KEGG   ENZYME: 1.14.14.96
Entry
EC 1.14.14.96               Enzyme                                 
Name
5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase;
5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase;
coumaroylquinate(coumaroylshikimate) 3'-monooxygenase;
CYP98A3 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
trans-5-O-(4-coumaroyl)-D-quinate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3'-hydroxylating)
Reaction(IUBMB)
trans-5-O-(4-coumaroyl)-D-quinate + [reduced NADPH---hemoprotein reductase] + O2 = trans-5-O-caffeoyl-D-quinate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R04342]
Reaction(KEGG)
R04342;
(other) R06582
Substrate
trans-5-O-(4-coumaroyl)-D-quinate [CPD:C12208];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
trans-5-O-caffeoyl-D-quinate [CPD:C00852];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein, found in plants. It also acts on trans-5-O-(4-coumaroyl)shikimate.
History
EC 1.14.14.96 created 1990 as EC 1.14.13.36, transferred 2018 to EC 1.14.14.96
Pathway
ec00940  Phenylpropanoid biosynthesis
ec00941  Flavonoid biosynthesis
ec00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09754  5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase
Genes
ATHAT2G40890(CYP98A3)
ALY9315964
CRB17887658
CSAT104782574 104785308 104792955
EUSEUTSA_v10016538mg
BRP103857960 103865848 103866522
BNA106352767 106386334 106391625 106395719 106431114 106438010
BOE106335822 106340718 106342398
RSZ108847330 108848401 108858042
THJ104803227
CPAP110811301
CIT102623337 102624231 127902134
CICCICLE_v10000848mg CICLE_v10003647mg CICLE_v10011520mg CICLE_v10019813mg
PVY116130453
MINC123211020 123211225 123224750
TCC18598608
GRA105782306 105786247
GHI107920919 107935532 107950342 121229624
GAB108464295 108466431
HSYR120139846 120154034
DZI111293639
EGR104443712 104443731 104443755 104454510
GMX100811080 606506(CYP98A2)
GSJ114399785 114406591
PVUPHAVU_001G117900g
VRA106753926
VAR108346061
VUN114186352
VUM124835773
CCAJ109802555
APRC113861260
MTR120576930
TPRA123888242
CAM101502624
PSAT127126484
VVO131609986 131622232
LJALj1g3v4081860.1(Lj1g3v4081860.1)
ADU107494128
AIP107604697
AHF112696779 112754637
LANG109326958
PCIN129311613
FVE101310387
RCN112191575
PPER18789678 18789708 18789709 18792412
PMUM103319005 103319006 103319007
PAVI110765625 110765626 110765627 110765628 110771536
PDUL117612862 117616059 117616060 117629116
MDM103402429 103425389 103428961 103441965
MSYL126599158 126603427 126605902 126631773 126631775
PXB103944996 103944997 103944999 103946365 103946366
ZJU107431535
MNT21410476
CSAV115712743 115724660
CSV101217257
CMO103486874
BHJ120091747
CMAX111482281
CMOS111441713
CPEP111790179
RCU8277408 8277879 8277880
JCU105636120
HBR110668477
MESC110621178
POP18106094 7458907 7495679
PEU105136908 105137345
PALZ118033187 118033188 118052995
JRE109008126 109008127 109019007
CILL122275816 122276443 122278307
CAVE132161799 132161912
QSU112007479 112007503
QLO115953326
TWL119992803
VVI100263633
VRI117920828
SLY101246092 101247849 101261765 101262063 101262367
SPEN107001769 107001863 107002593 107008188 107028331
SOT102578406 102578747 102586130 102590105 102590484 102590830 102590870 102606401
SSTN125863836 125865331 125865642 125865643 125865644 125865645 125871059
SDUL129876173 129876783 129876993 129877011 129886387 129887625
CANN107839366 107844023 107844024 107844025
LBB132607582 132607583 132607584 132607585 132607586 132607587 132626332 132645355
NTA107767804 107768690 107771987 107792896 107797681 107800961 107803600 107824233(CYP98A33v1)
NSY104216569 104221515 104228627 104235549
NTO104088297 104092594 104112912 104119156
NAU109221014 109228215 109239726 109239730
INI109159148
ITR115996353 116029460
SIND105162700 105172202
OEU111391169 111401521
EGT105949334 105949335 105951765 105951768 105951769 105963605
SSPL121747388 121747439 121751565 121753302 121804071 121805425 121805775 121806378 121808561
SMIL130990242 131006470 131022484 131022485
APAN127256589 127260999
HAN110865896 110895770
ECAD122579549 122582247
LSV111877005 111891710 111908828 111919428
CCAV112504027 112512472
DCR108209804 108227431
CSIN114298795 114303480 114303482
RVL131323005 131323006 131323008
AEW130755199 130777412 130786255
BVG104887604 104889547 104889649 104889748
SOE110778982 110779503 110799229
CQI110709209 110711729 110714717 110714951 110717575 110720052
ATRI130800658 130821286 130827890
MOF131146393 131160666
NNU104588272
MING122063491 122063496 122068462 122069164 122088749
TSS122666848 122669889
PSOM113298939 113358675
OSA4339188
DOSAOs05t0494000-01(Os05g0494000)
OBR102712257
OGL127752952 127773835
BDI100835531
ATS109731922 109752053 109757203 109771149 109775586
TDC119269306 119277305 119284878 119348794
TAES123060768 123062331 123071098 123079468 123100799 123108593 123137844 123182452
TUA125506560 125522601 125545066
LPER127318794 127344160
LRD124662229 124707437
SBI8077042 8082405
ZMA100191539 100274274
SITA101771055
SVS117849885
PVIR120665065 120673263 120698273
PHAI112887100 112894578
PDA103705056 103706282
EGU105033349 105052441
MUS103995155
ZOF121971833 122002816 122007084 122030545
DCT110101632
PEQ110024997
AOF109819911
MSIN131226852 131227290 131227703 131227845 131227846
NCOL116245980
ATR18427105 18441256
SMOSELMODRAFT_450942(C3'H1-1) SELMODRAFT_450943(C3'H1-2)
PPP112275074
 » show all
Reference
1  [PMID:2821918]
  Authors
Kuhnl T, Koch U, Heller W, Wellmann E.
  Title
Chlorogenic acid biosynthesis: characterization of a light-induced microsomal 5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase from carrot (Daucus carota L.) cell suspension cultures.
  Journal
Arch Biochem Biophys 258:226-32 (1987)
DOI:10.1016/0003-9861(87)90339-0
Reference
2  [PMID:11429408]
  Authors
Schoch G, Goepfert S, Morant M, Hehn A, Meyer D, Ullmann P, Werck-Reichhart D
  Title
CYP98A3 from Arabidopsis thaliana is a 3'-hydroxylase of phenolic esters, a missing link in the phenylpropanoid pathway.
  Journal
J Biol Chem 276:36566-74 (2001)
DOI:10.1074/jbc.M104047200
  Sequence
[ath:AT2G40890]
Reference
3  [PMID:11967091]
  Authors
Franke R, Humphreys JM, Hemm MR, Denault JW, Ruegger MO, Cusumano JC, Chapple C
  Title
The Arabidopsis REF8 gene encodes the 3-hydroxylase of phenylpropanoid metabolism.
  Journal
Plant J 30:33-45 (2002)
DOI:10.1046/j.1365-313X.2002.01266.x
  Sequence
[ath:AT2G40890]
Reference
4  [PMID:19779199]
  Authors
Matsuno M, Compagnon V, Schoch GA, Schmitt M, Debayle D, Bassard JE, Pollet B, Hehn A, Heintz D, Ullmann P, Lapierre C, Bernier F, Ehlting J, Werck-Reichhart D
  Title
Evolution of a novel phenolic pathway for pollen development.
  Journal
Science 325:1688-92 (2009)
DOI:10.1126/science.1174095
  Sequence
[ath:AT2G40890]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.96
IUBMB Enzyme Nomenclature: 1.14.14.96
ExPASy - ENZYME nomenclature database: 1.14.14.96
BRENDA, the Enzyme Database: 1.14.14.96
CAS: 112131-08-5

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