KEGG   ENZYME: 1.14.14.92
Entry
EC 1.14.14.92               Enzyme                                 

Name
benzoate 4-monooxygenase;
benzoic acid 4-hydroxylase;
benzoate 4-hydroxylase;
benzoic 4-hydroxylase;
benzoate-p-hydroxylase;
p-hydroxybenzoate hydroxylase;
CYP53A1 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
benzoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
Reaction(IUBMB)
benzoate + [reduced NADPH---hemoprotein reductase] + O2 = 4-hydroxybenzoate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R01295]
Reaction(KEGG)
R01295
Substrate
benzoate [CPD:C00180];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
4-hydroxybenzoate [CPD:C00156];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein found in Aspergillus fungi.
History
EC 1.14.14.92 created 1976 as EC 1.14.13.12, transferred 2018 to EC 1.14.14.92
Pathway
ec00362  Benzoate degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K07824  benzoate 4-monooxygenase
Genes
QSU: 112021863 112023807
NCR: NCU01086
NTE: NEUTE1DRAFT98143(NEUTE1DRAFT_98143)
SMP: SMAC_03160
PAN: PODANSg8616
TTT: THITE_2107910
MTM: MYCTH_2301715
CTHR: CTHT_0069080
MGR: MGG_13928
SSCK: SPSK_01114 SPSK_09137
MAW: MAC_01732
CMT: CCM_08604
MBE: MBM_02231
ANG: ANI_1_2020144(An16g08060) ANI_1_2992024(An02g10840) ANI_1_3226024(An02g13270) ANI_1_418084(An09g03500)
PBL: PAAG_11325(PAAG_01629)
ZTR: MYCGRDRAFT_53213(CYP-69)
TASA: A1Q1_06680
ABP: AGABI1DRAFT115220(AGABI1DRAFT_115220) AGABI1DRAFT115340(AGABI1DRAFT_115340)
ABV: AGABI2DRAFT194181(AGABI2DRAFT_194181) AGABI2DRAFT194303(AGABI2DRAFT_194303)
 » show all
Reference
1  [PMID:236777]
  Authors
Reddy CC, Vaidyanathan CS.
  Title
Purification, properties and induction of a specific benzoate-4-hydroxylase from Aspergillus niger (UBC 814).
  Journal
Biochim Biophys Acta 384:46-57 (1975)
DOI:10.1016/0005-2744(75)90094-7
Reference
2  [PMID:11594739]
  Authors
Faber BW, van Gorcom RF, Duine JA
  Title
Purification and characterization of benzoate-para-hydroxylase, a cytochrome P450 (CYP53A1), from Aspergillus niger.
  Journal
Arch Biochem Biophys 394:245-54 (2001)
DOI:10.1006/abbi.2001.2534
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.92
IUBMB Enzyme Nomenclature: 1.14.14.92
ExPASy - ENZYME nomenclature database: 1.14.14.92
BRENDA, the Enzyme Database: 1.14.14.92
CAS: 39391-25-8

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