KEGG   ENZYME: 1.14.17.4
Entry
EC 1.14.17.4                Enzyme                                 
Name
aminocyclopropanecarboxylate oxidase;
ACC oxidase;
ethylene-forming enzyme;
1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
1-aminocyclopropane-1-carboxylate oxygenase (ethene-forming)
Reaction(IUBMB)
1-aminocyclopropane-1-carboxylate + ascorbate + O2 = ethene + cyanide + dehydroascorbate + CO2 + 2 H2O [RN:R07214]
Reaction(KEGG)
R07214
Substrate
1-aminocyclopropane-1-carboxylate [CPD:C01234];
ascorbate [CPD:C00072];
O2 [CPD:C00007]
Product
ethene [CPD:C06547];
cyanide [CPD:C00177];
dehydroascorbate [CPD:C05422];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
A nonheme iron enzyme. Requires CO2 for activity. In the enzyme from plants, the ethene has signalling functions such as stimulation of fruit-ripening.
History
EC 1.14.17.4 created 2003
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K05933  aminocyclopropanecarboxylate oxidase
Genes
AJM119040831
ATHAT1G05010(EFE) AT1G12010 AT1G62380(ACO2) AT1G77330 AT2G19590(ACO1)
ALY9320049 9322539 9323742 9325597 9328732
CRB17890827 17895320 17896063 17897371 17898510
CSAT104702510 104702691 104703842 104713401 104714576 104739032 104751628 104752897 104754646 104755464 104762852 104766879 104770859 104773072
EUSEUTSA_v10002047mg EUTSA_v10008207mg EUTSA_v10008225mg EUTSA_v10018919mg EUTSA_v10023595mg
BRP103828296 103830571 103832184 103838399 103842633 103843208 103844184 103848186 103853067 103872037 117126758
BNA106349119 106353485 106365298 106365779 106366841 106374519 106376208 106376249 106385998 106390528 106397796 106400855 106401155 106401189 106407006 106412278 106412394 106422042 106423689 106436068 106450750 111200995 111210370 111213114
BOE106292830 106295480 106298654 106309653 106311615 106319188 106321415 106325048 106339340
RSZ108809037 108813154 108820869 108828443 108829559 108834808 108836259 108850553
THJ104801008 104801879 104809474 104812086 104818598
CPAP110808078 110808805 110813532
CIT102577997 102609002 102611528 102622142
CICCICLE_v10001927mg CICLE_v10008993mg CICLE_v10015962mg CICLE_v10015965mg
PVY116110311 116114196 116117086 116120277 116137593 116140175
MINC123192406 123195020 123195746 123200372 123206891 123207130 123218435 123222989 123224438 123230132
TCC18588418 18592410 18597239 18612358
GRA105769639 105773340 105783020 105789924 105789967 105790536 105791688 105796114 105797149 105802573 105803453
GHI107903979 107905674 107905899 107908352 107910369 107912629 107915412 107923209 107932273 107945007 107950208 107951489 107952114 107952577 107954048 107955055 107956389 107957214 107962059 121202830 121231941 121232137
GAB108452932 108456403 108466969 108467901 108472809 108481125 108482076 108483351 108484630 108489640
DZI111274040 111278683 111283785 111283833 111286434 111298503 111305593 111312261 111314546 111315666
EGR104424713 104424714 104424715 104424716 104424717 104424718 104424719 104424720 104424721 104436497 104438309 104440284 104441437 104445669 104450538 104450539
GMX100784455 100784459 100785514 100789627 100790622 100792063 100793294 100794816 100796909 100807427 100808025 100814810 100815336 100819184 100820256
GSJ114368076 114384776 114384777 114384779 114385106 114386448 114392269 114400145 114400152 114410387 114413507 114415450 114418905 114420206 114424407 114424467
PVUPHAVU_002G304200g PHAVU_002G326600g PHAVU_003G082300g PHAVU_006G144900g PHAVU_007G135600g PHAVU_008G213800g PHAVU_008G214200g PHAVU_009G129500g
VRA106762735 106763329 106765078 106765079 106765175 106766639 106766745 106769830 106776177
VAR108322886 108323412(AB-ACO1) 108330808 108336202 108338025 108338027 108341045 108342451 108345036
VUN114163926 114176120 114179148 114179298 114181211 114187947 114193022 114193537 114195675
CCAJ109793755 109797540 109799389 109803578 109804404 109808078 109817071 109817981 109818885
APRC113848032 113848101 113848132 113852871 113855602 113867580 113867978 113874873
MTRMTR_2g025120 MTR_3g083370 MTR_3g088565 MTR_4g132770 MTR_5g085330 MTR_6g092620
CAM101490526 101495891 101500864(aco) 101505638 101514819
LJALj0g3v0109219.1(Lj0g3v0109219.1) Lj0g3v0109219.2(Lj0g3v0109219.2) Lj1g3v0884400.1(Lj1g3v0884400.1) Lj2g3v0911850.1(Lj2g3v0911850.1) Lj2g3v0911860.1(Lj2g3v0911860.1) Lj2g3v2879460.1(Lj2g3v2879460.1) Lj4g3v0120430.1(Lj4g3v0120430.1) Lj6g3v1789900.1(Lj6g3v1789900.1)
ADU107460718 107466373 107482960 107490141 107496871 107496872 107496874
AIP107606021 107608930 107608931 107609126 107609932 107636528 107638664 107644485
AHF112702258 112702261 112702266 112706026 112706058 112722852 112741262 112751340 112762594 112764097 112764645 112766489 112766935 112795960 112802019
LANG109326282 109328346 109330191 109333359 109334607 109356783 109361097
FVE101290700 101291370 101295098 101298627 101306888
RCN112173192 112184269 112190393 112202148
PPER18770210 18781368 18782609 18784056 18791775
PMUM103319772 103324450 103329345 103340748
PAVI110748428 110750565 110750990 110764549 110771420
PDUL117622847 117624545 117632124 117636001
MDM103400792 103404960 103411280 103434461 103446762 103453365
PXB103933106 103937366 103937371 103943975 103946813 103948231 103954990
ZJU107414763 107417150 107421119 107423970
MNT21388310 21396574 21397287 21409884
CSV101203726 101204103 101209525(CS-ACO1) 101221460 101221653 116406307
CMO103484645(ACO3) 103487610 103491357(ACO1) 103496355 103498449
BHJ120072772 120077485 120080149 120086275 120088696
MCHA111005318 111006422 111010009 111016812 111017974
CMAX111465402 111469659 111477086 111478800 111480303 111485921 111497285
CMOS111433496 111437208 111443415 111444278 111446734 111451379 111453828
CPEP111781519 111785854 111787897 111792121 111795552 111797232 111798454 111803966
RCU8260997 8265073 8267624 8270983
JCU105638993 105640861 105640863 105649282
HBR110632629 110639602 110642549 110642550 110650986 110654496 110656687 110667377
MESC110602827 110607019 110609941 110610900 110627264 110629005
POP18097294 7467861 7468528 7469176 7484327 7489875 7497621
PEU105108143 105109412 105114995 105118688 105127751 105141475 105141621
PALZ118029287 118031964 118031965 118031977 118036545 118048022 118049392 118058404 118060471
JRE108984687 108989101 108992749 108993967 108995818 108995846 108996458 109006073 109009857 109015492 109021627 109022125
QSU111997351 111997410 111999284 112025431 112025434 112025436
QLO115957337 115957349 115957361 115958993 115978140 115978964 115992552
TWL119988290 119999321 120005171 120005791 120008095 120016629
VVI100232928(ACO1) 100252394 100256784(ACO2) 100257676(ACO3)
VRI117906345 117923450 117925646 117927303
SLY100125909 101251255(ACO2) 101266529 543506 543800(aco5) 544052(ACO1) 544285(ACO4)
SPEN107005451 107010265 107011760 107023167 107024027 107024035 107024353 107024662
SOT102577542 102577821(ACO2) 102577917(ACO1) 102578788 102582504 102584001 102584835 102592023
CANN107842189 107850880 107853805 107855271 107857536 107859589 107859634 107869652
NTA107759912 107759913 107765010 107774406 107777719 107781126(ACO) 107784583 107785346 107786673 107788083 107790081 107792913 107796076 107802926 107808257 107809374 107815999(TEFE) 107822912
NSY104219213 104221150 104230666 104233765 104237525 104238280 104238726 104240667 104247729
NTO104090220 104096624 104098908 104103068 104106731 104108073 104117743 104118461 104119828 104120231
NAU109205942 109218050 109220508 109222014 109223193 109226594 109228672 109228673 109229011 109240562
INI109158714 109159218(ACO1) 109164607 109167198(ACO3) 109169737 109171074 109186912
ITR116013809 116018517 116028433 116028541 116029376 116030409 116030497 116031441
SIND105155254 105159448 105161839 105162912 105162915 105162916 105162918 105162919 105162920 105162921 105162966 105168010 105173607 105175306 105180280
OEU111366119 111370655 111370656 111370659 111370660 111380251 111380476 111389646 111407173 111409650
EGT105962208 105963449 105968528 105968771 105969222 105972927
SSPL121740832 121746222 121747826 121751490 121754211 121758094 121769383 121773658 121776181 121786058 121791655 121803055 121803202
HAN110885987 110885989 110888109 110910493 110910826 110928496 110939598 110941265 110941268
ECAD122578935 122578936 122596311 122600660 122602130 122609861
LSV111878839 111879600 111879601 111879602 111890969 111904962 111905714 111921123
CCAV112500179 112500615 112502811 112504904 112510752 112514345 112516346 112516542
DCR108200468 108209046 108211649 108217904 108219042 108223209 108223430
CSIN114256693 114261019 114281233 114289476 114289676 114299309 114306545 114314435 114316574 114317275 114317853
BVG104884391 104893204 104900929 104902721
SOE110777334 110779136 110781996 110803795
CQI110685944 110687417 110691904 110701957 110712995 110716847 110725726 110731284
NNU104586595 104594112 104600753 104605834 104606504 104606667
MING122057709 122069649 122075434 122083118 122083290 122087417
TSS122640436 122642019 122653769 122668204 122669381
PSOM113288051 113295123 113303747 113315055 113318228 113335816 113348538
NCOL116249975 116258121 116268022
OSA107278688 4324194 4330873 4337818 4347224 4347225 4349970
DOSAOs01t0580500-01(Os01g0580500) Os02t0771600-01(Os02g0771600) Os05t0149300-00(Os05g0149300) Os05t0149400-01(Os05g0149400) Os06t0573900-00(Os06g0573900) Os09t0451000-01(Os09g0451000) Os09t0451400-01(Os09g0451400) Os11t0186900-01(Os11g0186900)
OBR102702762 102702913 102704086 102706500 102712043 102712857 102717708 102717987
BDI100825510 100826347 100826865 100827208 100831517 100838946 100839084
ATS109735112 109739668 109746094 109752652 109754988 109754989 109770324 109772806
TDC119286479 119295291 119301783 119301784 119309902 119309907 119318031 119318032 119318033 119318035 119320090 119320303 119323684 119325003 119325893 119325903 119326530 119334362 119335741 119340494 119364849 119364859
TAES123082206 123094574 123099646 123103933 123103934 123112162 123112163 123112607 123112615 123121702 123121703 123128527 123128530 123128531 123131506 123134621 123138394 123138395 123138396 123138397 123145647 123145648 123145650 123148051 123158434 123163108 123166803 123170011 123180499 123180500 123191167 123191186
SBI8069498 8072801 8075978 8078636 8078948 8079305 8079762 8081032
ZMA100191321 100273458 100280566 100283053 100382364 103628432 103631299 103640166 103641390 103641391 103642621 103646970 542136 542137
SITA101756803 101766113 101766368 101766733 101780742 101780769 101781172 101781542
SVS117839667 117845000 117846380 117847745 117851022 117851710 117855377 117866893
PVIR120643379 120643852 120657324 120660836 120660837 120660840 120667208 120667527 120671060 120671963 120680733 120685179 120685694 120697439 120697440 120703739 120707190
PHAI112876977 112881839 112883521 112883923 112885787 112889898 112895078 112902902 112903366
PDA103699725 103701356 103702049 103709582 103713801 103713802 103713805 103713806 103717060 103718519 103718638 103718711 103719939 103720320 120111741 120112130 120112250 120112251
EGU105032553 105035107 105038434 105038435 105039092 105040421 105047690 105047965 105051796 105061033
MUS103968395 103972710 103974167 103974593 103974594 103974595 103974656 103984705 103986610 103987677 103992167 103994603
DCT110104247 110104251 110105140 110105328
PEQ110018547 110018548 110026262 110034969 110035000 110036329 110036729
AOF109824676 109828066 109830301 109841065 109841066 109841068 109847782
ATR18428159 18434128 18436883
 » show all
Reference
1  [PMID:7717997]
  Authors
Zhang Z, Schofield CJ, Baldwin JE, Thomas P, John P.
  Title
Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli.
  Journal
Biochem J 307 ( Pt 1):77-85 (1995)
DOI:10.1042/bj3070077
Reference
2  [PMID:9398335]
  Authors
Zhang Z, Barlow JN, Baldwin JE, Schofield CJ.
  Title
Metal-catalyzed oxidation and mutagenesis studies on the iron(II) binding site of 1-aminocyclopropane-1-carboxylate oxidase.
  Journal
Biochemistry 36:15999-6007 (1997)
DOI:10.1021/bi971823c
Reference
3
  Authors
Pirrung, M.C.
  Title
Ethylene biosynthesis from 1-aminocyclopropanecarboxylic acid.
  Journal
Acc Chem Res 32:711-718 (1999)
Reference
4  [PMID:11361015]
  Authors
Charng YY, Chou SJ, Jiaang WT, Chen ST, Yang SF.
  Title
The catalytic mechanism of 1-aminocyclopropane-1-carboxylic acid oxidase.
  Journal
Arch Biochem Biophys 385:179-85 (2001)
DOI:10.1006/abbi.2000.2138
Reference
5  [PMID:11583172]
  Authors
Thrower JS, Blalock R 3rd, Klinman JP.
  Title
Steady-state kinetics of substrate binding and iron release in tomato ACC oxidase.
  Journal
Biochemistry 40:9717-24 (2001)
DOI:10.1021/bi010329c
Other DBs
ExplorEnz - The Enzyme Database: 1.14.17.4
IUBMB Enzyme Nomenclature: 1.14.17.4
ExPASy - ENZYME nomenclature database: 1.14.17.4
BRENDA, the Enzyme Database: 1.14.17.4
CAS: 98668-53-2

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