KEGG   ENZYME: 1.14.14.62
Entry
EC 1.14.14.62               Enzyme                                 

Name
salviol synthase;
CYP71BE52
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
ferruginol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (salviol-forming)
Reaction(IUBMB)
ferruginol + [reduced NADPH---hemoprotein reductase] + O2 = salviol + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R11974]
Reaction(KEGG)
R11974
Substrate
ferruginol [CPD:C09092];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
salviol [CPD:C21819];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein isolated from the plant Salvia pomifera (apple sage).
History
EC 1.14.14.62 created 2018
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K22634  salviol synthase
Reference
1  [PMID:26976595]
  Authors
Ignea C, Athanasakoglou A, Ioannou E, Georgantea P, Trikka FA, Loupassaki S, Roussis V, Makris AM, Kampranis SC
  Title
Carnosic acid biosynthesis elucidated by a synthetic biology platform.
  Journal
Proc Natl Acad Sci U S A 113:3681-6 (2016)
DOI:10.1073/pnas.1523787113
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.62
IUBMB Enzyme Nomenclature: 1.14.14.62
ExPASy - ENZYME nomenclature database: 1.14.14.62
BRENDA, the Enzyme Database: 1.14.14.62

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