Entry
Name
plasmanylethanolamine desaturase;
TMEM189 (gene name);
2-acyl-1-alkyl-sn-glycero-3-phosphoethanolamine desaturase;
alkylacylglycerophosphoethanolamine desaturase;
alkylacylglycero-phosphorylethanolamine dehydrogenase;
alkyl-acylglycerophosphorylethanolamine dehydrogenase;
1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase;
1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
BRITE hierarchy
Sysname
plasmanylethanolamine,ferrocytochrome b5:oxygen oxidoreductase (plasmenylethanolamine-forming)
Reaction(IUBMB)
a plasmanylethanolamine + 2 ferrocytochrome b5 + O2 + 2 H+ = a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O [RN:
R04571 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme catalyses the introduction of a double bond at position 1 of the alkyl group attached by an ether bond at the sn-1 position of plasmanylethanolamine, generating a vinyl ether-containing plasmenylethanolamine. The enzyme is found in animals and some bacteria, but not in plants, fungi, or most aerobic bacteria.
History
EC 1.14.19.77 created 1976 as EC 1.14.99.19, transferred 2020 to EC 1.14.19.77
Pathway
Orthology
K20656 plasmanylethanolamine desaturase
Genes
HSA : 387521(PEDS1) 387522(PEDS1-UBE2V1)
CCAY : 125620817 125622117(PEDS1)
CPIC : 101931926 101952652
CABI : 116828653 116838672
MUO : 115459000 115475523(TMEM189)
DRE : 450031(peds1) 492735(si:ch211-212o1.2)
SRX : 107711858 107738740 107740306 107751443
SANH : 107669672 107672277 107679882 107686280 107686334
SGH : 107549643 107556313 107583780 107594514
CCAR : 109072739 109083335 109094798
CAUA : 113061476 113072099 113107526 113107549 113118339
CGIB : 127934370 127963826 127977594(si:ch211-212o1.2) 128018559
PTET : 122322892(si:ch211-212o1.2) 122350566(peds1)
LROH : 127169780(peds1) 127180937(si:ch211-212o1.2)
OMC : 131524444(si:ch211-212o1.2) 131546253(peds1)
PPRM : 120484235(peds1) 120493902(si:ch211-212o1.2)
RKG : 130071755(peds1) 130087556(si:ch211-212o1.2)
MAMB : 125253853(si:ch211-212o1.2) 125279730(peds1)
CIDE : 127499693(si:ch211-212o1.2) 127517935
CERY : 137022810(si:ch211-212o1.2) 137027098(peds1)
MASI : 127414932 127417413 127424263 127456506
TROS : 130562962(si:ch211-212o1.2) 130568012(peds1)
TDW : 130435587(si:ch211-212o1.2) 130440038(peds1)
MANU : 129413613(peds1) 129419451(si:ch211-212o1.2)
IPU : 100528160(peds1) 108264382(si:ch211-212o1.2)
IFU : 128606677(si:ch211-212o1.2) 128608024(peds1)
PHYP : 113528134 113534524
SMEO : 124395820(si:ch211-212o1.2) 124399753(peds1)
TFD : 113652612(si:ch211-212o1.2) 113655710(peds1)
TVC : 132851260(si:ch211-212o1.2) 132854235(peds1)
TRN : 134318229(peds1) 134323247(si:ch211-212o1.2)
AMEX : 103038667(si:ch211-212o1.2)
CMAO : 118813420(peds1) 118817899(si:ch211-212o1.2)
CHAR : 105892558(si:ch211-212o1.2) 105894251(peds1)
TBEN : 117470661(tmem189) 117491536(si:ch211-212o1.2)
GACU : 117539659(si:ch211-212o1.2)
EMAC : 134862328(peds1) 134873706(si:ch211-212o1.2)
ELY : 117258150(tmem189) 117262447(si:ch211-212o1.2)
EFO : 125887319(si:ch211-212o1.2) 125891910(peds1)
PLEP : 121947283(peds1) 121950077(si:ch211-212o1.2)
SLUC : 116043606(peds1) 116046469(si:ch211-212o1.2)
ECRA : 117947032(tmem189) 117948510(si:ch211-212o1.2)
PFLV : 114558639 114560362
PPUG : 119206802 119222094(peds1)
AFB : 129099481(peds1) 129108519(si:ch211-212o1.2)
CANA : 137800263(peds1) 137803571(si:ch211-212o1.2)
CVE : 137888574(si:ch211-212o1.2) 137889670(peds1)
MSAM : 119893928(si:ch211-212o1.2) 119905214(peds1)
SCHU : 122875028(si:ch211-212o1.2) 122883629(peds1)
CUD : 121514918(si:ch211-212o1.2) 121517279(peds1)
ALAT : 119022220(peds1) 119024883(si:ch211-212o1.2)
OAU : 116317188(peds1) 116327365(si:ch211-212o1.2)
OLA : 101156405(tmem189) 101171992
OML : 112152183(si:ch211-212o1.2) 112159000(peds1)
PRET : 103466733 103467757
PFOR : 103138816 103139104
PLAI : 106952836 106963665
PMEI : 106916791 106921426
GAF : 122836108(si:ch211-212o1.2) 122838757(peds1)
PPRL : 129364250(si:ch211-212o1.2) 129370111(peds1)
CTUL : 119789137(si:ch211-212o1.2) 119799408(peds1)
GMU : 124855908(si:ch211-212o1.2) 124867048(peds1)
KMR : 108249565(peds1) 108251456(si:ch211-212o1.2)
AOCE : 111572077 111581635
MCEP : 125004401(peds1) 125015460
CSEM : 103379655 103385608 103385617
HHIP : 117762948(si:ch211-212o1.2) 117764114(tmem189)
HSP : 118109100(si:ch211-212o1.2) 118111559(peds1)
PPLT : 128443029(peds1) 128444955(si:ch211-212o1.2)
SMAU : 118315530(si:ch211-212o1.2) 118317483(peds1)
LCF : 108890485(peds1) 108901902(si:ch211-212o1.2)
SLAL : 111654944 111661889
XGL : 120793020(si:ch211-212o1.2) 120804464(peds1)
HCQ : 109507661 109526876(ube2v1)
SBIA : 133502650(si:ch211-212o1.2) 133514899(peds1)
PEE : 133401700(peds1) 133402842(si:ch211-212o1.2)
PTAO : 133477770(peds1) 133478630(si:ch211-212o1.2)
BPEC : 110164595 110169509(tmem189)
MALB : 109962562 109970305
BSPL : 114857162(si:ch211-212o1.2) 114858657(peds1)
SJO : 128357398(peds1) 128358946(si:ch211-212o1.2)
SASA : 100195807(tm189) 106560866
STRU : 115168030 115196842
OTW : 112218501(si:ch211-212o1.2) 112221864(peds1)
OMY : 110492131(peds1) 110494576(si:ch211-212o1.2)
OGO : 124037573(si:ch211-212o1.2) 124045951(peds1)
OKE : 118359929(peds1) 118396642(si:ch211-212o1.2)
SALP : 111962343 111976475
SNH : 120061128(peds1) 120066225(si:ch211-212o1.2)
CCLU : 121531838(si:ch211-212o1.2) 121545700(peds1)
PKI : 111850707 111851842 111855731
AANG : 118207626(peds1) 118211046 118228211(si:ch211-212o1.2)
PSPA : 121296409(si:ch211-212o1.2) 121297917(peds1) 121326222
ARUT : 117424038(si:ch211-212o1.2) 117425022 117430609
PSEX : 120535195(si:ch211-212o1.2)
CMK : 103176074(si:ch211-212o1.2)
RTP : 109928512(si:ch211-212o1.2)
CPLA : 122558404(si:ch211-212o1.2) 122560066
HOC : 132822916 132823719(si:ch211-212o1.2)
LERI : 129705022 129707446
DSI : Dsimw501_GD24246(Dsim_GD24246)
CCAT : 101451618 111591542
PPYR : 116158929 116164489
CSCU : 111615989 111616728
LPOL : 106459754 106460046
CEL : CELE_Y53C10A.5(tmem-189)
LMAT : 92514638(LSCM1_04628)
LOI : 92361625(LSCM4_05760)
LEIS : 94181085(GH5_05729)
LENR : 94173369(CUR178_06185)
LEIN : 94188896(JIQ42_05258)
PHET : 94291065(JKF63_05018)
» show all
Taxonomy
Reference
Authors
Stoffel W, LeKim D
Title
Studies on the biosynthesis of plasmalogens. Precursors in the biosynthesis of plasmalogens: on the stereospecificity of the biochemical dehydrogenation of the 1-O-alkyl glyceryl to the 1-O-alk-1'-enyl glyceryl ether bond.
Journal
Reference
Authors
Paltauf F
Title
Biosynthesis of plasmalogens from alkyl- and alkyl-acyl-glycerophosphoryl ethanolamine in the rat brain.
Journal
Reference
Authors
Paltuaf F, Prough RA, Masters BS, Johnston JM
Title
Evidence for the participation of cytochrome b5 in plasmalogen biosynthesis.
Journal
J Biol Chem 249:2661-2 (1974)
Reference
Authors
Wykle RL, Schremmer Lockmiller JM
Title
The biosynthesis of plasmalogens by rat brain: involvement of the microsomal electron transport system.
Journal
Reference
Authors
Gallego-Garcia A, Monera-Girona AJ, Pajares-Martinez E, Bastida-Martinez E, Perez-Castano R, Iniesta AA, Fontes M, Padmanabhan S, Elias-Arnanz M
Title
A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis.
Journal
Other DBs