KEGG   ENZYME: 1.14.14.79Help
Entry
EC 1.14.14.79               Enzyme                                 

Name
docosahexaenoic acid omega-hydroxylase;
CYP4F3B;
CYP4V2;
docosahexaenoate,NADPH:O2 oxidoreductase (22-hydroxydocosahexaenoate forming)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
docosahexaenoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (22-hydroxydocosahexaenoate forming)
Reaction(IUBMB)
docosahexaenoate + [reduced NADPH---hemoprotein reductase] + O2 = 22-hydroxydocosahexaenoate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R10795]
Reaction(KEGG)
Substrate
docosahexaenoate [CPD:C06429];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
22-hydroxydocosahexaenoate [CPD:C20855];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein isolated from human eye tissue. Defects in the enzyme are associated with Bietti crystalline corneoretinal dystrophy. The enzyme also produces some 21-hydroxydocosahexaenoate. Acts in a similar way on icosapentaenoic acid.
History
EC 1.14.14.79 created 2014 as EC 1.14.13.199, transferred 2018 to EC 1.14.14.79
Orthology
K07427  docosahexaenoic acid omega-hydroxylase
K17726  phylloquinone omega-hydroxylase / docosahexaenoic acid omega-hydroxylase / leukotriene-B4 20-monooxygenase
Genes
HSA: 285440(CYP4V2) 4051(CYP4F3) 8529(CYP4F2)
PTR: 744981(CYP4V2) 748117(CYP4F3) 748531(CYP4F2)
PPS: 100967411 100969141 100969847 100982619 100985937
GGO: 101125692 101135418 101136503 101142243 101151919 101152881
PON: 100172140(CYP4V2) 100434096
NLE: 100579320 100588006 100592938 100602871
MCC: 696520(CYP4V2) 718349 719317
MCF: 102120579 102130440(CYP4F3v2) 102134301(CYP4F45) 102141321
CSAB: 103234077 103234079 103234089 103236636
RRO: 104661012 104661014 104661137 104673816
CJC: 100408123(CYP4V2) 100411160 100412575(CYP4F2)
MMU: 102294(Cyp4v3) 170716(Cyp4f13) 64385(Cyp4f14) 72054(Cyp4f18)
RNO: 266689(Cyp4f6) 266761(Cyp4v3) 290623(Cyp4f18) 56266(Cyp4f1)
BTA: 100295883 507016(CYP4F2) 507615(CYP4F2) 509506 510156(CYP4V2) 534967
SSC: 100113469(CYP4V2) 100113470(CYP4F2) 100620559(CYP4F55) 110259329
BACU: 102999883
PALE: 102883230
OAA: 100090407
GGA: 415121(CYP4V2)
MGP: 100549160
CJO: 107313678
APLA: 101790057
ACYG: 106035235
TGU: 100230859
LSR: 110484918
SCAN: 103825461
GFR: 102033190
FAB: 101813952
PMAJ: 107203122
CCAE: 111927975
CCW: 104690591
ETL: 114067779
FPG: 101918235
FCH: 102054486
CLV: 102094289
EGZ: 104129484
NNI: 104021298
ACUN: 113479206
AAM: 106484032
AMJ: 102563402(CYP4V2) 102563645(CYP4V2) 102570586
CMY: 102943258
ACS: 100557625
PVT: 110077895
PBI: 103052236
PMUR: 107302659
GJA: 107121984
XLA: 100036997(CYP4V4) 100337567(cyp4v4) 444482(cyp4v2.S)
XTR: 100485929 780124(cyp4v2)
DRE: 100037390(cyp4f3) 558851(cyp4v8) 562008(cyp4v7)
IPU: 108260937 108269274(CYP4V2) 108274321(CYP4F66)
NFU: 107374000
LCM: 102361464
CMK: 103178199
APLC: 110987520
SKO: 100375440
HST: 105188429
DQU: 106749785
PGC: 109860817
TCA: 100142020(Cyp4bn11)
BMOR: 100141433(Cyp366a1) 101744852 101744921 101744935 101745062(CYP340A1)
DPTE: 113793077
CEL: CELE_Y80D3A.5(cyp-42A1)
CBR: CBG20323(Cbr-cyp-42A1)
BMY: Bm1_51195
TSP: Tsp_10837
MYI: 110451224
EPA: 110235098
HMG: 100198963
 » show all
Taxonomy
Reference
1  [PMID:22772592]
  Authors
Nakano M, Kelly EJ, Wiek C, Hanenberg H, Rettie AE
  Title
CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of omega-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant.
  Journal
Mol Pharmacol 82:679-86 (2012)
DOI:10.1124/mol.112.080085
  Sequence
[hsa:285440]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.79
IUBMB Enzyme Nomenclature: 1.14.14.79
ExPASy - ENZYME nomenclature database: 1.14.14.79
BRENDA, the Enzyme Database: 1.14.14.79

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