KEGG   ENZYME: 1.14.15.14
Entry
EC 1.14.15.14               Enzyme                                 
Name
methyl-branched lipid omega-hydroxylase;
CYP124
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
methyl-branched lipid,reduced-ferredoxin:oxygen oxidoreductase (omega-hydroxylating)
Reaction(IUBMB)
a methyl-branched lipid + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = an omega-hydroxy-methyl-branched lipid + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster
Substrate
methyl-branched lipid;
O2 [CPD:C00007];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
H+ [CPD:C00080]
Product
omega-hydroxy-methyl-branched lipid;
H2O [CPD:C00001];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139]
Comment
The enzyme, found in pathogenic and nonpathogenic mycobacteria species, actinomycetes, and some proteobacteria, hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. It is a P-450 heme-thiolate enzyme.
History
EC 1.14.15.14 created 2015
Orthology
K20497  methyl-branched lipid omega-hydroxylase
Genes
MTURv2266(cyp124)
MTVRVBD_2266
MTCMT2328
MRAMRA_2286(cyp124)
MTFTBFG_12293
MTBTBMG_01716
MTKTBSG_01726
MTZTBXG_001698
MTGMRGA327_13975
MTECCDC5079_2102
MTURCFBS_2399(cyp124)
MTLCCDC5180_2074
MTOMTCTRI2_2301(cyp124)
MTDUDA_2266(cyp124)
MTNERDMAN_2490(cyp124)
MTJJ112_12165
MTUBMT7199_2297(cyp124)
MTUCJ113_15800
MTUEJ114_12155
MTXM943_11730
MTUHI917_15990
MTULTBHG_02216
MTUTHKBT1_2390(cyp124)
MTUUHKBT2_2392(cyp124)
MTQHKBS1_2396(cyp124)
MBOBQ2027_MB2289(cyp124)
MBBBCG_2283(cyp124)
MBTJTY_2277(cyp124)
MBMBCGMEX_2271(cyp124)
MBKK60_023510
MBXBCGT_2089
MAFMAF_22760(cyp124)
MMICRN08_2514
MCEMCAN_22901(cyp124)
MCQBN44_50212(cyp)
MCVBN43_31508(cyp)
MCXBN42_40188(cyp)
MCZBN45_50597(cyp)
MPAMAP_2015
MAOMAP4_1810
MAVIRC58_09040
MAVURE97_09045
MAVMAV_2174
MITOCO_21580
MIAOCU_21760
MIDMIP_03049
MYOOEM_19490
MCHIAN480_11180
MIROCQ_20680
MMALCKJ54_09630
MMANMMAN_18210(cyp124_1)
MSAMycsm_03362
MULMUL_1282(cyp124A1)
MMCMmcs_2742 Mmcs_2991
MKMMkms_2786 Mkms_3035
MJLMjls_2772 Mjls_3006
MMIMMAR_3361(cyp124A1)
MMAEMMARE11_32610(cyp124A1)
MMMW7S_10140
MLIMULP_03625(cyp124A1)
MKNMKAN_03480
MYVG155_16190
MYEAB431_15885 AB431_16625
MGOAFA91_22075
MHADB586_09820
MDXBTO20_16125
MSHGMSG_03191(cyp124)
MFJMFLOJ_00260(cyp124) MFLOJ_59110
MSTOMSTO_00890(cyp124)
MSIMMSIM_44970(cyp124)
MSAKMSAS_12420(cyp124)
MKUI2456_16160
MGROFZ046_20300
MXEMYXE_20490(cyp124_2)
MNVMNVI_45420(cyp124)
MPAGC0J29_18745
MGORH0P51_17465
MCOOMCOO_13040(cyp124)
MBAIMB901379_03033
MSEOMSEO_19780(cyp124)
MSHOMSHO_47750(cyp124)
MHEKJMUB5695_02065(cyp124_3)
MGAUMGALJ_16330(cyp124_1) MGALJ_19280(cyp124_2)
MLJMLAC_22790(cyp124)
MBRDMBRA_58180(cyp124)
MSHJMSHI_09980(cyp124)
MDFK0O62_15555
MMAMK3U93_14985
MHOLK3U96_12440
MSENK3U95_13655
MPAEK0O64_14945 K0O64_15740
MSPGF6B93_14060
MOTLTS72_07685
MRFMJO55_14425
MCROMI149_15940 MI149_16695
MSMMSMEG_3551
MSGMSMEI_3470(cyp124)
MSBLJ00_17675
MSNLI99_17680
MSHLI98_17685
MVAMvan_3029
MGIMflv_3307
MSPMspyr1_26350
MCBMycch_2589 Mycch_2853
MNED174_15450
MYNMyAD_15175
MFTXA26_33180
MPHLMPHLCCUG_02433
MVQMYVA_3042
MLLB1R94_13480
MRHMycrhN_4629 MycrhN_4917
MTHN4412656_02310(cyp124_2)
MDUMDUV_12270
MCHTMCHIJ_09550(cyp124_1) MCHIJ_38170(cyp124_2)
MAUUNCTC10437_02924
MMAGMMAD_29660
MMORMMOR_33770(cyp124)
MAICMAIC_28850(cyp124)
MALVMALV_06760
MTYMTOK_12370(cyp124) MTOK_47990
MPSCMPSYJ_35430
MARZMARA_09040 MARA_52060
MGADMGAD_05490(cyp124_1) MGAD_08500(cyp124_2)
MHEVMHEL_52500(cyp124)
MSARMSAR_39650
MANYMANY_14570
MAUBMAUB_06780 MAUB_40940
MPOFMPOR_34320
MPHUMPHO_05900
MMUCC1S78_003945 C1S78_015380
MMATMMAGJ_65750
MBOKMBOE_41250 MBOE_47370(cyp124_1)
MFGK6L26_15710
MSEIMSEDJ_42730
MFLVNCTC10271_02487
MCEEMCEL_07530(cyp124)
SVLStrvi_3964
SRCM271_05620
SMALSMALA_7272
SSOII1A49_40125
SBHSBI_08399(nanP)
SGMGCM10017557_10840
SAUOBV401_39970
SBYH7H31_00670
SMOBJ7W19_02520
NGVCDO52_10130
STRREKD16_17690
TCUTcur_1580
ACTWF7P10_06655 F7P10_07660 F7P10_18535 F7P10_22425 F7P10_41715
AGRAAGRA3207_001650 AGRA3207_007609 AGRA3207_007747
SROSros_7140 Sros_7141 Sros_7142
NOABKM31_16295 BKM31_57925 BKM31_57940
NOWGBF35_38505
NCXNocox_31440 Nocox_31455
NGNLCN96_42915
TBITbis_2431
FRIFraEuI1c_5327
BSDBLASA_4033(cyp)
MMARMODMU_4611(cyp)
APRTMUY14_02400
PDXPsed_5473
PSEEFRP1_01500
PSEQAD006_09125 AD006_31290
PECQAD017_16955 AD017_29945
PHHAFB00_14855
PBROHOP40_11870 HOP40_25115
CAICaci_0813
ABAIIMCC26256_111881
AYMYM304_17460 YM304_26560 YM304_26850
ATQGH723_04580
IAMHC251_05490
 » show all
Reference
1  [PMID:19933331]
  Authors
Johnston JB, Kells PM, Podust LM, Ortiz de Montellano PR
  Title
Biochemical and structural characterization of CYP124: a methyl-branched lipid omega-hydroxylase from Mycobacterium tuberculosis.
  Journal
Proc Natl Acad Sci U S A 106:20687-92 (2009)
DOI:10.1073/pnas.0907398106
  Sequence
[mtu:Rv2266]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.15.14
IUBMB Enzyme Nomenclature: 1.14.15.14
ExPASy - ENZYME nomenclature database: 1.14.15.14
BRENDA, the Enzyme Database: 1.14.15.14

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