KEGG   ENZYME: 1.14.14.79
Entry
EC 1.14.14.79               Enzyme                                 
Name
docosahexaenoic acid omega-hydroxylase;
CYP4F3B;
CYP4V2;
docosahexaenoate,NADPH:O2 oxidoreductase (22-hydroxydocosahexaenoate forming)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
docosahexaenoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (22-hydroxydocosahexaenoate-forming)
Reaction(IUBMB)
docosahexaenoate + [reduced NADPH---hemoprotein reductase] + O2 = 22-hydroxydocosahexaenoate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R10795]
Reaction(KEGG)
R10795
Substrate
docosahexaenoate [CPD:C06429];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
22-hydroxydocosahexaenoate [CPD:C20855];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein isolated from human eye tissue. Defects in the enzyme are associated with Bietti crystalline corneoretinal dystrophy. The enzyme also produces some 21-hydroxydocosahexaenoate. Acts in a similar way on icosapentaenoic acid.
History
EC 1.14.14.79 created 2014 as EC 1.14.13.199, transferred 2018 to EC 1.14.14.79
Orthology
K07427  docosahexaenoic acid omega-hydroxylase
K17726  phylloquinone omega-hydroxylase / docosahexaenoic acid omega-hydroxylase / leukotriene-B4 20-monooxygenase
Genes
HSA285440(CYP4V2) 4051(CYP4F3) 8529(CYP4F2)
PTR100609185 744981(CYP4V2) 748117(CYP4F3) 748531(CYP4F2)
PPS100967411(CYP4F2) 100969141(CYP4F3) 100985937(CYP4V2)
GGO101125692 101135418 101142243 101152881
PON100172140(CYP4V2) 100434096 100437847 100453229
PPYG129020906 129020916 129034690
NLE100579320 100588006 100602871 115836096 115836968
HMH116466087 116478624 116478627
SSYN129459452 129460821 129481340
MCC696520(CYP4V2) 718349 719317
MCF102130440(CYP4F3) 102134301(CYP4F2) 102141321(CYP4V2)
MTHB126942252 126942253 126955236
MNI105466554 105494188 105494717
CSAB103234079 103234089 103236636
CATY105594263 105601614 105601627
PANU101003969 101005940 101010705
TGE112612404 112613097 112625202
MLEU105540101 105540126 105540250
RRO104661012 104661014 104673816
RBB108522429 108543262 108543288 108543294
TFN117076174 117086225
PTEH111548494 111554233 111554287
CANG105519773 105519778 105524323
CJC100408123(CYP4V2) 100411160 100412575
SBQ101049306 101050944 101051361
CIMI108288136(CYP4V2) 108298561(CYP4F2)
ANAN105717580(CYP4V2) 105729220 105729221
CSYR103250633 103271968
MMUR105867925 105867928 105867931 105867933 105882473
LCAT123629269 123634142 123636956 123636960 123636967 123638621 123639775 123639780
PCOQ105810090 105810118 105825072 105825741 105827104
OGA100942215 100943471 100952962 100956186
MMU102294(Cyp4v3)
MCAL110300005
MPAH110337006
RNO266761(Cyp4v3)
MCOC116069215
ANU117721866
MUN110558009
CGE100750743
MAUA101842758
PROB127220460
PLEU114701165
MORG121433839
MFOT126504756
AAMP119811191
NGI103750492
HGL101716986
CPOC100716074 100733735
CCAN109684291
DORD105991323
DSP122127372
PLOP125339439
NCAR124982271
MMMA107142651
OCU100348038 100350957 100356012
OPI101524068
TUP102483333 102485250
GVR103593427 103606854 103610570
CFA102152484(CYP4V2)
CLUD112675196
VVP112934751
VLG121489190 121495723
NPO129503583
AML100468607
UMR103681006
UAH113262286
UAR123779961 123780007 123784493
ELK111144567
LLV125083145 125091643
MPUF101684052
MNP132006302
MLK131820384
NVS122889964
ORO101378686
EJU114206180
ZCA113917975 113924431
MLX118005050 118010048
NSU110584266
LWW102726129
FCA101097556(CYP4V2)
PYU121039710
PCOO112869968
PBG122471005
PVIV125163421
LRUF124520538
PTG102960154
PPAD109250992
PUC125923457
AJU106982209
HHV120237797
BTA510156(CYP4V2)
BOM102268997
BIU109553482
BBUB102394892
BBIS104985559
CHX102183680 102188826
OAS101116121
BTAX128050384 128068363
ODA120864165 120865741
CCAD122432373
MBEZ129549321
SSC100113469(CYP4V2)
CFR102512100
CBAI105067667
CDK105102385
VPC102525832
BACU102999883
BMUS118888005
LVE103081363
OOR101278344
DLE111173427
PCAD102990897
PSIU116746666
NASI112409665
ECB100056687
EPZ103543058
EAI106840365
MYB102240114 102240725 102242692 102247921 102260288
MYD102754363 102756718 102762764 102763048 102765134 102765327
MMYO118650029 118650794
MLF102425173 102427238 102427536 102427859 102428489 102428801 102429106 102429710 102436085
MDT132228720 132228721 132228722 132228724 132228725 132228726 132234883 132234884
PKL118706555 118730056 118730057 118730058 118730060
EFUS103295448 114229835 114233228 129150009 129150124
MNA107534032
DRO112305042 112306751
SHON118993095
AJM119036852
PDIC114503445 114508725
PHAS123807470
MMF118623007
PPAM129064875
HAI109395858
RFQ117021398 117038128
PALE102883230
PGIG120606485 120618464
PVP105294689 105311420
RAY107510438 107517263
MJV108396407
TOD119240020 119257928 119257929 119257930
SARA101551663 101556979 101557255
SETR126006827 126006835 126006895 126007211
LAV100657832 100659260 100661067
TMU101342431
ETF101648603
DNM101424148 101441145
MDO100014017
GAS123251454
SHR100917708
AFZ127539657
PCW110222598
TVP118852593
OAA100090407
GGA415121(CYP4V2)
PCOC116238901
MGP100549160
CJO107313678
TPAI128080416
LMUT125691634
APLA101790057
CATA118253505
AFUL116488669
TGU100230859
LSR110484918
SCAN103825461
PMOA120497991
OTC121331412
PRUF121360302
GFR102033190
FAB101813952
OMA130252010
PHI102107875
PMAJ107203122
CCAE111927975
CCW104690591
CBRC103622483
ETL114067779
ZAB102064910
ZLE135446563
ACHL103810795
SVG106861357
MMEA130575959
HRT120752998
SATI136360016(CYP4V2)
FPG101918235
FCH102054486
CCRI104158115
NNT104401741
SHAB115610388
ACUN113479206
TALA104358687
ACHC115341167
HALD104315325 104322980
HLE104833395
AGEN126037341
GCL127016010
CSTI104564114
LDI104354849
MNB103780297
DPUB104301789
BRHI104500235
EGZ104129484
NNI104021298
PCRI104029040
PCAO104047317
PADL103922516
AFOR103897378
FGA104080000
GSTE104262044
CLV102094289
MUI104546959
PGUU104462378
PLET104624448
EHS104508114
CMAC104483329
CUCA104063478
TEO104376290
BREG104629519
OHA104334544
ACAR104518228
CPEA104393017
CVF104285445
RTD128910094
AAM106484032
AROW112964066
NPD112949823
TGT104575333
DNE112986138
SCAM104145247
ASN102369346 102369869 112550784
AMJ102563402(CYP4V2) 102563645(CYP4V2) 102570586
CPOO109321858 109322022 109322023
GGN109303665 109303762 109303763 109303764
PSS102455571 102455815
CMY102938005 102943258
CCAY125635829 125635830
DCC119854647 119855078
CPIC101941514 101941793 101952270
TST117878349
CABI116835909 116835915
MRV120405535 120405610 120406861
ACS100557625
ASAO132776687
PVT110077895
SUND121931691
PBI103052236
PMUR107302659
CTIG120316638
TSR106542020
PGUT117680125
APRI131203549
PTEX113434654
NSS113411842
VKO123036294
PMUA114604215 114604282 114604283 114604284
PRAF128420684 128420685 128420686 128420687
ZVI118083468 118083469 118083470
HCG128328192
GJA107121984
STOW125440340
EMC129336663
XLA100337567(cyp4v4) 444482(cyp4v2.1.L)
XTR100485929(cyp4v2.1) 780124(cyp4v2.2)
NPR108784939 108794276
RTEM120921880 120921889
BBUF120990164
BGAR122940960
MUO115461567
GSH117360138
DRE558851(cyp4v2a) 562008(cyp4v2b)
SRX107707218 107736720 107752071 107754133
SANH107656409 107658042 107670167
SGH107558204 107561656 107562739 107600159
CCAR109073701
CAUA113044178 113057798 113057916 113107224
CGIB127949601 127965982 128027293
PTET122347771 122357457
LROH127165332 127176363
OMC131532214 131553037
PPRM120461003 120493055 120493130
RKG130071425 130089493
MAMB125259134 125272564
CIDE127494341 127512551
CERY137008755(cyp4v2b) 137032267(cyp4v2a)
MASI127418316 127444337
TROS130553560 130564112
TDW130413464 130413558 130437557
MANU129421952 129444777
IPU108260937 108269274
IFU128604351 128611325
PHYP113528690 113547369
SMEO124381082 124385624
TFD113635486 113635594
TVC132841972 132856281
TRN134318834 134326109
AMEX103031293 111195187
CMAO118806941 118816991
EEE113579251
CHAR105901765 105907500
TRU101061436
TFS130527645
TNGGSTEN00013691G001
LCO104917763
NCC104952998
TBEN117481516 117481946
CGOB115011785
PGEO117443593 117443594
GACU117556067 117556081
EMAC134864058
ELY117254651
EFO125886063
PLEP121942358
SLUC116051748
ECRA117954687
ESP116701830
PFLV114569292
GAT120824559
PPUG119218150
AFB129095682
CLUM117734859
PSWI130190629
MSAM119898795
SCHU122873754
CUD121508566
ALAT119027599
MZE101485601
ONL100703355
OAU116312391
OLA101162575
OML112137079
CSAI133441599 133441608
XMA102237202
XCO114145628
XHE116720394
PRET103461721
PFOR103136377
PLAI106953322
PMEI106931969
GAF122829941
PPRL129376953
CVG107094912 107094916
CTUL119797184 119797185
GMU124868668
NFU107374000
KMR108231369
ALIM106519688 106519689
NWH119423011
AOCE111582916
MCEP125004692
CSEM103384330
POV109641907
SSEN122771630
HHIP117767577
HSP118122569
PPLT128437213
SMAU118312997
LCF108901662
SDU111216661
SLAL111663247
XGL120800930
HCQ109510969
SSCV125969326
SBIA133505650
PEE133403760
PTAO133476736
BPEC110166101 110166102
MALB109968238
BSPL114862008
SJO128370519
SASA106602559 106612026
STRU115191902 115201982 115205526
OTW112231806 112255983
OMY110504717 110534411
OGO124011109 124012828
ONE115129253 115137326
OKI109901132 109904993
OKE118363290 118395425
SALP111971620 112074167
SNH120052871 120062472
CCLU121561203 121563044 121586966
ELS105022860 105026638
SFM108924579 108931099
PKI111853609 111859276
AANG118227724 118231082
LOC102683375
PSPA121297888
ARUT117409049
PSEX120527497
LCM102361464
CMK103178199
RTP109916600
CPLA122549769
HOC132815103
LERI129697013
PMRN116950898
LRJ133354321
BFO118407885
BBEL109477858
CIN100180750 100183395
SCLV120342785 120342788 120344346 120344612
SPU100893947 115918097 115918464 577955 579739 581875 594737 762892
LPIC129266044 129282146 129282170 129282308
APLC110987520
ARUN117303653
AJC117117008 117117030 117121847
SKO100375440
RZE108368329 108377766 108378434 108378788 108381916
ACOZ120951683
AARA120895624 120896510 120896512 120896513 120897018 120897050 120897515 120901996
AMER121588241 121588244 121588245 121588246 121588247 121588858 121590396 121591179 121596520
ASTE118502450 118504587 118504593 118508259 118515262
AFUN125761426 125765044 125765932 125765939
AMOU128297945 128299284 128299285 128299287 128310404
AALI118456656 118458068 118458071 118458072 118460866 118464423 118469054
AAG5567661
AALB109411363
CQUCpipJ_CPIJ005683 CpipJ_CPIJ005684 CpipJ_CPIJ007085 CpipJ_CPIJ007089 CpipJ_CPIJ007090 CpipJ_CPIJ007092 CpipJ_CPIJ007093 CpipJ_CPIJ007095
CPII120417522 120417528 120421611 120421612 120421615 120424836 120424837 120424866 120431553 120431555 120431725
CNS116345516 116347675 116347967 116348422 116350509 116351388 116351389 116351390 116351391
BCOO119069540 119071872 119073031 119078024 119078035 119078036 119078519 119083265
ACER107997710
PFUC122513580 122514292 122514925 122515566 122515567 122515568 122515587 122517710 122517774 122517839 122518856 122518857 122518922 122518941 122520409 122520498 122521032 122521752 122522732 122522733 122523798 122523799 122524229 122524230 122524526 122524527 122524532 122525657 122525658 122525686 122525688 122525689 122525691 122525693 122526167
VPS122635813 122635814 122635815
VCRB124428328 124428331 124428361 124428369 124428373 124429126
TPRE106648534 106649101 106649102 106649184 106649330 106650915 106651281 106651572 106653058 106654078
LBD127278347 127288831 127290048
CGLO123259233 123259234 123259602 123264579 123267240 123273420
FAS105263310 105263312 105270877 105270987
DAM107039824 107039826 107039828 107039829 107043861 107047963 107048684 107048697
AGIF122853693 122853949 122855220 122855221 122860411
CCIN107272935 107274457
DSM124404675 124404806 124404807 124406530 124411307 124411389 124411390 124411420 124411696
NPT124211339 124212071 124212148 124212150 124212151 124218520 124218521 124218719 124218720 124218911 124218913 124218914 124218915 124218917 124219339 124219340
NFB124175032 124175083 124175779 124182404 124182405 124182839 124184070 124184072 124184073 124184074
NLO107217531 107217532 107219858 107221257 107221597 107223330 107223331 107223823 107223824 107225542 107225547 107225778 107225953 124294406 124294507
NVG124297846 124298074 124299945 124304404 124304405 124304410 124305546 124305603
AROA105685549 105686879 105686880 105692482
SOY115874320 115874482 115877484 115880077 115880922 115880923 115881582 115881583 115881664 115881704 115881719 115881735 115888687
AGRG126734081 126735884 126738584 126745073 126745160 126745242 126745254 126747596 126749738 126750073
ATD109606373
CSET123321060
AGB108904168 108905403 108906962 108911484 111691345 111693089
LDC111504218 111510743
DVV114332503 114335929 126880495 126881508
APLN108736863 112904022
PPYR116159257 116165076 116167564 116170339 116172291 116172361 116177880 116177881 116177882 116177885 116177886 116177887 116177888
OTU111413314 111416483 111418207 111418402 111419493 111421753 111421875 111421945 111422059 111422074 111422210 111422421 111422514 111423053 111424102 111424154 111425838 111427012 111427333 111427382 111427936 111428978 111428979 111428982 111428983 111429322 111429505
MSEX115443293 115444780 115444887 115449016 115449044 115451411 115454101 115455802 119188928
BANY112046024 112049165 112051069 112051904 112055100 112055634 112055643 112055677 112057624 128198279
MJU123867310 123871017 123873641
VCD124530256 124530483 124530484 124530563 124531803 124532630 124533282 124533283 124534644 124536884
MCIX123653860 123655060 123656050 123656066 123660084 123663715
PPOT106100072 106105327 106105328 106105618
PXU106124585 106125043 106125217 106125231 106125542 106125543
PRAP110993186 110994344 110994420 110995875 110995886 111000470 123689605
PNAP125050232 125050233
ZCE119831326
LSIN126964957 126968171 126968172 126969466 126970548 126971893 126977482
SLIU111349291 111349292 111349331 111349484 111349528 111360017 111360018 111360019 111360469
OFU114353129 114355081 114356078 114362233 114365283
PGW126366610 126366620 126366833 126366916 126366917 126369472 126369591 126370869 126373029 126373030 126373031 126373567 126376235 126376245 126376251
CFEL113363865 113377060 113385375
CCRN123290800 123292008 123292024 123292034 123292045 123292075 123292826 123293093 123293211 123293471 123294967 123296059 123296239 123296240 123300385 123300521 123300794 123301068 123301170 123301201 123301202 123301295 123301330 123301333 123301334 123301687 123304931 123305203
API100160629 100166760
DNX107163873 107163874 107163881
AGS114121961 114121962 114121977
RMD113554854 113554855
ACOO126836190 126836345 126836915 126837041 126837043 126837044 126837220 126837221 126837386 126837438 126838019 126838020 126838647 126839043 126839764 126839943 126840050 126841636 126841637 126841638 126841639 126841648 126841650 126842339 126842441 126843337 126844048 126844169 126844170 126845491 126845493 126845494 126845497 126847942 126847944 126847961 126847962 126847963 126847964 126847966 126847967 126847968 126847980 126847992 126847993 126847995 126847998
DVT126893736 126895835 126899352 126899353 126899717 126899735 126903315 126903316 126904886 126906193 126906349 126907741 126907743 126907746 126907908
BTAB109030014 109030151 109031969 109036074 109036972 109036973 109037834 109038941 109040639 109040640 109043040 109043831 109044441
DCI103506319 103507738 103510882 103511778 103515115 103515942 103516706 103516895 113469017
CLEC106672025
HHAL106677250 106678066 106678472 106678588 106679066 106679197 106679207 106680051 106680054 106682501 106683607 106683620 106683621 106683623 106686317
HVI124355669 124360844 124362254 124365950 124365952 124365953 124365954 124365955 124365957 124365958 124365983 124365984 124365991 124365992 124366536 124366756 124366759 124366760 124366790 124372492 124373044
MQU128982134 128982135 128985097 128985239 128985255 128986025 128986429 128986437 128986448 128986453 128986572 128986706 128986918 128987187 128987237 128987422 128988048 128988399 128995923 129003190 129003477 129005437
FOC113202370 113202374 113203168 113203280 113203758 113205100 113206492 113208681 113209238 113209348 113210186 113210762 113210802 113212592 113212737 113213039 113214245 113215794
TPAL117641045 117641094 117641118 117641244 117641416 117641570 117642561 117643291 117643540 117644026 117644036 117644669 117645135 117645526 117645727 117647338 117647438 117647805 117647806 117649385 117649485 117649707 117650517 117650556 117650605 117651230 117653089 117653090 117653828
CSEC111862487 111863323 111863395 111864296 111864297 111864307
SGRE126281314 126298354
BROR134531401 134535077 134538760 134540753 134542580 134542926 134542939 134543050
IEL124167993 124168080 124168186
FCD110862369
DMK116927068 116934248 116934506 123475997
DPZ124315080 124327130 124348966
PJA122245276 122261367
PCHN125029046
PMOO119578646
CQD128686658 128692288 128692430 128692432
HAZT108679188
TCF131881455
PPOI119098772 119101356 119101456 119101563 119101701
DSV119436562 119436669 119436670 119436672 119436678 119436679 119436878 119437020 119437021 119437022 119438566 119439862 119441446 119447252 119456484 119458628 119464912
RSAN119378826 119386632 119389477 119393194 119393687 119393693 119394404 119394422 119394432 119394445 119394458 119395113 119395138 119395151 119395164 119397961 119402449
RMP119161155 119161157 119161233 119161234 119161235 119161237 119161238 119161239 119161241 119161314 119161448 119162010 119162051 119171835 119177153 119177950 119181658
VDE111243321 111244152 111246554 111248731 111249946 111252654 111252664 111253965
VJA111259234 111259235 111260960 111261338 111261710 111268873 111273090 111273739
TUT107360193 107361555 107361951 107362192 107362448 107363943 107366931 107368146 107368147 107369794 107369959 107371897 107372191
DPTE113793077
DFR124492534 124492679 124495885 124496436 124496437 124496438 124496439 124496868 124496869 124497018 124499987
CSCU111612503 111613750 111613800 111614327 111614707 111614911 111614915 111616480 111616481 111617004 111617105 111617625 111621817 111622186 111623434 111624260 111625199 111625200 111625806 111625807 111626390 111627630 111627631 111627633 111631621 111632089 111633067 111634551 111634987 111634990 111635853 111639943
CVS136970208 136970249 136970290 136970407 136970846 136970862 136971672 136971708 136972301 136973201 136973964 136974883 136978312 136978330 136979306 136979308 136979334 136981848 136984807 136984822 136984824 136984836 136986197 136986282 136986287 136986386 136987119 136989442 136989450
PTEP107436838 107441954 107443360 107443468 107443469 107443641 107443713 107443864 107446851 107447204 107447784 107450173 107450174 107456117
ABRU129957058 129957653 129962876 129963124 129963929 129963992 129964001 129964128 129969565 129969567 129980667 129980776 129981056 129981084 129981340 129981470 129981471 129981592 129981618 129981705 129981717 129981730 129981731 129987563 129987995 129988525 129988685 129988686 129988688
UDV129216289 129216293 129217575 129217596 129217636 129221152 129221503 129222693 129223759 129224510 129225562 129230185 129233825 129234049 129234860 129235108
SDM118181948 118185968 118188928 118189905 118191056 118191192 118192212 118192753 118192978 118194678 118194680 118197240 118200418 118204276 118204389 118205520
LPOL106457031 106465510 106472426
PMEO129592772 129600716
CELCELE_Y80D3A.5(cyp-42A1)
CBRCBG_20323(Cbr-cyp-42A1)
CRQGCK72_021617
NAINECAME_03284 NECAME_06856 NECAME_15256
BMYBM_BM7159(Bma-cyp-42A1.1) BM_BM8635(Bma-cyp-42A1.2)
LOALOAG_16760
TSPTsp_10837
LGILOTGIDRAFT_206515
PVUL126811371
PCAN112556660
BGT106065596
GAE121378638
HRF124113704
HRJ124277695
CRG105323364
CANU128166212 128166213
CVN111121213 111121239
OED125669947
MYI110451224
PMAX117331221
MCAF127709804
MMER123527893 123563759
RPHI132753954 132756361
DPOL127868477
MAEA128212086 128244718
OBI106876141 106876144 106878048
OSN115211833 115212028 115212039 115212041 115212257 115212422
LJP135467631
LAK106156039
LLON135485980
NVE5502706 5502709
EPA110235098
ATEN116295183 116295184
ADF107329895 107329913 107330438 107330484 107335891
AMIL114965427 114965429 114965430 114965431
PDAM113664116 113664119
SPIS111325112 111341124 111347199 111347203
DGT114524910 114537125 114539322 114539407 114539409 114540646 114541977
XEN124454973
HMG100198963 105845269
HSY130623762 130636133 130637698 130641129 130644192 130654956 130654958
RES135689581
RIEOCT59_000088 OCT59_008802 OCT59_011439 OCT59_025186 OCT59_025236 OCT59_025759
 » show all
Reference
1  [PMID:22772592]
  Authors
Nakano M, Kelly EJ, Wiek C, Hanenberg H, Rettie AE
  Title
CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of omega-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant.
  Journal
Mol Pharmacol 82:679-86 (2012)
DOI:10.1124/mol.112.080085
  Sequence
[hsa:285440]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.79
IUBMB Enzyme Nomenclature: 1.14.14.79
ExPASy - ENZYME nomenclature database: 1.14.14.79
BRENDA, the Enzyme Database: 1.14.14.79

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