KEGG   ENZYME: 1.14.19.24
Entry
EC 1.14.19.24               Enzyme                                 

Name
acyl-CoA 11-(E)-desaturase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (11,12 trans-dehydrogenating)
Reaction(IUBMB)
an acyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = an (11E)-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O
Substrate
acyl-CoA [CPD:C00040];
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
(11E)-enoyl-CoA;
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001]
Comment
Involved in sex pheromone synthesis in the Lepidoptera (moths). The enzyme from the moth Spodoptera littoralis prefers 13:0 and 14:0 substrates. The product is formed by the stereospecific removal of the pro-R H at C-11 and the pro-S H at C-12. cf. EC 1.14.19.5, acyl-CoA 11-(Z)-desaturase.
History
EC 1.14.19.24 created 2000 as EC 1.14.99.31, transferred 2015 to EC 1.14.19.24
Reference
1
  Authors
Foster, S. P. and Roelofs, W. L.
  Title
Biosynthesis of a monoene and a conjugated diene sex pheromone component of the lightbrown apple moth by 11 desaturation.
  Journal
Experientia 46:269-273 (1990)
Reference
2  [PMID:2295634]
  Authors
Martinez T, Fabrias G, Camps F
  Title
Sex pheromone biosynthetic pathway in Spodoptera littoralis and its activation by a neurohormone.
  Journal
J Biol Chem 265:1381-7 (1990)
Reference
3
  Authors
Navarro, I., Font, I., Fabrias, G. and Camps, F.
  Title
Stereospecificity of the (E)- and (Z)-11 myristoyl desaturases in the biosynthesis of Spodoptera littoralis sex pheromone.
  Journal
J Am Chem Soc 119:11335-11336 (1997)
Reference
4  [PMID:10563812]
  Authors
Pinilla A, Camps F, Fabrias G
  Title
Cryptoregiochemistry of the delta11-myristoyl-CoA desaturase involved in the biosynthesis of Spodoptera littoralis sex pheromone.
  Journal
Biochemistry 38:15272-7 (1999)
DOI:10.1021/bi990972n
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.24
IUBMB Enzyme Nomenclature: 1.14.19.24
ExPASy - ENZYME nomenclature database: 1.14.19.24
BRENDA, the Enzyme Database: 1.14.19.24
CAS: 199543-17-4

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