KEGG   ENZYME: 1.14.19.42
Entry
EC 1.14.19.42               Enzyme                                 

Name
palmitoyl-[glycerolipid] 7-desaturase;
FAD5
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
1-acyl-2-palmitoyl-[glycerolipid],ferredoxin:oxygen oxidoreductase (7,8-cis-dehydrogenating)
Reaction(IUBMB)
a 1-acyl-2-palmitoyl-[glycerolipid] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = a 1-acyl-2-[(7Z)-hexadec-7-enoyl]-[glycerolipid] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O
Substrate
1-acyl-2-palmitoyl-[glycerolipid];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
1-acyl-2-[(7Z)-hexadec-7-enoyl]-[glycerolipid];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139];
H2O [CPD:C00001]
Comment
The enzyme introduces a cis double bond at carbon 7 of a palmitoyl group attached to the sn-2 position of glycerolipids. The enzyme from the plant Arabidopsis thaliana is specific for palmitate in monogalactosyldiacylglycerol.
History
EC 1.14.19.42 created 2015
Orthology
K20416  palmitoyl-[glycerolipid] 7-desaturase
Genes
ATH: AT3G15850(FAD5)
ALY: 110229983 9321178 9325649 9325650 9328382 9328398 9328399
CRB: 17892436 17900910
CSAT: 104739156 104739157 104739158 104739188 104743165 104745901 104745903 104745905 104754764 104754768 104764004 104764230 104765420 104767539 104778585 104780697 104780716
EUS: EUTSA_v10008319mg EUTSA_v10020955mg
BRP: 103836480 103836481 103836493 103838455 103843571 103844047 103844072 103859642 103859643 103859645 103869868 103870140
BNA: 106362210 106365702 106370165 106371147 106399300 106399393 106400080 106400093 106401219 106401310 106405157 106405307 106406041 106406784 106420060 106421809 106427048 106427049 106439426 106440507 106444038 106444040 111208482 111208520 111213569
BOE: 106292919 106293674 106295280 106295281 106295907 106308104 106310104 106310248 106310502 106330253 106333239 106334850 106345017
RSZ: 108813043 108819638 108820590 108820997 108853403 108853906 108854149 108855890 108857754 108861055 108862476 108863387 108863460
THJ: 104800890 104801541 104810511 104810512 104818022 104818023
CPAP: 110821049
CIT: 102621512
PVY: 116129461
GRA: 105770835
GAB: 108450769
EGR: 104423180
GMX: 100527024(FAD5.2) 100786391(FAD5.1)
VRA: 106773545
VAR: 108320643
VUN: 114166036
CCAJ: 109808338
APRC: 113857121
CAM: 101495366
LJA: Lj3g3v2187030.1(Lj3g3v2187030.1)
AIP: 107619531
ZJU: 107407905
MNT: 21408455
RCU: 8282342
JCU: 105634849
HBR: 110649623
MESC: 110613368
PEU: 105136814
PALZ: 118040840
JRE: 108998330
VVI: 100249077
VRI: 117922182
SLY: 101250586
SPEN: 107014969
SOT: 102601797
CANN: 107861959
NSY: 104223253
NTO: 104106571
NAU: 109231949
SIND: 105158379
EGT: 105975820
DCR: 108219979
CSIN: 114255780
NNU: 104592471
MING: 122091646
AOF: 109828798
 » show all
Reference
1  [PMID:16666902]
  Authors
Kunst L, Browse J, Somerville C
  Title
A mutant of Arabidopsis deficient in desaturation of palmitic Acid in leaf lipids.
  Journal
Plant Physiol 90:943-7 (1989)
DOI:10.1104/pp.90.3.943
  Sequence
[ath:AT3G15850]
Reference
2  [PMID:15579662]
  Authors
Heilmann I, Mekhedov S, King B, Browse J, Shanklin J
  Title
Identification of the Arabidopsis palmitoyl-monogalactosyldiacylglycerol delta7-desaturase gene FAD5, and effects of plastidial retargeting of Arabidopsis desaturases on the fad5 mutant phenotype.
  Journal
Plant Physiol 136:4237-45 (2004)
DOI:10.1104/pp.104.052951
  Sequence
[ath:AT3G15850]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.42
IUBMB Enzyme Nomenclature: 1.14.19.42
ExPASy - ENZYME nomenclature database: 1.14.19.42
BRENDA, the Enzyme Database: 1.14.19.42

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