KEGG   ENZYME: 1.14.14.58Help
Entry
EC 1.14.14.58               Enzyme                                 

Name
trimethyltridecatetraene synthase;
CYP82G1;
CYP92C5;
CYP92C6;
DMNT/TMTT homoterpene synthase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
(6E,10E)-geranyllinalool,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
(6E,10E)-geranyllinalool + [reduced NADPH---hemoprotein reductase] + O2 = (3E,7E)-4,8,12-trimethyltrideca-1,3,7,11-tetraene + [oxidized NADPH---hemoprotein reductase] + but-3-en-2-one + 2 H2O [RN:R10562]
Reaction(KEGG)
Substrate
(6E,10E)-geranyllinalool [CPD:C20681];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
(3E,7E)-4,8,12-trimethyltrideca-1,3,7,11-tetraene [CPD:C20700];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
but-3-en-2-one [CPD:C20701];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein isolated from the plants Arabidopsis thaliana (thale cress) and Zea mays (maize). It forms this C16 homoterpene in response to herbivore attack. In vitro some variants of the enzyme also convert (3S,6E)-nerolidol to (3E)-4,8-dimethylnona-1,3,7-triene (see EC 1.14.14.59, dimethylnonatriene synthase).
History
EC 1.14.14.58 created 2018
Pathway
ec00904  Diterpenoid biosynthesis
Orthology
K17961  trimethyltridecatetraene/dimethylnonatriene synthase
K22639  trimethyltridecatetraene/dimethylnonatriene synthase
K22640  trimethyltridecatetraene synthase
Genes
ATH: AT3G25180(CYP82G1)
ALY: ARALYDRAFT_319208 ARALYDRAFT_319209 ARALYDRAFT_333194 ARALYDRAFT_497169 ARALYDRAFT_655670 ARALYDRAFT_673591 ARALYDRAFT_899117 ARALYDRAFT_920444
CRB: 17893119
CSAT: 104747068 104766436 104789998
EUS: EUTSA_v10002489mg
BRP: 103860272
BNA: 106361807 106447410 111204589
BOE: 106331605
THJ: 104804632 104804634 109115973
CPAP: 110823399
TCC: 18612710
CAM: 105852562
LJA: Lj3g3v0718740.1(Lj3g3v0718740.1) Lj3g3v0718760.1(Lj3g3v0718760.1) Lj3g3v0718770.1(Lj3g3v0718770.1)
LANG: 109361544
ZJU: 107426783
RCU: 8286091
HBR: 110667432
SLY: 101246085
SPEN: 107029603
NSY: 104229803
NAU: 109231518
INI: 109182929
OEU: 111379861
DCR: 108213090
BVG: 104908785
SOE: 110803253
OSA: 4333585
BDI: 100834983
ATS: 109773640(LOC109773640)
SITA: 101776952
 » show all
Taxonomy
Reference
1  [PMID:21088219]
  Authors
Lee S, Badieyan S, Bevan DR, Herde M, Gatz C, Tholl D.
  Title
Herbivore-induced and floral homoterpene volatiles are biosynthesized by a single P450 enzyme (CYP82G1) in Arabidopsis.
  Journal
Proc Natl Acad Sci U S A 107:21205-10 (2010)
DOI:10.1073/pnas.1009975107
  Sequence
[ath:AT3G25180]
Reference
2  [PMID:27662898]
  Authors
Richter A, Schaff C, Zhang Z, Lipka AE, Tian F, Kollner TG, Schnee C, Preiss S, Irmisch S, Jander G, Boland W, Gershenzon J, Buckler ES, Degenhardt J
  Title
Characterization of Biosynthetic Pathways for the Production of the Volatile Homoterpenes DMNT and TMTT in Zea mays.
  Journal
Plant Cell 28:2651-2665 (2016)
DOI:10.1105/tpc.15.00919
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.58
IUBMB Enzyme Nomenclature: 1.14.14.58
ExPASy - ENZYME nomenclature database: 1.14.14.58
BRENDA, the Enzyme Database: 1.14.14.58

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