KEGG   ENZYME: 1.14.16.5
Entry
EC 1.14.16.5                Enzyme                                 
Name
alkylglycerol monooxygenase;
glyceryl-ether monooxygenase;
glyceryl-ether cleaving enzyme;
glyceryl ether oxygenase;
glyceryl etherase;
O-alkylglycerol monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
1-alkyl-sn-glycerol,tetrahydrobiopteridine:oxygen oxidoreductase
Reaction(IUBMB)
1-O-alkyl-sn-glycerol + a 5,6,7,8-tetrahydropteridine + O2 = 1-O-(1-hydroxyalkyl)-sn-glycerol + a 4a-hydroxy-5,6,7,8-tetrahydropteridine [RN:R12593]
Reaction(KEGG)
R12593
Substrate
1-O-alkyl-sn-glycerol [CPD:C02773];
5,6,7,8-tetrahydropteridine [CPD:C05650];
O2 [CPD:C00007]
Product
1-O-(1-hydroxyalkyl)-sn-glycerol [CPD:C03658];
4a-hydroxy-5,6,7,8-tetrahydropteridine [CPD:C22239]
Comment
The enzyme cleaves alkylglycerols, but does not cleave alkenylglycerols (plasmalogens). Requires non-heme iron [7], reduced glutathione and phospholipids for full activity. The product spontaneously breaks down to form a fatty aldehyde and glycerol. The co-product, 4a-hydroxytetrahydropteridine, is rapidly dehydrated to 6,7-dihydropteridine, either spontaneously or by EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase.
History
EC 1.14.16.5 created 1972 as EC 1.14.99.17, transferred 1976 to EC 1.14.16.5, modified 2010, modified 2020
Orthology
K15537  alkylglycerol monooxygenase
Genes
HSA392636(AGMO)
PTR463272(AGMO)
PPS100988512(AGMO)
GGO101133058(AGMO)
PON100438998(AGMO)
NLE100598360(AGMO)
MCC709963(AGMO)
MCF102140354(AGMO)
CSAB103226453(AGMO)
CATY105589570(AGMO)
PANU101003237(AGMO)
TGE112621019(AGMO)
RRO104668141(AGMO)
RBB108540080(AGMO)
TFN117072816(AGMO)
PTEH111545099(AGMO)
CJC100393907(AGMO)
SBQ101046685(AGMO)
CSYR103267762(AGMO)
MMUR105858663(AGMO)
OGA100945203(AGMO)
MMU319660(Agmo)
MCAL110306859(Agmo)
MPAH110324866(Agmo)
RNO362732(Agmo)
MCOC116080835(Agmo)
MUN110555952(Agmo)
CGE100752746(Agmo)
PLEU114695090(Agmo)
NGI103726803(Agmo)
HGL106008946(Agmo)
CCAN109676238(Agmo)
DORD105991418(Agmo)
DSP122121575(Agmo)
OCU100339522(AGMO)
OPI101527882(AGMO)
TUP102487435(AGMO)
CFA475247(AGMO)
VVP112915821(AGMO)
VLG121474525(AGMO)
AML100473316(AGMO)
UMR103658833(AGMO)
UAH113260890(AGMO)
UAR123788688(AGMO)
ELK111147401
LLV125081114
MPUF101687082(AGMO)
ORO101371286(AGMO)
EJU114219724(AGMO)
ZCA113911353(AGMO)
MLX118020820(AGMO)
FCA101082991(AGMO)
PYU121028679(AGMO)
PBG122487946(AGMO)
PTG102953129(AGMO)
PPAD109263769(AGMO)
AJU106971349(AGMO)
HHV120220362(AGMO)
BTA613658(AGMO)
BOM102287910(AGMO)
BIU109557267(AGMO)
BBUB102409220(AGMO)
CHX102177125(AGMO)
OAS101103313(AGMO)
ODA120878030(AGMO)
CCAD122438157(AGMO)
SSC100513371(AGMO)
CFR102508044(AGMO)
CBAI105078576(AGMO)
CDK105092904(AGMO)
VPC102541163(AGMO)
BACU103007090(AGMO)
LVE103084449(AGMO)
OOR101269844(AGMO)
DLE111181706(AGMO)
PCAD102992958(AGMO)
PSIU116759360(AGMO)
ECB100052771(AGMO)
EPZ103557963
EAI106837998(AGMO)
MYB102253210(AGMO)
MYD102767015(AGMO)
MMYO118666574(AGMO)
MLF102428853(AGMO)
MNA107541755(AGMO)
PKL118714238(AGMO)
HAI109391917(AGMO)
DRO112319873(AGMO)
SHON118993758(AGMO)
AJM119062846(AGMO)
PDIC114507845(AGMO)
PHAS123811588(AGMO)
MMF118620188(AGMO)
RFQ117012510(AGMO)
PALE102888896(AGMO)
PGIG120602298(AGMO)
PVP105295042(AGMO)
RAY107521306(AGMO)
MJV108400072
TOD119250156(AGMO)
SARA101555347(AGMO)
LAV100659232(AGMO)
DNM101428899
MDO100022353(AGMO)
GAS123250468(AGMO)
SHR100934114(AGMO)
PCW110217588(AGMO)
OAA100080816(AGMO)
GGA772374(AGMO)
PCOC116226989(AGMO)
MGP100545428(AGMO)
CJO107309232(AGMO)
NMEL110394580(AGMO)
APLA101801837(AGMO)
ACYG106037493(AGMO)
AFUL116485340(AGMO)
TGU100223605(AGMO)
LSR110474701(AGMO)
SCAN103812853(AGMO)
PMOA120504208(AGMO)
OTC121343248(AGMO)
PRUF121352982(AGMO)
GFR102041091(AGMO)
FAB101808659(AGMO)
PHI102106287(AGMO)
PMAJ107200909(AGMO)
CCAE111924407(AGMO)
CCW104689135(AGMO)
ETL114054594(AGMO)
ZAB102062339(AGMO)
FPG101915982(AGMO)
FCH102045933(AGMO)
CLV102091863(AGMO)
EGZ104134572(AGMO)
NNI104009220(AGMO)
ACUN113477042(AGMO)
TALA104360724(AGMO)
PADL103918728(AGMO)
ACHC115339706(AGMO)
AAM106483529(AGMO)
AROW112971555(AGMO)
NPD112952132(AGMO)
DNE112985995(AGMO)
ASN102377527(AGMO)
AMJ102576260(AGMO)
CPOO109309348(AGMO)
GGN109291458(AGMO)
PSS102463873(AGMO)
CMY102934438(AGMO)
CPIC101939766(AGMO)
TST117872268(AGMO)
CABI116826993(AGMO)
MRV120397562(AGMO)
ACS100564327(agmo)
PVT110072843(AGMO)
SUND121935396(AGMO)
PBI103059739(AGMO)
PMUR107288187(AGMO)
TSR106557083(AGMO)
PGUT117654998(AGMO)
VKO123022906(AGMO)
PMUA114607615(AGMO)
ZVI118092338(AGMO)
XLA108718854(agmo.L)
XTR496770(agmo)
NPR108788016(AGMO)
RTEM120939855(AGMO)
BBUF121000693(AGMO)
BGAR122938326
DRE405819(agmo)
SRX107752262(agmo)
SANH107704769
SGH107582294 107587066(agmo)
CCAR109103636
CAUA113058607 113059029 113072163 113114993
IPU108278345(agmo)
PHYP113539030(agmo)
SMEO124395095(agmo)
AMEX103030268(agmo)
EEE113587111(agmo)
TRU101062615(agmo)
LCO104937453(agmo)
NCC104960391(agmo)
CGOB115021377(agmo)
ELY117266362(agmo)
PLEP121945793(agmo)
SLUC116036086(agmo)
ECRA117945837(agmo)
PFLV114557290(agmo)
GAT120810977(agmo)
PPUG119197999(agmo)
MSAM119897049(agmo)
CUD121513193(agmo)
MZE101470736(agmo)
ONL100701382(agmo)
OAU116334992(agmo)
OLA101160098(agmo)
OML112136723(agmo)
XMA102222346(agmo)
XCO114142127(agmo)
XHE116717739(agmo)
PRET103477678(agmo)
PFOR103150330
PLAI106945211(agmo)
PMEI106926195(agmo)
GAF122830708(agmo)
CVG107100906(agmo)
CTUL119779797(agmo)
GMU124865041(agmo)
NFU107379193(agmo)
KMR108243277(agmo)
ALIM106524960(agmo)
NWH119409612(agmo)
AOCE111589047(agmo)
CSEM103388988(agmo)
POV109639773(agmo)
SSEN122774145(agmo)
HHIP117776962(agmo)
LCF108883212(agmo)
SDU111222442(agmo)
SLAL111644543(agmo)
XGL120784377(agmo)
HCQ109521066(agmo)
BPEC110159168(agmo)
MALB109968958(agmo)
SASA106582276 106605209(agmo)
OTW112230866
OMY110515972
OGO124005107(agmo)
ONE115104861(agmo) 115142243
SALP111958789
SNH120031038(agmo)
ELS105021899(agmo)
SFM108927432(agmo)
PKI111839082(agmo)
AANG118224182(agmo)
LOC102693161(agmo)
PSPA121313585
ARUT117400687
LCM102351412(AGMO)
CMK103182639(agmo)
RTP109919315(agmo)
BFO118407134 118409835 118426718
BBEL109462439 109471980 109480254
CIN100176978
SCLV120348138
SPU579307 579365
APLC110974514
SKO102805565 102805677
AME413590
ACER107996068
ALAB122719855
BIM100744163
BBIF117204167
BVK117235668
BVAN117159574
BTER100651518
BPYO122566879
CCAL108626094
OBB114872703
MGEN117220804
NMEA116427258
CGIG122405334
SOC105197322
MPHA105837313
AEC105154653
ACEP105622458
PBAR105432235
VEM105564679
HST105190251
DQU106751242
CFO105248680
FEX115239492
LHU105672268
OBO105276370 105286522
PCF106789619 106792961
PFUC122513287
VPS122636949
NVI100119956
CSOL105362558
TPRE106653962
MDL103577028
CGLO123270719
FAS105265238
DAM107044581
AGIF122848115
CCIN107265010
TCA657448
DPA109538878
SOY115884788
ATD109608644
CSET123318430
AGB108906848
LDC111514096
NVL108558948
PPYR116163164
OTU111418305
BMOR101737166 105842328
BMAN114245243 114245256
MSEX115440656 115440664
DPLKGM_205556
BANY112046255
PMAC106716198
PPOT106103788
PXU106115981
PRAP110998846 110998847
ZCE119840359 119840365
HAW110374334
TNL113500515
OFU114360645 114360764
PXY105398573
API100159128
DNX107173082
AGS114121679
RMD113552844
BTAB109034813
DCI103512570
CLEC106669438
HHAL106677317
NLU111046928 120352861
FOC113208554
CSEC111874864
FCD110848089 110852668 110861407
DPXDAPPUDRAFT_319865
DMK116918055
PVM113804078 113805694 113810649 113816761 113825862
PJA122248229 122248235 122248237 122248239 122248240 122252777 122257228 122257229 122264921 122268123 122268124
HAME121865315 121867482 121867483 121871485 121872475
PCLA123752128 123753958 123757330 123757331 123759290 123760868 123767341 123769653
PTRU123498036 123501971 123502098 123504796 123505021 123517978
HAZT108670880 108672448
EAF111702857 111704547
DSV119456225 119456966
RSAN119393312
RMP119171739
VDE111253490 111255204
VJA111265131 111267410
TUT107360152 107365017
DPTE113789385 113791878 113799386
DFR124495252 124495253 124496345 124497444
CSCU111616966 111636774 111636955
PTEP107443242 107443243 107443245 107443251 107445122 107447730 107450414 122271360
SDM118192157 118192158 118197707 118204023 118205856
CELCELE_BE10.2(agmo-1)
CBRCBG_15741(Cbr-agmo-1)
BMYBM_BM1857(Bma-agmo-1)
NAINECAME_15863
LGILOTGIDRAFT_210842
PCAN112556675
GAE121369220 121385612 121391694
HRF124116096 124119061 124119063
HRJ124283320 124284682
CRG105322698 105343373
MYI110442646
PMAX117322434 117322435
MMER123559732 123561506 123562170
OBI106872128
OSN115210760
LAK106168064 106178694
NVE5506132
EPA110239716
ATEN116296930
ADF107330726 107344636
AMIL114976944
SPIS111328858
DGT114529783 114530347
XEN124439217 124445466
TADTRIADDRAFT_3988 TRIADDRAFT_53564
AQU100640784
DDIDDB_G0277137 DDB_G0281443
DPPDICPUDRAFT_51289 DICPUDRAFT_79521 DICPUDRAFT_97231
DFADFA_08160
ACANACA1_215910
SMINv1.2.017513.t1(symbB.v1.2.017513.t1)
NGRNAEGRDRAFT_81535(AM51)
 » show all
Reference
1  [PMID:6840084]
  Authors
Ishibashi T, Imai Y.
  Title
Solubilization and partial characterization of alkylglycerol monooxygenase from rat liver microsomes.
  Journal
Eur J Biochem 132:23-7 (1983)
DOI:10.1111/j.1432-1033.1983.tb07320.x
Reference
2  [PMID:4383918]
  Authors
Pfleger RC, Piantadosi C, Snyder F.
  Title
The biocleavage of isomeric glyceryl ethers by soluble liver enzymes in a variety of species.
  Journal
Biochim Biophys Acta 144:633-48 (1967)
DOI:10.1016/0005-2760(67)90052-5
Reference
3  [PMID:4355017]
  Authors
Snyder F, Malone B, Piantadosi C.
  Title
Tetrahydropteridine-dependent cleavage enzyme for O-alkyl lipids: substrate specificity.
  Journal
Biochim Biophys Acta 316:259-65 (1973)
DOI:10.1016/0005-2760(73)90018-0
Reference
4  [PMID:4402391]
  Authors
Soodsma JF, Piantadosi C, Snyder F.
  Title
Partial characterization of the alkylglycerol cleavage enzyme system of rat liver.
  Journal
J Biol Chem 247:3923-9 (1972)
Reference
5  [PMID:14247652]
  Authors
TIETZ A, LINDBERG M, KENNEDY EP.
  Title
A NEW PTERIDINE-REQUIRING ENZYME SYSTEM FOR THE OXIDATION OF GLYCERYL ETHERS.
  Journal
J Biol Chem 239:4081-90 (1964)
Reference
6  [PMID:9436181]
  Authors
Taguchi H, Armarego WL
  Title
Glyceryl-ether monooxygenase [EC 1.14.16.5]. A microsomal enzyme of ether lipid metabolism.
  Journal
Reference
7  [PMID:19007315]
  Authors
Watschinger K, Keller MA, Hermetter A, Golderer G, Werner-Felmayer G, Werner ER
  Title
Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal  ion and tetrahydrobiopterin dependence.
  Journal
Biol Chem 390:3-10 (2009)
DOI:10.1515/BC.2009.010
Reference
8  [PMID:17303893]
  Authors
Werner ER, Hermetter A, Prast H, Golderer G, Werner-Felmayer G
  Title
Widespread occurrence of glyceryl ether monooxygenase activity in rat tissues detected by a novel assay.
  Journal
J Lipid Res 48:1422-7 (2007)
DOI:10.1194/jlr.D600042-JLR200
Other DBs
ExplorEnz - The Enzyme Database: 1.14.16.5
IUBMB Enzyme Nomenclature: 1.14.16.5
ExPASy - ENZYME nomenclature database: 1.14.16.5
BRENDA, the Enzyme Database: 1.14.16.5
CAS: 37256-82-9

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