KEGG   ENZYME: 1.14.15.20
Entry
EC 1.14.15.20               Enzyme                                 

Name
heme oxygenase (biliverdin-producing, ferredoxin);
HO1 (gene name);
HY1 (gene name);
HO3 (gene name);
HO4 (gene name);
pbsA1 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
protoheme,reduced ferredoxin:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
Reaction(IUBMB)
protoheme + 6 reduced ferredoxin [iron-sulfur] cluster + 3 O2 + 6 H+ = biliverdin + Fe2+ + CO + 6 oxidized ferredoxin [iron-sulfur] cluster + 3 H2O [RN:R11579]
Reaction(KEGG)
R11579
Substrate
protoheme [CPD:C00032];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
biliverdin [CPD:C00500];
Fe2+ [CPD:C14818];
CO [CPD:C00237];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139];
H2O [CPD:C00001]
Comment
The enzyme, found in plants, algae, and cyanobacteria, participates in the biosynthesis of phytochromobilin and phytobilins. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules. The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. Unlike this enzyme, which uses ferredoxin as its electron donor, the electron source for the related mammalian enzyme (EC 1.14.14.18) is EC 1.6.2.4, NADPH---hemoprotein reductase.
History
EC 1.14.15.20 created 2016
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K21480  heme oxygenase (biliverdin-producing, ferredoxin)
Genes
ATH: AT1G58300(HO4) AT1G69720(HO3) AT2G26670(TED4)
ALY: 9316882 9322785 9323317
CRB: 17888722 17894910 17895767
CSAT: 104700848 104701610 104705114 104750204 104750820 104754063 104787073 104787265 104788043
EUS: EUTSA_v10002061mg EUTSA_v10024084mg EUTSA_v10024132mg
BRP: 103829625 103838625 103847911
BNA: 106358404 106358466 106367415 106367419 106397058 106436728 106450232
BOE: 106295105 106301427 106316701 106343551
RSZ: 108805692 108825379 108826678 108839034 108840570 108852638
THJ: 104808987 104815277
CIT: 102628729
TCC: 18588759
GMX: 547612(HO1) 547613(HO3)
VRA: 106757916
VAR: 108332029
VUN: 114163333
CCAJ: 109791128
LJA: Lj1g3v0672150.1(Lj1g3v0672150.1)
FVE: 101296421
PMUM: 103341070
PAVI: 110759943
ZJU: 107434821
CSV: 101214191
CMO: 103487455
MCHA: 111014559
RCU: 8275886
MESC: 110599679
VVI: 100249078
SLY: 101257539(HO1)
SOT: 102600014
NTA: 107792958(HO1) 107818591(HO1)
NSY: 104210066
NTO: 104097544
NAU: 109226495
SIND: 105162092
BVG: 104902038
NNU: 104592431
OSA: 4341462
DOSA: Os06t0603000-01(Os06g0603000)
OBR: 102712820
BDI: 100841507
ATS: 109740964(LOC109740964) 109760370(LOC109760370) 109775269(LOC109775269)
ATR: 18431901
SMO: SELMODRAFT_97989(HO-1)
MNG: MNEG_4534
MIS: MICPUN_108005(HY1)
CNE: CNF01200
CNB: CNBF3510
TASA: A1Q1_07162
ABP: AGABI1DRAFT40682(AGABI1DRAFT_40682)
ABV: AGABI2DRAFT73107(AGABI2DRAFT_73107)
SPAR: SPRG_11703
ALG: AQULUS_22280(pbsA1)
ASIP: AQUSIP_01960(hmuO)
LPN: lpg0229
LPH: LPV_0309
LPO: LPO_0268
LPM: LP6_0230
LPF: lpl0282
LPP: lpp0288
LPC: LPC_0304
LPA: lpa_00413
LPE: lp12_0233
LFA: LFA_0258
LHA: LHA_0250
MXA: MXAN_5679
CCX: COCOR_04338(pbsA1)
BRA: BRADO1626(hmuO)
BBT: BBta_6429(hmuO)
BRS: S23_19350(hmuO)
AOL: S58_59100
BRO: BRAD285_5773(hmuO)
RPA: RPA1539
RPB: RPB_3984
RPC: RPC_1310
RPD: RPD_3739
RPE: RPE_1344
RPT: Rpal_1727
SHUM: STHU_01090(ho1)
SVC: STVA_47230(ho1)
CPE: CPE0214
CPF: CPF_0205
CPR: CPR_0203
CTC: CTC_02478
CBV: U729_1397
MGI: Mflv_0990
MAB: MAB_4773
MABB: MASS_4843
MSAL: DSM43276_04597(pbsA1)
MMIN: MMIN_34630
ASD: AS9A_1954(hmuO)
CGL: NCgl2146(Cgl2227)
CGB: cg2445(hmuO)
CGU: WA5_2146(HmuO)
CGT: cgR_2104
CGM: cgp_2445(hmuO)
CGJ: AR0_10620
CDI: DIP1669(hmuO)
CDP: CD241_1603(hmuO)
CDH: CDB402_1558(hmuO)
CDT: CDHC01_1605(hmuO)
CDE: CDHC02_1539(hmuO)
CDR: CDHC03_1567(hmuO)
CDA: CDHC04_1567(hmuO)
CDZ: CD31A_1669(hmuO)
CDB: CDBH8_1642(hmuO)
CDD: CDCE8392_1562(hmuO)
CDW: CDPW8_1660(hmuO)
CDV: CDVA01_1528(hmuO)
CDIP: ERS451417_01679(hmuO)
CJK: jk0320(hmuO)
CUR: cu1670
CUA: CU7111_1238(hmuO1) CU7111_1609(hmuO2)
CAR: cauri_1721(hmuO)
CPL: Cp3995_1522(hmuO)
CPP: CpP54B96_1507(hmuO)
CPZ: CpPAT10_1480(hmuO)
COR: Cp267_1543(hmuO)
COD: Cp106_1443(hmuO)
COS: Cp4202_1471(hmuO)
CPSE: CPTA_02073
CPSU: CPTB_01688
CPSF: CPTC_02070
CRD: CRES_0229(hmuO)
CUL: CULC22_01581(hmuO)
CUC: CULC809_01565(hmuO)
CUE: CULC0102_1701(hmuO)
CUN: Cul210932_1652(humO)
CUS: CulFRC11_1555(humO)
CUQ: Cul210931_1537(humO)
CUZ: Cul05146_1623(humO)
CUJ: CUL131002_1575c(humO)
CVA: CVAR_1101(hmuO)
CTER: A606_04360
CGY: CGLY_10035(hmuO)
COA: DR71_1158(hmuO)
CSX: CSING_09420(hmuO)
CMQ: B840_00470(hmuO)
CKU: UL82_03880(hmuO)
CMV: CMUST_11220(hmuO)
CDX: CDES_10095(hmuO)
CSP: WM42_1293(hmuO)
CPHO: CPHO_00285
CAQU: CAQU_08755
CAMG: CAMM_00890
NFA: NFA_24730
NFR: ERS450000_01625(pbsA1)
NCY: NOCYR_2556(isdG)
NSR: NS506_00356(hmoX)
RER: RER_32040(hmuO)
REY: O5Y_14730
ROP: ROP_06190(hmuO)
REQ: REQ_22910
RRT: 4535765_02331(hmuO)
RCR: NCTC10994_00512(pbsA1)
GBR: Gbro_3085
GPO: GPOL_c28450(hmuO)
GOR: KTR9_3073
GRU: GCWB2_15980(hmuO)
GOM: D7316_00195(hmuO)
SCO: SCO2267(SCC75A.13)
SALB: XNR_4617
SMA: SAVERM_5930(hmuO)
SGR: SGR_5243
SGB: WQO_09115
SCT: SCAT_1359
SFA: Sfla_4565
SBH: SBI_05872
SVE: SVEN_1952
SALS: SLNWT_5615
STRP: F750_2124
SFI: SFUL_1847
SALU: DC74_2749
SALL: SAZ_15110
STRE: GZL_06256
SLD: T261_5887
STRM: M444_11545
SAMB: SAM23877_2345(hmuO)
SPRI: SPRI_5243
SRW: TUE45_02829(hmuO)
SRN: A4G23_01425(hmuO)
STRD: NI25_27775
SMAL: SMALA_2190
SLAU: SLA_1855
SALJ: SMD11_4813
SLX: SLAV_25920(hmuO)
SFK: KY5_2267
SGE: DWG14_06055(hmuO)
SRJ: SRO_5192
KSK: KSE_73640
LXL: KDY119_03307(hmuO)
LXX: Lxx24860(hmuO)
CMI: CMM_0601(hemO)
CMS: CMS2835
CMC: CMN_00562(hemO)
MTS: MTES_1696(hmuO)
MLV: CVS47_03229(pbsA1)
MOY: CVS54_03565(pbsA1)
MALK: MalAC0309_0627(hmuO)
ARM: ART_2870
RDN: HMPREF0733_11210(hmuO)
BCV: Bcav_3872
XCE: Xcel_2758
IDO: I598_2675(pbsA1)
CFL: Cfla_1054
CFI: Celf_2819
SERJ: SGUI_2299
BLIN: BLSMQ_2954
PSIM: KR76_20475
TFU: Tfu_2345
NDA: Ndas_0441
NAL: B005_3314
STRR: EKD16_19935(pbsA1)
TCU: Tcur_0079
SRO: Sros_3241
AMD: AMED_8476
AMN: RAM_43510
AMM: AMES_8347
AMZ: B737_8348
AOI: AORI_7263(hmuO)
AMYY: YIM_03710(pbsA1)
PDX: Psed_5881
PSEA: WY02_05140
PSEE: FRP1_08215
PSEH: XF36_12405
PAUT: Pdca_26610
AMI: Amir_3062
KAL: KALB_7768
ACTI: UA75_30280
ACAD: UA74_29745
ALO: CRK57436
MIL: ML5_4741
ACTN: L083_0856
AFS: AFR_04095
SNA: Snas_4613
SYN: sll1184(ho1) sll1875(ho2)
SYZ: MYO_116590(ho2) MYO_12900(ho1)
SYY: SYNGTS_0288(ho1) SYNGTS_1644(ho2)
SYT: SYNGTI_0288(ho1) SYNGTI_1644(ho2)
SYS: SYNPCCN_0288(ho1) SYNPCCN_1643(ho2)
SYQ: SYNPCCP_0288(ho1) SYNPCCP_1643(ho2)
SYJ: D082_08260(ho2) D082_19530(ho1)
SYC: syc2236_c(ho1)
SYW: SYNW0171(ho1)
SYG: sync_0216
SYR: SynRCC307_0155(ho1)
SYX: SynWH7803_0221(ho1)
CYA: CYA_0408
CYB: CYB_2435
SYNR: KR49_09805
SYND: KR52_01675
SYH: Syncc8109_0174(ho1)
SYNW: SynWH8103_00191(ho1)
TEL: tll0365(ho1) tll1721(ho2)
THN: NK55_00245(hox1) NK55_05250(hox2)
LET: O77CONTIG1_01000(pbsA1)
HHG: XM38_016560(ho1)
PMA: Pro_1750(ho1)
PMM: PMM1594(ho1)
PMT: PMT_1685
PMB: A9601_18031(ho1)
PMC: P9515_17811(ho1)
PMF: P9303_22411(ho1)
PMG: P9301_17861(ho1)
PMH: P9215_18671(ho1)
PMJ: P9211_17151(ho1)
PME: NATL1_20441(ho1)
PRC: EW14_1951
PRM: EW15_2115
MAR: MAE_14930(ho1)
MPK: VL20_4109
MVZ: myaer102_48720(ho1)
CYL: AA637_01575(hugZ)
CYT: cce_2324(ho2) cce_2573(ho1)
TER: Tery_0335
ARP: NIES39_Q00930(ho)
PAGH: NIES204_07040(ho)
GVI: gvip040(ho1)
GLJ: GKIL_1562(hmuO)
NSP: BMF81_01826(hmuO)
DOU: BMF77_02275(pbsA1_1) BMF77_03298(pbsA1_2)
CTHE: Chro_3999
LIL: LB_186
LIE: LIF_B150
LIC: LIC_20148(hol)
LIS: LIL_20159
LBJ: LBJ_4165
LBL: LBL_4180
LBI: LEPBI_I0669(hmuO)
LBF: LBF_0647
LST: LSS_07279
 » show all
Reference
1  [PMID:12167331]
  Authors
Montgomery BL, Lagarias JC
  Title
Phytochrome ancestry: sensors of bilins and light.
  Journal
Trends Plant Sci 7:357-66 (2002)
DOI:10.1016/S1360-1385(02)02304-X
Reference
2  [PMID:15560792]
  Authors
Sugishima M, Migita CT, Zhang X, Yoshida T, Fukuyama K
  Title
Crystal structure of heme oxygenase-1 from cyanobacterium Synechocystis sp. PCC 6803 in complex with heme.
  Journal
Eur J Biochem 271:4517-25 (2004)
DOI:10.1111/j.1432-1033.2004.04411.x
  Sequence
[syn:sll1184]
Reference
3  [PMID:18846276]
  Authors
Dammeyer T, Frankenberg-Dinkel N
  Title
Function and distribution of bilin biosynthesis enzymes in photosynthetic organisms.
  Journal
Photochem Photobiol Sci 7:1121-30 (2008)
DOI:10.1039/b807209b
Other DBs
ExplorEnz - The Enzyme Database: 1.14.15.20
IUBMB Enzyme Nomenclature: 1.14.15.20
ExPASy - ENZYME nomenclature database: 1.14.15.20
BRENDA, the Enzyme Database: 1.14.15.20

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