KEGG   ENZYME: 1.14.20.5Help
Entry
EC 1.14.20.5                Enzyme                                 

Name
flavone synthase I;
FNSI (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and the other dehydrogenated
BRITE hierarchy
Sysname
flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating)
Reaction(IUBMB)
a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O [RN:R07367]
Reaction(KEGG)
Substrate
flavanone [CPD:C00766];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
flavone [CPD:C10043];
succinate [CPD:C00042];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
The enzyme, which has been found in rice and in members of the Apiaceae (a plant family), is a member of the 2-oxoglutarate-dependent dioxygenases, and requires ascorbate and Fe2+ for full activity.
History
EC 1.14.20.5 created 2004 as EC 1.14.11.22, transferred 2018 to EC 1.14.20.5
Pathway
ec00941  Flavonoid biosynthesis
ec00943  Isoflavonoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13077  flavone synthase I
Reference
1  [PMID:11524111]
  Authors
Martens S, Forkmann G, Matern U, Lukacin R.
  Title
Cloning of parsley flavone synthase I.
  Journal
Phytochemistry 58:43-6 (2001)
DOI:10.1016/S0031-9422(01)00191-1
  Sequence
Reference
2  [PMID:11516175]
  Authors
Lukacin R, Matern U, Junghanns KT, Heskamp ML, Britsch L, Forkmann G, Martens S.
  Title
Purification and antigenicity of flavone synthase I from irradiated parsley cells.
  Journal
Arch Biochem Biophys 393:177-83 (2001)
DOI:10.1006/abbi.2001.2491
Reference
3  [PMID:12782296]
  Authors
Martens S, Forkmann G, Britsch L, Wellmann F, Matern U, Lukacin R.
  Title
Divergent evolution of flavonoid 2-oxoglutarate-dependent dioxygenases in parsley.
  Journal
FEBS Lett 544:93-8 (2003)
DOI:10.1016/S0014-5793(03)00479-4
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.20.5
IUBMB Enzyme Nomenclature: 1.14.20.5
ExPASy - ENZYME nomenclature database: 1.14.20.5
BRENDA, the Enzyme Database: 1.14.20.5
CAS: 138263-98-6

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