KEGG ENZYME: 1.14.14.92

ENZYME: 1.14.14.92

Entry

EC 1.14.14.92               Enzyme

Name

benzoate 4-monooxygenase;
benzoic acid 4-hydroxylase;
benzoate 4-hydroxylase;
benzoic 4-hydroxylase;
benzoate-p-hydroxylase;
p-hydroxybenzoate hydroxylase;
CYP53A1 (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

benzoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)

Reaction(IUBMB)

benzoate + [reduced NADPH---hemoprotein reductase] + O2 = 4-hydroxybenzoate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R01295]

Reaction(KEGG)

R01295

Substrate

benzoate [CPD:C00180];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

4-hydroxybenzoate [CPD:C00156];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

A cytochrome P-450 (heme-thiolate) protein found in Aspergillus fungi.

History

EC 1.14.14.92 created 1976 as EC 1.14.13.12, transferred 2018 to EC 1.14.14.92

Pathway

ec00362

Benzoate degradation

ec00627

Aminobenzoate degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K07824

benzoate 4-monooxygenase

Genes

BCOO:

119075328

NCR:

NCU01086

NTE:	NEUTE1DRAFT98143(NEUTE1DRAFT_98143)

SMP:	10807067(SMAC4_03160)

PAN:	PODANSg8616

PBEL:

QC761_207780

PPSD:

QC762_207780

PPSP:

QC763_207780

PPSA:

QC764_207780

TTT:	THITE_2107910

MTM:	MYCTH_2301715

MGR:

MGG_13928

PPEI:

PpBr36_03941

PGRI:

PgNI_09136

SSCK:

SPSK_09137

FGR:	FGSG_08079 FGSG_10451 FGSG_13445

FPU:	FPSE_07525 FPSE_07532 FPSE_10672

FPOA:

FPOAC1_003589 FPOAC1_004069 FPOAC1_004076

FVN:	FVRRES_03939 FVRRES_04560 FVRRES_04574

FVR:	FVEG_01611 FVEG_03183

FOX:	FOXG_02776 FOXG_04952

NHE:	NECHADRAFT_35086 NECHADRAFT_50496

FFC:	NCS54_00337700 NCS54_00464500 NCS54_01235600

FKR:	NCS57_00339800 NCS57_00470200 NCS57_01225100

FMU:	J7337_006086 J7337_007982

TRE:	TRIREDRAFT_65107

TRR:	M419DRAFT_101946

TATV:

25784724(TrAtP1_010387)

TASP:

36609312(TrAFT101_010875)

MAW:	19246043(J3458_004346)

MAJ:	MAA_04436 MAA_05461

MBRN:

26238986(bphA)

PCHM:

VFPPC_03315

CMT:

CCM_08604

AMUS:

LMH87_000366

PLJ:	28886044(PLICBS_007555)

PTKZ:

JDV02_002467

VAL:	VDBG_01360

VDA:	VDAG_07887

CFJ:	CFIO01_09741

CLUP:

CLUP02_07112

CHIG:

CH63R_03578

CDET:

87940597(CDEST_04094)

SAPO:

SAPIO_CDS0587

ELA:	UCREL1_629

PFY:	PFICI_03289 PFICI_09162

SSL:	SS1G_01843

BFU:	BCIN_02g02100

MBE:

MBM_02231

PSCO:

LY89DRAFT_606417 LY89DRAFT_689095 LY89DRAFT_720118

GLZ:	GLAREA_05688

ANI:	ANIA_10950

AFM:	AFUA_2G15230

ACT:	ACLA_074210

NFI:	NFIA_090480

AOR:	AO090001000079 AO090012000307

ANG:	An09g03500(bphA)

AFV:	AFLA_002023

ALUC:

AKAW2_11103S AKAW2_40396S

ACHE:

ACHE_31376S

APUU:

APUU_10385S APUU_80357A

PCS:	N7525_002386 N7525_004657 N7525_005492

PDP:	PDIP_04680 PDIP_32830

POU:	POX_h09880

TMF:	EYB26_000882 EYB26_008757

TRG:	TRUGW13939_05701

CIM:	CIMG_09108

CPW:	CPC735_015320

URE:	UREG_05168

PBL:	PAAG_11325(PAAG_01629)

PNO:	SNOG_04264

PTE:

PTT_11926

PTRR:

6346059(PtrM4_138750)

BZE:	COCCADRAFT_104303

BSC:	COCSADRAFT_120080

BOR:	COCMIDRAFT_80498

AALT:

CC77DRAFT_933446

ARAB:

EKO05_0002151

ZTR:	MYCGRDRAFT_53213(CYP-69)

PFJ:	MYCFIDRAFT_71345

FFU:	CLAFUR5_07071

CBET:

CB0940_00546

BCOM:

BAUCODRAFT_238892

NPA:	UCRNP2_7626

TASA:

A1Q1_06680

CCAC:

CcaHIS019_0108670(CcaverHIS019_0108670)

TVS:	TRAVEDRAFT_129211 TRAVEDRAFT_37267

DSQ:	DICSQDRAFT_55106

PCO:	PHACADRAFT_183109

SHS:	STEHIDRAFT_94174

HIR:	HETIRDRAFT_325050

PSQ:	PUNSTDRAFT_101387 PUNSTDRAFT_68781

ADL:	AURDEDRAFT_56813 AURDEDRAFT_70450

FME:	FOMMEDRAFT_115179 FOMMEDRAFT_128292 FOMMEDRAFT_130308 FOMMEDRAFT_143663 FOMMEDRAFT_149618 FOMMEDRAFT_154594 FOMMEDRAFT_162664 FOMMEDRAFT_24265 FOMMEDRAFT_94457

GTR:	GLOTRDRAFT_80617

RSX:	RhiXN_03253 RhiXN_03298 RhiXN_03413 RhiXN_03564 RhiXN_04223 RhiXN_05777 RhiXN_05964 RhiXN_06181 RhiXN_06183 RhiXN_06539 RhiXN_06976 RhiXN_07022 RhiXN_07035 RhiXN_08403 RhiXN_09640 RhiXN_10260 RhiXN_10275 RhiXN_10307 RhiXN_10308 RhiXN_10500 RhiXN_10516 RhiXN_10563 RhiXN_11738 RhiXN_12204

LBC:	LACBIDRAFT_291185

CCI:	CC1G_11080

ABP:	AGABI1DRAFT115220(AGABI1DRAFT_115220) AGABI1DRAFT115340(AGABI1DRAFT_115340)

ABV:	AGABI2DRAFT194181(AGABI2DRAFT_194181) AGABI2DRAFT194303(AGABI2DRAFT_194303)

PCUB:

JR316_0009077

MRR:	Moror_1895

E1B28_005038

SCM:	SCHCO_02640550(SCHCODRAFT_02640550)

CPUT:

CONPUDRAFT_105834 CONPUDRAFT_127772 CONPUDRAFT_83844

SLA:	SERLADRAFT_359647

UMA:	UMAG_00005

PFP:	PFL1_00403

SGRA:

EX895_000034

PGR:	PGTG_21421

PTRC:

PtA15_10A238

PSTR:

Pst134EA_019278

MLR:	MELLADRAFT_36399

» show all

Reference

1 [PMID:236777]

Authors

Reddy CC, Vaidyanathan CS.

Title

Purification, properties and induction of a specific benzoate-4-hydroxylase from Aspergillus niger (UBC 814).

Journal

Biochim Biophys Acta 384:46-57 (1975)
DOI:10.1016/0005-2744(75)90094-7

Reference

2 [PMID:11594739]

Authors

Faber BW, van Gorcom RF, Duine JA

Title

Purification and characterization of benzoate-para-hydroxylase, a cytochrome P450 (CYP53A1), from Aspergillus niger.

Journal

Arch Biochem Biophys 394:245-54 (2001)
DOI:10.1006/abbi.2001.2534

Sequence

[ang:An09g03500]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.14.92

IUBMB Enzyme Nomenclature:

1.14.14.92

ExPASy - ENZYME nomenclature database:

1.14.14.92

BRENDA, the Enzyme Database:

1.14.14.92

CAS:	39391-25-8

DBGET integrated database retrieval system