KEGG   ENZYME: 1.14.19.8
Entry
EC 1.14.19.8                Enzyme                                 

Name
pentalenolactone synthase;
penM (gene name);
pntM (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
pentalenolactone-reduced-ferredoxin:oxygen oxidoreductase (pentalenolactone forming)
Reaction(IUBMB)
pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+ = pentalenolactone + 2 oxidized ferredoxin + 2 H2O [RN:R10162]
Reaction(KEGG)
R10162
Substrate
pentalenolactone F [CPD:C20397];
O2 [CPD:C00007];
reduced ferredoxin [CPD:C00138];
H+ [CPD:C00080]
Product
pentalenolactone [CPD:C20407];
oxidized ferredoxin [CPD:C00139];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450). Isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae.
History
EC 1.14.19.8 created 2012 as EC 1.3.7.10, transferred 2013 to EC 1.14.19.8
Pathway
ec00999  Biosynthesis of various secondary metabolites - part 1
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17476  pentalenolactone synthase
Genes
SBH: SBI_09672(cyp47)
SCW: TU94_27370
SLE: sle_13230(sle_13230)
SSIA: A7J05_09275
Reference
1  [PMID:21284395]
  Authors
Zhu D, Seo MJ, Ikeda H, Cane DE
  Title
Genome mining in streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone.
  Journal
J Am Chem Soc 133:2128-31 (2011)
DOI:10.1021/ja111279h
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.8
IUBMB Enzyme Nomenclature: 1.14.19.8
ExPASy - ENZYME nomenclature database: 1.14.19.8
BRENDA, the Enzyme Database: 1.14.19.8

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