KEGG   ENZYME: 1.14.19.10Help
Entry
EC 1.14.19.10               Enzyme                                 

Name
icosanoyl-CoA 5-desaturase;
acyl-CoA Delta5-desaturase (ambiguous)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
BRITE hierarchy
Sysname
icosanoyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (5,6 cis-dehydrogenating)
Reaction(IUBMB)
icosanoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (Z)-icos-5-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R10926]
Reaction(KEGG)
Substrate
icosanoyl-CoA [CPD:C02041];
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
(Z)-icos-5-enoyl-CoA [CPD:C20947];
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the plant Limnanthes douglasii (meadowfoam), is involved in the biosynthesis of (5Z)-icos-5-enoate, an unusual monounsaturated fatty acid that makes up to 60% of the total fatty acids in Limnanthes sp. seed oil. The enzyme only acts on saturated fatty acids.
History
EC 1.14.19.10 created 2015
Orthology
K21705  icosanoyl-CoA 5-desaturase
Reference
1  [PMID:10982439]
  Authors
Cahoon EB, Marillia EF, Stecca KL, Hall SE, Taylor DC, Kinney AJ
  Title
Production of fatty acid components of meadowfoam oil in somatic soybean embryos.
  Journal
Plant Physiol 124:243-51 (2000)
DOI:10.1104/pp.124.1.243
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.10
IUBMB Enzyme Nomenclature: 1.14.19.10
ExPASy - ENZYME nomenclature database: 1.14.19.10
BRENDA, the Enzyme Database: 1.14.19.10

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