KEGG   ENZYME: 1.14.15.30
Entry
EC 1.14.15.30               Enzyme                                 
Name
3-ketosteroid 9alpha-monooxygenase;
KshA;
3-ketosteroid 9alpha-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
androsta-1,4-diene-3,17-dione,[reduced ferredoxin]:oxygen oxidoreductase (9alpha-hydroxylating)
Reaction(IUBMB)
androsta-1,4-diene-3,17-dione + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O [RN:R09860]
Reaction(KEGG)
R09860
Substrate
androsta-1,4-diene-3,17-dione [CPD:C20144];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
9alpha-hydroxyandrosta-1,4-diene-3,17-dione [CPD:C14909];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139];
H2O [CPD:C00001]
Comment
The enzyme is involved in the cholesterol degradation pathway of several bacterial pathogens, such as Mycobacterium tuberculosis. It forms a two-component system with a ferredoxin reductase (KshB). The enzyme contains a Rieske-type iron-sulfur center and non-heme iron. The product of the enzyme is unstable, and spontaneously converts to 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione.
History
EC 1.14.15.30 created 2012 as EC 1.14.13.142, transferred 2018 to EC 1.14.15.30
Pathway
ec00984  Steroid degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K15982  3-ketosteroid 9alpha-monooxygenase subunit A
K15983  3-ketosteroid 9alpha-monooxygenase subunit B
Genes
SPAQSTNY_R14730
RGLCS053_01730 CS053_01930
VAFD1115_22765 D1115_23260
PSGG655_23840
PREPCA10_12240(kshA) PCA10_43650(kshB)
PFUWKF707C_11570 KF707C_11880
PPUTL483_14105 L483_14320
PPUNPP4_26740(kshA) PP4_27180(kshB)
PVRPverR02_11715 PverR02_11735
PSCA458_17160
PSHPsest_3453
PSTUUIB01_04060
PCHLLLJ08_16585
PBMCL52_03850 CL52_10355
PPUUPputUW4_01666 PputUW4_01678
PKCPKB_4313(ksha1) PKB_4319(kshB) PKB_4338(ksha3)
PFZAV641_09605
PLQAA042_00420 AA042_20380
PPSYAOC04_06430 AOC04_07880
PSETTHL1_1304 THL1_4407
PSILPMA3_11750 PMA3_11875
PSEDDM292_14720
PKEDLD99_14675 DLD99_14730
PUMHGP31_20625 HGP31_20745
PPSHG5J76_13535 G5J76_17295
PLALFXN65_05725 FXN65_21125
PKHJLK41_05750 JLK41_05865
PPRGHU725_015180
PAZEKSS91_19205 KSS91_19265
PPHABVH74_17575 BVH74_17920
PTAENCTC10697_01839(kshA) NCTC10697_02066(hmp_2)
PCAVD3880_17050 D3880_17450
SPLSpea_2121 Spea_2130
SHLShal_2093 Shal_2102
COLWA3Q33_18555 A3Q33_18810
CBERB5D82_11010 B5D82_11285
PHAPSHAa0878 PSHAa2137
PTNPTRA_a1005(kshB) PTRA_a2590(kshA)
PNGPNIG_a1057(kshB) PNIG_a2784(kshA)
SNANI6N98_00555 I6N98_01445 I6N98_05770 I6N98_10760
ZALAZF00_00470 AZF00_04635 AZF00_12085 AZF00_12900 AZF00_15655
HJABST95_04800
HALCEY643_17500
AFUSEYZ66_12990 EYZ66_13035
AXEP40_21405
KAKKalk_07500
MSECLN244_04810 LN244_04920
ENWMJO57_10955 MJO57_21295
SOKD0B54_03435 D0B54_05260 D0B54_05645 D0B54_08470 D0B54_08675
SINIGT972_09345
FCEJN531_005745 JN531_007625
GPBHDN1F_02750
AQLBXU06_10045
AQSDKK66_00835
RINACS15_4367 ACS15_4387 ACS15_4390
REHH16_B0643(h16_B0643) H16_B0672(hcaE)
CNCCNE_2c05890 CNE_2c06190(kshA) CNE_BB1p00120(kshA)
CUHBJN34_30925 BJN34_31150
REUReut_A1546 Reut_A1576
RMERmet_0543
CTIRALTA_B0492 RALTA_B0514
CBWRR42_m2029 RR42_s2318 RR42_s2340
CGDCR3_2920(kshA)
CCUPBKK81_32785
CUPBKK80_23495
CUUBKK79_28795
COXE0W60_08160 E0W60_08305
BMABMAA1220
BMVBMASAVP1_0187
BMLBMA10229_0463
BMNBMA10247_A1112
BMALDM55_4293
BMAEDM78_3877
BMAQDM76_3245
BMAIDM57_10905
BMAFDM51_4883
BMAZBM44_4256
BMABBM45_3379
BPSBPSS0996
BPMBURPS1710b_A2607
BPLBURPS1106A_A1377
BPDBURPS668_A1464
BPSEBDL_4290
BPSMBBQ_5138
BPSUBBN_4458
BPSDBBX_6131
BPZBP1026B_II1091
BPQBPC006_II1385
BPKBBK_6151
BPSHDR55_4337
BPSABBU_5033
BPSOX996_4235
BUTX994_6124
BURBcep18194_B1416 Bcep18194_B1448
BCJBCAM1620 BCAM1644
BCENDM39_3466 DM39_6206(hmp) DM39_6233(kshA)
BCEOI35_5481 I35_5504
BCTGEM_4012 GEM_4096 GEM_4102
BCEDDM42_6314(hmp) DM42_6338(kshA)
BCEPAPZ15_30835 APZ15_31110
BPYRABD05_27655 ABD05_27770
BCONNL30_03965 NL30_04080
BDFWI26_21190 WI26_21235 WI26_21355
BTEIWS51_05735 WS51_05845
BPSLWS57_05865 WS57_06000 WS57_06445
BMECWJ16_26825 WJ16_26955
BSTLBBJ41_21390 BBJ41_21510 BBJ41_35425
BANNJFN94_25695 JFN94_25735 JFN94_26155
BGDbgla_2g02180
BURKDM992_32470 DM992_32590
BFNOI25_4592 OI25_4611
PVEUC34_06905 UC34_06920
CABASBC2_48790(kshB_1) SBC2_48980(kshA)
CTTCtCNB1_1306 CtCNB1_1359
CTESO987_07520 O987_07770
HYNF9K07_31150
DIHG7047_09735 G7047_10060
AZIAzCIB_1457 AzCIB_1462
AZDCDA09_09680 CDA09_09705
THUAC731_008070 AC731_008185
THKCCZ27_15785
ADEAdeh_0398
ACPA2cp1_0427
ANKAnaeK_0426
MRMA7982_01269 A7982_10481
NTDEGO55_02315 EGO55_02665 EGO55_03045 EGO55_04130 EGO55_13445 EGO55_16290 EGO55_16310
NARSaro_3601 Saro_3649 Saro_3666
NPPPP1Y_Mpl3383
NPNJI59_09815
NOVTQ38_027405
NOTC7W88_20195 C7W88_20485 C7W88_20690
SPHKSKP52_00800
SWISwit_1829 Swit_2053 Swit_3307
SPHDHY78_09015 HY78_15255 HY78_16435
RDICMV14_16795 CMV14_16825
SPHMG432_11540 G432_14050 G432_14385 G432_16975
SSANNX02_07805 NX02_17130
SKRBRX40_00225 BRX40_00230
SPKCKC8_00700 KC8_06855 KC8_08825 KC8_10270 KC8_14070 KC8_16645 KC8_19680
SPHAD3Y57_15525
SLANGV829_01745
SYBTZ53_23495
SPHBEP837_02947 EP837_03216 EP837_03246 EP837_03584 EP837_03637
SPHJBSL82_11680 BSL82_11870
PHAOHF685_05250 HF685_05340 HF685_05370
PHZCHX26_05450
MTURv3526(kshA) Rv3571(kshB)
MTVRVBD_3526 RVBD_3571
MTCMT3676
MRAMRA_3565 MRA_3610(hmp)
MTFTBFG_13559 TBFG_13604
MTBTBMG_03565 TBMG_03610
MTKTBSG_03592 TBSG_03637
MTZTBXG_003541 TBXG_003585
MTGMRGA327_21785 MRGA327_22045
MTECCDC5079_3267 CCDC5079_3312
MTURCFBS_3742 CFBS_3788(hmp)
MTLCCDC5180_3219 CCDC5180_3264
MTOMTCTRI2_3590 MTCTRI2_3636(hmp)
MTDUDA_3526 UDA_3571(hmp)
MTNERDMAN_3866 ERDMAN_3918(hmp)
MTJJ112_18980 J112_19230
MTUBMT7199_3587 MT7199_3634
MTUCJ113_24655
MTUEJ114_18850 J114_19100
MTXM943_18130 M943_18365
MTUHI917_24735 I917_25090
MTULTBHG_03466 TBHG_03512
MTUTHKBT1_3727 HKBT1_3773(hmp)
MTUUHKBT2_3736 HKBT2_3782(hmp)
MTQHKBS1_3739 HKBS1_3785(hmp)
MBOBQ2027_MB3556(ksha) BQ2027_MB3602(kshb)
MBBBCG_3590 BCG_3636(hmp)
MBTJTY_3591 JTY_3637(hmp)
MBMBCGMEX_3588 BCGMEX_3634(hmp)
MBKK60_036610 K60_037090
MBXBCGT_3389 BCGT_3438
MAFMAF_35380 MAF_35840(hmp)
MMICRN08_3901 RN08_3948
MCEMCAN_35371 MCAN_35841(hmp)
MCQBN44_110015 BN44_110066(hmp)
MCVBN43_90021 BN43_90072(hmp)
MCXBN42_90018 BN42_90069(hmp)
MCZBN45_100018 BN45_100085(hmp)
MPAMAP_0496c MAP_1434 MAP_2377 MAP_2882c
MAOMAP4_0925 MAP4_1446 MAP4_2411 MAP4_3328 MAP4_3371
MAVIRC58_04545 RC58_07170 RC58_11985 RC58_16505 RC58_16720
MAVURE97_04545 RE97_07170 RE97_11995 RE97_16540 RE97_16755
MAVMAV_0590 MAV_0633 MAV_1603 MAV_1857 MAV_3037 MAV_3666
MITOCO_04980 OCO_05430 OCO_28760 OCO_34910 OCO_37890
MIAOCU_05020 OCU_05470 OCU_28620 OCU_34960 OCU_37970
MIDMIP_00939 MIP_00998 MIP_03683 MIP_05257 MIP_05742
MYOOEM_05040 OEM_05500 OEM_27250 OEM_35350 OEM_38530
MCHIAN480_02490 AN480_02715 AN480_15050 AN480_18495 AN480_19995
MIROCQ_05140 OCQ_05580 OCQ_27340 OCQ_36130 OCQ_39120
MMALCKJ54_02420 CKJ54_02640 CKJ54_13075 CKJ54_16420 CKJ54_18030
MLPMLM_0734 MLM_0777
MMANMMAN_03030 MMAN_10160 MMAN_41010 MMAN_41330 MMAN_47930(hmp) MMAN_48390(kshA)
MSAMycsm_04176 Mycsm_04590 Mycsm_05671 Mycsm_05761 Mycsm_05841
MULMUL_2161 MUL_4089 MUL_4142(hmp)
MMCMmcs_0296 Mmcs_0319 Mmcs_1788 Mmcs_3569 Mmcs_3712 Mmcs_4640 Mmcs_4710
MKMMkms_0306 Mkms_0329 Mkms_1835 Mkms_3642 Mkms_3785 Mkms_4728 Mkms_4796
MJLMjls_0287 Mjls_0310 Mjls_1769 Mjls_3574 Mjls_3725 Mjls_4115 Mjls_5022 Mjls_5095
MMIMMAR_1935 MMAR_5015 MMAR_5066(hmp)
MMAEMMARE11_18630 MMARE11_48250 MMARE11_48810(hmp)
MMMW7S_02435 W7S_02660 W7S_13945 W7S_17465 W7S_18975
MLIMULP_02106 MULP_05266 MULP_05324(hmp)
MKNMKAN_11805 MKAN_12135 MKAN_24985
MYVG155_01230 G155_03705 G155_04100 G155_04260 G155_04755 G155_07820 G155_09255 G155_10850 G155_24375 G155_26490
MYEAB431_00270 AB431_11155 AB431_15090 AB431_17425 AB431_24925 AB431_26315 AB431_26560
MGOAFA91_10575 AFA91_11130
MHADB586_04440 B586_04665
MDXBTO20_04370 BTO20_24105 BTO20_26115 BTO20_31150 BTO20_33265
MSHGMSG_00805(kshA_1) MSG_01415 MSG_01753 MSG_02466 MSG_04513(kshA_2) MSG_04564(hmp)
MFJMFLOJ_08010 MFLOJ_15040 MFLOJ_37900 MFLOJ_40640(hmp) MFLOJ_41090(kshA)
MSTOMSTO_09240 MSTO_16460 MSTO_41650 MSTO_44590(hmp) MSTO_45060(kshA)
MSIMMSIM_05770 MSIM_29080(hmp) MSIM_29510 MSIM_53050
MSAKMSAS_01950 MSAS_05490 MSAS_28680(kshA) MSAS_29180(hmp) MSAS_51690 MSAS_55210
MKUI2456_13035 I2456_21945 I2456_25455 I2456_25690
MGROFZ046_02575 FZ046_02955 FZ046_08935
MXEMYXE_05050(hmp) MYXE_06210 MYXE_09820
MNVMNVI_10350 MNVI_10880 MNVI_11900 MNVI_12100(kshA) MNVI_12540(hmp)
MPAGC0J29_08865 C0J29_19365 C0J29_22020 C0J29_27500 C0J29_27840
MNMMNVM_02730 MNVM_19150 MNVM_19370 MNVM_23420(hmp) MNVM_24080(kshA) MNVM_25620 MNVM_27170
MGORH0P51_05885 H0P51_07835 H0P51_17940 H0P51_19995 H0P51_25550 H0P51_25880
MCOOMCOO_16460 MCOO_24770 MCOO_26240 MCOO_26790(kshA) MCOO_27340(hmp) MCOO_32620
MBAIMB901379_01756(kshA_1) MB901379_04408(kshA_3) MB901379_04455(hmp_2)
MSEOMSEO_05640 MSEO_08800 MSEO_12570 MSEO_23830 MSEO_34070(kshA) MSEO_34590(hmp)
MPSEMPSD_19540 MPSD_52140(kshA) MPSD_52670(hmp)
MSHOMSHO_04870(kshA) MSHO_05500(hmp) MSHO_52600
MHEKJMUB5695_00466(hmp) JMUB5695_00520 JMUB5695_00538 JMUB5695_00733 JMUB5695_00940
MGAUMGALJ_04040 MGALJ_04550 MGALJ_23030 MGALJ_25620 MGALJ_30410 MGALJ_31940 MGALJ_37890(kshA) MGALJ_38590(kshB)
MLJMLAC_00150(kshA_1) MLAC_47210(hmp) MLAC_47870(kshA_2)
MBRDMBRA_19980(hmp) MBRA_20460(kshA) MBRA_22880 MBRA_33050 MBRA_50470
MSHJMSHI_38510(hmp) MSHI_39140
MKRMKOR_24880 MKOR_35310(hmp) MKOR_35890(kshA) MKOR_36630
MDFK0O62_02770 K0O62_15775 K0O62_15940 K0O62_25360 K0O62_25980
MMAMK3U93_08570 K3U93_11775 K3U93_22435 K3U93_22700
MHOLK3U96_03065 K3U96_03360 K3U96_09525 K3U96_17790 K3U96_18060
MHERK3U94_08890 K3U94_19910 K3U94_20720 K3U94_21035
MSENK3U95_03580 K3U95_09605 K3U95_12885 K3U95_20520 K3U95_25050 K3U95_25525
MPAEK0O64_00245 K0O64_10800 K0O64_14540 K0O64_20470 K0O64_24620 K0O64_25805 K0O64_26070
MSPGF6B93_00890 F6B93_12430 F6B93_20245 F6B93_20500
MOTLTS72_00025 LTS72_15090 LTS72_27905
MVMMJO54_08985 MJO54_19815 MJO54_20640 MJO54_20930
MRFMJO55_17045 MJO55_23860 MJO55_24190
MPAAMKK62_02380 MKK62_02645 MKK62_02840 MKK62_07940 MKK62_09895
MCROMI149_15395 MI149_15520 MI149_21050 MI149_26115 MI149_26370
MSMMSMEG_0734 MSMEG_2870 MSMEG_2893 MSMEG_5925 MSMEG_6039
MSGMSMEI_2796 MSMEI_2819(hmp) MSMEI_5766 MSMEI_5878(hmp)
MSBLJ00_14275 LJ00_14390 LJ00_29300 LJ00_29855
MSNLI99_14280 LI99_14395 LI99_29305 LI99_29860
MSHLI98_14285 LI98_14400 LI98_29310 LI98_29865
MVAMvan_2012 Mvan_2869 Mvan_2893 Mvan_4186 Mvan_5211 Mvan_5225 Mvan_5309
MGIMflv_1462 Mflv_1533 Mflv_1546 Mflv_2468 Mflv_4333 Mflv_4566
MSPMspyr1_09170 Mspyr1_09300 Mspyr1_18940 Mspyr1_21920 Mspyr1_36780 Mspyr1_39660 Mspyr1_47050
MCBMycch_1569 Mycch_1592 Mycch_1754 Mycch_3303 Mycch_3622 Mycch_4570 Mycch_4587 Mycch_4676
MNED174_08275 D174_24200 D174_24715
MYNMyAD_08130 MyAD_21895 MyAD_23740 MyAD_24250
MFTXA26_02660 XA26_06910 XA26_07730 XA26_08090 XA26_09130 XA26_15580 XA26_18510 XA26_22320 XA26_49330 XA26_53640
MPHLMPHLCCUG_00490(hmp_1) MPHLCCUG_00577(kshA_1) MPHLCCUG_00595(kshA_2) MPHLCCUG_01926(kshA_4) MPHLCCUG_02604(kshA_6) MPHLCCUG_03747(hmp_4)
MVQMYVA_1646 MYVA_1666(kshB) MYVA_1911 MYVA_3602 MYVA_3985 MYVA_5096(kshA) MYVA_5113 MYVA_5219
MLLB1R94_00400 B1R94_14190 B1R94_20075 B1R94_20210 B1R94_20780 B1R94_24935 B1R94_25475
MRHMycrhN_2242 MycrhN_2306 MycrhN_3476 MycrhN_4240 MycrhN_6043 MycrhN_6097
MTHN4412656_00943(kshA_4) 4412656_00961(hmp_2) 4412656_01450(kshA_5) 4412656_03040(hmp_3) 4412656_03259(kshA_6) 4412656_04042(kshA_8) 4412656_04095(hmp_6)
MHASMHAS_00793(kshA_2) MHAS_00844(kshA_3) MHAS_02479(kshA_4) MHAS_02573(kshB) MHAS_03041(kshA_5) MHAS_03182(kshA_7) MHAS_03697(kshA_8) MHAS_03711(kshA_9) MHAS_03780(hmp)
MDUMDUV_04890 MDUV_07840 MDUV_19840 MDUV_19850 MDUV_19890 MDUV_24890 MDUV_26640 MDUV_26870 MDUV_31180 MDUV_31190 MDUV_48980(kshB) MDUV_49830(kshA) MDUV_49950
MCHTMCHIJ_12540 MCHIJ_12740 MCHIJ_12900 MCHIJ_19280(kshB) MCHIJ_20060(kshA) MCHIJ_21220 MCHIJ_47580
MAUUNCTC10437_01869(kshA_1) NCTC10437_02719(kshA_2) NCTC10437_02741(hmp_2) NCTC10437_03541(kshA_3) NCTC10437_03926(hmp_3) NCTC10437_04973(kshA_5) NCTC10437_04990(kshA_6) NCTC10437_05070(hmp_5)
MMAGMMAD_02700 MMAD_47870(kshA) MMAD_48600(kshB)
MMORMMOR_10320 MMOR_11730(kshB) MMOR_12370(kshA) MMOR_26640 MMOR_44820 MMOR_45300
MFXMFAL_16460 MFAL_27870(kshA_1) MFAL_32570(kshB) MFAL_33700(kshA_2) MFAL_34890
MAICMAIC_05160(hmp) MAIC_05860(kshA) MAIC_07830 MAIC_26600 MAIC_30570 MAIC_56030
MIJMINS_00070(kshA_1) MINS_00720(kshB) MINS_06060 MINS_18900 MINS_42010 MINS_43000 MINS_43130(kshA_2)
MALVMALV_16800 MALV_19850 MALV_21750 MALV_29210 MALV_29530 MALV_30220 MALV_33090 MALV_42110(kshB) MALV_42940(kshA) MALV_46370
MTYMTOK_21970(kshB) MTOK_23000(kshA) MTOK_23190 MTOK_60760
MPSCMPSYJ_15740(kshB) MPSYJ_16390(kshA) MPSYJ_16560 MPSYJ_29890
MARZMARA_20680 MARA_32980 MARA_47410(kshB) MARA_48540(kshA)
MGADMGAD_00940 MGAD_19550 MGAD_20060 MGAD_30280 MGAD_36970(kshA) MGAD_37710(kshB) MGAD_56920
MHEVMHEL_21480 MHEL_27620(hmp) MHEL_28320(kshA) MHEL_44410 MHEL_49770 MHEL_50140
MSARMSAR_10460(kshA) MSAR_11000(hmp) MSAR_16650 MSAR_32120 MSAR_41460
MANYMANY_15950 MANY_32520(kshA) MANY_33070(hmp) MANY_33930 MANY_37610
MAUBMAUB_13170 MAUB_13780 MAUB_26190(kshA) MAUB_27110(kshB) MAUB_35870 MAUB_38560 MAUB_51360 MAUB_54660
MPOFMPOR_23460 MPOR_39600 MPOR_53110 MPOR_53290(kshA) MPOR_54020(kshB)
MPHUMPHO_14510 MPHO_31660 MPHO_34400 MPHO_43350(kshB) MPHO_44160(kshA_1) MPHO_45360 MPHO_55450(kshA_2)
MMUCC1S78_000955 C1S78_002100 C1S78_009420 C1S78_011035 C1S78_018450 C1S78_019240 C1S78_019360 C1S78_019890 C1S78_024600 C1S78_025205 C1S78_025625
MMATMMAGJ_15440 MMAGJ_33750(kshB) MMAGJ_34960(kshA) MMAGJ_47430
MBOKMBOE_03820(kshA) MBOE_04990(kshB) MBOE_18780 MBOE_19670 MBOE_20130 MBOE_42950 MBOE_56150 MBOE_59170 MBOE_60810
MFGK6L26_05330 K6L26_05780 K6L26_16780 K6L26_23275 K6L26_27675 K6L26_27820 K6L26_28195
MSEIMSEDJ_01820(kshA) MSEDJ_02540(kshB) MSEDJ_18360
MFLVNCTC10271_00464(hmp_1) NCTC10271_00524(kshA_1) NCTC10271_02165(kshA_2) NCTC10271_03524(kshA_5) NCTC10271_03628(kshA_6)
MCEEMCEL_05830 MCEL_08780 MCEL_18020 MCEL_37710(kshB) MCEL_38400(kshA)
MABMAB_0080c MAB_0583c MAB_0726 MAB_4173
MMVMYCMA_0050 MYCMA_1991 MYCMA_2177 MYCMA_2322
MABBMASS_0082 MASS_0552 MASS_3633 MASS_3931 MASS_4172
MABLMMASJCM_0083 MMASJCM_0572 MMASJCM_3622 MMASJCM_3937 MMASJCM_4259
MCHEBB28_00390 BB28_02780 BB28_18525 BB28_20180 BB28_21490 BB28_22430
MIZBAB75_00690 BAB75_03530 BAB75_20635 BAB75_22365 BAB75_23955
MSTEMSTE_00075 MSTE_00540 MSTE_03759 MSTE_04090 MSTE_04349 MSTE_04547
MSAOMYCSP_02485 MYCSP_15855 MYCSP_16680 MYCSP_18190 MYCSP_19530 MYCSP_20445
MSALDSM43276_00501(hmp_1) DSM43276_03419(kshA_2) DSM43276_03727(hmp_4) DSM43276_04014(kshA_3)
MJDJDM601_1615 JDM601_3357 JDM601_3518(hmp) JDM601_3668 JDM601_3855(hmp) JDM601_4248(hmp) JDM601_4270
MTER4434518_01527(kshA_1) 4434518_03344(kshA_2) 4434518_03494(hmp_1) 4434518_03640(kshA_3) 4434518_03730(hmp_2)
MMINMMIN_06680 MMIN_06920 MMIN_11900(kshA) MMIN_12550(hmp) MMIN_32160
MHIBMHIB_10560 MHIB_23820 MHIB_24030 MHIB_27800 MHIB_29150 MHIB_30580(kshA) MHIB_31190(hmp)
ASDAS9A_0920 AS9A_0922(kshA) AS9A_2419
MPAKMIU77_01960 MIU77_02235
NFANFA_22480 NFA_33560 NFA_33740 NFA_40990 NFA_4750 NFA_50680
NFRERS450000_00679(kshA_1) ERS450000_00697(kshA_2) ERS450000_01849(kshA_3) ERS450000_03761(kshA_5) ERS450000_04823(hmp_4) ERS450000_05814(hmp_5)
NCYNOCYR_0504 NOCYR_1557 NOCYR_2402 NOCYR_2420(ksh) NOCYR_2512 NOCYR_4851
NBRO3I_002680 O3I_006885 O3I_038125
NNONONO_c05000 NONO_c21270 NONO_c33260 NONO_c36770 NONO_c43500 NONO_c44660 NONO_c51650(kshB1) NONO_c58770(kshB2) NONO_c58790(kshA) NONO_c68680
NSLBOX37_02190 BOX37_11740 BOX37_11865 BOX37_15565 BOX37_18490 BOX37_27470 BOX37_29000
NSRNS506_01263(kshA) NS506_02682 NS506_04325 NS506_06286 NS506_06779 NS506_06781 NS506_07836
NTPCRH09_03320 CRH09_36350
NOZDMB37_16935 DMB37_23605 DMB37_40335
NODFOH10_00665 FOH10_14610 FOH10_16055 FOH10_20585 FOH10_22600 FOH10_22610 FOH10_28730
NAHF5544_02645 F5544_20855 F5544_40650
NADNCTC11293_01248(kshA_1) NCTC11293_04392(kshA_2) NCTC11293_04411(hmp_1) NCTC11293_04696(hmp_2) NCTC11293_06443(hmp_4)
NWLNWFMUON74_04960 NWFMUON74_14510 NWFMUON74_16510 NWFMUON74_27890 NWFMUON74_64550
NIEKV110_03040 KV110_07440 KV110_37315
NTCKHQ06_03660 KHQ06_09230 KHQ06_09790 KHQ06_26970 KHQ06_27550 KHQ06_35115 KHQ06_35125
NHUH0264_03865 H0264_09095 H0264_13430 H0264_27825 H0264_31525 H0264_34225 H0264_34235
NYALTV02_02155 LTV02_08320 LTV02_23905 LTV02_28875 LTV02_36570 LTV02_38685 LTV02_38695
NGPLTT66_15435 LTT66_16795 LTT66_21200 LTT66_28755 LTT66_28765 LTT66_30525
RHARHA1_ro02490 RHA1_ro04538(kshA) RHA1_ro05811 RHA1_ro05833(kshB) RHA1_ro06056 RHA1_ro09002(kshB) RHA1_ro09003(kshA)
RERRER_07540(kshA) RER_09150(kshA2) RER_13800(kshA) RER_17750(kshB) RER_51130(kshA)
REYO5Y_03665 O5Y_04070 O5Y_06500 O5Y_08515 O5Y_18435 O5Y_24235
REBXU06_03905 XU06_04315 XU06_06760 XU06_08755 XU06_24655
RQIC1M55_04145 C1M55_04545 C1M55_07005 C1M55_08985 C1M55_25820
ROPROP_22170(kshA) ROP_44530(kshA) ROP_58730(kshA2) ROP_58950(kshB) ROP_61150(kshB)
ROAPd630_LPD00990 Pd630_LPD02435 Pd630_LPD02458 Pd630_LPD02696 Pd630_LPD06716
REQREQ_06790 REQ_08980(kshA) REQ_15470 REQ_36320 REQ_40110 REQ_42740 REQ_43730 REQ_45190
RPYY013_08850 Y013_19020 Y013_19240 Y013_19255
RBYCEJ39_05385 CEJ39_05605 CEJ39_05620 CEJ39_19740 CEJ39_21920
RHBNY08_2915
RAVAAT18_03960 AAT18_18675 AAT18_21250 AAT18_21975
RFAA3L23_01127(hmp_2)
RHSA3Q41_00422(hmp_1) A3Q41_02260(hmp_2)
RHWBFN03_03160 BFN03_15205
RRZCS378_08145 CS378_10105 CS378_10555 CS378_11435 CS378_19600
RHQIM25_00690 IM25_02790 IM25_08870
RHODAOT96_05570 AOT96_14540 AOT96_14950 AOT96_17400 AOT96_19355
RRT4535765_00581(kshA_1) 4535765_00622(kshA_2) 4535765_00625(kshB_1) 4535765_03583(hmp_2) 4535765_04053(kshA_4) 4535765_04385(kshB_2)
RCRNCTC10994_02095(kshB_1) NCTC10994_02098(kshA_1) NCTC10994_02139(kshA_2) NCTC10994_02986(kshB_2) NCTC10994_03234(kshA_3) NCTC10994_03286(kshA_4) NCTC10994_03312(kshA_5) NCTC10994_03677(hmp_2)
RTMG4H71_04465 G4H71_04560 G4H71_07400 G4H71_13750 G4H71_16250
RKOJWS14_13070 JWS14_20720 JWS14_24480 JWS14_31790 JWS14_31900 JWS14_33035
RGOKYT97_09650 KYT97_11690 KYT97_12275 KYT97_15615 KYT97_16665 KYT97_18410 KYT97_23230
GBRGbro_0320 Gbro_0919 Gbro_3782 Gbro_4325
GPOGPOL_c00590 GPOL_c36520 GPOL_c41100(kshA1) GPOL_c41200(kshA2) GPOL_c41340 GPOL_c46160
GORKTR9_0819(kshA) KTR9_3740(kshB) KTR9_4196 KTR9_5394
GOQACH46_03115 ACH46_03235 ACH46_15935
GTABCM27_00520 BCM27_04760 BCM27_04885 BCM27_05105 BCM27_19590 BCM27_22040 BCM27_22340
GOCCXX93_06455 CXX93_06935
GITC6V83_04270 C6V83_16235
GRUGCWB2_04170(kshA1) GCWB2_11625(kshA2) GCWB2_19200(hmp6) GCWB2_21220(hmp7) GCWB2_21605(kshA4)
GOMD7316_02031(kshA_1) D7316_02407(hmp_2) D7316_02456(kshA_2) D7316_02565(kshA_3) D7316_02584(kshB_1) D7316_03108(kshA_4) D7316_04922(kshB_2)
GAVC5O27_00865 C5O27_06840 C5O27_07040 C5O27_08940 C5O27_10695 C5O27_10760 C5O27_16275
GODGKZ92_00215 GKZ92_03965 GKZ92_16370 GKZ92_16435 GKZ92_18130 GKZ92_19660 GKZ92_20570
GAMGII34_03585 GII34_04990 GII34_18075 GII34_18815 GII34_19625
GPDGII33_03230 GII33_03925 GII33_04450 GII33_17530 GII33_19165 GII33_21770 GII33_21775
GJIH1R19_03895 H1R19_04045 H1R19_12650 H1R19_12715 H1R19_17950 H1R19_20600
GOILK459_05090 LK459_05150 LK459_06945 LK459_09025 LK459_15780
GHNMVF96_04245 MVF96_18515 MVF96_21255
GAMIIHQ52_00755 IHQ52_01025 IHQ52_06825 IHQ52_22105
SPINKV203_03665 KV203_13540 KV203_17355
TPRTpau_3447 Tpau_3517 Tpau_3849 Tpau_3851
TSMASU32_19920 ASU32_20040 ASU32_21925 ASU32_21935
SRTSrot_0411
DTMBJL86_0694 BJL86_0697
DITC3V38_09250 C3V38_09260
DIZCT688_03170 CT688_03180
DPCA6048_03115 A6048_03125 A6048_14145
DLUA6035_03410 A6035_03420
TOYFO059_00150 FO059_01345 FO059_05540 FO059_14015 FO059_14025 FO059_16350 FO059_17440 FO059_17470
SALUDC74_7441 DC74_7443
SALLSAZ_38410 SAZ_38420
SVTSVTN_35870 SVTN_35880
SLDT261_3457
SRWTUE45_04033(hmp_3)
SPLULK06_026215
SLXSLAV_27410(kshA) SLAV_27420(hmp4)
SNKCP967_03265 CP967_03300
SVRCP971_15305
SGXH4W23_38505 H4W23_38515
SXNIAG42_03495 IAG42_26625 IAG42_26635
LXYO159_24870
MRNK8F61_04970 K8F61_04990
ARLAFL94_16990 AFL94_17000 AFL94_17140
ARYATC04_01230 ATC04_01245 ATC04_01315
ASUNKG104_04210 KG104_04220
GPRJQN66_16875 JQN66_16945 JQN66_16955
PAEYKUF55_17910 KUF55_17955 KUF55_17965
LMOIVV02_06590
JTEASJ30_13635 ASJ30_13640
NCANoca_2518 Noca_2520
NDKI601_0574(kshA_1) I601_3442(hmp_2) I601_3444(kshA_2)
NOYEXE57_01175
NBEBack2_27910 Back2_27930
NANOG5V58_10115 G5V58_10125
NAROCFH99_05075 CFH99_13240 CFH99_13250
NPIG7071_12480 G7071_12670 G7071_15685 G7071_15695
NROK8W59_09520
NPCKUV85_04490 KUV85_04500 KUV85_12205
PSIMKR76_14160 KR76_14170 KR76_18045 KR76_27070 KR76_27080
AEBC6I20_03500 C6I20_03510
TCUTcur_3509 Tcur_3520
ACTWF7P10_03565 F7P10_14665 F7P10_28350 F7P10_28445 F7P10_38145
FREFranean1_2973 Franean1_3372 Franean1_4306
FRIFraEuI1c_4270 FraEuI1c_5408
FALFRAAL3502
FSYFsymDg_0014
SVISvir_18640
AMDAMED_2517 AMED_2519
AMNRAM_12795 RAM_12805
AMMAMES_2489 AMES_2491
AMZB737_2490 B737_2492
AOIAORI_2479 AORI_2481
AJAAJAP_26420(kshA) AJAP_26430(kshB)
AMQAMETH_4841 AMETH_4843
AMYCCU254_10435 CU254_10445 CU254_23465 CU254_23475
AMYBBKN51_04995 BKN51_05005
AABA4R43_16060 A4R43_16070
AMYYYIM_14425(hmp1) YIM_14435(kshA1) YIM_36730(hmp4) YIM_36740(kshA2)
AORISD37_13460 SD37_13470
AACDLWP59_17310 LWP59_23965 LWP59_29215 LWP59_29225
KALKALB_5125 KALB_5127
KPHYAOZ06_42845 AOZ06_42855
LEDBBK82_38955 BBK82_38965
ALOCRK57807 CRK57817 CRK59604 CRK59606
PMADBAY61_10930 BAY61_10940
SACEGIY23_13370 GIY23_13380
STPStrop_2672 Strop_2674
SAQSare_2880 Sare_2882
AMSAMIS_19150 AMIS_19170
AIHAiant_18900 Aiant_18920(hmp)
AQZKSP35_09030
IAMHC251_17785
PSLPsta_0972
GMRGmarT_59890(ndoA)
CFILMYF79_01955
MGOTMgSA37_00351(hmp)
MGINFRZ54_02620
SRHOHH216_04920
RUPDTQ70_25235
FAEFAES_0794(paaE)
HYGAUC43_05755
HBNGUY19_11450
PACTCA264_03205
RTIDC20_21170
MAQILDL77_14770
TAJC1A40_00410
HALXM0R89_10990
SAIMK0C01_00010
 » show all
Reference
1  [PMID:19561185]
  Authors
Petrusma M, Dijkhuizen L, van der Geize R
  Title
Rhodococcus rhodochrous DSM 43269 3-ketosteroid 9alpha-hydroxylase, a two-component iron-sulfur-containing monooxygenase with subtle steroid substrate  specificity.
  Journal
Appl Environ Microbiol 75:5300-7 (2009)
DOI:10.1128/AEM.00066-09
  Sequence
Reference
2  [PMID:19234303]
  Authors
Capyk JK, D'Angelo I, Strynadka NC, Eltis LD
  Title
Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis.
  Journal
J Biol Chem 284:9937-46 (2009)
DOI:10.1074/jbc.M900719200
  Sequence
Reference
3  [PMID:21987574]
  Authors
Capyk JK, Casabon I, Gruninger R, Strynadka NC, Eltis LD
  Title
Activity of 3-ketosteroid 9alpha-hydroxylase (KshAB) indicates cholesterol side chain and ring degradation occur simultaneously in Mycobacterium tuberculosis.
  Journal
J Biol Chem 286:40717-24 (2011)
DOI:10.1074/jbc.M111.289975
Other DBs
ExplorEnz - The Enzyme Database: 1.14.15.30
IUBMB Enzyme Nomenclature: 1.14.15.30
ExPASy - ENZYME nomenclature database: 1.14.15.30
BRENDA, the Enzyme Database: 1.14.15.30

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