Entry
Name
tryptophan 5-monooxygenase;
L-tryptophan hydroxylase;
indoleacetic acid-5-hydroxylase;
tryptophan 5-hydroxylase;
tryptophan hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
L-tryptophan,tetrahydropteridine:oxygen oxidoreductase (5-hydroxylating)
Reaction(IUBMB)
L-tryptophan + a 5,6,7,8-tetrahydropteridine + O2 = 5-hydroxy-L-tryptophan + a 4a-hydroxy-5,6,7,8-tetrahydropteridine [RN:
R12542 ]
Reaction(KEGG)
Substrate
Product
5-hydroxy-L-tryptophan [CPD:
C00643 ];
4a-hydroxy-5,6,7,8-tetrahydropteridine [CPD:
C22239 ]
Comment
The active centre contains mononuclear iron(II). The enzyme is activated by phosphorylation, catalysed by a Ca2+-activated protein kinase. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC
4.2.1.96 , 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC
1.5.1.34 , 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine.
History
EC 1.14.16.4 created 1972, modified 2003, modified 2019
Pathway
Orthology
K00502 tryptophan 5-monooxygenase
Genes
HSA : 121278(TPH2) 7166(TPH1)
PTR : 466453(TPH1) 467070(TPH2)
PPS : 100977344(TPH2) 103782654(TPH1)
GGO : 101132108(TPH1) 101146582(TPH2)
PON : 100459809(TPH2) 103891844(TPH1)
PPYG : 129007957(TPH1) 129010163(TPH2)
NLE : 100588345(TPH2) 100601780(TPH1)
HMH : 116476462(TPH1) 116479653(TPH2)
SSYN : 129459252(TPH2) 129484345(TPH1)
MCC : 664730(TPH2) 695363(TPH1)
MCF : 102124167(TPH2) 102145077(TPH1)
MTHB : 126931259 126934661
MNI : 105473363(TPH2) 105486968(TPH1)
CSAB : 103238730(TPH2) 103239320(TPH1)
CATY : 105581034(TPH2) 105598886(TPH1)
PANU : 101001223(TPH2) 103875499(TPH1)
TGE : 112606866(TPH1) 112635076(TPH2)
MLEU : 105538610(TPH2) 105548757(TPH1)
RRO : 104667637(TPH1) 104668095(TPH2)
RBB : 108526665(TPH2) 108528377(TPH1)
TFN : 117081781(TPH1) 117089733(TPH2)
PTEH : 111552365(TPH2) 111555044(TPH1)
CANG : 105502696(TPH2) 105508574(TPH1)
CJC : 100403096(TPH2) 100415029(TPH1)
SBQ : 101051709(TPH2) 104652952(TPH1)
CIMI : 108290291(TPH2) 108302268(TPH1)
ANAN : 105709404(TPH2) 105720204(TPH1)
CSYR : 103257543(TPH2) 103265117(TPH1)
MMUR : 105856884(TPH2) 105879970(TPH1)
LCAT : 123640652(TPH2) 123642496(TPH1)
PCOQ : 105808391(TPH2) 105818320(TPH1)
OGA : 100953596(TPH2) 105886446(TPH1)
MMU : 216343(Tph2) 21990(Tph1)
MCAL : 110298535(Tph1) 110303601(Tph2)
MPAH : 110326744(Tph2) 110330199(Tph1)
RNO : 24848(Tph1) 317675(Tph2)
MCOC : 116076348(Tph2) 116102248(Tph1)
ANU : 117696548(Tph2) 117717401(Tph1)
MUN : 110550489(Tph1) 110555372(Tph2)
CGE : 100763947(Tph2) 100767923(Tph1)
MAUA : 101833802(Tph1) 101838885(Tph2)
PROB : 127213722(Tph1) 127215751(Tph2)
PLEU : 114699018(Tph2) 114700529(Tph1)
MORG : 121435671(Tph1) 121460400(Tph2)
MFOT : 126493307 126497516
AAMP : 119802810(Tph1) 119803543(Tph2)
NGI : 103734460(Tph1) 103735331(Tph2)
HGL : 101710219(Tph1) 101714361(Tph2)
CPOC : 100718189(Tph1) 100724594(Tph2)
DORD : 105988605(Tph2) 105999169(Tph1)
DSP : 122117778(Tph1) 122124215(Tph2)
PLOP : 125354051(Tph2) 125361447(Tph1)
NCAR : 124960036 124983401
MMMA : 107134236(Tph1) 107140050(Tph2)
OCU : 100009100(TPH1) 100344397
OPI : 101517264(TPH1) 101524788(TPH2)
TUP : 102481223(TPH2) 102487889(TPH1)
GVR : 103583323 103599893(TPH2) 103605039(TPH1)
CFA : 481165(TPH2) 611956(TPH1)
CLUD : 112667710(TPH1) 112677769(TPH2)
VVP : 112922180(TPH2) 112927027(TPH1)
VLG : 121476514(TPH1) 121491914(TPH2)
NPO : 129505083(TPH1) 129511893(TPH2)
AML : 100467699(TPH1) 100472165(TPH2)
UMR : 103656892(TPH2) 103679407(TPH1)
UAH : 113246602(TPH1) 113256261(TPH2)
UAR : 123787118(TPH2) 123791643(TPH1)
MPUF : 101678853(TPH2) 101685595(TPH1)
MNP : 132012086(TPH1) 132020562(TPH2)
MLK : 131810080(TPH1) 131839175(TPH2)
NVS : 122891145(TPH2) 122914281(TPH1)
ORO : 101364741(TPH1) 101369839(TPH2)
EJU : 114202737 114202738 114219387(TPH1)
ZCA : 113914718(TPH1) 113922464(TPH2) 113933908
MLX : 118004319(TPH1) 118008557(TPH2)
NSU : 110570541(TPH2) 110576620(TPH1)
LWW : 102744671(TPH2) 102751193(TPH1)
FCA : 101082165(TPH2) 101098575(TPH1)
PYU : 121040737(TPH2) 121043698(TPH1)
PCOO : 112863248(TPH2) 112865183(TPH1)
PBG : 122474068(TPH2) 122484410(TPH1)
PVIV : 125171142(TPH2) 125176723(TPH1)
LRUF : 124502124 124505757
PTG : 102948910(TPH2) 102969936(TPH1)
PPAD : 109270520(TPH2) 109271211(TPH1)
HHV : 120223353(TPH2) 120234792(TPH1)
BTA : 100336620(TPH2) 781941(TPH1)
BOM : 102269915(TPH1) 102275621(TPH2)
BIU : 109558652(TPH2) 109569943(TPH1)
BBUB : 102396992(TPH2) 102411029(TPH1)
BBIS : 104981427(TPH1) 104989308(TPH2)
CHX : 102174722(TPH2) 102184739(TPH1)
OAS : 101113620(TPH1) 101120314(TPH2)
BTAX : 128047987(TPH2) 128060565(TPH1)
CSUM : 138078314(TPH2) 138092467(TPH1)
ODA : 120857959(TPH2) 120876397(TPH1)
CCAD : 122427666(TPH2) 122450434(TPH1)
MREE : 136167889(TPH2) 136174323(TPH1)
MBEZ : 129536337(TPH2) 129554463(TPH1)
SSC : 100511002(TPH1) 100627725(TPH2)
CFR : 102512650(TPH2) 102522464(TPH1)
CBAI : 105072045(TPH2) 105076585(TPH1)
CDK : 105086665(TPH1) 105095994(TPH2)
VPC : 102533847(TPH1) 102534379(TPH2)
BACU : 102997866(TPH1) 103006656(TPH2)
BMUS : 118899786(TPH1) 118902274(TPH2)
LVE : 103083324(TPH1) 103087968(TPH2)
OOR : 101271217(TPH2) 101273510(TPH1)
DLE : 111165253(TPH1) 111173732(TPH2)
PCAD : 102985446(TPH2) 102994832(TPH1)
PSIU : 116758349(TPH1) 116761326(TPH2)
NASI : 112390601(TPH1) 112394157(TPH2)
ECB : 100009684(TPH2) 100056614(TPH1)
EPZ : 103559190(TPH1) 103561950(TPH2)
EAI : 106826108(TPH2) 106835485(TPH1)
MYB : 102241626(TPH2) 102244804(TPH1)
MYD : 102753485(TPH2) 102767513(TPH1)
MMYO : 118651936(TPH2) 118663522(TPH1)
MLF : 102418890(TPH1) 102434305(TPH2)
MDT : 132227943(TPH2) 132241035(TPH1)
PKL : 118712480(TPH1) 118730418(TPH2)
EFUS : 103292802(TPH1) 103298765(TPH2)
MNA : 107526733(TPH2) 107546725(TPH1)
DRO : 112303363(TPH1) 112319064(TPH2)
SHON : 118989337(TPH2) 118989705(TPH1)
AJM : 119053091(TPH1) 119055866
PDIC : 114499999(TPH1) 114513219(TPH2)
PHAS : 123810024(TPH1) 123812692(TPH2)
MMF : 118624020(TPH2) 118628186(TPH1)
PPAM : 129076059(TPH2) 129080764(TPH1)
HAI : 109387680(TPH2) 109388096(TPH1)
RFQ : 117028733(TPH2) 117030182(TPH1)
PALE : 102882683(TPH1) 102891331(TPH2)
PGIG : 120593610(TPH1) 120605080(TPH2)
PVP : 105301629(TPH2) 105304216(TPH1)
RAY : 107508027(TPH1) 107512624(TPH2)
MJV : 108400665(TPH2) 108404860(TPH1)
TOD : 119248285(TPH2) 119254591(TPH1)
SARA : 101549071(TPH1) 101551893(TPH2)
SETR : 126018561(TPH1) 126021883(TPH2)
LAV : 100658860(TPH1) 100669911(TPH2)
ETF : 101652906(TPH2) 101664474(TPH1)
DNM : 101414982(TPH2) 101440944(TPH1)
MDO : 100011937(TPH2) 100020009(TPH1)
GAS : 123250170(TPH2) 123251417(TPH1)
SHR : 100915442(TPH1) 100923184(TPH2)
PCW : 110195961(TPH2) 110221097(TPH1)
TVP : 118851764(TPH2) 118854195(TPH1)
PBRV : 138149912(TPH1) 138156719(TPH2)
OAA : 100079349(TPH2) 100090381(TPH1)
GGA : 395799(TPH1) 408026(TPH2)
PCOC : 116226749(TPH2) 116242903(TPH1)
MGP : 100303678(TPH2) 100549515(TPH1)
CJO : 107310284(TPH2) 107314681(TPH1)
TPAI : 128073769(TPH2) 128087405(TPH1)
LMUT : 125691631(TPH2) 125694772(TPH1)
NMEL : 110392823(TPH2) 110401279(TPH1)
APLA : 101793780(TPH2) 101797806
ACYG : 106042628 106046728(TPH2)
CATA : 118244570 118246808(TPH2) 118249932(TPH1)
AFUL : 116490046(TPH1) 116495542(TPH2)
TGU : 100228542(TPH2) 100229598(TPH1)
LSR : 110468084(TPH1) 110469834(TPH2)
SCAN : 103813668(TPH2) 103826774(TPH1)
PMOA : 120499841(TPH2) 120501148(TPH1)
OTC : 121339484(TPH2) 121341539(TPH1)
PRUF : 121352558(TPH2) 121360970(TPH1)
GFR : 102036017(TPH2) 102041307(TPH1)
FAB : 101817911(TPH2) 101820220(TPH1)
OMA : 130253785(TPH1) 130266285(TPH2)
PHI : 102103962(TPH2) 102106431(TPH1)
PMAJ : 107204683(TPH2) 107205260(TPH1)
CCAE : 111930805(TPH1) 111937577(TPH2)
CCW : 104685325(TPH1) 104698473(TPH2)
CBRC : 103614898(TPH2) 103624915(TPH1)
ACOE : 138101369(TPH2) 138111324(TPH1)
ETL : 114059440(TPH1) 114059989(TPH2)
ZAB : 102063944(TPH1) 102067699(TPH2)
ZLE : 135442297(TPH2) 135448177(TPH1)
ACHL : 103800451(TPH1) 103809635(TPH2)
SVG : 106853185(TPH1) 106854886(TPH2)
MMEA : 130575401(TPH1) 130580424(TPH2)
HRT : 120751822(TPH2) 120754668(TPH1)
SATI : 136361344(TPH2) 136362393(TPH1)
FPG : 101914983(TPH1) 101918183(TPH2)
FCH : 102052919(TPH2) 102057315(TPH1)
CCRI : 104158110(TPH2) 104161755(TPH1)
NNT : 104399707(TPH1) 104403148(TPH2)
SHAB : 115605118(TPH2) 115607463(TPH1)
ACUN : 113481125(TPH1) 113489370(TPH2)
TALA : 104356202(TPH1) 104369069(TPH2)
ACHC : 115336364(TPH2) 115352028(TPH1)
HALD : 104321339(TPH1) 104321563(TPH2)
HLE : 104828241(TPH2) 104829601(TPH1)
AGEN : 126034393 126047373
HHAR : 128135684(TPH2) 128152876(TPH1)
CSTI : 104557256(TPH1) 104560164
LDI : 104341063(TPH1) 104354075(TPH2)
MNB : 103780427(TPH2) 103780565(TPH1)
DPUB : 104300970(TPH2) 104304405(TPH1)
PPUS : 135186143(TPH1) 135187505(TPH2)
AVIT : 104267077(TPH1) 104275630(TPH2)
EGZ : 104123206(TPH1) 104132957(TPH2)
NNI : 104010591(TPH1) 104011038(TPH2)
PCRI : 104024209(TPH1) 104036613
PCAO : 104039703(TPH1) 104050425(TPH2)
PADL : 103920030(TPH2) 103920766(TPH1)
AFOR : 103893934(TPH2) 103906829(TPH1)
FGA : 104069814(TPH1) 104082213(TPH2)
GSTE : 104252045(TPH2) 104254424(TPH1)
CLV : 102092014(TPH2) 102095810(TPH1)
MUI : 104538948(TPH1) 104546764(TPH2)
PGUU : 104458251(TPH1) 104468846(TPH2)
PLET : 104613795(TPH1) 104621467
EHS : 104502752(TPH1) 104505787
CMAC : 104473198(TPH1) 104480211
CUCA : 104064049(TPH2) 104068887(TPH1)
TEO : 104369783(TPH1) 104375964(TPH2)
BREG : 104629753(TPH1) 104638963(TPH2)
OHA : 104326797(TPH2) 104330103(TPH1)
ACAR : 104522683(TPH1) 104530654(TPH2)
CPEA : 104386741(TPH1) 104393568(TPH2)
CVF : 104288943(TPH2) 104292606(TPH1)
RTD : 128909452(TPH1) 128915943(TPH2)
AAM : 106488161(TPH2) 106497047(TPH1)
AROW : 112964095(TPH2) 112972385(TPH1)
NPD : 112951457(TPH1) 112958850(TPH2)
TGT : 104567854(TPH1) 104578034(TPH2)
DNE : 112978923(TPH1) 112983291(TPH2)
SCAM : 104140418(TPH1) 104140703(TPH2)
ASN : 102376121(TPH2) 102380987(TPH1)
AMJ : 102560538(TPH1) 102572294(TPH2)
CPOO : 109315970(TPH2) 109321541(TPH1)
GGN : 109297011(TPH2) 109299139(TPH1)
PSS : 102445658(TPH2) 102460535(TPH1)
CMY : 102930035(TPH2) 102934830(TPH1)
CCAY : 125630179(TPH2) 125638860(TPH1)
DCC : 119857137(TPH1) 119859596(TPH2)
CPIC : 101933912(TPH2) 101948172(TPH1)
TST : 117877260(TPH1) 117877915(TPH2)
CABI : 116817165(TPH2) 116838939(TPH1)
MRV : 120383209(TPH2) 120402771(TPH1)
ACS : 100562860(tph1) 100564918(tph2)
ASAO : 132770755(TPH1) 132776152(TPH2)
PVT : 110084890(TPH2) 110088804(TPH1)
SUND : 121929851(TPH1) 121931396(TPH2)
PBI : 103048564(TPH1) 103062013
PMUR : 107283841(TPH2) 107296796(TPH1)
CTIG : 120308418(TPH2) 120311382(TPH1)
TSR : 106541682(TPH2) 106552357
PGUT : 117655482(TPH2) 117665266(TPH1)
APRI : 131189079(TPH1) 131202686(TPH2)
PTEX : 113440210(TPH1) 113452850 113452851
NSS : 113412206(TPH2) 113412476(TPH1)
VKO : 123021233(TPH1) 123033286(TPH2)
PMUA : 114598774(TPH1) 114605959(TPH2)
PRAF : 128416012(TPH1) 128422419(TPH2)
ZVI : 118089013(TPH1) 118090812(TPH2)
HCG : 128325738(TPH2) 128343186(TPH1)
GJA : 107115340(TPH2) 107115550(TPH1)
STOW : 125427565(TPH1) 125435960(TPH2)
EMC : 129324601(TPH1) 129335890(TPH2)
XLA : 108710258 108713144(tph2.S) 387560(tph1.L)
XTR : 100486097(tph2) 100497239(tph1)
NPR : 108785999(TPH1) 108788312(TPH2)
RTEM : 120917010(TPH1) 120931964(TPH2)
BBUF : 120980604(TPH1) 120980734(TPH2)
BGAR : 122920144(TPH1) 122925790(TPH2)
MUO : 115461820(TPH1) 115477669(TPH2)
GSH : 117352288(TPH1) 117363842(TPH2)
DRE : 352943(tph1a) 407712(tph2) 415103(tph1b)
SRX : 107720785(tph1) 107740327 107740493 107749937 107750725 107755016
SANH : 107663941 107670227 107672314 107673292 107686260 107700369
SGH : 107553080 107557706 107559977 107564603 107569655 107583800
CCAR : 109074194 109086690 109110720
CAUA : 113043713 113052380 113066434 113105990 113118311
CGIB : 127934104 127947262 127961777 128014601
PTET : 122330389(tph1a) 122348206 122363078(tph2)
LROH : 127156394(tph1a) 127167688(tph1b) 127181037(tph2)
OMC : 131524368(tph2) 131534072(tph1a) 131543626(tph1b)
PPRM : 120468429(tph1b) 120475344 120475345(tph1a) 120493909(tph2)
RKG : 130073714(tph1a) 130082993(tph1b) 130094750(tph2)
MAMB : 125246817(tph1a) 125254019(tph2) 125264770(tph1b)
CIDE : 127499661 127507163 127516700
CERY : 137014718(tph1a) 137023323(tph2) 137030442(tph1b)
MASI : 127412238 127416723 127435820 127437503 127443973 127456398
TROS : 130551755(tph1a) 130559461(tph1b) 130562815(tph2)
TDW : 130414135(tph1a) 130421248(tph1b) 130435730(tph2)
MANU : 129418947(tph2) 129434084(tph1a) 129443604(tph1b)
IPU : 108259139(tph1b) 108263971(tph2) 108274454(tph1a)
IFU : 128603091(tph1b) 128606652(tph2) 128617896(tph1a)
PHYP : 113529905(tph1) 113534273 113540934
SMEO : 124379583(tph1b) 124392964(tph1a) 124395690(tph2)
TFD : 113636847(tph1b) 113652620(tph2) 113653920(tph1a)
TVC : 132838695(tph1b) 132851283(tph2) 132857334(tph1a)
TRN : 134303919(tph1b) 134321589(tph1a) 134323264(tph2)
AMEX : 103025693(tph1b) 103043966(tph1a) 103046451(tph2)
CMAO : 118811325(tph1a) 118817337(tph1b) 118818068(tph2)
EEE : 113582098 113582294 113584487(tph1)
CHAR : 105893026 105900781(tph2) 105905120(tph1a)
TRU : 446047(tph1) 446048(tph2)
TFS : 130535736(tph1a) 130536099(tph2)
LCO : 104921438 104932027(tph1) 104938290
NCC : 104964502(tph1) 104965427
TBEN : 117491105 117491916(tph1a) 117496619(tph2)
CGOB : 115004781 115009666(tph1)
PGEO : 117441501 117447770(tph1a) 117462532
GACU : 117534623 117538804(tph1a) 117558984(tph2)
EMAC : 134862518 134873986(tph2) 134877217(tph1a)
ELY : 117257841 117261799(tph1a) 117261880(tph2)
EFO : 125880460 125886864(tph1a) 125887303(tph2)
PLEP : 121943098 121950084(tph1a)
SLUC : 116038510(tph1a) 116061876(tph2) 116067391
ECRA : 117947847 117949802(tph1a)
ESP : 116679171 116686028 116693678(tph1)
PFLV : 114557592 114559910(tph1) 114560174(tph2)
GAT : 120808697(tph1a) 120809623(tph2) 120833009
PPUG : 119195577(tph2) 119196279(tph1a) 119229676
AFB : 129106351 129107816(tph1a) 129108042(tph2)
CLUM : 117732252(tph2) 117732472(tph1a)
PSWI : 130193164 130195624(tph1a) 130195809
CANA : 137782757 137799698(tph2) 137804477(tph1a)
CVE : 137872341 137880888(tph1a)
MSAM : 119889771 119893900 119894244(tph2)
SCHU : 122875262(tph2) 122875401(tph1a)
CUD : 121515571(tph2) 121515765(tph1a)
ALAT : 119017846 119023813(tph2) 119024442(tph1a)
ASTR : 137593660(tph1a) 137593733(tph2) 137593767 137594104
MZE : 101480764(tph2) 101484460 101486409(tph1)
ONL : 100691623(tph1) 100694382 100696141
OAU : 116311354(tph2) 116319109 116326748(tph1a)
OLA : 101166957(tph2) 101170994 101175562(tph1)
OML : 112141172 112152292(tph1a) 112161307
CSAI : 133444137(tph1a) 133444816(tph2) 133457766
XMA : 102216868(tph1) 102234879 102236889(tph2)
XCO : 114142506 114150104(tph2) 114151044(tph1)
XHE : 116710961(tph2) 116718124 116729036(tph1)
PRET : 103462259 103466377(tph2) 103466482(tph1)
PFOR : 103130852 103149204 103156520(tph1)
PLAI : 106942220 106947747(tph1) 106959120
PMEI : 106905963(tph2) 106925763 106933112(tph1)
GAF : 122835380(tph1a) 122836199(tph2) 122846231
PPRL : 129367105(tph2) 129370942(tph1a) 129379373
CVG : 107099807(tph2) 107101475 107103791(tph1)
CTUL : 119773716 119781658(tph2) 119787407(tph1a)
GMU : 124867496 124879600(tph2) 124881668(tph1a)
NFU : 107381938 107388661(tph1) 107389098(tph2)
KMR : 108229864(tph1a) 108237877 108251439(tph2)
ALIM : 106516735 106521168(tph1) 106531022(tph2)
NWH : 119415797(tph1a) 119416121(tph2) 119423870
AOCE : 111578292 111584097(tph1)
EJA : 138206507(tph1a) 138212448(tph2)
MCEP : 125004919 125014355(tph2) 125014726(tph1a)
CSEM : 103379608(tph2) 103380212(tph1)
POV : 109624178(tph1) 109644721
SSEN : 122775398(tph2) 122776545(tph1a)
HHIP : 117762606(tph1a) 117762648(tph2)
HSP : 118109473(tph1a) 118109701(tph2)
PPLT : 128444444(tph1a) 128445123(tph2)
SMAU : 118314831(tph2) 118315261(tph1a)
LCF : 108876698(tph1a) 108891738
SDU : 111229584(tph1) 111233710(tph2)
SLAL : 111648930 111667055(tph1)
XGL : 120793262(tph2) 120793556(tph1a)
HCQ : 109507516(tph1) 109518199(tph2) 109529786
SSCV : 125966836 125970122 125970124(tph1a)
SBIA : 133497598 133502239(tph1a) 133512358
PEE : 133399406 133402408(tph1a) 133402897(tph2)
PTAO : 133468963 133478519(tph1a) 133478734(tph2)
BPEC : 110162577 110168313(tph2) 110169358(tph1)
MALB : 109951036(tph1) 109969076(tph2)
BSPL : 114857110(tph2) 114857595(tph1a)
SJO : 128359041(tph2) 128359249(tph1a) 128380979
SASA : 106561539 106562311 106584760 106587468
STRU : 115167134 115192917(tph1) 115197528 115203199
OTW : 112218837(tph2) 112236633 112237058(tph1a) 112249279
OMY : 110499357(tph2) 110506638 110521183(tph1a) 110526507
OGO : 124033100 124033744(tph2) 124035648 124037467(tph1a)
ONE : 115111128 115113690 115126650 115133981
OKI : 109867169 109873104 109883269(tph1) 109894986
OKE : 118358808 118360071 118394316 118395937(tph2)
SALP : 111962707 111969461 111974702 112073037
SNH : 120025196 120051724(tph1a) 120056450 120066714(tph2)
CCLU : 121540750(tph1a) 121559019(tph2) 121561317
ELS : 105018201(tph1) 105018238(tph2)
SFM : 108936426(tph2) 108941264 108942210
PKI : 111834510 111835440 111851447(tph2)
AANG : 118214860 118219170(tph2) 118227486
LOC : 102682173(tph2) 102697783(tph1)
PSPA : 121294421 121318037 121320056 121330423(tph1a)
ARUT : 117415915 117419550 117432389 117434745(tph1a)
PSEX : 120529467 120534373(tph2)
LCM : 102362567(TPH1) 102363250(TPH2)
RTP : 109927655 109935866(tph1a)
CPLA : 122557902 122559755
LERI : 129705810(tph1a) 129706437
PMRN : 116945540 116952575
DSI : Dsimw501_GD13494(Dsim_GD13494)
DCOR : 135794753 135801697
PPOI : 119113741 119113797 119114133
LPOL : 106459616 106470412
CEL : CELE_ZK1290.2(tph-1)
CBR : CBG_12991(Cbr-tph-1)
DPOL : 127852644 127853382
» show all
Taxonomy
Reference
Authors
Friedman PA, Kappelman AH, Kaufman S.
Title
Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain.
Journal
J Biol Chem 247:4165-73 (1972)
Reference
Authors
Hamon M, Bourgoin S, Artaud F, Glowinski J.
Title
The role of intraneuronal 5-HT and of tryptophan hydroxylase activation in the control of 5-HT synthesis in rat brain slices incubated in K+-enriched medium.
Journal
Reference
Authors
Ichiyama A, Nakamura S, Nishizuka Y, Hayaishi O.
Title
Enzymic studies on the biosynthesis of serotonin in mammalian brain.
Journal
J Biol Chem 245:1699-709 (1970)
Reference
Authors
Jequier E, Robinson DS, Lovenberg W, Sjoerdsma A.
Title
Further studies on tryptophan hydroxylase in rat brainstem and beef pineal.
Journal
Reference
Authors
Wang L, Erlandsen H, Haavik J, Knappskog PM, Stevens RC.
Title
Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.14.16.4