KEGG   ENZYME: 1.14.20.8
Entry
EC 1.14.20.8                Enzyme                                 

Name
(-)-deoxypodophyllotoxin synthase;
2-ODD (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and the other dehydrogenated
Sysname
(-)-yatein,2-oxoglutarate:oxygen oxidoreductase (ring-forming)
Reaction(IUBMB)
(-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + succinate + CO2 + H2O [RN:R11210]
Reaction(KEGG)
R11210
Substrate
(-)-yatein [CPD:C10557];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
(-)-deoxypodophyllotoxin [CPD:C10556];
succinate [CPD:C00042];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the plant Sinopodophyllum hexandrum (mayapple), is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs. It catalyses the closure of the central six-membered ring in the aryltetralin scaffold.
History
EC 1.14.20.8 created 2016 as EC 1.14.11.50, transferred 2018 to EC 1.14.20.8
Pathway
ec00998  Biosynthesis of various secondary metabolites - part 2
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K21202  (-)-deoxypodophyllotoxin synthase
Reference
1  [PMID:26359402]
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.20.8
IUBMB Enzyme Nomenclature: 1.14.20.8
ExPASy - ENZYME nomenclature database: 1.14.20.8
BRENDA, the Enzyme Database: 1.14.20.8

DBGET integrated database retrieval system