KEGG   ENZYME: 1.14.16.4
Entry
EC 1.14.16.4                Enzyme                                 
Name
tryptophan 5-monooxygenase;
L-tryptophan hydroxylase;
indoleacetic acid-5-hydroxylase;
tryptophan 5-hydroxylase;
tryptophan hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
L-tryptophan,tetrahydropteridine:oxygen oxidoreductase (5-hydroxylating)
Reaction(IUBMB)
L-tryptophan + a 5,6,7,8-tetrahydropteridine + O2 = 5-hydroxy-L-tryptophan + a 4a-hydroxy-5,6,7,8-tetrahydropteridine [RN:R12542]
Reaction(KEGG)
R12542;
(other) R01814 R07213
Substrate
L-tryptophan [CPD:C00078];
5,6,7,8-tetrahydropteridine [CPD:C05650];
O2 [CPD:C00007]
Product
5-hydroxy-L-tryptophan [CPD:C00643];
4a-hydroxy-5,6,7,8-tetrahydropteridine [CPD:C22239]
Comment
The active centre contains mononuclear iron(II). The enzyme is activated by phosphorylation, catalysed by a Ca2+-activated protein kinase. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC 1.5.1.34, 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine.
History
EC 1.14.16.4 created 1972, modified 2003, modified 2019
Pathway
ec00380  Tryptophan metabolism
ec00790  Folate biosynthesis
ec01100  Metabolic pathways
Orthology
K00502  tryptophan 5-monooxygenase
Genes
HSA121278(TPH2) 7166(TPH1)
PTR466453(TPH1) 467070(TPH2)
PPS100977344(TPH2) 103782654(TPH1)
GGO101132108(TPH1) 101146582(TPH2)
PON100459809(TPH2) 103891844(TPH1)
PPYG129007957(TPH1) 129010163(TPH2)
NLE100588345(TPH2) 100601780(TPH1)
HMH116476462(TPH1) 116479653(TPH2)
SSYN129459252(TPH2) 129484345(TPH1)
MCC664730(TPH2) 695363(TPH1)
MCF102124167(TPH2) 102145077(TPH1)
MTHB126931259 126934661
MNI105473363(TPH2) 105486968(TPH1)
CSAB103238730(TPH2) 103239320(TPH1)
CATY105581034(TPH2) 105598886(TPH1)
PANU101001223(TPH2) 103875499(TPH1)
TGE112606866(TPH1) 112635076(TPH2)
MLEU105538610(TPH2) 105548757(TPH1)
RRO104667637(TPH1) 104668095(TPH2)
RBB108526665(TPH2) 108528377(TPH1)
TFN117081781(TPH1) 117089733(TPH2)
PTEH111552365(TPH2) 111555044(TPH1)
CANG105502696(TPH2) 105508574(TPH1)
CJC100403096(TPH2) 100415029(TPH1)
SBQ101051709(TPH2) 104652952(TPH1)
CIMI108290291(TPH2) 108302268(TPH1)
ANAN105709404(TPH2) 105720204(TPH1)
CSYR103257543(TPH2) 103265117(TPH1)
MMUR105856884(TPH2) 105879970(TPH1)
LCAT123640652(TPH2) 123642496(TPH1)
PCOQ105808391(TPH2) 105818320(TPH1)
OGA100953596(TPH2) 105886446(TPH1)
MMU216343(Tph2) 21990(Tph1)
MCAL110298535(Tph1) 110303601(Tph2)
MPAH110326744(Tph2) 110330199(Tph1)
RNO24848(Tph1) 317675(Tph2)
MCOC116076348(Tph2) 116102248(Tph1)
ANU117696548(Tph2) 117717401(Tph1)
MUN110550489(Tph1) 110555372(Tph2)
CGE100763947(Tph2) 100767923(Tph1)
MAUA101833802(Tph1) 101838885(Tph2)
PROB127213722(Tph1) 127215751(Tph2)
PLEU114699018(Tph2) 114700529(Tph1)
MORG121435671(Tph1) 121460400(Tph2)
MFOT126493307 126497516
AAMP119802810(Tph1) 119803543(Tph2)
NGI103734460(Tph1) 103735331(Tph2)
HGL101710219(Tph1) 101714361(Tph2)
CPOC100718189(Tph1) 100724594(Tph2)
CCAN109679995(Tph1)
DORD105988605(Tph2) 105999169(Tph1)
DSP122117778(Tph1) 122124215(Tph2)
PLOP125354051(Tph2) 125361447(Tph1)
NCAR124960036 124983401
MMMA107134236(Tph1) 107140050(Tph2)
OCU100009100(TPH1) 100344397
OPI101517264(TPH1) 101524788(TPH2)
TUP102481223(TPH2) 102487889(TPH1)
GVR103583323 103599893(TPH2) 103605039(TPH1)
CFA481165(TPH2) 611956(TPH1)
CLUD112667710(TPH1) 112677769(TPH2)
VVP112922180(TPH2) 112927027(TPH1)
VLG121476514(TPH1) 121491914(TPH2)
NPO129505083(TPH1) 129511893(TPH2)
AML100467699(TPH1) 100472165(TPH2)
UMR103656892(TPH2) 103679407(TPH1)
UAH113246602(TPH1) 113256261(TPH2)
UAR123787118(TPH2) 123791643(TPH1)
ELK111142174 111150060
LLV125078834 125106719
MPUF101678853(TPH2) 101685595(TPH1)
MNP132012086(TPH1) 132020562(TPH2)
MLK131810080(TPH1) 131839175(TPH2)
NVS122891145(TPH2) 122914281(TPH1)
ORO101364741(TPH1) 101369839(TPH2)
EJU114202737 114202738 114219387(TPH1)
ZCA113914718(TPH1) 113922464(TPH2) 113933908
MLX118004319(TPH1) 118008557(TPH2)
NSU110570541(TPH2) 110576620(TPH1)
LWW102744671(TPH2) 102751193(TPH1)
FCA101082165(TPH2) 101098575(TPH1)
PYU121040737(TPH2) 121043698(TPH1)
PCOO112863248(TPH2) 112865183(TPH1)
PBG122474068(TPH2) 122484410(TPH1)
PVIV125171142(TPH2) 125176723(TPH1)
LRUF124502124 124505757
PTG102948910(TPH2) 102969936(TPH1)
PPAD109270520(TPH2) 109271211(TPH1)
PUC125913401 125919350
AJU106967384 106977480
HHV120223353(TPH2) 120234792(TPH1)
BTA100336620(TPH2) 781941(TPH1)
BOM102269915(TPH1) 102275621(TPH2)
BIU109558652(TPH2) 109569943(TPH1)
BBUB102396992(TPH2) 102411029(TPH1)
BBIS104981427(TPH1) 104989308(TPH2)
CHX102174722(TPH2) 102184739(TPH1)
OAS101113620(TPH1) 101120314(TPH2)
BTAX128047987(TPH2) 128060565(TPH1)
CSUM138078314(TPH2) 138092467(TPH1)
ODA120857959(TPH2) 120876397(TPH1)
CCAD122427666(TPH2) 122450434(TPH1)
MREE136167889(TPH2) 136174323(TPH1)
MBEZ129536337(TPH2) 129554463(TPH1)
SSC100511002(TPH1) 100627725(TPH2)
CFR102512650(TPH2) 102522464(TPH1)
CBAI105072045(TPH2) 105076585(TPH1)
CDK105086665(TPH1) 105095994(TPH2)
VPC102533847(TPH1) 102534379(TPH2)
BACU102997866(TPH1) 103006656(TPH2)
BMUS118899786(TPH1) 118902274(TPH2)
LVE103083324(TPH1) 103087968(TPH2)
OOR101271217(TPH2) 101273510(TPH1)
DLE111165253(TPH1) 111173732(TPH2)
PCAD102985446(TPH2) 102994832(TPH1)
PSIU116758349(TPH1) 116761326(TPH2)
NASI112390601(TPH1) 112394157(TPH2)
ECB100009684(TPH2) 100056614(TPH1)
EPZ103559190(TPH1) 103561950(TPH2)
EAI106826108(TPH2) 106835485(TPH1)
MYB102241626(TPH2) 102244804(TPH1)
MYD102753485(TPH2) 102767513(TPH1)
MMYO118651936(TPH2) 118663522(TPH1)
MLF102418890(TPH1) 102434305(TPH2)
MDT132227943(TPH2) 132241035(TPH1)
PKL118712480(TPH1) 118730418(TPH2)
EFUS103292802(TPH1) 103298765(TPH2)
MNA107526733(TPH2) 107546725(TPH1)
DRO112303363(TPH1) 112319064(TPH2)
SHON118989337(TPH2) 118989705(TPH1)
AJM119053091(TPH1) 119055866
PDIC114499999(TPH1) 114513219(TPH2)
PHAS123810024(TPH1) 123812692(TPH2)
MMF118624020(TPH2) 118628186(TPH1)
PPAM129076059(TPH2) 129080764(TPH1)
HAI109387680(TPH2) 109388096(TPH1)
RFQ117028733(TPH2) 117030182(TPH1)
PALE102882683(TPH1) 102891331(TPH2)
PGIG120593610(TPH1) 120605080(TPH2)
PVP105301629(TPH2) 105304216(TPH1)
RAY107508027(TPH1) 107512624(TPH2)
MJV108400665(TPH2) 108404860(TPH1)
TOD119248285(TPH2) 119254591(TPH1)
SARA101549071(TPH1) 101551893(TPH2)
SETR126018561(TPH1) 126021883(TPH2)
LAV100658860(TPH1) 100669911(TPH2)
TMU101355042 101360632
ETF101652906(TPH2) 101664474(TPH1)
DNM101414982(TPH2) 101440944(TPH1)
MDO100011937(TPH2) 100020009(TPH1)
GAS123250170(TPH2) 123251417(TPH1)
SHR100915442(TPH1) 100923184(TPH2)
AFZ127540574 127564310
PCW110195961(TPH2) 110221097(TPH1)
TVP118851764(TPH2) 118854195(TPH1)
PBRV138149912(TPH1) 138156719(TPH2)
OAA100079349(TPH2) 100090381(TPH1)
GGA395799(TPH1) 408026(TPH2)
PCOC116226749(TPH2) 116242903(TPH1)
MGP100303678(TPH2) 100549515(TPH1)
CJO107310284(TPH2) 107314681(TPH1)
TPAI128073769(TPH2) 128087405(TPH1)
LMUT125691631(TPH2) 125694772(TPH1)
NMEL110392823(TPH2) 110401279(TPH1)
APLA101793780(TPH2) 101797806
ACYG106042628 106046728(TPH2)
CATA118244570 118246808(TPH2) 118249932(TPH1)
AFUL116490046(TPH1) 116495542(TPH2)
TGU100228542(TPH2) 100229598(TPH1)
LSR110468084(TPH1) 110469834(TPH2)
SCAN103813668(TPH2) 103826774(TPH1)
PMOA120499841(TPH2) 120501148(TPH1)
OTC121339484(TPH2) 121341539(TPH1)
PRUF121352558(TPH2) 121360970(TPH1)
GFR102036017(TPH2) 102041307(TPH1)
FAB101817911(TPH2) 101820220(TPH1)
OMA130253785(TPH1) 130266285(TPH2)
PHI102103962(TPH2) 102106431(TPH1)
PMAJ107204683(TPH2) 107205260(TPH1)
CCAE111930805(TPH1) 111937577(TPH2)
CCW104685325(TPH1) 104698473(TPH2)
CBRC103614898(TPH2) 103624915(TPH1)
ACOE138101369(TPH2) 138111324(TPH1)
ETL114059440(TPH1) 114059989(TPH2)
ZAB102063944(TPH1) 102067699(TPH2)
ZLE135442297(TPH2) 135448177(TPH1)
ACHL103800451(TPH1) 103809635(TPH2)
SVG106853185(TPH1) 106854886(TPH2)
MMEA130575401(TPH1) 130580424(TPH2)
HRT120751822(TPH2) 120754668(TPH1)
SATI136361344(TPH2) 136362393(TPH1)
FPG101914983(TPH1) 101918183(TPH2)
FCH102052919(TPH2) 102057315(TPH1)
CCRI104158110(TPH2) 104161755(TPH1)
NNT104399707(TPH1) 104403148(TPH2)
SHAB115605118(TPH2) 115607463(TPH1)
ACUN113481125(TPH1) 113489370(TPH2)
TALA104356202(TPH1) 104369069(TPH2)
ACHC115336364(TPH2) 115352028(TPH1)
HALD104321339(TPH1) 104321563(TPH2)
HLE104828241(TPH2) 104829601(TPH1)
AGEN126034393 126047373
HHAR128135684(TPH2) 128152876(TPH1)
GCL127016664 127021245
CSTI104557256(TPH1) 104560164
LDI104341063(TPH1) 104354075(TPH2)
MNB103780427(TPH2) 103780565(TPH1)
DPUB104300970(TPH2) 104304405(TPH1)
PPUS135186143(TPH1) 135187505(TPH2)
AVIT104267077(TPH1) 104275630(TPH2)
BRHI104497204(TPH1)
EGZ104123206(TPH1) 104132957(TPH2)
NNI104010591(TPH1) 104011038(TPH2)
PCRI104024209(TPH1) 104036613
PCAO104039703(TPH1) 104050425(TPH2)
PADL103920030(TPH2) 103920766(TPH1)
AFOR103893934(TPH2) 103906829(TPH1)
FGA104069814(TPH1) 104082213(TPH2)
GSTE104252045(TPH2) 104254424(TPH1)
CLV102092014(TPH2) 102095810(TPH1)
MUI104538948(TPH1) 104546764(TPH2)
PGUU104458251(TPH1) 104468846(TPH2)
PLET104613795(TPH1) 104621467
EHS104502752(TPH1) 104505787
CMAC104473198(TPH1) 104480211
CUCA104064049(TPH2) 104068887(TPH1)
TEO104369783(TPH1) 104375964(TPH2)
BREG104629753(TPH1) 104638963(TPH2)
OHA104326797(TPH2) 104330103(TPH1)
ACAR104522683(TPH1) 104530654(TPH2)
CPEA104386741(TPH1) 104393568(TPH2)
CVF104288943(TPH2) 104292606(TPH1)
RTD128909452(TPH1) 128915943(TPH2)
AAM106488161(TPH2) 106497047(TPH1)
AROW112964095(TPH2) 112972385(TPH1)
NPD112951457(TPH1) 112958850(TPH2)
TGT104567854(TPH1) 104578034(TPH2)
DNE112978923(TPH1) 112983291(TPH2)
SCAM104140418(TPH1) 104140703(TPH2)
ASN102376121(TPH2) 102380987(TPH1)
AMJ102560538(TPH1) 102572294(TPH2)
CPOO109315970(TPH2) 109321541(TPH1)
GGN109297011(TPH2) 109299139(TPH1)
PSS102445658(TPH2) 102460535(TPH1)
CMY102930035(TPH2) 102934830(TPH1)
CCAY125630179(TPH2) 125638860(TPH1)
DCC119857137(TPH1) 119859596(TPH2)
CPIC101933912(TPH2) 101948172(TPH1)
TST117877260(TPH1) 117877915(TPH2)
CABI116817165(TPH2) 116838939(TPH1)
MRV120383209(TPH2) 120402771(TPH1)
ACS100562860(tph1) 100564918(tph2)
ASAO132770755(TPH1) 132776152(TPH2)
PVT110084890(TPH2) 110088804(TPH1)
SUND121929851(TPH1) 121931396(TPH2)
PBI103048564(TPH1) 103062013
PMUR107283841(TPH2) 107296796(TPH1)
CTIG120308418(TPH2) 120311382(TPH1)
TSR106541682(TPH2) 106552357
PGUT117655482(TPH2) 117665266(TPH1)
APRI131189079(TPH1) 131202686(TPH2)
PTEX113440210(TPH1) 113452850 113452851
NSS113412206(TPH2) 113412476(TPH1)
VKO123021233(TPH1) 123033286(TPH2)
PMUA114598774(TPH1) 114605959(TPH2)
PRAF128416012(TPH1) 128422419(TPH2)
ZVI118089013(TPH1) 118090812(TPH2)
HCG128325738(TPH2) 128343186(TPH1)
GJA107115340(TPH2) 107115550(TPH1)
STOW125427565(TPH1) 125435960(TPH2)
EMC129324601(TPH1) 129335890(TPH2)
XLA108710258 108713144(tph2.S) 387560(tph1.L)
XTR100486097(tph2) 100497239(tph1)
NPR108785999(TPH1) 108788312(TPH2)
RTEM120917010(TPH1) 120931964(TPH2)
BBUF120980604(TPH1) 120980734(TPH2)
BGAR122920144(TPH1) 122925790(TPH2)
MUO115461820(TPH1) 115477669(TPH2)
GSH117352288(TPH1) 117363842(TPH2)
DRE352943(tph1a) 407712(tph2) 415103(tph1b)
SRX107720785(tph1) 107740327 107740493 107749937 107750725 107755016
SANH107663941 107670227 107672314 107673292 107686260 107700369
SGH107553080 107557706 107559977 107564603 107569655 107583800
CCAR109074194 109086690 109110720
CAUA113043713 113052380 113066434 113105990 113118311
CGIB127934104 127947262 127961777 128014601
PTET122330389(tph1a) 122348206 122363078(tph2)
LROH127156394(tph1a) 127167688(tph1b) 127181037(tph2)
OMC131524368(tph2) 131534072(tph1a) 131543626(tph1b)
PPRM120468429(tph1b) 120475344 120475345(tph1a) 120493909(tph2)
RKG130073714(tph1a) 130082993(tph1b) 130094750(tph2)
MAMB125246817(tph1a) 125254019(tph2) 125264770(tph1b)
CIDE127499661 127507163 127516700
CERY137014718(tph1a) 137023323(tph2) 137030442(tph1b)
MASI127412238 127416723 127435820 127437503 127443973 127456398
TROS130551755(tph1a) 130559461(tph1b) 130562815(tph2)
TDW130414135(tph1a) 130421248(tph1b) 130435730(tph2)
MANU129418947(tph2) 129434084(tph1a) 129443604(tph1b)
IPU108259139(tph1b) 108263971(tph2) 108274454(tph1a)
IFU128603091(tph1b) 128606652(tph2) 128617896(tph1a)
PHYP113529905(tph1) 113534273 113540934
SMEO124379583(tph1b) 124392964(tph1a) 124395690(tph2)
TFD113636847(tph1b) 113652620(tph2) 113653920(tph1a)
TVC132838695(tph1b) 132851283(tph2) 132857334(tph1a)
TRN134303919(tph1b) 134321589(tph1a) 134323264(tph2)
AMEX103025693(tph1b) 103043966(tph1a) 103046451(tph2)
CMAO118811325(tph1a) 118817337(tph1b) 118818068(tph2)
EEE113582098 113582294 113584487(tph1)
CHAR105893026 105900781(tph2) 105905120(tph1a)
TRU446047(tph1) 446048(tph2)
TFS130535736(tph1a) 130536099(tph2)
TNGGSTEN00006938G001
LCO104921438 104932027(tph1) 104938290
NCC104964502(tph1) 104965427
TBEN117491105 117491916(tph1a) 117496619(tph2)
CGOB115004781 115009666(tph1)
PGEO117441501 117447770(tph1a) 117462532
GACU117534623 117538804(tph1a) 117558984(tph2)
EMAC134862518 134873986(tph2) 134877217(tph1a)
ELY117257841 117261799(tph1a) 117261880(tph2)
EFO125880460 125886864(tph1a) 125887303(tph2)
PLEP121943098 121950084(tph1a)
SLUC116038510(tph1a) 116061876(tph2) 116067391
ECRA117947847 117949802(tph1a)
ESP116679171 116686028 116693678(tph1)
PFLV114557592 114559910(tph1) 114560174(tph2)
GAT120808697(tph1a) 120809623(tph2) 120833009
PPUG119195577(tph2) 119196279(tph1a) 119229676
AFB129106351 129107816(tph1a) 129108042(tph2)
CLUM117732252(tph2) 117732472(tph1a)
PSWI130193164 130195624(tph1a) 130195809
CANA137782757 137799698(tph2) 137804477(tph1a)
CVE137872341 137880888(tph1a)
MSAM119889771 119893900 119894244(tph2)
SCHU122875262(tph2) 122875401(tph1a)
CUD121515571(tph2) 121515765(tph1a)
ALAT119017846 119023813(tph2) 119024442(tph1a)
ASTR137593660(tph1a) 137593733(tph2) 137593767 137594104
MZE101480764(tph2) 101484460 101486409(tph1)
ONL100691623(tph1) 100694382 100696141
OAU116311354(tph2) 116319109 116326748(tph1a)
OLA101166957(tph2) 101170994 101175562(tph1)
OML112141172 112152292(tph1a) 112161307
CSAI133444137(tph1a) 133444816(tph2) 133457766
XMA102216868(tph1) 102234879 102236889(tph2)
XCO114142506 114150104(tph2) 114151044(tph1)
XHE116710961(tph2) 116718124 116729036(tph1)
PRET103462259 103466377(tph2) 103466482(tph1)
PFOR103130852 103149204 103156520(tph1)
PLAI106942220 106947747(tph1) 106959120
PMEI106905963(tph2) 106925763 106933112(tph1)
GAF122835380(tph1a) 122836199(tph2) 122846231
PPRL129367105(tph2) 129370942(tph1a) 129379373
CVG107099807(tph2) 107101475 107103791(tph1)
CTUL119773716 119781658(tph2) 119787407(tph1a)
GMU124867496 124879600(tph2) 124881668(tph1a)
NFU107381938 107388661(tph1) 107389098(tph2)
KMR108229864(tph1a) 108237877 108251439(tph2)
ALIM106516735 106521168(tph1) 106531022(tph2)
NWH119415797(tph1a) 119416121(tph2) 119423870
AOCE111578292 111584097(tph1)
EJA138206507(tph1a) 138212448(tph2)
MCEP125004919 125014355(tph2) 125014726(tph1a)
CSEM103379608(tph2) 103380212(tph1)
POV109624178(tph1) 109644721
SSEN122775398(tph2) 122776545(tph1a)
HHIP117762606(tph1a) 117762648(tph2)
HSP118109473(tph1a) 118109701(tph2)
PPLT128444444(tph1a) 128445123(tph2)
SMAU118314831(tph2) 118315261(tph1a)
LCF108876698(tph1a) 108891738
SDU111229584(tph1) 111233710(tph2)
SLAL111648930 111667055(tph1)
XGL120793262(tph2) 120793556(tph1a)
HCQ109507516(tph1) 109518199(tph2) 109529786
SSCV125966836 125970122 125970124(tph1a)
SBIA133497598 133502239(tph1a) 133512358
PEE133399406 133402408(tph1a) 133402897(tph2)
PTAO133468963 133478519(tph1a) 133478734(tph2)
BPEC110162577 110168313(tph2) 110169358(tph1)
MALB109951036(tph1) 109969076(tph2)
BSPL114857110(tph2) 114857595(tph1a)
SJO128359041(tph2) 128359249(tph1a) 128380979
SASA106561539 106562311 106584760 106587468
STRU115167134 115192917(tph1) 115197528 115203199
OTW112218837(tph2) 112236633 112237058(tph1a) 112249279
OMY110499357(tph2) 110506638 110521183(tph1a) 110526507
OGO124033100 124033744(tph2) 124035648 124037467(tph1a)
ONE115111128 115113690 115126650 115133981
OKI109867169 109873104 109883269(tph1) 109894986
OKE118358808 118360071 118394316 118395937(tph2)
SALP111962707 111969461 111974702 112073037
SNH120025196 120051724(tph1a) 120056450 120066714(tph2)
CCLU121540750(tph1a) 121559019(tph2) 121561317
ELS105018201(tph1) 105018238(tph2)
SFM108936426(tph2) 108941264 108942210
PKI111834510 111835440 111851447(tph2)
AANG118214860 118219170(tph2) 118227486
LOC102682173(tph2) 102697783(tph1)
PSPA121294421 121318037 121320056 121330423(tph1a)
ARUT117415915 117419550 117432389 117434745(tph1a)
PSEX120529467 120534373(tph2)
LCM102362567(TPH1) 102363250(TPH2)
CMK103174831 103185330
RTP109927655 109935866(tph1a)
CPLA122557902 122559755
HOC132824170 132824901
LERI129705810(tph1a) 129706437
PMRN116945540 116952575
LRJ133347546 133351366
BFO118406289 118406966
BBEL109480215
CIN100049066
SCLV120335756
SPU115922565 578903
LPIC129282517
APLC110981081
ARUN117291294
AJC117104886
SKO100329006(tph-1)
DMEDmel_CG9122(Trhn)
DER6543860
DSE6610268
DSIDsimw501_GD13494(Dsim_GD13494)
DYADyak_GE20982
DAN6492953
DSR110178615
DPO4812462
DPE6603951
DMN108153552
DWI6639428
DGR6558602
DMODmoj_GI12709
DAZ108614428
DNV108651306
DHE111600458
DVI6623307
CCAT101460734
BOD106622704
BDR105232770
RZE108377146 108379342
AOQ129241820 129242669
TDA119672813 119673169
MDE101893101
SCAC106092589
LCQ111676820
LSQ119607280
GFS119632169
ECOE129947572
CLON129613820
HIS119648909
AGA1276687
ACOZ120952581
AARA120896557
AMER121594201
ASTE118510078
AFUN125770368
AMOU128301382
AALI118465569
AAG23687540
AALB109413958
ASUA134214293
CQUCpipJ_CPIJ019741
CPII120412891
CNS116345266
BCOO119083668
LLL129794002
PPAP129803887
AME411200
ACER108003440
ALAB122716618
ADR102672109
AFLR100863891
BIM100742465
BBIF117204398
BVK117233459
BVAN117153441
BHUN126863883
BTER100647460
BAFF126914146
BPYO122569193
BPAS132916467
FVI122532724
CCAL108624633
OBB114876888
OLG117606514
MGEN117223613
NMEA116424137
CGIG122395229
SOC105194454
MPHA105839937
AEC105145053
ACEP105619346
PBAR105430282
VEM105567116
HST105182103
DQU106750935
CFO105251016
FEX115233862
LHU105678051(Trhn)
PGC109861523
OBO105279028
PCF106791737
PFUC122524389
VPS122634219
VCRB124430590
VVE124954465
NVI100123183
CSOL105363200
TPRE106653657
LHT122497926
LBD127282419
MDL103579283
CGLO123267565
FAS105264297
DAM107046653
AGIF122856599
CINS118066672
VCAN122417081
CCIN107267966
DSM124405771
NPT124210952(Trhn)
NFB124175292
NLO107220787
NVG124297148
AROA105693587
TCA655758
DPA109539121
SOY115885880
AGRG126739092
ATD109598736
CSET123314709
AGB108910106
LDC111504779
DVV126886746
NVL108562706
DCOR135794753 135801697
APLN108740743
PPYR116173900
OTU111419229
BMOR101740691
BMAN114244523
MSEX115446095
DPLKGM_207185
BANY112048662
MJU123880615
NIQ126780494
VCD124543141
MCIX123668659
PMAC106717008
PPOT106111764
PXU106126099
BPHI137932921(Trhn)
PRAP110999042
PBX123718921
PNAP125062475
ZCE119835587
CCRC123705172
LSIN126978924
AAGE121738650
HAW110378221
HZE124645008
TNL113499708
SLIU111360759
OFU114352766
ATRA106133789
GMW113519292
PXY105389797
PGW126380692
LGLY125240725
CSTB134754296
CFEL113384686
CCRN123296522
API100158737
DNX107164769
RMD113549417
ACOO126839216
DVT126894916
BTAB109030678
DCI113470334
CLEC106661596
HHAL106682080(Trh)
NLU111064340
HVI124367570
MQU128994138 128994923
PHUPhum_PHUM538550
FOC113217977
TPAL117653321
ZNE110836317
CSEC111875212
SGRE126266708
BROR134541627
IEL124159321
FCD110856969
DPXDAPPUDRAFT_44381
DMK116922854
DPZ124320752
AFRA136043945
PVM113812558
PJA122249658
PMOO119584979
HAME121870165
PCLA123762829(Trhn)
CQD128702043
PTRU123501987
ESN127000857
MNZ135196018
MRJ136841216(Trh)
HAZT108665761
EAF111699592
LSM121122516
TCF131877746
PPOI119113741 119113797 119114133
ISC8024705
DSV119465379
RSAN119403156
RMP119165283
VDE111248677
VJA111271616
TUT107363777
DPTE113789434
DFR124497515
CVS136980735
PTEP107448718
ABRU129963249
UDV129230446
SDM118191490
LPOL106459616 106470412
PMEO129590610
CELCELE_ZK1290.2(tph-1)
CBRCBG_12991(Cbr-tph-1)
CRQGCK72_006546
NAINECAME_08210
LOALOAG_01930
HROHELRODRAFT_79745
LGILOTGIDRAFT_229367
PVUL126810924
PCAN112566861
BGT106070864
GAE121372139
HRF124111829
HRJ124255210
HASI137287282
CANU128184254
CVN111134247
OED125673005
MYI110454322
PMAX117327242
AIRR138336286
MCAF127726022
MMER123552557
RPHI132758663
DPOL127852644 127853382
MAEA128236528
OBI106875341
OSN115215674
LJP135462892
LAK106175748
SMMSmp_174920
OVIT265_11906
EGLEGR_07589
LLON135487474
APROF751_2362
 » show all
Reference
1  [PMID:4402511]
  Authors
Friedman PA, Kappelman AH, Kaufman S.
  Title
Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain.
  Journal
J Biol Chem 247:4165-73 (1972)
Reference
2  [PMID:315449]
  Authors
Hamon M, Bourgoin S, Artaud F, Glowinski J.
  Title
The role of intraneuronal 5-HT and of tryptophan hydroxylase activation in the control of 5-HT synthesis in rat brain slices incubated in K+-enriched medium.
  Journal
J Neurochem 33:1031-42 (1979)
DOI:10.1111/j.1471-4159.1979.tb05239.x
Reference
3  [PMID:5309585]
  Authors
Ichiyama A, Nakamura S, Nishizuka Y, Hayaishi O.
  Title
Enzymic studies on the biosynthesis of serotonin in mammalian brain.
  Journal
J Biol Chem 245:1699-709 (1970)
Reference
4  [PMID:5789774]
  Authors
Jequier E, Robinson DS, Lovenberg W, Sjoerdsma A.
  Title
Further studies on tryptophan hydroxylase in rat brainstem and beef pineal.
  Journal
Biochem Pharmacol 18:1071-81 (1969)
DOI:10.1016/0006-2952(69)90111-7
Reference
5  [PMID:12379098]
  Authors
Wang L, Erlandsen H, Haavik J, Knappskog PM, Stevens RC.
  Title
Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin.
  Journal
Biochemistry 41:12569-74 (2002)
DOI:10.1021/bi026561f
  Sequence
[hsa:7166]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.16.4
IUBMB Enzyme Nomenclature: 1.14.16.4
ExPASy - ENZYME nomenclature database: 1.14.16.4
BRENDA, the Enzyme Database: 1.14.16.4
CAS: 9037-21-2

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