KEGG   ENZYME: 1.14.14.67
Entry
EC 1.14.14.67               Enzyme                                 
Name
11-hydroxysugiol 20-monooxygenase;
CYP76AK1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
11-hydroxysugiol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (11,20-dihydroxysugiol-forming)
Reaction(IUBMB)
11-hydroxysugiol + [reduced NADPH---hemoprotein reductase] + O2 = 11,20-dihydroxysugiol + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R11979]
Reaction(KEGG)
R11979;
(other) R11987
Substrate
11-hydroxysugiol [CPD:C21823];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
11,20-dihydroxysugiol [CPD:C21824];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein isolated from the plant Salvia miltiorrhiza (danshen). The enzyme also oxidizes 11-hydroxyferruginol to 11,20-dihydroxyferruginol.
History
EC 1.14.14.67 created 2018
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K22637  11-hydroxysugiol 20-monooxygenase
Reference
1  [PMID:26682704]
  Authors
Guo J, Ma X, Cai Y, Ma Y, Zhan Z, Zhou YJ, Liu W, Guan M, Yang J, Cui G, Kang L, Yang L, Shen Y, Tang J, Lin H, Ma X, Jin B, Liu Z, Peters RJ, Zhao ZK, Huang L
  Title
Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones.
  Journal
New Phytol 210:525-34 (2016)
DOI:10.1111/nph.13790
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.67
IUBMB Enzyme Nomenclature: 1.14.14.67
ExPASy - ENZYME nomenclature database: 1.14.14.67
BRENDA, the Enzyme Database: 1.14.14.67

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