KEGG   ENZYME: 1.14.99.29Help
Entry
EC 1.14.99.29               Enzyme                                 

Name
deoxyhypusine monooxygenase;
deoxyhypusine hydroxylase;
deoxyhypusine dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)
Reaction(IUBMB)
[eIF5A]-deoxyhypusine + reduced acceptor + O2 = [eIF5A]-hypusine + acceptor + H2O [RN:R04437]
Reaction(KEGG)
Substrate
[eIF5A]-deoxyhypusine;
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
[eIF5A]-hypusine;
acceptor [CPD:C00028];
H2O [CPD:C00001]
Comment
The enzyme catalyses the final step in the formation of the amino acid hypusine in the eukaryotic initiation factor 5A.
History
EC 1.14.99.29 created 1989
Orthology
K06072  deoxyhypusine monooxygenase
Genes
HSA: 83475(DOHH)
PTR: 455584(DOHH)
PPS: 100973656(DOHH)
GGO: 101131463(DOHH)
PON: 100431459(DOHH)
NLE: 100586450(DOHH)
MCC: 713046(DOHH)
MCF: 102127219(DOHH)
CSAB: 103233681(DOHH)
RRO: 104665447(DOHH)
RBB: 108512647(DOHH)
CJC: 100396021(DOHH)
SBQ: 101033544(DOHH)
MMU: 102115(Dohh)
RNO: 314644(Dohh)
CGE: 100771021(Dohh)
NGI: 103737252(Dohh)
HGL: 101714719(Dohh)
CCAN: 109687042(Dohh)
TUP: 102467940(DOHH)
CFA: 485060(DOHH)
AML: 100474985(DOHH)
UMR: 103681817(DOHH)
ORO: 101382295(DOHH)
FCA: 101087818(DOHH)
BTA: 526521(DOHH)
BOM: 102285210(DOHH)
BIU: 109560968(DOHH)
PHD: 102317870(DOHH)
CHX: 102175947(DOHH)
OAS: 100135444(DOHH)
SSC: 100519411(DOHH)
CFR: 102516932(DOHH)
CDK: 105102659(DOHH)
BACU: 103003472(DOHH)
LVE: 103079508(DOHH)
OOR: 101272998(DOHH)
ECB: 100146733(DOHH)
EAI: 106832312(DOHH)
MYB: 102257864(DOHH)
MYD: 102770038(DOHH)
HAI: 109388551(DOHH)
RSS: 109453946(DOHH)
PALE: 102889609(DOHH)
LAV: 100677317(DOHH)
TMU: 101357973
MDO: 100011238(DOHH)
SHR: 100919837(DOHH)
OAA: 100080366(DOHH)
GGA: 427066(DOHH)
MGP: 100542254(DOHH)
CJO: 107325561(DOHH)
ACYG: 106045642(DOHH)
GFR: 102039097(DOHH)
FAB: 101807533(DOHH)
PHI: 102102650(DOHH)
PMAJ: 107215414(DOHH)
CCW: 104696954(DOHH)
FPG: 101912874(DOHH)
FCH: 102047893(DOHH)
CLV: 102095236(DOHH)
EGZ: 104125045(DOHH)
AAM: 106486016(DOHH)
ASN: 102377351(DOHH)
AMJ: 102559276(DOHH)
PSS: 102452792(DOHH)
CMY: 102936318(DOHH)
CPIC: 101937590(DOHH)
PVT: 110079308(DOHH)
PBI: 103063683(DOHH)
GJA: 107115447(DOHH)
XLA: 447153(dohh.L)
XTR: 100145112(dohh)
NPR: 108802976(DOHH)
DRE: 321732(dohh)
SRX: 107731234(dohh) 107745802
SANH: 107676882(dohh) 107695215
CCAR: 109095170(dohh)
IPU: 108264976(dohh)
AMEX: 103039788(dohh)
TRU: 101076303(dohh)
LCO: 104927275(dohh)
NCC: 104964265(dohh)
MZE: 101473972(dohh)
OLA: 101174172(dohh)
XMA: 102219939(dohh)
PRET: 103464220(dohh)
NFU: 107387340(dohh)
CSEM: 103396847(dohh)
LCF: 108900699(dohh)
HCQ: 109516962(dohh)
ELS: 105011648(dohh)
SFM: 108939549(dohh)
LCM: 102349837(DOHH)
CMK: 103181911(dohh)
CIN: 100180246
SPU: 582221
APLC: 110984371
DME: Dmel_CG2245(nero)
DSI: Dsimw501_GD16326(Dsim_GD16326)
MDE: 101897972
AAG: 5567528
AME: 410763
BIM: 100744112
BTER: 100647775
SOC: 105199065
AEC: 105151414
ACEP: 105617358
PBAR: 105433719
HST: 105185531
CFO: 105251444
LHU: 105677857
PGC: 109863023
TCA: 659262
DPA: 109536937
NVL: 108561238
BMOR: 100188970(Dohh)
PMAC: 106718125
PXY: 105393841
API: 100161493(Dohh)
DNX: 107165433
ZNE: 110836130
FCD: 110859186
TUT: 107359333
CEL: CELE_C14A4.1(dohh-1)
BMY: Bm1_56815
TSP: Tsp_00421
CRG: 105337125
MYI: 110446923
OBI: 106882333
LAK: 106153717
SHX: MS3_00076
EPA: 110241098
ADF: 107331466
AQU: 100633136
ATH: AT3G58180
CRB: 17886718
BRP: 103841712
THJ: 104802841
CPAP: 110815116
CIT: 102622276
TCC: 18613188
GRA: 105767611
DZI: 111305270
EGR: 104426600
GMX: 100815364
VRA: 106757610
VAR: 108347998
CCAJ: 109798159
CAM: 101511485
LJA: Lj1g3v4483390.1(Lj1g3v4483390.1)
LANG: 109334722
FVE: 101303571
PPER: 18768946
PMUM: 103334512
PAVI: 110757485
ZJU: 107425835
CSV: 101220154
CMO: 103489734
MCHA: 111023477
CMAX: 111497653
CMOS: 111460813
CPEP: 111808421
RCU: 8274768
JCU: 105649873
JRE: 108996054
VVI: 100256697
SLY: 101249195
SPEN: 107026805
SOT: 102590353
CANN: 107868535
NSY: 104224664
NTO: 104106487
INI: 109171906
SIND: 105163395
HAN: 110884015
LSV: 111881252
BVG: 104894634
SOE: 110784195
DOSA: Os12t0163300-01(Os12g0163300) Os12t0626100-01(Os12g0626100)
OBR: 102712678
BDI: 100823998
ATS: 109737651(LOC109737651) 109757236(LOC109757236)
SBI: 8055325
SITA: 101757748
EGU: 105055595
MUS: 103973500
DCT: 110111583
AOF: 109850288
ATR: 18445675
PPP: 112288669
CRE: CHLREDRAFT_135382(DOH1)
VCN: VOLCADRAFT_102662(doh1)
MNG: MNEG_5690
APRO: F751_1748
SCE: YJR070C(LIA1)
ERC: Ecym_3146
KMX: KLMA_30041(LIA1)
NCS: NCAS_0G03470(NCAS0G03470)
NDI: NDAI_0D01500(NDAI0D01500)
TPF: TPHA_0F03590(TPHA0F03590)
TBL: TBLA_0D03650(TBLA0D03650)
TDL: TDEL_0F00400(TDEL0F00400)
KAF: KAFR_0E00270(KAFR0E00270)
PIC: PICST_79203(PPL1)
CAL: CAALFM_C207290WA(CaO19.2286)
CAUR: QG37_00660
SLB: AWJ20_5315(LIA1)
NCR: NCU05252
NTE: NEUTE1DRAFT80458(NEUTE1DRAFT_80458)
MGR: MGG_01725
MAW: MAC_01359
MAJ: MAA_06384
CMT: CCM_07698
MBE: MBM_00755
ANI: AN7498.2
ANG: ANI_1_1172094(An11g09380)
ABE: ARB_03888
TVE: TRV_06623
PTE: PTT_06531
SPO: SPAC30C2.02(mmd1)
CNE: CNL05340
CNB: CNBI1470
SCM: SCHCODRAFT_48631(MFBC)
ABP: AGABI1DRAFT120859(AGABI1DRAFT_120859)
ABV: AGABI2DRAFT119601(AGABI2DRAFT_119601) AGABI2DRAFT186631(AGABI2DRAFT_186631)
MGL: MGL_2350
DDI: DDB_G0272634(dohh-1) DDB_G0274079(dohh-2)
DFA: DFA_11694(dohh-2)
PYO: PY17X_1402700(PY00741)
PCB: PCHAS_140300(PC000483.00.0)
TAN: TA05925
TPV: TP01_0705
BBO: BBOV_IV009880(23.m06294)
SPAR: SPRG_05701
NMR: Nmar_1251
NCT: NMSP_0427
NBV: T478_1018
NDV: NDEV_1229
 » show all
Taxonomy
Reference
1  [PMID:3949761]
  Authors
Abbruzzese A, Park MH, Folk JE.
  Title
Deoxyhypusine hydroxylase from rat testis. Partial purification and characterization.
  Journal
J Biol Chem 261:3085-9 (1986)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.29
IUBMB Enzyme Nomenclature: 1.14.99.29
ExPASy - ENZYME nomenclature database: 1.14.99.29
BRENDA, the Enzyme Database: 1.14.99.29
CAS: 101920-83-6

DBGET integrated database retrieval system