KEGG   ENZYME: 1.14.15.27
Entry
EC 1.14.15.27               Enzyme                                 
Name
beta-dihydromenaquinone-9 omega-hydroxylase;
cyp128 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
beta-dihydromenaquinone-9,reduced ferredoxin:oxygen oxidoreductase (omega-hydroxylating)
Reaction(IUBMB)
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2 = omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O [RN:R12073]
Reaction(KEGG)
R12073
Substrate
beta-dihydromenaquinone-9 [CPD:C21527];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
O2 [CPD:C00007]
Product
omega-hydroxy-beta-dihydromenaquinone-9 [CPD:C21885];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139];
H2O [CPD:C00001]
Comment
The bacterial cytochrome P-450 enzyme is involved in the biosynthesis of omega-sulfo-beta-dihydromenaquinone-9 by members of the Mycobacterium tuberculosis complex.
History
EC 1.14.15.27 created 2018
Orthology
K21199  beta-dihydromenaquinone-9 omega-hydroxylase
Genes
MTURv2268c(cyp128)
MTVRVBD_2268c
MTCMT2330
MRAMRA_2288(cyp128)
MTFTBFG_12295
MTBTBMG_01714
MTKTBSG_01724
MTZTBXG_001696
MTIMRGA423_14110
MTECCDC5079_2104
MTURCFBS_2401(cyp128)
MTLCCDC5180_2076
MTOMTCTRI2_2303(cyp128)
MTDUDA_2268c(cyp128)
MTNERDMAN_2492
MTJJ112_12175
MTUBMT7199_2299(cyp128)
MTUCJ113_15810
MTUEJ114_12165
MTXM943_11740
MTUHI917_16005 I917_16010
MTULTBHG_02218
MTUTHKBT1_2392(cyp128)
MTUUHKBT2_2394(cyp128)
MTQHKBS1_2398(cyp128)
MBOBQ2027_MB2291C(cyp128)
MBBBCG_2285c(cyp128)
MBTJTY_2279(cyp128)
MBMBCGMEX_2273c(cyp128)
MBKK60_023530
MBXBCGT_2091
MAFMAF_22780(cyp128)
MMICRN08_2516
MCEMCAN_05821 MCAN_22921(cyp128)
MCQBN44_50214(cyp)
MCVBN43_31510(cyp)
MCXBN42_20320(cyp) BN42_40190(cyp)
MCZBN45_10648(cyp)
MORYMO_002377
MKNMKAN_03520
MSHGMSG_00557(cyp128)
MPAGC0J29_29690
MNMMNVM_38540(cyp128)
MCOOMCOO_18140(cyp128)
MGAUMGALJ_29100
MLJMLAC_22890(cyp128)
MSHJMSHI_09960(cyp128)
MMAMK3U93_19825 K3U93_21455
MPAAMKK62_06670
MWUPT015_10735
MMORMMOR_46050(cyp128_2)
MGADMGAD_53320(cyp128_2)
MANYMANY_06260(cyp128_1) MANY_39810(cyp128_2)
MPAEK0O64_08735
MCROMI149_10205
MCHEBB28_22795
MIZBAB75_25240
MSAOMYCSP_20800
MSALDSM43276_04313
MHERK3U94_12375
MVMMJO54_12320
CATICS0771_54690
 » show all
Reference
1  [PMID:18928249]
  Authors
Holsclaw CM, Sogi KM, Gilmore SA, Schelle MW, Leavell MD, Bertozzi CR, Leary JA
  Title
Structural characterization of a novel sulfated menaquinone produced by stf3 from Mycobacterium tuberculosis.
  Journal
ACS Chem Biol 3:619-24 (2008)
DOI:10.1021/cb800145r
Reference
2  [PMID:27933784]
  Authors
Sogi KM, Holsclaw CM, Fragiadakis GK, Nomura DK, Leary JA, Bertozzi CR
  Title
Biosynthesis and Regulation of Sulfomenaquinone, a Metabolite Associated with Virulence in Mycobacterium tuberculosis.
  Journal
ACS Infect Dis 2:800-806 (2016)
DOI:10.1021/acsinfecdis.6b00106
  Sequence
[mtu:Rv2268c]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.15.27
IUBMB Enzyme Nomenclature: 1.14.15.27
ExPASy - ENZYME nomenclature database: 1.14.15.27
BRENDA, the Enzyme Database: 1.14.15.27

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