KEGG   ENZYME: 1.14.14.9
Entry
EC 1.14.14.9                Enzyme                                 
Name
4-hydroxyphenylacetate 3-monooxygenase;
p-hydroxyphenylacetate 3-hydroxylase;
4-hydroxyphenylacetic acid-3-hydroxylase;
p-hydroxyphenylacetate hydroxylase (FAD);
4 HPA 3-hydroxylase;
p-hydroxyphenylacetate 3-hydroxylase (FAD);
HpaB
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
4-hydroxyphenylacetate,FADH2:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H2O
Reaction(KEGG)
(other) R02698 R03299
Substrate
4-hydroxyphenylacetate [CPD:C00642];
FADH2 [CPD:C01352];
O2 [CPD:C00007]
Product
3,4-dihydroxyphenylacetate [CPD:C01161];
FAD [CPD:C00016];
H2O [CPD:C00001]
Comment
The enzyme from Escherichia coli attacks a broad spectrum of phenolic compounds. The enzyme uses FADH2 as a substrate rather than a cofactor [4]. FADH2 is provided by EC 1.5.1.36, flavin reductase (NADH) [5,6].
History
EC 1.14.14.9 created 1972 as EC 1.14.13.3, transferred 2011 to EC 1.14.14.9
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00483  4-hydroxyphenylacetate 3-monooxygenase
K16901  anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase
K23492  4-hydroxyphenylacetate 3-monooxygenase
Genes
EOIECO111_5206(hpaB)
EOJECO26_5549(hpaB)
EOHECO103_5128(hpaB)
ECOOECRM13514_5600
ECOHECRM13516_5313
ECOAAPECO78_02880
ECXEcHS_A4576(hpaB)
ECYECSE_4621
ECRECIAI1_4567(hpaB)
EUMECUMN_4966(hpaB)
EBRECB_04222(hpaB)
EBLECD_04222(hpaB)
EBEB21_04188(hpaB)
EBDECBD_3674
ECLEcolC_3710
EKOEKO11_3968
EKFKO11_23365(hpaB)
ELWECW_m4705(hpaB)
ELLWFL_22920(hpaB)
ECOLLY180_22800
EFEEFER_3070(hpaB)
STYSTY1131(hpaB)
STTt1820(hpaB)
SEXSTBHUCCB_19360
SENTTY21A_09265
STMSTM1099(hpaB)
SEOSTM14_1247(hpaB)
SEVSTMMW_11091
SEYSL1344_1038(hpaB)
SEMSTMDT12_C11180
SEJSTMUK_1068(hpaB)
SEBSTM474_1091(hpaB)
SEFUMN798_1140(hpaB)
SETUSTU288_01825
SETCCFSAN001921_11680
SENRSTMDT2_10351(hpaB)
SENDDT104_10811(hpaB)
SENICY43_05615
SEENSE451236_11345
SPTSPA1751(hpaB)
SEKSSPA1627
SPQSPAB_02454
SEISPC_2651(hpaB)
SECSCH_1049(hpaB)
SEHSeHA_C1209(hpaB)
SHBSU5_01730
SENHCFSAN002069_03525
SEEHSEEH1578_14720
SEESNSL254_A1194(hpaB)
SENNSN31241_21660
SEWSeSA_A1163(hpaB)
SEASeAg_B1058(hpaB)
SENSQ786_04910
SEDSeD_A1174(hpaB)
SEGSG0988(hpaB)
SELSPUL_1958(hpaB)
SEGASPUCDC_1944(hpaB)
SETSEN0963(hpaB)
SENAAU38_04970
SENOAU37_04960
SENVAU39_04960
SENQAU40_05575
SENLIY59_05060
SENJCFSAN001992_06150
SEECCFSAN002050_11890
SEEBSEEB0189_014075
SEEPI137_08900
SENBBN855_10540
SENEIA1_05410
SENCSEET0819_12155
SESSARI_01904
SBGSBG_0945(hpaB)
SBZA464_1038
SALZEOS98_14120(hpaB)
SFNSFy_6275
SFSSFyv_6346
SFTNCTC1_04750(hpaB_1)
SSNSSON_4489(hpaB)
SBOSBO_4404(hpaB)
SBCSbBS512_E4882(hpaB)
SHQA0259_03505
ENCECL_00750(hpaB)
ENLA3UG_03000
ECLGEC036_05870
ECLEECNIH2_03900
ECLNECNIH4_19900
ECLIECNIH5_03025
ECLXLI66_03020
ECLYLI62_03490
ECLZLI64_02995
ECLOENC_44640
EHMAB284_21985
EXFBFV63_02975
ECLAECNIH3_03025
ECLCECR091_03005
EAUDI57_15620
EKBBFV64_02640
ENOECENHK_03095
EECEcWSU1_00548(hpaB)
ELGBH714_17625
ECANCWI88_19295(hpaB)
ERNBFV67_02810
ECLSLI67_003955
ECHGFY206_03530(hpaB)
ESHC1N69_02860(hpaB)
EASEntas_0528
ENXNI40_002865
LNICWR52_09245(hpaB)
EBGFAI37_03685(hpaB)
ENZG0034_02890(hpaB)
ENSHWQ15_11430(hpaB)
ENKLOC22_13770(hpaB)
EHUD5067_0020035(hpaB)
EMORL6Y89_02800(hpaB)
ENBELK40_03590(hpaB)
KPNKPN_04780(hpaB)
KPUKP1_0734(hpaB)
KPMKPHS_06260
KPPA79E_4372
KPHKPNIH24_03225
KPZKPNIH27_03100
KPVKPNIH29_03415
KPWKPNIH30_03375
KPYKPNIH31_04690
KPGKPNIH32_03380
KPCKPNIH10_03205
KPQKPR0928_03215
KPTVK055_2659(hpaB)
KPOKPN2242_02035
KPRKPR_0857 KPR_0858
KPJN559_4516
KPID364_24355
KPAKPNJ1_04832
KPSKPNJ2_04780
KPXPMK1_02239(hpaB)
KPBFH42_20420
KPNEKU54_023370
KPNULI86_23210
KPNKBN49_4414(hpaB)
KVAKvar_4472
KPKA593_13955
KVDKR75_11405
KVQSP68_18040
KOXKOX_10015
KOEA225_0705
KOYJ415_27720
KOMHR38_08740
KOKKONIH1_03740
KOCAB185_20685 AB185_32450
KQUAVR78_07750
EAEEAE_10315
EARCCG31932
KQVB8P98_24240(hpaB)
KLLBJF97_04290
KLWDA718_24790(hpaB)
KARLGL98_21845(hpaB)
KGRJJJ10_13550 JJJ10_24255(hpaB)
RORRORB6_15565
RONTE10_05455
RPLNB1209_23525
RAODSD31_22280(hpaB)
RTGNCTC13098_06430(hpaB_2)
REEelectrica_04380(hpaB)
CBRAA6J81_18505(hpaB)
EBTEBL_c34040(hpaB)
PGELG71_25560
ESCEntcl_3805
KLEAO703_02890
KIENCTC12125_02693(hpaB_1) NCTC12125_02694(hpaB_2)
KASKATP_35160
LAXAPT61_19365
LEIC2U54_07965(hpaB)
LEHC3F35_08740(hpaB)
LEEDVA44_20850(hpaB)
LERGNG29_03170(hpaB)
LEAGNG26_02765(hpaB)
LPNUKQ929_17905(hpaB)
BUFD8682_01795(hpaB)
BFTMNO13_13700(hpaB)
YREHEC60_20785(hpaB)
IZHFEM41_12670(hpaB)
PSGCG163CM_29820(hpaB)
EBFD782_3927
EBUCUC76_12085(hpaB)
YPEYPO1769(hpaB)
YPKy2539(hpaB)
YPHYPC_2512(hpaB)
YPAYPA_1141
YPNYPN_2354
YPMYP_1624(hpaB)
YPPYPDSF_1354
YPGYpAngola_A1640(hpaB)
YPZYPZ3_1949(hpaB)
YPTA1122_17020
YPDYPD4_1567(hpaB)
YPXYPD8_1987(hpaB)
YPWCH59_3398(hpaB)
YPJCH55_908(hpaB)
YPVBZ15_1780(hpaB)
YPLCH46_3354(hpaB)
YPSYPTB1645(hpaB)
YPOBZ17_857(hpaB)
YPIYpsIP31758_2357(hpaB)
YPYYPK_2453
YPBYPTS_1769
YPQDJ40_578(hpaB)
YPUBZ21_995(hpaB)
YPRBZ20_330(hpaB)
YPCBZ23_1273(hpaB)
YPFBZ19_1072(hpaB)
SMARSM39_4967(hpaB)
SMACSMDB11_4710(hpaB)
SMWSMWW4_v1c05900
SPESpro_0634
SRRSerAS9_0570
SRLSOD_c05020(hpaB)
SRYM621_02650
SPLYQ5A_002640(hpaB)
SRSSerAS12_0570
SRASerAS13_0570
SMAFD781_0578
SLQM495_02515
SERFL085_01150
SERSSERRSCBI_02790
SFWWN53_24640
SFGAV650_20290
SRZAXX16_4529
SERMCLM71_02800(hpaB)
SQUE4343_13485(hpaB)
SFJSAMEA4384070_0661(hpaB)
SOFNCTC11214_00922(hpaB)
SSURATE40_023630
SURIJ0X03_21035(hpaB)
SRHZFO014_07040(hpaB)
SENPKHA73_02685(hpaB)
SFOZ042_02305 Z042_16840
PPAVLOZ86_20135
DZEDd1591_0652
CEDLH89_16320
DFNCVE23_18605
EPECI789_23845(hpaB)
PLUplu0246 plu0975(hpaB) plu4027 plu4258
PLUMA4R40_01205 A4R40_04870 A4R40_20005 A4R40_21115
PAYPAU_00189(hpaB) PAU_00478 PAU_00910(hpaB)
PTTVY86_09160 VY86_13810
PAKHB0X70_01060 B0X70_02985 B0X70_05280
PLUICE143_01060 CE143_02970 CE143_05210(hpaB)
XBOXBJ1_3600
XBVXBW1_1452(hpaB) XBW1_4467
XNEXNC1_0446 XNC1_0449 XNC1_0811
XNMXNC2_0437 XNC2_0439 XNC2_0797
XDOXDD1_0415 XDD1_1013(hpaB)
XHOA9255_13900 A9255_13930 A9255_20565
XBUHGO23_05330(hpaB) HGO23_17980
PSIS70_06520
PSXDR96_1964(hpaB)
PSTABGK56_09560
PRGRB151_008030(hpaB)
PALACO695_00795(hpaB)
PHEINCTC12003_00816(hpaB)
PRQCYG50_11520(hpaB)
PRJNCTC6933_00873(hpaB)
PVCG3341_03820(hpaB)
PMAGJI723_04280(hpaB)
MWIMNY66_12740(hpaB)
ETEETEE_3249(hsaA)
EDWQY76_13810
EDLAAZ33_06645
HAVAT03_16960
HPARAL518_09695(hpaB)
PFQQQ39_14505
PRAGEKN56_03285
PMUPM1523
PMVPMCN06_1790(hpaB)
PULNT08PM_1850
PMPPmu_17900(hpaB)
PMULDR93_372(hpaB)
PCAIK7G93_001658(hpaB)
VVYVV1591
VNIVIBNI_B1950(C2-hpah)
VSIMTO69_16135
VMIAL543_16470
PAEPA4091(hpaA)
PAEVN297_4221(hpaB)
PAEIN296_4221(hpaB)
PAUPA14_11000(hpaA)
PAPPSPA7_1007(hpaB)
PAGPLES_08851(hpaA)
PAFPAM18_0849(hpaA)
PNCNCGM2_5292(hpaA)
PAEBNCGM1900_0869(hpaA)
PDKPADK2_03870
PSGG655_04225
PRPM062_21575
PAEPPA1S_04375
PAERPA1R_gp1980
PAEMU769_04385
PAELT223_04325
PAESSCV20265_0881
PAEUBN889_04541(hpaB)
PAEGAI22_29240
PAECM802_4219(hpaB)
PAEOM801_4087(hpaB)
PREPCA10_16270
PFUWKF707C_17640
PCQPcP3B5_43330(C2-hpah)
PPGPputGB1_3505
PPUNPP4_18910
PMOSO165_008860
PMOLCLJ08_26065
PFLPFL_3356(hpaB)
PPRCPFLCHA0_c33860(hpaB)
PPROPPC_3380(hpaB)
PFEPSF113_2541
PFNHZ99_04680
PFSPFLU_3290
PFCPflA506_3413
PFBVO64_1115
PTVAA957_24835
PCGAXG94_26660
PAZOAYR47_26870
PMEDE3Z27_12185
PFWPF1751_v1c34970
PFFPFLUOLIPICF718420
PENPSEEN3105(C2-hpah)
PLULFOB45_04640(hpaB)
PBAPSEBR_a2734
PBCCD58_13800
PDRH681_09045
PSKU771_15550
PKCPKB_2463(C2-hpah)
PCHEY04_16655 EY04_26305
PCZPCL1606_27180
PCPJM49_05440 JM49_14085
PSWLK03_18060
PSESPSCI_3395
PSEMTO66_17310
PSECCCOS191_2761(C2-hpah)
PSOSPOS17_3333(hpaB)
PANRA7J50_3697
PSETTHL1_2773
PYMAK972_3769
POJPtoMrB4_16900
PVKEPZ47_13725
PEZHWQ56_10220
PBZGN234_04580
PKHJLK41_06165
PDWBV82_1320 BV82_1423
PSEPC4K39_5324
PVWHU752_019640
PTRTHU722_0018845
PSAMHU731_005480
PQIKH389_10295
PSHHHU773_015390
PXNHU772_012305 HU772_018355
PPRGHU725_013785
PASGKSS96_11875
PMUYKSS95_15520
PMAMKSS90_12090
PORYEJA05_13105
PTKEXN22_11260 EXN22_16475
PTWTUM18999_28940
PZAHU749_016655
AVNAvin_32180
AVLAvCA_32180
AVDAvCA6_32180
EMODM558_04925(hpaB)
ABAZP795_7490 P795_8065
ABKLX00_09700 LX00_09960
ABAUIX87_20440 IX87_20745
ADVDJ533_16250
AGUAS4_29660(nphA1)
ACHICDG60_14185
ABOUACBO_11760
ACIUA3K93_02950
SWDSwoo_2019
CPSCPS_2047
KIMG3T16_00445 G3T16_00495
CZACYCME_2117(hpaB)
HTTHZS52_07390
HAAA5892_03490
MMWMmwyl1_3188
MPRIMP3633_3060
MGEOCFI10_04410
MSECLN244_12255
AJPAMJAP_1775
GSNYC6258_01805 YC6258_05643
GBIPG2T_12225
IGNMMG00_11010
CRZD1345_13760
CHAECH06BL_29110
AMAHDLM_0606
AQSDKK66_02155
RPJN234_22475 N234_29420
REHH16_B0496(h16_B0496)
CNCCNE_2c04450(hpaH)
CUHBJN34_24170
REUReut_C6314
COXE0W60_08660 E0W60_22670
BURBcep18194_B2410
BCMBcenmc03_3821
BCHBcen2424_3700
BCJBCAM0734
BCENDM39_4430
BCEOI35_4633
BCTGEM_5625
BCEDDM42_4353
BCEPAPZ15_20730
BCONNL30_22200
BLATWK25_13940
BSEMWJ12_23670
BPSLWS57_10300
BMECWJ16_22580
BSTLBBJ41_31275
BYIBYI23_C002090 BYI23_C002900
BUEBRPE67_CCDS09320 BRPE67_CCDS10130
BUMAXG89_38880
BUIAX768_21460
PPKU875_16245
PPNODA70_08135
PPNMLV28_22445
PRBX636_18135
PPULRO07_16865
PAPISG18_15675
PANDDRB87_07390
PFIBPI93_019750
HYFDTO96_101742(hpaB)
CABASBC2_49520(hpaH)
BOJCBF45_15850 CBF45_15870
CDNBN940_14331
PIGEGT29_10635
KGYEHF36_15900(hpaB) EHF36_15920
RHFEUB48_08820
DACDaci_3024
DELDelCs14_3704
DTSBI380_08205
DHKBO996_13935
DLAI6G47_08245
DIHG7047_27660
DRGH9K76_01275
RBUPG1C_06920
SCUSCE1572_13565
PAUUE8A73_016385
MCIMesci_0674
MOPMesop_0688
MAMOA6B35_09760
MESWA9K65_003390
MESPC1M53_16535
MESRFGU64_08630
MESMeso_2465
AAKAA2016_5887
AMIHCO731_05316
PLAPlav_1785
RHINGR_b20090(hpaB)
SFHSFHH103_05222(hpaB)
SIXBSY16_2360 BSY16_3678 BSY16_4601
EADOV14_a0070(hpaB)
EAHFA04_27315
ESJSJ05684_b51280
RLTRleg2_4429
RTRRTCIAT899_PC03915
RHRCKA34_25750
RGRFZ934_23355
RADCO657_33830
RHIDFFM81_027330
RBQJ2J99_22425
RRGJ3P73_20055
RLSHB780_12585
NEOCYG48_12340
SHZshn_16275
BRKCWS35_28620
BGZXH91_23405
BARHWN72_40660
BVZBRAD3257_2210(nphA)
BELBE61_64500(hpaB) BE61_86820
BSEPHAP48_0033845
BQBJ4P68_0035140
RBKE0H22_01685
VGOGJW-30_1_02620(hpaB)
TRBHB776_00730 HB776_12250 HB776_24575
XAUXaut_0377 Xaut_2574
XDIEZH22_02415 EZH22_03590 EZH22_12875 EZH22_14710 EZH22_30930
AZCAZC_4189
SNOSnov_2630
STARG3545_06640 G3545_07185 G3545_20115 G3545_23450
LNEFZC33_03830 FZC33_08785
APRAG3A50_15685 G3A50_19050 G3A50_19060
APOLK9D25_00935
MEEDA075_32995
CHELAL346_04825
HMCHYPMC_0261
RHZRHPLAN_16150 RHPLAN_17100 RHPLAN_22700 RHPLAN_32460 RHPLAN_51690 RHPLAN_54270 RHPLAN_62260
METGHT051_03955
DEQXM25_03690(pvcC)
YTIFNA67_07520
PLEOOHA_1_00476 OHA_1_01081(hpaH) OHA_1_03164(npcA)
HDIHDIA_0239(npcA)
PSINCAK95_10695 CAK95_16885 CAK95_27280
NOHG5V57_04365 G5V57_17175
TSOIZ6_13900
LAPACP90_16480
LABRCHH27_13370
LABTFIU93_23110(nphA1)
LAGGB0E33_28320
PSTGE8M01_14155 E8M01_21585 E8M01_25625
ACUTMRB58_18980
CEHCEW89_08830 CEW89_12085
CONTQ29_11625 TQ29_16040
THAACFI11_12510
MALUKU6B_25150
PALXGQA70_15525
RSPRSP_3018
RSHRsph17029_3744
RHPLPB142_07400
PAMIJCM7686_pAMI6p015
PYEA6J80_01470
PTPRCA23_c29330(hpaH)
RSUNHU_03033(C2-hpah)
DAAAKL17_0233 AKL17_3242 AKL17_3250
TECAKL02_008305
SEDIEBB79_22945
PPRUFDP22_03070
PAEDG5B38_20485
PALWPSAL_024270(npcA)
THASC6Y53_07030
SPHOC3E99_15575
SWISwit_1536
RDICMV14_14760
SECHB18_03560
GXLH845_1141
KEUS101446_00275(hpaB)
KSCCD178_01478(hpaH)
KREGWK63_12530
ASZASN_1362(hpaB)
AACEA0U92_02580
ATOCIW82_05255
SRFLHU95_08245 LHU95_08695
HTQFRZ44_13830
HADHFRZ61_13620
APBSAR116_0256
BSUBSU18620(yoaI)
BSRI33_2090(hpaB)
BSLA7A1_2448
BSHBSU6051_18620(yoaI)
BSYI653_09690
BSUTBSUB_02002(yoaI)
BSULBSUA_02002(yoaI)
BSUSQ433_11010
BSNBSn5_00675
BSQB657_18620(yoaI)
BSXC663_1926
BSPU712_09805
BSSBSUW23_09940(yoaI)
BSTGYO_2242(hpaB)
BAYRBAM_002630(hpaB)
BAQBACAU_0205(yoaI)
BYABANAU_0209(yoaI)
BAMPB938_01060
BQYMUS_0220(yoaI)
BAMLBAM5036_0217(yoaI)
BAMARBAU_0233(yoaI)
BAMNBASU_0220(yoaI)
BAMBBAPNAU_0209(yoaI)
BAMTAJ82_01435
BAMYV529_02230
BMPNG74_00247
BAOBAMF_0207(yoaI)
BAZBAMTA208_01065(yoaI)
BQLLL3_00211(yoaI)
BXHBAXH7_00218
BAMIKSO_018345
BAMCU471_02150
BAMFU722_01355
BSIACWD84_20685(hpaB)
BVMB9C48_01310
BTEQG4P54_10690(hpaB)
BIQAN935_09720
BCABCE_2148 BCE_2601
BCBBCB4264_A2558
BCXBCA_2146
BCFbcf_10170
BCERBCK_24265
BCEFBcrFT9_01682 BcrFT9_02035
BCYBcer98_0966
BTLBALH_1835
BTBBMB171_C2288
BTTHD73_3424
BTHRYBT1520_16870
BTHIBTK_16895
BTCCT43_CH2513
BTFYBT020_12875 YBT020_29196
BTGBTB_c26350
BTHTH175_ch2554
BTHUYBT1518_14245
BTHYAQ980_14115
BMYCDJ92_4629
BBYCY96_11695
BTROFJR70_06330 FJR70_09265
BNTGSN03_10105
BIFN288_24560
BSMBSM4216_0733 BSM4216_2177
BGYBGLY_3123
BWHA9C19_03240
BITBIS30_20495
BFDNCTC4823_00762 NCTC4823_00782 NCTC4823_00810(hpaB) NCTC4823_01206 NCTC4823_02215(yoaI) NCTC4823_03859
BSHILGQ02_18510
BBADK7T73_02505(hpaB) K7T73_04805 K7T73_16300(hpaB) K7T73_21240
BCABEFK13_10315(hpaB)
BRYM0696_10075(hpaB)
BJSMY9_2034
BACIB1NLA3E_10730 B1NLA3E_17945 B1NLA3E_17950
GSTHW35_13010
BACPSB24_08490
BACBOY17_04010
BACOOXB_2499 OXB_2686 OXB_3446 OXB_3454
BACYQF06_08435
BACLBS34A_20630(yoaI)
BALMBsLM_1985
BACSAUL54_09490
BACQDOE78_09930(hpaB)
BACAFAY30_12455(hpaB) FAY30_13510 FAY30_13525
BAQUK6959_02270
BCOBcell_2010
BHKB4U37_04110 B4U37_13975
BCOHBC6307_00940
BCIRC2I06_15050(hpaB)
BMQBMQ_2417(hpaB) BMQ_3596(hpaB)
BMDBMD_2382(hpaB) BMD_3581(hpaB)
BMHBMWSH_2819(pvcC)
BMEGBG04_470 BG04_4791(hpaB)
BEOBEH_04630 BEH_12545
PKSIE339_14145(hpaB)
BHABH3836
BCLABC0890
BLEBleG1_3140
BKWBkAM31D_17795
BGIBGM20_03880
BKOCKF48_02440 CKF48_12865(hpaB)
CGOTJ1899_15635(hpaB)
CSUAIM538_04930(hpaB)
OIHOB2872
OCNCUC15_07490(hpaB)
GKAGK2138 GK3034
GTEGTCCBUS3UF5_24190 GTCCBUS3UF5_33960
GTKGT3570_10150 GT3570_14800
GTMGT3921_03955
BCALCWI35_12845(hpaB) CWI35_17760(hpaB)
GTNGTNG_2992(hpaB) GTNG_3160
GYCGYMC61_3113
GYAGYMC52_3140
GCTGC56T3_0470
GMCGY4MC1_0462 GY4MC1_1588
GGHGHH_c22230(yoaI) GHH_c31080(hpaB)
GJFM493_12230 M493_15810 M493_17955
GSEGT50_06875
GZAIC807_06805(hpaB) IC807_11295(hpaB)
GTHGeoth_0530 Geoth_1671
PTLAOT13_00545 AOT13_14480
PTBDER53_14690(hpaB)
PCALBV455_00235(nphA1) BV455_02281
ANMGFC28_1574(hpaB) GFC28_3725(hpaB)
AAMYGFC30_1755(hpaB)
ANLGFC29_1708(hpaB) GFC29_54(hpaB)
ANDGRQ40_05030(hpaB) GRQ40_12980(hpaB)
ASEDIRT44_17665
LSPBsph_3875(pvcC)
LGYT479_15720 T479_19670
LFUHR49_07505
LYSLBYS11_11740 LBYS11_15360(hpaB)
LYBC3943_11775(hpaB) C3943_22700
LYZDCE79_01715 DCE79_11215(hpaB)
LYGC1N55_11360(hpaB)
LPAKGDS87_16685(hpaB) GDS87_20255
LAGRFJQ98_19945(hpaB)
LMACI6G82_04210(hpaB)
LYCFH508_0016465(hpaB)
LCAPICJ70_08325(hpaB)
HHDHBHAL_2383(hpaB) HBHAL_3970(yoaI)
HMNHM131_07195 HM131_18375
HLIHLI_17040(hpaB) HLI_19760(hpaB)
TAPGZ22_02140
TAIDKS242_03225(hpaB)
VIRX953_15535
VHLBME96_15020
VIGBKP57_18425
VILCFK37_10560(hpaB) CFK37_10890(hpaB)
VNECFK40_05945(hpaB)
VPNA21D_03946
VIMGWK91_09765(hpaB)
VPTKBP50_11285(hpaB)
FPNABE65_004705 ABE65_007020 ABE65_019825
FARABE41_002760 ABE41_004850 ABE41_008075
APAKAP3564_00570
BSJUP17_10485 UP17_15195 UP17_22410
BMURABE28_014085 ABE28_020060
PASABAOM_0489 BAOM_2294(hpaB) BAOM_2295(hpaB)
PPSRI6J18_05330(hpaB)
PFRIL8956_05235 L8956_11350 L8956_15915(hpaB)
AQTFN924_04995(hpaB)
PSYHD0S48_01905(hpaB) D0S48_11000(hpaB)
PSYOPB01_01290(hpaB) PB01_10745(hpaB) PB01_19030(hpaB)
PRDF7984_03855(hpaB)
GRCGI584_18890(hpaB)
RUEDT065_12605 DT065_13750 DT065_14095(hpaB) DT065_14180 DT065_15175
POFGS400_10225(hpaB)
NMKCHR53_04775 CHR53_09955(hpaB) CHR53_10175(hpaB) CHR53_16415
NDTL1999_03220(hpaB) L1999_17470
MEKUHUW50_04520(hpaB)
MSEMGMB29_05745(hpaB) GMB29_05780 GMB29_08290 GMB29_22845(hpaB)
MDGK8L98_21235(hpaB)
MLITKDJ21_010190(hpaB)
BVJI5776_09945(hpaB) I5776_15190(hpaB)
BOUI5818_04760 I5818_11355(hpaB) I5818_18885(hpaB)
CTHUHUR95_08550(hpaB)
GAJMY490_08530
HYIK2M58_04775 K2M58_04815 K2M58_06415(hpaB) K2M58_09755
BBEBBR47_29710
BFMBP422_09685
GYMGYMC10_2686
PMSKNP414_04955
PMQPM3016_4358
PMWB2K_22570
PLVERIC2_c16720(hpaB)
PBDPBOR_19255
PAEFR50345_13370
PAEJH70737_12745
PBJVN24_08080 VN24_09465 VN24_09470 VN24_23030 VN24_23040
PIHUB51_09320
PRIPRIO_3489
PNPIJ22_02430 IJ22_35230 IJ22_35330 IJ22_36190 IJ22_40300 IJ22_40320 IJ22_47340 IJ22_47350
POWIJ21_24840 IJ21_24850
PXLBS614_17050 BS614_22065
PCXLPB68_02885
PVOPVOR_16179
PLWD5F53_16310
PLUTEI981_20145
PCHIPC41400_28695(hpaB)
PBKBack11_14430(yoaI)
PPRTET464_01455
PBACHUB98_04515
PSOPKP014_04835
PCELHUB94_10130 HUB94_10140 HUB94_23490
ANXACH33_11740 ACH33_14090
ASOCCB4_02002(hpaH) CB4_02465
ATHEK3F53_04820(hpaB) K3F53_07200
COHNKCTCHS21_16060 KCTCHS21_49750
CCHLFPL14_21605
AACAaci_0339
AADTC41_0460(hpaB)
AACOK1I37_05145
BTSBtus_1571 Btus_2072
KYRCVV65_03310 CVV65_08580(hpaB) CVV65_10375
EFFskT53_05560(yoaI)
SIVSSIL_0564(yoaI)
SSILSOLI23_15940
SOBCSE16_08880(hpaB) CSE16_18810(hpaB)
SPSYAZE41_13970 AZE41_14175
SPORSporoP33_07570
SPOPSporoP37_08005
SURESporoP32a_08025
SPOSDV702_11180 DV702_12005(hpaB)
SPAEE2C16_06870 E2C16_12310
RSTATY39_04190
PANCE2636_09660(hpaB) E2636_17240(hpaB)
VIJJNUCC6_17985(hpaB)
LPLlp_0070
LPJJDM1_0079
LPSLPST_C0059
LARGLPA65_00300
TMRTmar_1818
SAYTPY_2462(hpaB)
SAPSulac_3216
STHRBXT84_13350
MMCMmcs_2605 Mmcs_2617
MKMMkms_2649 Mkms_2661
MJLMjls_2635 Mjls_2646
MSIMMSIM_36600
MSAKMSAS_12990
MDFK0O62_16240
MVAMvan_3156
MFTXA26_16640
MVQMYVA_2937
MTHN4412656_02473(C2-hpah)
MMAGMMAD_31860
MHEVMHEL_41210
MMATMMAGJ_45110
CIICIMIT_11890
CHMB842_09825
CTEDCTEST_09800(nphA1)
CCOECETAM_00340(nphA1)
COKCOCCU_02390(nphA1)
CCYCSCMU_01870
NFANFA_20870 NFA_30560 NFA_43650
NFRERS450000_01009(hpaB_1) ERS450000_02023(hpaB_2) ERS450000_05550(hpaB_3)
NBRO3I_018985
NTPCRH09_09070
NOZDMB37_02710
RHARHA1_ro01782 RHA1_ro02380 RHA1_ro02514(pheA1) RHA1_ro03853 RHA1_ro03872 RHA1_ro08077
RERRER_54270
REYO5Y_25790 O5Y_28105
REBXU06_26125
RQIC1M55_27390
ROPROP_14550 ROP_20940 ROP_22410 ROP_37410(nphA1) ROP_pROB02-01900(hpaB)
ROAPd630_LPD00219 Pd630_LPD05941 Pd630_LPD06576 Pd630_LPD06741
RPYY013_12530 Y013_13560
RBYCEJ39_00005 CEJ39_00940
RAVAAT18_08140 AAT18_20190 AAT18_24410
RRZCS378_09635 CS378_13990 CS378_23155
RHUA3Q40_03004(nphA1)
RHQIM25_04905
RHODAOT96_07360
RRT4535765_04635(hpaB)
RKOJWS14_09035 JWS14_12385 JWS14_13195 JWS14_21190
RGOKYT97_17180
ROZCBI38_27095 CBI38_27550 CBI38_30670
GBRGbro_0220 Gbro_1818
GPOGPOL_c17090
GITC6V83_13720
GRUGCWB2_07650(nphA2)
GOMD7316_01448(nphA1)
GAVC5O27_20160
GODGKZ92_07270
GJIH1R19_06615 H1R19_07500
GAMIIHQ52_10425
TSMASU32_23285
DLUA6035_17385
SVESVEN_5100
SVTSVTN_26250
SXISXIM_24760
SPAVSpa2297_23925
SNWBBN63_09610
SALJSMD11_6592(hpaB)
STROSTRMOE7_28995
SLKSLUN_13730 SLUN_27520
SDXC4B68_05245
SQZFQU76_24155
SFICEIZ62_09270
SPHVF9278_28365
STSUB7R87_23890
SGXH4W23_27820
SBATG4Z16_05465(hpaB)
SPLACP981_35185(hpaB)
STUIGCM10017668_02130
SVDCP969_28360
SMOBJ7W19_28555
SPRACP972_28840 CP972_29130
STRYEQG64_09000
SACTDMT42_33040
SGOBtest1122_23020
KABB7C62_28875
KITCFP65_1244
MWAE4K62_17470
MLZF6J85_16555
AARCG127AT_14120
CPHYB5808_01110
SALCC2138_00815
SALDFVA74_01440
LEULeucomu_01850
AGGC1N71_05285
ARTArth_1935 Arth_2569
ARRARUE_c05860(hpaB)
ARHAHiyo8_57300
ARUASPU41_18785
ARQBWQ92_18670
ARNCGK93_03230
ACRYAC20117_08920 AC20117_12975 AC20117_15235
ARTHC3B78_09125
ARTPE5206_06020 E5206_09080(hpaB)
ACITHPK19_02390
ARIUM93_06905
AAUAAur_0618
GPRJQN66_14280 JQN66_16275
RSARSal33209_1499
KFVAS188_10310
SATKSA2016_3710
CIGE7744_15365
PAEYKUF55_15835
BCVBcav_0870
LMOIVV02_01280 VV02_15335
NAROCFH99_21920
NPCKUV85_11685
PSIMKR76_24440
AGRAAGRA3207_003235
FRAFrancci3_2770
BSDBLASA_1435
AOIAORI_4289(hpaB)
AJAAJAP_17445(hpaH)
AMQAMETH_1856 AMETH_5243
AMYCCU254_12330 CU254_16930
AMYBBKN51_14525
AMYYYIM_15275(nphA1)
AORISD37_21915
AACDLWP59_12455 LWP59_17440 LWP59_27055 LWP59_27200
PDXPsed_0216 Psed_2227 Psed_3087 Psed_6066
PSEAWY02_09470
PSEEFRP1_25220
PSEHXF36_28690
PSEQAD006_04400
PECQAD017_12220
PHHAFB00_29310
PAUTPdca_13110
PBROHOP40_33130(hpaB) HOP40_33375(hpaB)
APRECNX65_18395
SESPBN6_55630 BN6_58660(sam5)
SSYIEKG83_30765
LEDBBK82_43835
ACTIUA75_20985
ACADUA74_20490
SACEGIY23_17020
PRYPrubr_36820
FSLEJO69_05060
FLHEJ997_06155(hpaB)
RXYRxyl_1857
CWOCwoe_4365
SBAEDSM104329_01674 DSM104329_03719(nphA1_1) DSM104329_03725(nphA1_2) DSM104329_03727(nphA1_3)
CYJCyan7822_6021
RRSRoseRS_2569
RCARcas_2414
CAUCaur_1347
CHLChy400_1469
CAGCagg_2030
TROtrd_A0929 trd_A0931
STISthe_2805
CAPCLDAP_41000
KBSEPA93_17875(hpaB)
THUGKNN16_07250(hpaB)
DRADR_A0223
DGEDgeo_2418
DDRDeide_2p00060
DMRDeima_0220 Deima_1883
DPTDeipr_2619
DGODGo_CA0562
DPDDeipe_0884
DWUDVJ83_13505(hpaB)
DFCDFI_17460
DEINDAAJ005_01865(hpaB)
DGADEGR_32260
DPHEHF33_17480(hpaB)
DRDLMT64_12510(hpaB)
TRATrad_1888
TTHTT_C0594
TTJTTHA0960(TTHA0960) TTHB249(TTHB249)
TTSThthe16_0956
TTLTtJL18_1092
TSCTSC_c10450(hpaB)
THCTCCBUS3UF1_12430
TOSTheos_0972
TAQTO73_1002
TPARAV541_05910
TBCA0O31_00119
TANTKNN15_10285(hpaB)
MRBMrub_1332
MREK649_06315
MSVMesil_2312
MTAIMtai_v1c16440
MHDMarky_1264
AFUAF_0885
AFGAFULGI_00009740
HDLHALDL1_15845
STOSTK_07260(pheA1)
SOHD1869_03545
SSOSSO2053(hpaA)
SSHIJ5U23_02208
SCASSACC_13250
SAISaci_2294(hpaA)
SACNSacN8_11190
SACRSacRon12I_11430
SACSSUSAZ_10780
SISLS215_0936
SIAM1425_0686
SIMM1627_0691
SIDM164_0713
SIYYG5714_1009
SINYN1551_1864
SIILD85_0739
SIHSiH_0629
SIRSiRe_0706
SICSiL_0742
SULABFU36_08220
SULEGFS03_05910
SULOGFS33_11210
SULLEWF20_05040
MSEMsed_0996 Msed_1776
MEMJMJ1HA_1089 MJ1HA_2028
MCNMcup_0455 Mcup_1186
MHKDFR87_00965 DFR87_09780
MPRUDFR88_01535 DFR88_09340
MTENGWK48_00105 GWK48_02510
MJNMjAS7_1859 MjAS7_2927
AMANB6F84_05385
ABRIDFR85_15425
ASULDFR86_04660
ACIHHS5_11710
CSTYKN1_28510
SAHSHS7_01940
POGPogu_1357
 » show all
Reference
1  [PMID:14263147]
  Authors
ADACHI K, TAKEDA Y, SENOH S, KITA H.
  Title
METABOLISM OF P-HYDROXYPHENYLACETIC ACID IN PSEUDOMONAS OVALIS.
  Journal
Biochim Biophys Acta 93:483-93 (1964)
DOI:10.1016/0304-4165(64)90332-0
Reference
2  [PMID:8458860]
  Authors
Prieto MA, Perez-Aranda A, Garcia JL
  Title
Characterization of an Escherichia coli aromatic hydroxylase with a broad substrate range.
  Journal
J Bacteriol 175:2162-7 (1993)
DOI:10.1128/JB.175.7.2162-2167.1993
Reference
3  [PMID:8077235]
  Authors
Prieto MA, Garcia JL
  Title
Molecular characterization of 4-hydroxyphenylacetate 3-hydroxylase of Escherichia coli. A two-protein component enzyme.
  Journal
J Biol Chem 269:22823-9 (1994)
  Sequence
[elw:ECW_m4705]
Reference
4  [PMID:10653707]
  Authors
Xun L, Sandvik ER
  Title
Characterization of 4-hydroxyphenylacetate 3-hydroxylase (HpaB) of Escherichia coli as a reduced flavin adenine dinucleotide-utilizing monooxygenase.
  Journal
Appl Environ Microbiol 66:481-6 (2000)
DOI:10.1128/AEM.66.2.481-486.2000
  Sequence
[elw:ECW_m4705]
Reference
5  [PMID:10633095]
  Authors
Galan B, Diaz E, Prieto MA, Garcia JL
  Title
Functional analysis of the small component of the 4-hydroxyphenylacetate 3-monooxygenase of Escherichia coli W: a prototype of a new Flavin:NAD(P)H reductase subfamily.
  Journal
J Bacteriol 182:627-36 (2000)
DOI:10.1128/JB.182.3.627-636.2000
Reference
6  [PMID:12809507]
  Authors
Louie TM, Xie XS, Xun L
  Title
Coordinated production and utilization of FADH2 by NAD(P)H-flavin oxidoreductase  and 4-hydroxyphenylacetate 3-monooxygenase.
  Journal
Biochemistry 42:7509-17 (2003)
DOI:10.1021/bi034092r
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.9
IUBMB Enzyme Nomenclature: 1.14.14.9
ExPASy - ENZYME nomenclature database: 1.14.14.9
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.14.9
BRENDA, the Enzyme Database: 1.14.14.9
CAS: 37256-71-6

DBGET integrated database retrieval system