KEGG   ENZYME: 1.14.14.92
Entry
EC 1.14.14.92               Enzyme                                 
Name
benzoate 4-monooxygenase;
benzoic acid 4-hydroxylase;
benzoate 4-hydroxylase;
benzoic 4-hydroxylase;
benzoate-p-hydroxylase;
p-hydroxybenzoate hydroxylase;
CYP53A1 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
benzoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
Reaction(IUBMB)
benzoate + [reduced NADPH---hemoprotein reductase] + O2 = 4-hydroxybenzoate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R01295]
Reaction(KEGG)
R01295
Substrate
benzoate [CPD:C00180];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
4-hydroxybenzoate [CPD:C00156];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein found in Aspergillus fungi.
History
EC 1.14.14.92 created 1976 as EC 1.14.13.12, transferred 2018 to EC 1.14.14.92
Pathway
ec00362  Benzoate degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K07824  benzoate 4-monooxygenase
Genes
BCOO119075328
QSU112021863 112023807
NCRNCU01086
NTENEUTE1DRAFT98143(NEUTE1DRAFT_98143)
SMPSMAC_03160
PANPODANSg8616
TTTTHITE_2107910
MTMMYCTH_2301715
MGRMGG_13928
PPEIPpBr36_03941
SSCKSPSK_09137
FGRFGSG_08079 FGSG_10451 FGSG_13445
FPUFPSE_07525 FPSE_07532 FPSE_10672
FVRFVEG_01611 FVEG_03183
FOXFOXG_02776 FOXG_04952
NHENECHADRAFT_35086 NECHADRAFT_50496
TRETRIREDRAFT_65107
TRRM419DRAFT_101946
MAWMAC_01732
MAJMAA_04436 MAA_05461
CMTCCM_08604
PLJVFPFJ_03913
VALVDBG_01360
VDAVDAG_07887
CFJCFIO01_09741
CLUPCLUP02_07112
CHIGCH63R_03578
SAPOSAPIO_CDS0587
ELAUCREL1_629
PFYPFICI_03289 PFICI_09162
SSLSS1G_01843
BFUBCIN_02g02100
MBEMBM_02231
PSCOLY89DRAFT_606417 LY89DRAFT_689095 LY89DRAFT_720118
GLZGLAREA_05688
AFMAFUA_2G15230
ACTACLA_074210
NFINFIA_090480
AORAO090001000079 AO090012000307
ANGANI_1_418084(An09g03500)
AFVAFLA_002023
ALUCAKAW2_11103S AKAW2_40396S
ACHEACHE_31376S
APUUAPUU_10385S APUU_80357A
PCSPc12g00600 Pc22g07440
PDPPDIP_04680 PDIP_32830
TMFPMAA_001660 PMAA_024240
TRGTRUGW13939_05701
CIMCIMG_09108
CPWCPC735_015320
UREUREG_05168
PBLPAAG_11325(PAAG_01629)
PNOSNOG_04264
PTEPTT_11926
BZECOCCADRAFT_104303
BSCCOCSADRAFT_120080
BORCOCMIDRAFT_80498
AALTCC77DRAFT_933446
ZTRMYCGRDRAFT_53213(CYP-69)
PFJMYCFIDRAFT_71345
FFUCLAFUR5_07071
BCOMBAUCODRAFT_238892
NPAUCRNP2_7626
TASAA1Q1_06680
TVSTRAVEDRAFT_129211 TRAVEDRAFT_37267
DSQDICSQDRAFT_55106
PCOPHACADRAFT_183109
SHSSTEHIDRAFT_94174
HIRHETIRDRAFT_325050
PSQPUNSTDRAFT_101387 PUNSTDRAFT_68781
ADLAURDEDRAFT_56813 AURDEDRAFT_70450
FMEFOMMEDRAFT_115179 FOMMEDRAFT_128292 FOMMEDRAFT_130308 FOMMEDRAFT_143663 FOMMEDRAFT_149618 FOMMEDRAFT_154594 FOMMEDRAFT_162664 FOMMEDRAFT_24265 FOMMEDRAFT_94457
GTRGLOTRDRAFT_80617
LBCLACBIDRAFT_291185
CCICC1G_11080
ABPAGABI1DRAFT115220(AGABI1DRAFT_115220) AGABI1DRAFT115340(AGABI1DRAFT_115340)
ABVAGABI2DRAFT194181(AGABI2DRAFT_194181) AGABI2DRAFT194303(AGABI2DRAFT_194303)
PCUBJR316_0009077
MRRMoror_1895
MOREE1B28_005038
SCMSCHCO_02640550(SCHCODRAFT_02640550)
CPUTCONPUDRAFT_105834 CONPUDRAFT_127772 CONPUDRAFT_83844
SLASERLADRAFT_359647
UMAUMAG_00005
PFPPFL1_00403
PGRPGTG_21421
MLRMELLADRAFT_36399
 » show all
Reference
1  [PMID:236777]
  Authors
Reddy CC, Vaidyanathan CS.
  Title
Purification, properties and induction of a specific benzoate-4-hydroxylase from Aspergillus niger (UBC 814).
  Journal
Biochim Biophys Acta 384:46-57 (1975)
DOI:10.1016/0005-2744(75)90094-7
Reference
2  [PMID:11594739]
  Authors
Faber BW, van Gorcom RF, Duine JA
  Title
Purification and characterization of benzoate-para-hydroxylase, a cytochrome P450 (CYP53A1), from Aspergillus niger.
  Journal
Arch Biochem Biophys 394:245-54 (2001)
DOI:10.1006/abbi.2001.2534
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.92
IUBMB Enzyme Nomenclature: 1.14.14.92
ExPASy - ENZYME nomenclature database: 1.14.14.92
BRENDA, the Enzyme Database: 1.14.14.92
CAS: 39391-25-8

DBGET integrated database retrieval system