KEGG   ENZYME: 1.14.19.32
Entry
EC 1.14.19.32               Enzyme                                 
Name
palmitoyl-CoA 14-(E/Z)-desaturase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
palmitoyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (14,15 cis/trans-dehydrogenating)
Reaction(IUBMB)
(1) palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (14E)-hexadec-14-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R11011];
(2) palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (14Z)-hexadec-14-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R11012]
Reaction(KEGG)
R11011 R11012
Substrate
palmitoyl-CoA [CPD:C00154];
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
(14E)-hexadec-14-enoyl-CoA [CPD:C20996];
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001];
(14Z)-hexadec-14-enoyl-CoA [CPD:C20997]
Comment
The enzyme, found in the moth Ostrinia furnacalis (Asian corn borer), produces a mixture of (E)- and (Z)- isomers. The products are subsequently truncated by partial beta-oxidation to a blend of 12(E/Z)-tetradec-12-enoyl-CoA, which are converted to the species-specific sex pheromones (E)- and (Z)-tetradec-12-enoyl acetates.
History
EC 1.14.19.32 created 2015
Reference
1  [PMID:12237399]
  Authors
Roelofs WL, Liu W, Hao G, Jiao H, Rooney AP, Linn CE Jr
  Title
Evolution of moth sex pheromones via ancestral genes.
  Journal
Proc Natl Acad Sci U S A 99:13621-6 (2002)
DOI:10.1073/pnas.152445399
Reference
2  [PMID:17360547]
  Authors
Xue B, Rooney AP, Kajikawa M, Okada N, Roelofs WL
  Title
Novel sex pheromone desaturases in the genomes of corn borers generated through gene duplication and retroposon fusion.
  Journal
Proc Natl Acad Sci U S A 104:4467-72 (2007)
DOI:10.1073/pnas.0700422104
Reference
3  [PMID:18992816]
  Authors
Sakai R, Fukuzawa M, Nakano R, Tatsuki S, Ishikawa Y
  Title
Alternative suppression of transcription from two desaturase genes is the key for species-specific sex pheromone biosynthesis in two Ostrinia moths.
  Journal
Insect Biochem Mol Biol 39:62-7 (2009)
DOI:10.1016/j.ibmb.2008.10.001
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.32
IUBMB Enzyme Nomenclature: 1.14.19.32
ExPASy - ENZYME nomenclature database: 1.14.19.32
BRENDA, the Enzyme Database: 1.14.19.32

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