KEGG   ENZYME: 1.14.19.3
Entry
EC 1.14.19.3                Enzyme                                 
Name
acyl-CoA 6-desaturase;
Delta6-desaturase;
Delta6-fatty acyl-CoA desaturase;
Delta6-acyl CoA desaturase;
fatty acid Delta6-desaturase;
fatty acid 6-desaturase;
linoleate desaturase;
linoleic desaturase;
linoleic acid desaturase;
linoleoyl CoA desaturase;
linoleoyl-coenzyme A desaturase;
long-chain fatty acid Delta6-desaturase;
linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase;
linoleoyl-CoA desaturase;
FADS2 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (6,7 cis-dehydrogenating)
Reaction(IUBMB)
(1) linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R03814];
(2) alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R07933]
Reaction(KEGG)
Substrate
linoleoyl-CoA [CPD:C02050];
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080];
alpha-linolenoyl-CoA [CPD:C16162]
Product
gamma-linolenoyl-CoA [CPD:C03035];
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001];
stearidonoyl-CoA [CPD:C16163]
Comment
An iron protein. The enzyme introduces a cis double bond at carbon 6 of acyl-CoAs. It is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid. The human enzyme has a broad substrate range. It also acts on palmitoyl-CoA, generating sapienoyl-CoA [4], and on (9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoyl-CoA, converting it to (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoyl-CoA as part of a pathway that produces docosahexaenoate [3]. The enzyme contains a cytochrome b5 domain that is assumed to act in vivo as the electron donor to the active site of the desaturase.
History
EC 1.14.19.3 created 1986 as EC 1.14.99.25, transferred 2000 to EC 1.14.19.3, modified 2015
Pathway
ec00591  Linoleic acid metabolism
ec01040  Biosynthesis of unsaturated fatty acids
ec01100  Metabolic pathways
Orthology
K00508  linoleoyl-CoA desaturase
K10226  acyl-CoA 6-desaturase (Delta-6 desaturase)
Genes
HSA9415(FADS2)
PTR451244(FADS2)
PPS100980611(FADS2)
GGO109024898(FADS2)
PON100190814(FADS2)
NLE100596455(FADS2)
MCC719037(FADS2)
MCF101926688(FADS2)
CSAB103234245(FADS2)
CATY105577581(FADS2)
PANU100126749(FADS2)
TGE112606127(FADS2)
RRO104679373(FADS2)
RBB108533600(FADS2)
TFN117080261(FADS2)
PTEH111524318(FADS2)
CJC100387410(FADS2)
SBQ101051429(FADS2)
CSYR103269267(FADS2)
MMUR105878617(FADS2)
LCAT123641268(FADS2)
OGA100953713(FADS2)
MMU56473(Fads2)
MCAL110285898(Fads2)
MPAH110322460(Fads2)
RNO83512(Fads2)
MCOC116103546(Fads2)
MUN110548092(Fads2)
CGE100757464(Fads2)
MAUA101844598(Fads2)
PLEU114703436(Fads2)
MORG121453878(Fads2)
MFOT126498526
AAMP119814598(Fads2)
NGI103729125(Fads2)
HGL101726663(Fads2)
CPOC100724176(Fads2)
CCAN109695673(Fads2)
DORD105993195 105995277(Fads2)
DSP122104886(Fads2)
NCAR124958641
OCU100352712(FADS2)
OPI101520480(FADS2)
TUP102475407(FADS2)
CFA483792(FADS2)
CLUD112659414(FADS2)
VVP112911087(FADS2)
VLG121472257(FADS2)
AML100470289(FADS2)
UMR103678231(FADS2)
UAH113246983(FADS2)
UAR123785126(FADS2)
ELK111149586
LLV125078518
MPUF101675571(FADS2)
ORO101364529(FADS2)
EJU114220204(FADS2)
ZCA113914859(FADS2)
MLX118015922(FADS2)
NSU110576322(FADS2)
FCA101085071(FADS2)
PYU121043312(FADS2)
PBG122483864(FADS2)
LRUF124505588
PTG102968308(FADS2) 102969100
PPAD109246554(FADS2) 109261216
AJU106986967(FADS2) 106988351
HHV120227477 120227525 120246152(FADS2)
BTA521822(FADS2)
BOM102275533(FADS2)
BIU109554370(FADS2)
BBUB102405983(FADS2)
CHX100861212 102171133(FADS2)
OAS101108497 101108615(FADS2)
ODA120874547(FADS2)
CCAD122431166(FADS2) 122451127
SSC444997(FADS2)
CFR102506325(FADS2)
CBAI105070113(FADS2)
CDK105091525(FADS2) 105104977
VPC102535510 102543923(FADS2)
BACU103000252(FADS2)
LVE103083143(FADS2)
OOR101275563(FADS2)
DLE111183883(FADS2)
PCAD114487991(FADS2)
PSIU116757879(FADS2)
ECB100062709(FADS2)
EPZ103543786 103567043(FADS2)
EAI106847560(FADS2)
MYB102261893(FADS2)
MYD102773468(FADS2)
MMYO118649000(FADS2)
MLF102433969
MNA107527684(FADS2)
PKL118707198(FADS2)
HAI109390019(FADS2)
DRO112317237(FADS2)
SHON118996917(FADS2)
AJM119043681(FADS2)
PDIC114499454(FADS2)
PHAS123829520(FADS2)
MMF118627539(FADS2)
RFQ117030358(FADS2)
PALE102894063(FADS2)
PGIG120600650(FADS2)
PVP105297786(FADS2)
RAY107501589(FADS2)
MJV108407763(FADS2)
TOD119250071(FADS2)
SARA101540602(FADS2)
LAV100677680
TMU101347025
DNM101419118(FADS2)
MDO100009895(FADS2)
GAS123252763(FADS2)
SHR100930034(FADS2)
PCW110195307(FADS2)
OAA100086288
GGA423122(FADS2)
PCOC116239008(FADS2)
MGP100549977
CJO107314439(FADS2)
NMEL110400735(FADS2)
APLA101798758(FADS2)
ACYG106033870
AFUL116489695(FADS2)
TGU100222881(FADS2)
LSR110484926(FADS2)
SCAN103822123(FADS2)
PMOA120499564(FADS2)
OTC121339150(FADS2)
PRUF121354750(FADS2)
GFR102040567(FADS2)
FAB101810111(FADS2)
PHI102112585(FADS2)
PMAJ107205402
CCAE111930632
CCW104697641(FADS2)
CBRC103614698(FADS2)
ETL114067866
ZAB102066733
ACHL103799150
FPG101910606(FADS2)
FCH102058085(FADS2)
CLV102098615(FADS2)
EGZ104122147
NNI104009393(FADS2)
PLET104623342
PCRI104029808
ACUN113481354
TALA104369427(FADS2)
PADL103925785(FADS2)
AFOR103905746(FADS2)
ACHC115352166(FADS2)
HALD104323730
CCRI104168591
CSTI104556935
EHS104504871
CMAC104479690
MUI104535393
FGA104078771
GSTE104261724
LDI104349227
MNB103779901
OHA104339401(FADS2)
NNT104413574
DPUB104304413(FADS2)
PGUU104458947
ACAR104523447
AVIT104271174
AAM106490046
AROW112978021
NPD112948004(FADS2)
TGT104566742
DNE112991695(FADS2)
SCAM104139314(FADS2)
ASN102382989
AMJ102563693(FADS2)
CPOO109318131
GGN109295789(FADS2)
PSS102460236(FADS2)
CMY102933275
CPIC101936434(FADS2)
TST117877425(FADS2)
CABI116830902(FADS2)
MRV120403580
ACS100551818(fads2)
PVT110086191(FADS2)
SUND121930482
PBI103050551(FADS2)
PMUR107300095
CTIG120312451
TSR106538426(FADS2)
PGUT117667019
VKO123021211
PMUA114600538
ZVI118089026
GJA107108854(FADS2)
STOW125427058
XLA399058(fads2.S) 446688(fads2.L)
XTR100145314(fads2)
NPR108794176(FADS2)
RTEM120917257(FADS2)
BBUF120981189(FADS2)
BGAR122920199(FADS2)
DRE140615(fads2)
SRX107754339
SANH107655157 107674834
SGH107551431 107561173
CCAR109079315 109089845 109112895
CAUA113042868 113043033 113060802 113066630
PPRM120474050(fads2)
MAMB125246733(fads2)
IPU100305117 108275104
PHYP113529790 113529791
SMEO124392159 124392817(fads2)
TFD113660036 113660090
AMEX103027972(fads2)
EEE113588191(fads2)
LCO104937137(fads2)
NCC104956187(fads2)
CGOB115010175(fads2)
ELY117262279(fads2)
EFO125887440(fads2)
PLEP121949837(fads2)
SLUC116038811 116038812
ECRA117949003
ESP116693333 116693334
PFLV114560045 114560046(fads2)
GAT120809502(fads2) 120813621 120829775
PPUG119195671(fads2)
MSAM119884848 119893991(fads2) 119914409
CUD121515126(fads2)
ALAT119023767(fads2)
MZE101473241 101473919 101474216
ONL100534418(fadsd6) 100700077 100700348
OAU116326238 116326239 116326240
OLA101156321 101156571 101156814
OML112139866 112151777 112151778
XMA102222635 102222890 102223144
XCO114151212 114151221 114151228
XHE116729101 116729638 116732254
PRET103466509 103466510 103466511
PFOR103141299 103141300 103141301
PLAI106955830 106955832 106955833
PMEI106921859 106921860 106921863
GAF122835839 122835840(fads2) 122835841
CVG107096151 107096160 107096161
CTUL119787411 119787428 119787429
GMU124878229 124878243(fads2) 124878251
NFU107388683 107388684 107388685 107388686
KMR108230083(fads2) 108230084
ALIM106521189 106521190 106521191
NWH119416317 119416318(fads2) 119416319 119416460
AOCE111582148(fads2)
MCEP125014531(fads2)
CSEM103380276(fads2)
POV109623584(fads2)
SSEN122760510 122775367(fads2)
HHIP117763209(fads2) 117777344
HSP118109441(fads2)
LCF108886851
SDU111229900(fads2)
SLAL111666947(fads2)
XGL120793558(fads2)
HCQ109507604(fads2)
BPEC110167702(fads2)
MALB109971223 109971244
BSPL114856803(fads2)
SASA100136383(fadsd5) 100136441(fadsd6) 100329172(d6fadc) 100337624(d6fad_b) 106584797(D6fad_b)
STRU115192896 115192933 115192934 115192935
OTW112237565 112237566 112237567(fads2) 112264870
OMY100135943(fd6d) 110521168 110521170(fads2) 110522693
OGO124037455 124037456 124037457 124037484
ONE115124847 115124994 115128068 115144681
SALP112071110
SNH120042185 120042187 120042189 120052325
CCLU121540732 121540762 121540763 121540765
ELS105018065(fads2)
SFM108921004 108929076
PKI111833692 111846795
AANG118215202(fads2)
PSPA121330343
ARUT117434917(fads2)
LCM102349949(FADS2)
CMK103174861
RTP109937250(fads2)
BFO118428221
BBEL109463898
SPU105441844 581114 586594
APLC110985398 110985778 110985855 110985906
SKO100373185 100377526
DPA109544444
HROHELRODRAFT_76893
LGILOTGIDRAFT_113523 LOTGIDRAFT_143229 LOTGIDRAFT_198790
PCAN112556233 112566738
BGT106060307 106066585 106080202
GAE121387335 121387621 121387746
HRF124123564 124149223 124149233
HRJ124253964 124284977
CRG105318549 105330734
MYI110449385 110461670
PMAX117317607 117317694
MMER123538004 123538337 123563593
OBI106867675
OSN115223335
LAK106159034 106169957 112042655
SMMSmp_132740
SHXMS3_00001558(FADS1_1)
OVIT265_11098 T265_12033
AQU100632154
OLUOSTLU_3430
OTAOT_ostta13g01040
BPGBathy17g00650
MISMICPUN_82337
MPPMICPUCDRAFT_32578
ACANACA1_260130
ECGE2348C_1358
ENAECNA114_1401
ECOSEC958_1504
ECCc1695
ELNNRG857_06320
ESEECSF_1212
EABECABU_c15100
ELCi14_1525
ELDi02_1525
ELFLF82_208
ECOJP423_06960
EFEEFER_1726
EALEAKF1_ch0205c
EMAC1192_05945
ESZFEM44_21185
EECEcWSU1_02601(des6)
ELGBH714_08855
ESAESA_01449 ESA_01450
CSKES15_1651 ES15_1652
CSZCSSP291_07070 CSSP291_07075
CSJCSK29544_02752 CSK29544_02753
CCONAFK62_11310 AFK62_11315
CDMAFK67_11655 AFK67_11660
CMWAFK63_06925 AFK63_06930
CTUCTU_24860 CTU_24870
LPNUKQ929_10745
YSIBF17_18735 BF17_18740
SMARSM39_2335 SM39_2336
SMACSMDB11_2131 SMDB11_2132
SMWSMWW4_v1c28750 SMWW4_v1c28760
SPESpro_2862 Spro_2863
SRRSerAS9_2954 SerAS9_2955
SRLSOD_c26990(des1) SOD_c27000(des)
SRYM621_14700 M621_14705
SRSSerAS12_2955 SerAS12_2956
SRASerAS13_2956 SerAS13_2957
SLQM495_14805 M495_14810
SERFL085_14410 L085_14415
SERSSERRSCBI_13560 SERRSCBI_13565
SFWWN53_23625 WN53_23630
SFGAV650_19345 AV650_19350
SQUE4343_01725 E4343_01730
SSURATE40_010980 ATE40_010985
SURIJ0X03_09570 J0X03_09575
SENPKHA73_14160 KHA73_14165
SFOZ042_22645 Z042_22650
ECAECA0116
PATREV46_00590 EV46_00595
PATOGZ59_01200 GZ59_01210
PCTPC1_4135 PC1_4136
PCCPCC21_001080 PCC21_001090
PCVBCS7_00370 BCS7_00375
PWAPecwa_4416 Pecwa_4417
PPARA8F97_19355 A8F97_19360
PECW5S_4596 W5S_4597
PWSA7983_08465 A7983_08470
PPOABJK05_17125 BJK05_17130
PBRAB5S52_21360 B5S52_21365
PPUJE2566_20975 E2566_20980
PARII2D83_21425 I2D83_21430
PVZOA04_01280 OA04_01290
PPAVLOZ86_01345 LOZ86_01350
PPOOLW347_21025 LW347_21030
EPECI789_00700 CI789_00705
ERWIGN242_04345 GN242_04350
ERPLJN55_18055 LJN55_18060
PRGRB151_029770(desA3) RB151_039160
PALACO695_07030
PHEINCTC12003_01329 NCTC12003_03452
PRQCYG50_01490 CYG50_19130
PRJNCTC6933_03440
PVCG3341_06785 G3341_17290
PMAGJI723_06695 JI723_17570
MWIMNY66_10115
LRINCTC12151_00626
RGLCS053_14415
DTXATSB10_36650
DKOI596_2530
PPSEBN5_0558
PAVLBKM03_28990
PSYIMME58_25550
TOLTOL_2040
TORR615_07535
OAIOLEAN_C27500
BSANCHH28_12110
VCWGJQ55_07790
OMEOLMES_1114
FPPFPB0191_02197 FPB0191_02198
SALVSALWKB2_0699
CVICV_1644(desD) CV_2452
CVCBKX93_02755 BKX93_21455
CHRIDK842_15490
CHRBDK843_21020
RMNTK49_20560
RINACS15_5784
BUBBW23_4705
BSTGWT74_24150
JAZYQ44_03125
JALBZG29_24440
JSVCNX70_24830
JASFJQ89_14060
JLVG3257_25145
ADEAdeh_1021
ACPA2cp1_3380
AFWAnae109_3187
ANKAnaeK_0374 AnaeK_1080
AORYAMOR_37230
CCXCOCOR_07436(des6)
SURSTAUR_0738
AGEAA314_05794
MBDMEBOL_001021 MEBOL_004617
HOHHoch_5632
BSEDDN745_02880 DN745_05975
PCAYFRD00_03300 FRD00_23105
SYNsll0262(desD(des6))
SYZMYO_119490(desD(des6))
SYYSYNGTS_1931(desD)
SYTSYNGTI_1930(desD)
SYSSYNPCCN_1929(desD)
SYQSYNPCCP_1929(desD)
SYJD082_30330(desD)
SYOC7I86_10070
SYNPSyn7502_02943
CGCCyagr_2722
AMRAM1_1073
KOVK9N68_09575
PSERABRG53_2437
GEEGM3708_945
MARMAE_48160(desD)
MPKVL20_3454
MIQB5D77_04380
MVZmyaer102_21530(desD)
ARPNIES39_J03090(desD)
LFSHFV01_08435
MICMic7113_1421
OACOscil6304_3294
AWAAA650_11345 AA650_11350
CALTCal6303_1445
CALNNIES2098_27880(desD)
RIVRiv7116_4400
NSPHBDGGKGIB_02538(desA3)
TOQHCG51_19350
PUVPUV_10250(des6)
WCHwcw_0161
AMOBHG15A2_45670(desA3)
FMRFuma_00671(desA)
GESVT84_04450 VT84_12735
GOGC1280_12875
GMSSOIL9_48780 SOIL9_57870
FTJFTUN_3002
TSPHKIH39_09120
SACISinac_0398
HBSIPV69_24075
TPXTurpa_1866
ADINH7849_03985
MCOSGM418_05800 GM418_21175 GM418_23330
CPICpin_5676 Cpin_5677
CBAECOR50_08285
CHITFW415_01170 FW415_18530
CHIHGWR21_29075
CFILMYF79_18645
CHFKTO58_22430
NKONiako_0028 Niako_2214 Niako_5619 Niako_6564
NSONIASO_08625
NIAA8C56_04725
FLASY85_04130 SY85_23690 SY85_23835
FGGFSB75_19400
ARBA9P82_07590 A9P82_12885
ARKD6B99_14620
AGIFSB73_05040 FSB73_09885 FSB73_11865
ARACE0W69_012610
ATEEK9M52_05815 K9M52_10175
FLNFLA_2034 FLA_3880
PSEGD3H65_02955 D3H65_14270 D3H65_21685
PGINFRZ67_13380 FRZ67_21700
PGOFSB84_05680 FSB84_28195
FLSGLV81_10500
LACSH4075_12235 H4075_17930
FEIK9M53_08205
FLPLK994_06745 LK994_09070 LK994_14080
FLCKJS93_09095 KJS93_09225 KJS93_12245 KJS93_12775 KJS93_13655
FLVKJS94_07185 KJS94_10255 KJS94_17800
SEDTTEGAF0_01790
HHYHalhy_3263 Halhy_3651
SGNSGRA_0953 SGRA_3738
PHEPhep_0579
PEPAQ505_23795
PCMAY601_0291
PSTYBFS30_12445
PEKFFJ24_000610 FFJ24_000615 FFJ24_009255
PROEH9L23_04740 H9L23_11790
PEXIZT61_16130
PMUOLOK61_08145
PSNPedsa_0092
SHGSph21_1254
SHTKO02_08730
SPHNBV902_16925
SMIZ4412673_01383(desA3_1) 4412673_04012(desA3_2)
SPSCE2P86_12690 E2P86_12970
SPHEGFH32_00630 GFH32_03190 GFH32_06585 GFH32_11525
SPDRG6053_13355
SDJNCTC13534_02135(desA3)
SSPII6J01_08990
SSIYJVX97_14820
SCNSolca_2015
MGINFRZ54_12455
MDJLLH06_12505
AGDFRZ59_03065 FRZ59_14730
OLIFKG96_03215
SBXCA265_00630 CA265_00635 CA265_10185
CMRCycma_1461
CAMUCA2015_1137 CA2015_1138 CA2015_1357 CA2015_4277
BBDBelba_0611 Belba_0817
EVIEchvi_1008 Echvi_2487
ESTDN752_11560 DN752_18445
ECHIFKX85_04965 FKX85_20520
EMAIKZP23_05365
ALMAO498_08640
MDAIPZ59_05475 IPZ59_05660 IPZ59_16190
CHUCHU_3762 CHU_3764
SLISlin_4655
SRDSD10_21800
SMONAWR27_12490
SPIRCWM47_23570
SPIKEXU85_12795
SPIBG8759_25875
STAEHNV11_11570 HNV11_21120
CHRWKA713_17535
RHOZGXP67_00645 GXP67_00790 GXP67_19925 GXP67_34085 GXP67_34095
DFEDfer_0898 Dfer_3204
DSNHWI92_21275
DYCNFI80_21445
RSIRunsl_2603 Runsl_4114
RUNDR864_01875 DR864_13000
RUPDTQ70_15945
FAEFAES_3358 FAES_4414(desD)
FIBA6C57_20910
ALSDJ013_11725
MAQALAG90_05115 LAG90_08950 LAG90_18070
FLIFleli_2211 Fleli_3763
HSWHsw_0774 Hsw_3072
HYMN008_13645
HYDPK28_13650
HYEAM218_02795
HYGAUC43_10760 AUC43_17580
HYPA0257_10485
HYZAXW84_22490
HNVDDQ68_16005
HYHD3Y59_00565
HYJFHG12_14055 FHG12_18880
HRSHER32_05380 HER32_10030
HBNGUY19_19465 GUY19_19470
HTSHMJ29_01695 HMJ29_10905
HMTMTP16_22770
HTBMTX78_16955
PKOPKOR_12515 PKOR_12520 PKOR_15525
PACTCA264_02175 CA264_03165 CA264_03620
RUFTH63_04060 TH63_14235
RTIDC20_14245 DC20_14660
RUDTH61_12240
NIBGU926_18085
ADDHUW48_10675
ASWUHUW51_01025 HUW51_20485
MTTFtrac_1277 Ftrac_1374
FPFDCC35_20270
FBTD770_01380 D770_10140 D770_22385
CHKD4L85_06785 D4L85_13615 D4L85_30080
FUVJR347_07595 JR347_12655 JR347_15925
REKN6H18_09105
GFOGFO_1576
GRLLPB144_03720
GRSC7S20_13800 C7S20_17135 C7S20_18515
FPSFP0413
FPCFPSM_00450
FPYFPG101_02255
FPOFPG3_02170
FPQIB65_01940
FPVIA03_02025
FPWIA04_01965
FPKIA06_02005
FPSZAMR72_11020 AMR72_12580
FJOFjoh_1748 Fjoh_4604
FJGBB050_00859(desA3_1) BB050_02987(desA3_2)
FBRFBFL15_0640
FCOFCOL_03090
FINKQS_11875
FGLEM308_06050 EM308_06795
FCMBIW12_09460
FFAFFWV33_01325
FATDVK85_08110
FKIFK004_01385
FPALHYN49_01635
FMGHYN48_01600
FALBHYN59_06915
FCRHYN56_07485 HYN56_09200 HYN56_22190
FSEDI487_00875 DI487_09345
FSNGS03_00241
FNKE1750_13170
FAKFUA48_01500
FFLHYN86_08210 HYN86_18615
FENJ0383_06845 J0383_08685 J0383_18340
FCVAWN65_01780
FOEJJC03_07225
FSDLXD69_02525
FLOK1I41_01625
FCCLOS86_02380
FCBLOS89_10880
FPBNLJ00_09245
RBIRB2501_02670
ZPRZPR_0940 ZPR_1492
CATCA2559_07355
FBCFB2170_16751
MARMYQ22_03825
MARTBTR34_03930
MARBCJ263_13770
MAREEJ994_00970
CAOCelal_2252
CLYCelly_0637
CLHIX49_02930
CBALM667_08640
CBATM666_08605
KDIKrodi_1870
DOKMED134_12621
DDOI597_1302(desA3)
DODDCS32_02495
LANLacal_0517
LVNBWR22_13235
LACICW733_04270 CW733_09735
ZGAZOBELLIA_1067(des6-2) ZOBELLIA_755(des6-1)
MRSMurru_0575 Murru_2048
MLTVC82_2131
MUTGVT53_01095
MAQILDL77_10735 LDL77_12845
SPONHME9304_02346
ASLAeqsu_0518
AEVEI546_14540
AICJK629_01570 JK629_12490
PTQP700755_002699
POMMED152_06405
POBLPB03_14685
PRNBW723_00980
POLABXQ17_06895
POACW731_14315
PHALH9I45_13935
PLITK8354_11165
PPECH9W90_09185
PBATJL193_04995
PCEAJ3359_15260
PUNNQP51_15885
WINWPG_2001
WIJBWZ20_06125
SZEAW14_08200
AHZAPS56_08280
SYISB49_00400
TDIAUW17_12185
TENLPB136_09710
TJETJEJU_3739
TMARMARIT_2781
TMPF9Y86_06280
LUTLupro_06980
LULLPB138_09110
WFUAXE80_00775
FORFORMB_06270
FOHFORMA_06960
FOPFNB79_06940
SALTAO058_00115
SMISLDL76_09110
SEONBWZ22_11950 BWZ22_15155
AALGAREALGSMS7_02543(desA3)
OLLCW732_06150
OAQDZC78_12695
FEKC1H87_06880
TAJC1A40_11340
AUEC5O00_08760
MARFCJ739_552
AQBD1818_09380 D1818_09485 D1818_09490
AQAD1815_21665 D1815_21670 D1815_21765
AQDD1816_10945
EMARD1013_05915 D1013_15030
MUREQY75_02165
PSYNE9099_04030
AFLAFHG64_13475
ANPFK178_00105
OCIFEZ18_11675
MGELG5B37_12950
MESQC7H62_0634
GAAHX109_09955
CAGGHYG79_02970
MARXINR76_01415
LPALLDL79_12280
SINHLS482_08330 LS482_12605
ASAGFGM00_02900
FLGLV716_02865
SABUMBM09_05465
ZSPMQE36_09485
BIAGMA17_04560 GMA17_09985
FBEFF125_11040 FF125_18070
FBMMQE35_03580
SAHNJRG66_03265
EAOBD94_3599
EMNM876_15070
EENBBD30_08675
ELBVO54_03046
EMGBBD33_05475
EGMAYC65_19675
ELZFCS00_12860
CHZCHSO_0007
CGNOK18_10425
CIHATE47_14660
CIOCEQ15_20755
CPIPCJF12_09160 CJF12_11850
CARHEGY05_00090 EGY05_16690
CSHAEG350_17865
CNKEG343_16780
CJTEG359_17215
CILEG358_03810
CBENEG339_08225
CGLENCTC11432_03868
CTAINCTC12078_01616
CLACEG342_08295
CTAK4412677_01961
CNPM0D58_13535
CCAOH5J24_19795
CRHIKB553_18450
CIVIMZ16_00065
FTEFluta_0285 Fluta_0832 Fluta_1718 Fluta_4072
FLUCHH17_00735 CHH17_06930 CHH17_10485 CHH17_16625
CRMK6119_02165 K6119_02195 K6119_18185
OHOOweho_1245 Oweho_2759
CHYDH4K34_06255
PTANCRYO30217_01395
BBAUAEM51_07385 AEM51_12040
SRGXF24_00844(desA3)
 » show all
Reference
1  [PMID:7212717]
  Authors
Okayasu T, Nagao M, Ishibashi T, Imai Y.
  Title
Purification and partial characterization of linoleoyl-CoA desaturase from rat liver microsomes.
  Journal
Arch Biochem Biophys 206:21-8 (1981)
DOI:10.1016/0003-9861(81)90061-8
Reference
2  [PMID:9867867]
  Authors
Cho HP, Nakamura MT, Clarke SD
  Title
Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase.
  Journal
J Biol Chem 274:471-7 (1999)
DOI:10.1074/jbc.274.1.471
  Sequence
[hsa:9415] [mmu:56473]
Reference
3  [PMID:10903473]
  Authors
Sprecher H
  Title
Metabolism of highly unsaturated n-3 and n-6 fatty acids.
  Journal
Biochim Biophys Acta 1486:219-31 (2000)
DOI:10.1016/S1388-1981(00)00077-9
Reference
4  [PMID:12713571]
  Authors
Ge L, Gordon JS, Hsuan C, Stenn K, Prouty SM
  Title
Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity.
  Journal
J Invest Dermatol 120:707-14 (2003)
DOI:10.1046/j.1523-1747.2003.12123.x
Reference
5  [PMID:15769252]
  Authors
Domergue F, Abbadi A, Zahringer U, Moreau H, Heinz E
  Title
In vivo characterization of the first acyl-CoA Delta6-desaturase from a member of the plant kingdom, the microalga Ostreococcus tauri.
  Journal
Biochem J 389:483-90 (2005)
DOI:10.1042/BJ20050111
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.3
IUBMB Enzyme Nomenclature: 1.14.19.3
ExPASy - ENZYME nomenclature database: 1.14.19.3
BRENDA, the Enzyme Database: 1.14.19.3
CAS: 9082-66-0

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