Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy

ferruginol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (11-hydroxyferruginol forming)

ferruginol + [reduced NADPH---hemoprotein reductase] + O2 = 11-hydroxyferruginol + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R11951]

R11951;
(other) R11988
Reaction

ferruginol [CPD:C09092];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

A cytochrome P-450 (heme-thiolate) protein isolated from the plants Salvia pomifera (apple sage) and Salvia miltiorrhiza (danshen). 11-Hydroxyferruginol is a precursor of carnosic acid, a potent antioxidant.

EC 1.14.14.60 created 2018

1  [PMID:26976595]

Ignea C, Athanasakoglou A, Ioannou E, Georgantea P, Trikka FA, Loupassaki S, Roussis V, Makris AM, Kampranis SC

Carnosic acid biosynthesis elucidated by a synthetic biology platform.

Proc Natl Acad Sci U S A 113:3681-6 (2016)
DOI:10.1073/pnas.1523787113

[ag:ALM25796]

2  [PMID:27703160]

Scheler U, Brandt W, Porzel A, Rothe K, Manzano D, Bozic D, Papaefthimiou D, Balcke GU, Henning A, Lohse S, Marillonnet S, Kanellis AK, Ferrer A, Tissier A

Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast.

Nat Commun 7:12942 (2016)
DOI:10.1038/ncomms12942

3  [PMID:26682704]

Guo J, Ma X, Cai Y, Ma Y, Zhan Z, Zhou YJ, Liu W, Guan M, Yang J, Cui G, Kang L, Yang L, Shen Y, Tang J, Lin H, Ma X, Jin B, Liu Z, Peters RJ, Zhao ZK, Huang L

Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones.

New Phytol 210:525-34 (2016)
DOI:10.1111/nph.13790

[ag:AMB36496]