KEGG   ENZYME: 1.14.14.55Help
Entry
EC 1.14.14.55               Enzyme                                 

Name
quinine 3-monooxygenase;
CYP3A4 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
quinine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
quinine + [reduced NADPH---hemoprotein reductase] + O2 = 3-hydroxyquinine + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R05727]
Reaction(KEGG)
Substrate
quinine [CPD:C06526];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
3-hydroxyquinine [CPD:C07344];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein.
History
EC 1.14.14.55 created 2000 as EC 1.14.13.67, transferred 2017 to EC 1.14.14.55
Orthology
K17689  cytochrome P450 family 3 subfamily A polypeptide 4
Genes
HSA: 1576(CYP3A4)
PTR: 463582(CYP3A4)
PPS: 100976899
GGO: 101149513
PON: 100436782
NLE: 100593175
MCC: 678670(CYP3A4)
MCF: 102144258(CYP3A8)
CSAB: 103246766
RRO: 104673585
RBB: 108538168
TUP: 102494214
CFA: 479740(CYP3A4)
 » show all
Taxonomy
Reference
1  [PMID:1578365]
  Authors
Relling MV, Evans R, Dass C, Desiderio DM, Nemec J.
  Title
Human cytochrome P450 metabolism of teniposide and etoposide.
  Journal
J Pharmacol Exp Ther 261:491-6 (1992)
Reference
2  [PMID:9088578]
  Authors
Zhang H, Coville PF, Walker RJ, Miners JO, Birkett DJ, Wanwimolruk S.
  Title
Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine.
  Journal
Br J Clin Pharmacol 43:245-52 (1997)
DOI:10.1046/j.1365-2125.1997.00556.x
  Sequence
[hsa:1576]
Reference
3  [PMID:9456308]
  Authors
Zhao XJ, Kawashiro T, Ishizaki T.
  Title
Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways.
  Journal
Drug Metab Dispos 26:188-91 (1998)
  Sequence
[hsa:1576]
Reference
4  [PMID:8968357]
  Authors
Zhao XJ, Yokoyama H, Chiba K, Wanwimolruk S, Ishizaki T.
  Title
Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450.
  Journal
J Pharmacol Exp Ther 279:1327-34 (1996)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.55
IUBMB Enzyme Nomenclature: 1.14.14.55
ExPASy - ENZYME nomenclature database: 1.14.14.55
BRENDA, the Enzyme Database: 1.14.14.55
CAS: 50812-30-1 213327-78-7

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