KEGG   ENZYME: 1.14.14.31
Entry
EC 1.14.14.31               Enzyme                                 
Name
ipsdienol synthase;
myrcene hydroxylase;
CYP9T2;
CYP9T3
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
myrcene,NADPH---hemoprotein reductase:O2 oxidoreductase (hydroxylating)
Reaction(IUBMB)
myrcene + [reduced NADPH---hemoprotein reductase] + O2 = (R)-ipsdienol + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R11055]
Reaction(KEGG)
R11055
Substrate
myrcene [CPD:C06074];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
(R)-ipsdienol [CPD:C20943];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 heme-thiolate protein. Involved in the insect aggregation pheromone production. Isolated from the pine engraver beetle, Ips pini. A small amount of (S)-ipsdienol is also formed. In vitro it also hydroxylated (+)- and (-)-alpha-pinene, 3-carene, and (+)-limonene, but not alpha-phellandrene, (-)-beta-pinene, gamma-terpinene, or terpinolene.
History
EC 1.14.14.31 created 2015 as EC 1.14.13.207, transferred 2016 to EC 1.14.14.31
Pathway
ec00902  Monoterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K21069  ipsdienol synthase
Reference
1  [PMID:17046597]
  Authors
Sandstrom P, Welch WH, Blomquist GJ, Tittiger C
  Title
Functional expression of a bark beetle cytochrome P450 that hydroxylates myrcene to ipsdienol.
  Journal
Insect Biochem Mol Biol 36:835-45 (2006)
DOI:10.1016/j.ibmb.2006.08.004
  Sequence
[ag:ABG74909]
Reference
2  [PMID:23376633]
  Authors
Song M, Kim AC, Gorzalski AJ, MacLean M, Young S, Ginzel MD, Blomquist GJ, Tittiger C
  Title
Functional characterization of myrcene hydroxylases from two geographically distinct Ips pini populations.
  Journal
Insect Biochem Mol Biol 43:336-43 (2013)
DOI:10.1016/j.ibmb.2013.01.003
  Sequence
[ag:AGE93533]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.31
IUBMB Enzyme Nomenclature: 1.14.14.31
ExPASy - ENZYME nomenclature database: 1.14.14.31
BRENDA, the Enzyme Database: 1.14.14.31

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
All databases (15)   

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