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Entry
EC 1.14.20.10               Enzyme                                 

Name
L-tyrosine isonitrile desaturase/decarboxylase;
pvcB (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and the other dehydrogenated
BRITE hierarchy
Sysname
(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate,2-oxoglutarate:oxygen oxidoreductase (decarboxylating)
Reaction(IUBMB)
(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = 4-[(E)-2-isocyanoethenyl]phenol + succinate + 2 CO2 + H2O [RN:R12076]
Reaction(KEGG)
Substrate
(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate [CPD:C21889];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
4-[(E)-2-isocyanoethenyl]phenol [CPD:C21890];
succinate [CPD:C00042];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the bacterium Xenorhabdus nematophila, is involved in rhabduscin biosynthesis. The enzyme is a member of the Fe2+, 2-oxoglutarate-dependent oxygenases. It is similar to EC 1.14.20.9, L-tyrosine isonitrile desaturase. However, the latter does not catalyse a decarboxylation of the substrate.
History
EC 1.14.20.10 created 2018
Orthology
K22874  L-tyrosine isonitrile desaturase/decarboxylase
Genes
SPE: Spro_0704
SRR: SerAS9_0644
SRL: SOD_c05760
SRY: M621_03040
SPLY: Q5A_003040
SRS: SerAS12_0644
SRA: SerAS13_0644
SMW: SMWW4_v1c06960
SMAR: SM39_0024(pvcB)
SMAC: SMDB11_0022(pvcB)
SERF: L085_00780
ECA: ECA3380(pvcB)
PATR: EV46_16840
PATO: GZ59_34170(pvcB)
PEC: W5S_0996
EAM: EAMY_1787(pvcB)
EAY: EAM_1750(pvcB)
ERJ: EJP617_29220(pvcB)
PLU: plu2817
PAY: PAU_01720(pvcB)
XBO: XBJ1_1354
XBV: XBW1_1622
XNE: XNC1_1222
XNM: XNC2_1198(isnB)
XDO: XDD1_2892
XPO: XPG1_0844
LEZ: GLE_4812
VCH: VC1944
VCS: MS6_1705
VCE: Vch1786_I1437(pvcB)
VCI: O3Y_09405
VCO: VC0395_A1534(pvcB)
VCR: VC395_2059(pvcB)
VCM: VCM66_1868(pvcB)
VNI: VIBNI_A3570(pvcB)
VAN: VAA_02643
VAU: VANGNB10_cI2373c(pvcB)
PAE: PA2255(pvcB)
PAEV: N297_2328(pvcB)
PAEI: N296_2328(pvcB)
PAU: PA14_35420(pvcB)
PAP: PSPA7_2986(pvcB)
PAG: PLES_30491(pvcB)
PAF: PAM18_2785(pvcB)
PNC: NCGM2_3265(pvcB)
PAEB: NCGM1900_4275(pvcB)
PAEP: PA1S_14345
PAEM: U769_13930
PAEL: T223_15575
PAEU: BN889_02461(pvcB)
PAEG: AI22_19510
PAEC: M802_2325(pvcB)
PAEO: M801_2327(pvcB)
PSEN: PNC201_02370(carC)
LPN: lpg0175
LPH: LPV_0258(pvcB)
LPO: LPO_0206(pvcB)
LPM: LP6_0179(pvcB)
LPF: lpl0237
LPP: lpp0237
LPC: LPC_0257(pvcB)
LPA: lpa_00342
LPE: lp12_0177
LLO: LLO_2213
TOL: TOL_3183
AHA: AHA_3281
ASA: ASA_1025(pvcB)
BMA: BMAA1923(pvcB)
BMV: BMASAVP1_0938(pvcB)
BML: BMA10229_1223(pvcB)
BMN: BMA10247_A2200(pvcB)
BMAL: DM55_3864(pvcB)
BMAE: DM78_4783(pvcB)
BMAQ: DM76_4561(pvcB)
BMAI: DM57_06430
BMAF: DM51_3611
BMAZ: BM44_3823(pvcB)
BMAB: BM45_4600
BPS: BPSS0161
BPM: BURPS1710b_A1680(pvcB)
BPL: BURPS1106A_A0229(pvcB)
BPD: BURPS668_A0319(pvcB)
BPSE: BDL_6052(pvcB)
BPSM: BBQ_6053(pvcB)
BPSU: BBN_3541(pvcB)
BPSD: BBX_5222(pvcB)
BPK: BBK_5353(pvcB)
BPSH: DR55_5201(pvcB)
BPSA: BBU_3411(pvcB)
BPSO: X996_4969(pvcB)
BUT: X994_4518
BTE: BTH_II0230(pvcB)
BTQ: BTQ_3525(pvcB)
BTJ: BTJ_4562(pvcB)
BTZ: BTL_5349(pvcB)
BTV: BTHA_4852(pvcB)
BTHE: BTN_5020(pvcB)
BTHM: BTRA_5288(pvcB)
BTHA: DR62_5150
BTHL: BG87_5355
BOK: DM82_3790(pvcB)
BOC: BG90_4253
BUB: BW23_5843
BSTG: WT74_28465
SCL: sce8231
BBA: Bd1455(pvcB)
BBAT: Bdt_1441(pvcB)
BBAC: EP01_03535
RFA: A3L23_04936(carC)
SHY: SHJG_0583
SALS: SLNWT_6359
STRE: GZL_02118
SRN: A4G23_02273(tfdA)
ALO: CRK61877
 » show all
Taxonomy
Reference
1  [PMID:22711807]
  Authors
Crawford JM, Portmann C, Zhang X, Roeffaers MB, Clardy J
  Title
Small molecule perimeter defense in entomopathogenic bacteria.
  Journal
Proc Natl Acad Sci U S A 109:10821-6 (2012)
DOI:10.1073/pnas.1201160109
  Sequence
[xne:XNC1_1222] [plu:plu2817]
Reference
2  [PMID:25866990]
  Authors
Zhu J, Lippa GM, Gulick AM, Tipton PA
  Title
Examining Reaction Specificity in PvcB, a Source of Diversity in Isonitrile-Containing Natural Products.
  Journal
Biochemistry 54:2659-69 (2015)
DOI:10.1021/acs.biochem.5b00255
  Sequence
[xne:XNC1_1222]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.20.10
IUBMB Enzyme Nomenclature: 1.14.20.10
ExPASy - ENZYME nomenclature database: 1.14.20.10
BRENDA, the Enzyme Database: 1.14.20.10

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