KEGG   ENZYME: 1.14.19.53
Entry
EC 1.14.19.53               Enzyme                                 
Name
all-trans-retinol 3,4-desaturase;
CYP27C1 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
all-trans-retinol,reduced adrenodoxin:oxygen 3,4-oxidoreductase
Reaction(IUBMB)
all-trans-retinol + 2 reduced adrenodoxin + 2 H+ + O2 = all-trans-3,4-didehydroretinol + 2 oxidized adrenodoxin + 2 H2O [RN:R11952]
Reaction(KEGG)
R11952
Substrate
all-trans-retinol [CPD:C00473];
reduced adrenodoxin [CPD:C00662];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
all-trans-3,4-didehydroretinol [CPD:C21797];
oxidized adrenodoxin [CPD:C00667];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme thiolate) enzyme found in vertebrates. The enzyme is also active with retinal and retinoic acid.
History
EC 1.14.19.53 created 2018
Pathway
ec00830  Retinol metabolism
Orthology
K17951  all-trans-retinol 3,4-desaturase
Genes
HSA339761(CYP27C1)
PTR470525
PPS100975504(CYP27C1)
GGO101148971
PON100453764
NLE100600882
MCC713954
MCF102138872(CYP27C1)
CSAB103216882(CYP27C1)
CATY105592085
PANU101003912
TGE112636508
RRO104662434
RBB108533024
TFN117095437
PTEH111551563
CJC100407433
SBQ101050984
CSYR103276600
MMUR105857517
LCAT123643351
OGA100960218
NCAR124980573
OCU100355448
OPI101519867
TUP102486613
CFA483869(CYP27C1)
CLUD112652432
VVP112932715
VLG121482057
AML100475175
UMR103658573
UAH113263376
UAR123779504
ELK111160854
LLV125096318
MPUF101672135
ORO101369154
EJU114207320
ZCA113919425
MLX118012566
FCA101096908
PYU121030403
PBG122481228
PTG102957625
PPAD109278795
AJU106966380
HHV120245941
BTA617338(CYP27C1)
BOM102274061
BIU109565330
BBUB102407599
CHX102179328
OAS101118856
ODA120854056
CCAD122453906
SSC100517560
CFR102504552
CBAI105068581
CDK105084485
VPC102531160
BACU103017184
LVE103083694
OOR101269815
DLE111183411
PCAD102981411
PSIU116757039
ECB100051659(CYP27C1)
EPZ103562192
EAI106834094
SARA101545408
TMU101354619
DNM101412325
MDO100026810
GAS123239379
SHR100916977
PCW110194704
OAA100089911
GGA424227(CYP27C1)
PCOC116227347
MGP100542744
CJO107316860
NMEL110399800
APLA101801511
ACYG106045912
AFUL116490455
TGU100225584
LSR110468322
SCAN103814334
PMOA120497349
OTC121337872
PRUF121356668
GFR102033475
FAB101811458
PHI102112535
PMAJ107207282
CCAE111932211
CCW104693991
CBRC103625419
ETL114055572
ZAB102061648
ACHL103803665
FPG101921287
CLV102092786
EGZ104133721
NNI104020396
PLET104613748
PCRI104033283
ACUN113482262
TALA104355522
PADL103916539
ACHC115343271
HALD104319536
CCRI104169131
CSTI104560750
EHS104503200
CMAC104477361
MUI104539105
FGA104069301
GSTE104250432
LDI104339886
MNB103769754
OHA104335235
AAM106499209
AROW112972059
NPD112946090
DNE112980579
ASN102378794
AMJ102574953(CYP27C1)
CPOO109322640
GGN109301453
PSS102448341
CMY102940478
CPIC101935484
TST117885095
CABI116839281
MRV120375086
ACS100557779
PVT110085301
SUND121919156
PBI103048791
PMUR107302019
TSR106546919
PGUT117668268
VKO123027473
PMUA114603555 114603564
ZVI118091379
GJA107113561
STOW125427141
XLA108701260 447625(cyp27c1.L) 735141(cyp27c1.S)
XTR496805(cyp27c1)
NPR108785388
RTEM120944247
BBUF121008632
BGAR122923874
DRE558396(cyp27c1)
SRX107705550 107706664
SANH107660023 107677575
SGH107581347 107584837
CCAR109045192 109080434
CAUA113050868 113092310
PPRM120491640
MAMB125274239
IPU108272716
PHYP113538219
SMEO124393172
TFD113651072
AMEX103026207
EEE113584084
TRU101074060
LCO104918263
NCC104966145 104966146
CGOB115027128
ELY117260539
EFO125882369
PLEP121947707
SLUC116054722 116054723
ECRA117948167
ESP116670746 116671237
PFLV114556809 114558100
GAT120834626
PPUG119227784
MSAM119890195
CUD121514646
ALAT119018381
MZE101466396
ONL100700192
OAU116311706
OLA101157281
OML112160631
XMA102223373
XCO114142722
XHE116718483
PRET103461994
PFOR103143523
PLAI106944717
PMEI106914830
GAF122846514
CVG107082507
CTUL119771877
GMU124866500
NFU107381651
KMR108250623
ALIM106513953
NWH119428924
AOCE111564848
MCEP125005862
CSEM103398814
POV109624782
SSEN122772870
HHIP117759225
HSP118113895
LCF108887985
SDU111238623
SLAL111652557
XGL120793403
HCQ109524630
BPEC110173034
MALB109964498
BSPL114852263
SASA106575940 106595593
OTW112242330 121838678
OMY110510834 110519502
OGO124021071 124027374
SNH120035602 120040682
CCLU121563781
ELS105020091
SFM108920654 108942618
PKI111852224
AANG118213728
LOC102695873
PSPA121323562
ARUT117404920
LCM102367688
CMK103189034
RTP109912647
BANY112049828
PCHN125029948 125034086
HRF124116286
HRJ124292172
PMAX117337533
 » show all
Reference
1  [PMID:26549260]
  Authors
Enright JM, Toomey MB, Sato SY, Temple SE, Allen JR, Fujiwara R, Kramlinger VM, Nagy LD, Johnson KM, Xiao Y, How MJ, Johnson SL, Roberts NW, Kefalov VJ, Guengerich FP, Corbo JC
  Title
Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2.
  Journal
Curr Biol 25:3048-57 (2015)
DOI:10.1016/j.cub.2015.10.018
  Sequence
[dre:558396]
Reference
2  [PMID:27059013]
  Authors
Kramlinger VM, Nagy LD, Fujiwara R, Johnson KM, Phan TT, Xiao Y, Enright JM, Toomey MB, Corbo JC, Guengerich FP
  Title
Human cytochrome P450 27C1 catalyzes 3,4-desaturation of retinoids.
  Journal
FEBS Lett 590:1304-12 (2016)
DOI:10.1002/1873-3468.12167
  Sequence
[hsa:339761]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.53
IUBMB Enzyme Nomenclature: 1.14.19.53
ExPASy - ENZYME nomenclature database: 1.14.19.53
BRENDA, the Enzyme Database: 1.14.19.53

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