KEGG   ENZYME: 1.14.19.71
Entry
EC 1.14.19.71               Enzyme                                 

Name
fumitremorgin C synthase;
ftmE (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
tryprostatin A,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
tryprostatin A + [reduced NADPH---hemoprotein reductase] + O2 = fumitremorgin C + [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:R10416]
Reaction(KEGG)
R10416
Substrate
tryprostatin A [CPD:C20607];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
fumitremorgin C [CPD:C20604];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. The protein from the fungus Aspergillus fumigatus also has activity with tryprostatin B forming demethoxyfumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen.
History
EC 1.14.19.71 created 2013 as EC 1.14.21.10, transferred 2018 to EC 1.14.19.71
Pathway
ec00404  Staurosporine biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17827  fumitremorgin C synthase
Genes
AFM: AFUA_8G00220
NFI: NFIA_093730
Reference
1  [PMID:19226505]
  Authors
Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S, Sugimoto Y, Osada H
  Title
Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.
  Journal
Chembiochem 10:920-8 (2009)
DOI:10.1002/cbic.200800787
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.71
IUBMB Enzyme Nomenclature: 1.14.19.71
ExPASy - ENZYME nomenclature database: 1.14.19.71
BRENDA, the Enzyme Database: 1.14.19.71

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