KEGG   ENZYME: 1.14.19.74
Entry
EC 1.14.19.74               Enzyme                                 

Name
(+)-piperitol/(+)-sesamin synthase;
CYP81Q1;
CYP81Q2;
PS;
PSS;
SS;
piperitol synthase;
sesamin synthase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
(+)-pinoresinol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (cyclizing)
Reaction(IUBMB)
(1) (+)-pinoresinol + [reduced NADPH-hemoprotein reductase] + O2 = (+)-piperitol + [oxidized NADPH-hemoprotein reductase] + 2 H2O [RN:R12153];
(2) (+)-piperitol + [reduced NADPH-hemoprotein reductase] + O2 = (+)-sesamin + [oxidized NADPH-hemoprotein reductase] + 2 H2O [RN:R12154]
Reaction(KEGG)
R12153 R12154
Substrate
(+)-pinoresinol [CPD:C05366];
[reduced NADPH-hemoprotein reductase];
O2 [CPD:C00007];
(+)-piperitol [CPD:C21954]
Product
(+)-piperitol [CPD:C21954];
[oxidized NADPH-hemoprotein reductase];
H2O [CPD:C00001];
(+)-sesamin [CPD:C10882]
Comment
A cytochrome P-450 (heme-thiolate) protein. Isolated from Sesamum indicum (sesame) and S. radiatum (black sesame).
History
EC 1.14.19.74 created 2018
Orthology
K22995  (+)-piperitol/(+)-sesamin synthase
Genes
SIND: 105176326 105177765
OEU: 111401991
EGT: 105951153
Reference
1  [PMID:16785429]
  Authors
Ono E, Nakai M, Fukui Y, Tomimori N, Fukuchi-Mizutani M, Saito M, Satake H, Tanaka T, Katsuta M, Umezawa T, Tanaka Y
  Title
Formation of two methylenedioxy bridges by a Sesamum CYP81Q protein yielding a furofuran lignan, (+)-sesamin.
  Journal
Proc Natl Acad Sci U S A 103:10116-21 (2006)
DOI:10.1073/pnas.0603865103
  Sequence
[sind:105177765] [ag:BAE48235]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.74
IUBMB Enzyme Nomenclature: 1.14.19.74
ExPASy - ENZYME nomenclature database: 1.14.19.74
BRENDA, the Enzyme Database: 1.14.19.74

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