KEGG   ENZYME: 1.14.19.15Help
Entry
EC 1.14.19.15               Enzyme                                 

Name
(11Z)-hexadec-11-enoyl-CoA conjugase;
Bmpgdesat1 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
BRITE hierarchy
Sysname
(11Z)-hexadec-11-enoyl-CoA,reduced acceptor:oxygen 10,13-allylic oxidase (10E,12E-forming)
Reaction(IUBMB)
(11Z)-hexadec-11-enoyl-CoA + reduced acceptor + O2 = (10E,12Z)-hexadeca-10,12-dienoyl-CoA + acceptor + 2 H2O [RN:R11004]
Reaction(KEGG)
Substrate
(11Z)-hexadec-11-enoyl-CoA [CPD:C20998];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
(10E,12Z)-hexadeca-10,12-dienoyl-CoA [CPD:C20999];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the silk moth Bombyx mori, catalyses a step in the pathway for the biosynthesis of bombykol, a sex pheromone produced by the moth. The enzyme converts a single cis double bond at position 11 of (11Z)-hexadec-11-enoyl-CoA into conjugated 10 trans and 12 cis double bonds. Prior to catalysing this reaction, the enzyme catalyses the introduction of the cis bond in position 11 (cf. EC 1.14.19.5, acyl-CoA 11-desaturase).
History
EC 1.14.19.15 created 2015
Orthology
K21709  (11Z)-hexadec-11-enoyl-CoA conjugase
Genes
BMOR: 692567(Desat1)
Taxonomy
Reference
1  [PMID:15173596]
  Authors
Moto K, Suzuki MG, Hull JJ, Kurata R, Takahashi S, Yamamoto M, Okano K, Imai K, Ando T, Matsumoto S
  Title
Involvement of a bifunctional fatty-acyl desaturase in the biosynthesis of the silkmoth, Bombyx mori, sex pheromone.
  Journal
Proc Natl Acad Sci U S A 101:8631-6 (2004)
DOI:10.1073/pnas.0402056101
  Sequence
[bmor:692567]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.15
IUBMB Enzyme Nomenclature: 1.14.19.15
ExPASy - ENZYME nomenclature database: 1.14.19.15
BRENDA, the Enzyme Database: 1.14.19.15

DBGET integrated database retrieval system