Entry |
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Name |
4-hydroxybenzoate brominase (decarboxylating);
bmp5 (gene name)
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Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
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Sysname |
4-hydroxybenzoate:NADPH oxidoreductase (brominating, decarboxylating)
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Reaction(IUBMB) |
(1) 4-hydroxybenzoate + 2 NADPH + 2 bromide + 2 O2 + 2 H+ = 2,4-dibromophenol + 2 NADP+ + CO2 + 4 H2O (overall reaction) [RN: R12013];
(1a) 4-hydroxybenzoate + NADPH + bromide + O2 + H+ = 3-bromo-4-hydroxybenzoate + NADP+ + 2 H2O [RN: R12015];
(1b) 3-bromo-4-hydroxybenzoate + NADPH + bromide + O2 + H+ = 2,4-dibromophenol + NADP+ + CO2 + 2 H2O [RN: R12016];
(2) 3,4-dihydroxybenzoate + 2 NADPH + 2 bromide + 2 O2 + 2 H+ = 3,5-dibromobenzene-1,2-diol + 2 NADP+ + CO2 + 4 H2O (overall reaction) [RN: R12018];
(2a) 3,4-dihydroxybenzoate + NADPH + bromide + O2 + H+ = 3-bromo-4,5-dihydroxybenzoate + NADP+ + 2 H2O [RN: R12019];
(2b) 3-bromo-4,5-dihydroxybenzoate + NADPH + bromide + O2 + H+ = 3,5-dibromobenzene-1,2-diol + NADP+ + CO2 + 2 H2O [RN: R12020]
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Reaction(KEGG) |
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Substrate |
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Product |
2,4-dibromophenol [CPD: C14521];
NADP+ [CPD: C00006];
CO2 [CPD: C00011];
H2O [CPD: C00001];
3-bromo-4-hydroxybenzoate [CPD: C21850];
3,5-dibromobenzene-1,2-diol [CPD: C21852];
3-bromo-4,5-dihydroxybenzoate [CPD: C21853]
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Comment |
Contains FAD. The enzyme, described from epiphytic marine bacteria of the genera Pseudoalteromonas and Marinomonas, is an unusual single-component FAD-dependent halogenase that contains a distinct NAD(P)H binding domain and does not require an additional flavin reductase for activity. The enzyme catalyses a bromination of its substrate, followed by a second bromination concurrent with decarboxylation.
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History |
EC 1.14.19.55 created 2018
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Orthology |
K05918 | 4-hydroxybenzoate brominase (decarboxylating) |
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Genes |
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Reference |
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Authors |
Agarwal V, El Gamal AA, Yamanaka K, Poth D, Kersten RD, Schorn M, Allen EE, Moore BS |
Title |
Biosynthesis of polybrominated aromatic organic compounds by marine bacteria. |
Journal |
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Sequence |
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Reference |
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Authors |
Agarwal V, Moore BS |
Title |
Enzymatic synthesis of polybrominated dioxins from the marine environment. |
Journal |
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Other DBs |
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