
EPZ: 103565893
EAI: 106828769
MYB: 102256355
MYD: 102753466
MNA: 107536895
HAI: 109396002
DRO: 112302411
PALE: 102885315
RAY: 107517800
LAV: 100658257
TMU: 101347682
MDO: 100014394
SHR: 100919523
PCW: 110213567
OAA: 100080779
GGA: 422058(CYP39A1)
MGP: 104910041
CJO: 107312474
NMEL: 110397081
APLA: 101805427
ACYG: 106038153
TGU: 100225542
LSR: 110470248
SCAN: 103821075
GFR: 102042330
FAB: 101819354
PHI: 102113584
PMAJ: 107202268
CCAE: 111927420
CCW: 104685383
ETL: 114058828
FPG: 101916882
FCH: 102053587
CLV: 102093880
EGZ: 104126998
NNI: 104014664
ACUN: 113478761
PADL: 103913205
AAM: 106495198
ASN: 102388360
AMJ: 102560263(CYP39A1)
ACS: 100555389
PVT: 110083224
PMUA: 114593476
GJA: 107124890
XLA: 733346(cyp39a1.L)
XTR: 100486848(cyp39a1)
NPR: 108795524
DRE: 564475(cyp39a1)
SRX: 107727679
SANH: 107676273
SGH: 107602202
AMEX: 103046432
EEE: 113571629
SASA: 106607853
SALP: 111972540
SFM: 108925172
PKI: 111854036
LCM: 102362076
CMK: 103184994
SKO: 100367921
CRG: 105348418
MYI: 110465361
LAK: 106170353
PDAM: 113671873
SPIS: 111333593
AQU: 100641050
APRO: F751_6104
 » show all
Taxonomy
Reference
1  [PMID:10748047]
  Authors
Li-Hawkins J, Lund EG, Bronson AD, Russell DW.
  Title
Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol.
  Journal
J Biol Chem 275:16543-9 (2000)
DOI:10.1074/jbc.M001810200
  Sequence
[hsa:51302] [mmu:56050]
Reference
2  [PMID:12649335]
  Authors
Ikeda H, Ueda M, Ikeda M, Kobayashi H, Honda Y.
  Title
Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eye.
  Journal
Lab Invest 83:349-55 (2003)
DOI:10.1097/01.LAB.0000059933.35157.40
Reference
3  [PMID:12543708]
  Authors
Russell DW.
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.26
IUBMB Enzyme Nomenclature: 1.14.14.26
ExPASy - ENZYME nomenclature database: 1.14.14.26
BRENDA, the Enzyme Database: 1.14.14.26
CAS: 288309-90-0

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