KEGG   ENZYME: 1.14.14.8
Entry
EC 1.14.14.8                Enzyme                                 
Name
anthranilate 3-monooxygenase (FAD);
anthranilate 3-hydroxylase;
anthranilate hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
anthranilate,FADH2:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
anthranilate + FADH2 + O2 = 3-hydroxyanthranilate + FAD + H2O [RN:R09517]
Reaction(KEGG)
R09517
Substrate
anthranilate [CPD:C00108];
FADH2 [CPD:C01352];
O2 [CPD:C00007]
Product
3-hydroxyanthranilate [CPD:C00632];
FAD [CPD:C00016];
H2O [CPD:C00001]
Comment
This enzyme, isolated from the bacterium Geobacillus thermodenitrificans, participates in the pathway of tryptophan degradation. The enzyme is part of a system that also includes a bifunctional riboflavin kinase/FMN adenylyltransferase and an FAD reductase, which ensures ample supply of FAD to the monooxygenase.
History
EC 1.14.14.8 created 2010
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K16901  anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase
Genes
BCABCE_2148
BCXBCA_2146
BCFbcf_10170
BCERBCK_24265
BCEFBcrFT9_01682
BTLBALH_1835
BMYCDJ92_4629
BTROFJR70_09265
BNTGSN03_10105
GSTHW35_13010
BFDNCTC4823_00762 NCTC4823_00782
BHKB4U37_13975
BMQBMQ_3596(hpaB)
BMDBMD_3581(hpaB)
BMEGBG04_470
GTNGTNG_3160
ASEDIRT44_17665
LYZDCE79_01715
FPNABE65_004705
FARABE41_004850
BSJUP17_10485
PASABAOM_0489
RUEDT065_13750
MSEMGMB29_08290
BOUI5818_04760
HYIK2M58_04815
GAJMY490_08530
BBEBBR47_29710
BFMBP422_09685
PCELHUB94_10140 HUB94_23490
ANXACH33_11740
ATHEK3F53_07200
AACOK1I37_05145
MMAGMMAD_31860
MMATMMAGJ_45110
CCYCSCMU_01870
STUIGCM10017668_02130
SVDCP969_28360
SACTDMT42_33040
ACITHPK19_02390
GPRJQN66_16275
PAEYKUF55_15835
PDXPsed_0216
PBROHOP40_33130(hpaB) HOP40_33375(hpaB)
 » show all
Reference
1  [PMID:19942660]
  Authors
Liu X, Dong Y, Li X, Ren Y, Li Y, Wang W, Wang L, Feng L
  Title
Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2.
  Journal
Microbiology 156:589-95 (2010)
DOI:10.1099/mic.0.031880-0
  Sequence
[gtn:GTNG_3160]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.8
IUBMB Enzyme Nomenclature: 1.14.14.8
ExPASy - ENZYME nomenclature database: 1.14.14.8
BRENDA, the Enzyme Database: 1.14.14.8

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