KEGG   ENZYME: 1.14.14.51Help
Entry
EC 1.14.14.51               Enzyme                                 

Name
(S)-limonene 6-monooxygenase;
(-)-limonene 6-hydroxylase;
(-)-limonene 6-monooxygenase;
(-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
(S)-limonene,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6-hydroxylating)
Reaction(IUBMB)
(S)-limonene + [reduced NADPH---hemoprotein reductase] + O2 = (-)-trans-carveol + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R02468]
Reaction(KEGG)
Substrate
(S)-limonene;
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
(-)-trans-carveol [CPD:C00964];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme thiolate) enzyme. The enzyme participates in the biosynthesis of (-)-carvone, which is responsible for the aroma of spearmint.
History
EC 1.14.14.51 created 1992 as EC 1.14.13.48, modified 2003, transferred 2017 to EC 1.14.14.51
Pathway
ec00902  Monoterpenoid biosynthesis
ec00903  Limonene and pinene degradation
ec01110  Biosynthesis of secondary metabolites
Orthology
K07381  (S)-limonene 6-monooxygenase
K14732  limonene hydroxylase
K17719  cytochrome P450 family 2 subfamily C polypeptide 9
K17721  cytochrome P450 family 2 subfamily C polypeptide 19
Genes
HSA: 1557(CYP2C19) 1559(CYP2C9)
PTR: 100616515(CYP2C9) 740956(CYP2C19)
PPS: 100995695 100996034
PON: 100450749
NLE: 100601437
MCF: 102147103(CYP2C75)
CSAB: 103216299(CYP2C19)
RRO: 104666123
CJC: 100389947(CYP2C19)
SBQ: 101041912
TUP: 102501371
ECB: 100061542
MYD: 102759998
MDO: 100023149
SHR: 100915447
 » show all
Taxonomy
Reference
1  [PMID:2297225]
  Authors
Karp F, Mihaliak CA, Harris JL, Croteau R.
  Title
Monoterpene biosynthesis: specificity of the hydroxylations of (-)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata), and perilla (Perilla frutescens) leaves.
  Journal
Arch Biochem Biophys 276:219-26 (1990)
DOI:10.1016/0003-9861(90)90029-X
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.51
IUBMB Enzyme Nomenclature: 1.14.14.51
ExPASy - ENZYME nomenclature database: 1.14.14.51
BRENDA, the Enzyme Database: 1.14.14.51
CAS: 138066-93-0

DBGET integrated database retrieval system