KEGG   ENZYME: 1.14.15.27Help
Entry
EC 1.14.15.27               Enzyme                                 

Name
beta-dihydromenaquinone-9 omega-hydroxylase;
cyp128 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
beta-dihydromenaquinone-9,reduced ferredoxin:oxygen oxidoreductase (omega-hydroxylating)
Reaction(IUBMB)
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2 = omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O [RN:R12073]
Reaction(KEGG)
Substrate
beta-dihydromenaquinone-9 [CPD:C21527];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
O2 [CPD:C00007]
Product
omega-hydroxy-beta-dihydromenaquinone-9 [CPD:C21885];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139];
H2O [CPD:C00001]
Comment
The bacterial cytochrome P-450 enzyme is involved in the biosynthesis of omega-sulfo-beta-dihydromenaquinone-9 by members of the Mycobacterium tuberculosis complex.
History
EC 1.14.15.27 created 2018
Orthology
K21199  beta-dihydromenaquinone-9 omega-hydroxylase
Genes
MTU: Rv2268c(cyp128)
MTV: RVBD_2268c
MTC: MT2330
MRA: MRA_2288(cyp128)
MTF: TBFG_12295
MTB: TBMG_01714
MTK: TBSG_01724
MTZ: TBXG_001696
MTI: MRGA423_14110
MTE: CCDC5079_2104
MTUR: CFBS_2401(cyp128)
MTO: MTCTRI2_2303(cyp128)
MTD: UDA_2268c(cyp128)
MTUB: MT7199_2299(cyp128)
MTUC: J113_15810
MTUE: J114_12165
MTUL: TBHG_02218
MTUT: HKBT1_2392(cyp128)
MTUU: HKBT2_2394(cyp128)
MTQ: HKBS1_2398(cyp128)
MBO: BQ2027_MB2291C(cyp128)
MBB: BCG_2285c(cyp128)
MBT: JTY_2279(cyp128)
MBM: BCGMEX_2273c(cyp128)
MBX: BCGT_2091
MAF: MAF_22780(cyp128)
MMIC: RN08_2516
MCE: MCAN_05821 MCAN_22921(cyp128)
MCQ: BN44_50214(cyp)
MCV: BN43_31510(cyp)
MCX: BN42_20320(cyp) BN42_40190(cyp)
MCZ: BN45_10648(cyp)
MSHG: MSG_00557(cyp128)
MTHN: 4412656_02200(cyp123B1) 4412656_03698
MHAS: MHAS_01951
MCHE: BB28_22795
MSTE: MSTE_01972 MSTE_04626(cyp128_1) MSTE_04627(cyp128_2)
MJD: JDM601_2198(cyp123B1)
MTER: 4434518_02120(cyp123B1) 4434518_03896
 » show all
Taxonomy
Reference
1  [PMID:18928249]
  Authors
Holsclaw CM, Sogi KM, Gilmore SA, Schelle MW, Leavell MD, Bertozzi CR, Leary JA
  Title
Structural characterization of a novel sulfated menaquinone produced by stf3 from Mycobacterium tuberculosis.
  Journal
ACS Chem Biol 3:619-24 (2008)
DOI:10.1021/cb800145r
Reference
2  [PMID:27933784]
  Authors
Sogi KM, Holsclaw CM, Fragiadakis GK, Nomura DK, Leary JA, Bertozzi CR
  Title
Biosynthesis and Regulation of Sulfomenaquinone, a Metabolite Associated with Virulence in Mycobacterium tuberculosis.
  Journal
ACS Infect Dis 2:800-806 (2016)
DOI:10.1021/acsinfecdis.6b00106
  Sequence
[mtu:Rv2268c]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.15.27
IUBMB Enzyme Nomenclature: 1.14.15.27
ExPASy - ENZYME nomenclature database: 1.14.15.27
BRENDA, the Enzyme Database: 1.14.15.27

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