EC               Enzyme                                 

long-chain fatty acid omega-monooxygenase;
CYP704B1 (gene name);
CYP52M1 (gene name);
CYP4A (gene name);
CYP86A (gene name)
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
long-chain fatty acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating)
a long-chain fatty acid + [reduced NADPH---hemoprotein reductase] + O2 = an omega-hydroxy-long-chain fatty acid + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R12072]
R12072 > R07041 R09451 R09452;
(other) R01348 R07046
long-chain fatty acid [CPD:C00638];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
omega-hydroxy-long-chain fatty acid [CPD:C21886];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
A cytochrome P-450 (heme thiolate) enzyme. The plant enzyme CYP704B1, which is involved in the synthesis of sporopollenin, a complex polymer found at the outer layer of spores and pollen, acts on palmitate (18:0), stearate (18:0) and oleate (18:1). The plant enzyme CYP86A1 also acts on laurate (12:0). The enzyme from the yeast Starmerella bombicola (CYP52M1) acts on C16 to C20 saturated and unsaturated fatty acids and can also hydroxylate the (omega-1) position. The mammalian enzyme CYP4A acts on laurate (12:0), myristate (14:0), palmitate (16:0), oleate (18:1), and arachidonate (20:4).
EC created 2015 as EC, transferred 2018 to EC
ec00071  Fatty acid degradation
ec00073  Cutin, suberine and wax biosynthesis
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
K07422  long-chain fatty acid omega-monooxygenase
K07425  long-chain fatty acid omega-monooxygenase
K15401  long-chain fatty acid omega-monooxygenase
K20495  long-chain fatty acid omega-monooxygenase
K22887  long-chain fatty acid omega-monooxygenase
HSA: 113612(CYP2U1)
PTR: 471267(CYP2U1)
PPS: 100993565
GGO: 101138067
PON: 100172128(CYP2U1)
NLE: 100592267
MCC: 696076
MCF: 102136088
CSAB: 103236086
RRO: 104670048
RBB: 108515884
MMU: 100040843(Cyp4a32) 13117(Cyp4a10) 13118(Cyp4a12b) 13119(Cyp4a14) 230639(Cyp4a29) 277753(Cyp4a12a) 435802(Cyp4a30b) 666168(Cyp4a31) 71519(Cyp2u1)
RNO: 24306(Cyp4a2) 266674(Cyp4a8) 298423(Cyp4a3) 310848(Cyp2u1) 50549(Cyp4a1)
CFA: 100685915(CYP2U1) 475366(CYP4A38) 482506(CYP4A37) 610385(CYP4A11)
BTA: 511890(CYP4A11) 516085(CYP4A22) 535227(CYP2U1) 784417
MNA: 107538291
HAI: 109379478
PALE: 102882745
LAV: 100658393
OAA: 100088100
GGA: 422528(CYP2U1)
MGP: 100543147
CJO: 107313257
NMEL: 110398345
APLA: 101791848
ACYG: 106038668
TGU: 100229295
LSR: 110468021
SCAN: 103826258
GFR: 102035272
FAB: 101807569
PHI: 102112226
PMAJ: 107203267
CCAE: 111928332
CCW: 104697291
ETL: 114057903
FPG: 101918289
FCH: 102050655
CLV: 102085001
EGZ: 104135501
NNI: 104021317
ACUN: 113479675
PADL: 103919544
AMJ: 102561654(CYP2U1)
PSS: 102457687
CMY: 102945537
CPIC: 101939513
ACS: 100557193
PVT: 110080450
PBI: 103065133
PMUR: 107282661
TSR: 106551326
PMUA: 114604198
GJA: 107123074
XLA: 108710146(cyp2u1.L)
XTR: 100127656(cyp2u1)
NPR: 108785422
DRE: 556280(cyp2u1)
SANH: 107683164
IPU: 108262960
PHYP: 113544242
AMEX: 103032979
EEE: 113591288
TRU: 101074959
NCC: 104953567
MZE: 101466232
ONL: 100694260
OLA: 101167098
XMA: 102234763
XCO: 114145422
PRET: 103472722
CVG: 107094618
NFU: 107375264
KMR: 108233799
ALIM: 106517064
AOCE: 111570989
CSEM: 103384096
POV: 109638308
LCF: 108888243
SDU: 111236653
SLAL: 111671167
HCQ: 109511072
BPEC: 110165350
MALB: 109955577
OTW: 112241732
ELS: 105020991
SFM: 108936644
PKI: 111852140
LCM: 102348127
CMK: 103183746
RTP: 109928317
ATH: AT1G69500(CYP704B1) AT5G58860(CYP86A1)
LJA: Lj0g3v0102229.1(Lj0g3v0102229.1) Lj0g3v0132879.1(Lj0g3v0132879.1) Lj3g3v2576010.1(Lj3g3v2576010.1)
PXB: 103963213
MCHA: 111023497
DOSA: Os01t0854800-01(Os01g0854800) Os03t0168600-01(Os03g0168600)
ZMA: 100191749(ms26) 100192044(cl308_1) 100273463
 » show all
1  [PMID:9500987]
Benveniste I, Tijet N, Adas F, Philipps G, Salaun JP, Durst F
CYP86A1 from Arabidopsis thaliana encodes a cytochrome P450-dependent fatty acid omega-hydroxylase.
Biochem Biophys Res Commun 243:688-93 (1998)
2  [PMID:10620324]
Hoch U, Zhang Z, Kroetz DL, Ortiz de Montellano PR
Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases.
Arch Biochem Biophys 373:63-71 (2000)
3  [PMID:19700560]
Dobritsa AA, Shrestha J, Morant M, Pinot F, Matsuno M, Swanson R, Moller BL, Preuss D
CYP704B1 is a long-chain fatty acid omega-hydroxylase essential for sporopollenin synthesis in pollen of Arabidopsis.
Plant Physiol 151:574-89 (2009)
4  [PMID:24242247]
Huang FC, Peter A, Schwab W
Expression and characterization of CYP52 genes involved in the biosynthesis of sophorolipid and alkane metabolism from Starmerella bombicola.
Appl Environ Microbiol 80:766-76 (2014)
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