KEGG   ENZYME: 1.14.19.70
Entry
EC 1.14.19.70               Enzyme                                 
Name
mycocyclosin synthase;
CYP121;
rv2276 (locus name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
cyclo(L-tyrosyl-L-tyrosyl),reduced ferredoxin:oxygen oxidoreductase (diarylbridge-forming)
Reaction(IUBMB)
cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O [RN:R10323]
Reaction(KEGG)
R10323
Substrate
cyclo(L-tyrosyl-L-tyrosyl) [CPD:C20516];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
mycocyclosin [CPD:C20517];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein from the bacterium Mycobacterium tuberculosis catalysing an oxidative reaction that does not incorporate oxygen into the product.
History
EC 1.14.19.70 created 2013 as EC 1.14.21.9, transferred 2018 to EC 1.14.19.70
Orthology
K17483  mycocyclosin synthase
Genes
MTURv2276(cyp121)
MTVRVBD_2276
MTCMT2336
MRAMRA_2295(cyp121)
MTFTBFG_12301
MTBTBMG_01706
MTKTBSG_01716
MTZTBXG_001689
MTGMRGA327_14025
MTECCDC5079_2109
MTURCFBS_2409(cyp121)
MTLCCDC5180_2081
MTOMTCTRI2_2311(cyp121)
MTDUDA_2276(cyp121)
MTJJ112_12205
MTUCJ113_15840
MTUEJ114_12200
MTXM943_11770
MTUTHKBT1_2400(cyp121)
MTUUHKBT2_2402(cyp121)
MTQHKBS1_2406(cyp121)
MBOBQ2027_MB2299(cyp121)
MBBBCG_2293(cyp121)
MBTJTY_2287(cyp121)
MBMBCGMEX_2281(cyp121)
MBKK60_023610
MBXBCGT_2100
MMICRN08_2523
MCEMCAN_23001(cyp121)
MCQBN44_50222(cyp)
MCVBN43_31518(cyp)
MCXBN42_40197(cyp)
MCZBN45_50612(cyp)
MLJMLAC_22970(cyp121)
MOTLTS72_08580
NTPCRH09_14610
NOZDMB37_28475
NAHF5544_25075
NIEKV110_23805
SVESVEN_1865
SVTSVTN_10710
SLDT261_7888
SRWTUE45_00817
SGSAVL59_26765
SPUNBFF78_39740
SGVB1H19_37510
SLAUSLA_4278
SALJSMD11_0297
SLXSLAV_12480
SLKSLUN_02670
SCYAEJ357_25510
SGZC0216_06095
SVNCP980_02820
SRKFGW37_32710
SFICEIZ62_17685
SRIMCP984_00425 CP984_04050
SCHACP983_19790
SGXH4W23_11130
SNFJYK04_05847 JYK04_07983
SBROGQF42_05395
SHUNDWB77_02435
SFEUIM697_43415
SMOBJ7W19_32325
SHKJ2N69_29165
KITCFP65_6206
KPHYAOZ06_26070
 » show all
Reference
1  [PMID:19416919]
  Authors
Belin P, Le Du MH, Fielding A, Lequin O, Jacquet M, Charbonnier JB, Lecoq A, Thai R, Courcon M, Masson C, Dugave C, Genet R, Pernodet JL, Gondry M
  Title
Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis.
  Journal
Proc Natl Acad Sci U S A 106:7426-31 (2009)
DOI:10.1073/pnas.0812191106
  Sequence
[mtu:Rv2276]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.70
IUBMB Enzyme Nomenclature: 1.14.19.70
ExPASy - ENZYME nomenclature database: 1.14.19.70
BRENDA, the Enzyme Database: 1.14.19.70

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