KEGG   ENZYME: 1.14.99.29
Entry
EC 1.14.99.29               Enzyme                                 
Name
deoxyhypusine monooxygenase;
deoxyhypusine hydroxylase;
deoxyhypusine dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
Sysname
deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)
Reaction(IUBMB)
[eIF5A]-deoxyhypusine + reduced acceptor + O2 = [eIF5A]-hypusine + acceptor + H2O [RN:R04437]
Reaction(KEGG)
R04437
Substrate
[eIF5A]-deoxyhypusine;
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
[eIF5A]-hypusine;
acceptor [CPD:C00028];
H2O [CPD:C00001]
Comment
The enzyme catalyses the final step in the formation of the amino acid hypusine in the eukaryotic initiation factor 5A.
History
EC 1.14.99.29 created 1989
Orthology
K06072  deoxyhypusine monooxygenase
Genes
HSA83475(DOHH)
PTR455584(DOHH)
PPS100973656(DOHH)
GGO101131463(DOHH)
PON100431459(DOHH)
NLE100586450(DOHH)
MCC713046(DOHH)
MCF102127219(DOHH)
CSAB103233681(DOHH)
CATY105591778(DOHH)
PANU101023261(DOHH)
TGE112612623(DOHH)
RRO104665447(DOHH)
RBB108512647(DOHH)
TFN117075029(DOHH)
PTEH111520722(DOHH)
CJC100396021(DOHH)
SBQ101033544(DOHH)
CSYR103268782(DOHH)
MMUR105856686 105873999 105874000(DOHH)
OGA100951448(DOHH)
MMU102115(Dohh)
MCAL110303240(Dohh)
MPAH110326804(Dohh)
RNO314644(Dohh)
MCOC116076357(Dohh)
MUN110548542(Dohh)
CGE100771021(Dohh)
PLEU114688362(Dohh)
NGI103737252(Dohh)
HGL101714719(Dohh)
CPOC100732147(Dohh)
CCAN109687042(Dohh)
DSP122119840(Dohh)
NCAR124969301
OPI101519154(DOHH)
TUP102467940(DOHH)
CFA485060(DOHH)
VVP112935571(DOHH)
VLG121496089(DOHH)
AML100474985(DOHH)
UMR103681817(DOHH)
UAH113242799(DOHH)
UAR123796838(DOHH)
ELK111161770
LLV125086869
MPUF101693081(DOHH)
ORO101382295(DOHH)
EJU114226287(DOHH)
ZCA113918555(DOHH)
MLX118005538(DOHH)
FCA101087818(DOHH)
PYU121021548(DOHH)
PBG122486685(DOHH)
PPAD109255992(DOHH)
AJU113596411(DOHH)
HHV120242031(DOHH)
BTA526521(DOHH)
BOM102285210(DOHH)
BIU109560968(DOHH)
BBUB102394504(DOHH)
CHX102175947(DOHH)
OAS100135444(DOHH)
ODA120864803(DOHH)
CCAD122440209(DOHH)
SSC100519411(DOHH)
CFR102516932(DOHH)
CBAI105078188(DOHH)
CDK105102659(DOHH)
VPC102538670(DOHH)
BACU103003472(DOHH)
LVE103079508(DOHH)
OOR101272998(DOHH)
DLE111166146(DOHH)
PCAD102993841(DOHH)
PSIU116750804(DOHH)
ECB100146733(DOHH)
EAI106832312(DOHH)
MYB102257864(DOHH)
MYD102770038(DOHH)
MMYO118658239(DOHH)
MNA107525626(DOHH)
PKL118731369(DOHH)
HAI109388551(DOHH)
DRO112312462(DOHH)
SHON118984483(DOHH)
AJM119063718(DOHH)
PDIC114502394(DOHH)
PHAS123813799(DOHH)
MMF118615963(DOHH)
RFQ117038314(DOHH)
PALE102889609(DOHH)
PGIG120615354(DOHH)
PVP105300440(DOHH)
RAY107520141(DOHH)
MJV108393276(DOHH)
TOD119240558(DOHH)
SARA101540576 101540842
LAV100677317(DOHH)
TMU101357973
DNM101412093(DOHH)
MDO100011238(DOHH)
GAS123232156(DOHH)
SHR100919837(DOHH)
PCW110196234(DOHH)
OAA100080366(DOHH)
GGA427066(DOHH)
PCOC116236170(DOHH)
MGP100542254(DOHH)
CJO107325561(DOHH)
NMEL110388883(DOHH)
APLA113845620(DOHH)
AFUL116499100(DOHH)
TGU115490902(DOHH)
LSR110469466(DOHH)
SCAN103821896(DOHH)
PMOA120496368 120496420
OTC121345547(DOHH)
PRUF121352397(DOHH)
GFR102039097(DOHH)
FAB101807533(DOHH)
PHI102102650(DOHH)
PMAJ107215414(DOHH)
CCAE111943993(DOHH)
CCW104696954(DOHH)
ETL114073101
ZAB102063442(DOHH)
FPG101912874(DOHH)
FCH102047893(DOHH)
CLV102095236(DOHH)
NNI104019625(DOHH)
ACUN113489499(DOHH)
TALA104360979(DOHH)
ACHC115349093(DOHH)
AAM106486016(DOHH)
AROW112967637(DOHH)
NPD112952693(DOHH)
DNE112986270(DOHH)
ASN102377351(DOHH)
AMJ102559276(DOHH)
CPOO109320477(DOHH)
GGN109294800(DOHH)
PSS102452792(DOHH)
CMY102936318(DOHH)
CPIC101937590(DOHH)
TST117868921(DOHH)
CABI116826415(DOHH)
MRV120391511(DOHH)
PVT110079308(DOHH)
SUND121936445(DOHH)
PBI103063683(DOHH)
PMUR107282249(DOHH)
TSR106542093(DOHH)
PGUT117677477(DOHH)
VKO123035391(DOHH)
PMUA114588480(DOHH)
ZVI118087033(DOHH)
GJA107115447(DOHH)
XLA447153(dohh.L)
XTR100145112(dohh)
NPR108802976(DOHH)
RTEM120912317(DOHH)
BBUF120989561(DOHH)
BGAR122946751(DOHH)
DRE321732(dohh)
SRX107731234(dohh) 107745802
SANH107676882(dohh) 107695215
SGH107548993 107585881
CCAR109095170(dohh)
CAUA113107233(dohh)
IPU108264976(dohh)
PHYP113535316(dohh)
SMEO124399686(dohh)
TFD113654668(dohh)
AMEX103039788(dohh)
EEE113575154(dohh)
TRU101076303(dohh)
LCO104927275(dohh)
NCC104964265(dohh)
CGOB115007600(dohh)
ELY117254379(dohh)
PLEP121941249(dohh)
SLUC116058917(dohh)
ECRA117949982(dohh)
PFLV114561601(dohh)
GAT120823496(dohh)
PPUG119217084(dohh)
MSAM119901286 119903294
CUD121511874(dohh)
MZE101473972(dohh)
ONL100707462(dohh)
OAU116320847(dohh)
OLA101174172(dohh)
OML112136891(dohh)
XMA102219939(dohh)
XCO114151443(dohh)
XHE116716727(dohh)
PRET103464220(dohh)
PFOR103131978(dohh)
PMEI106909564(dohh)
GAF122838380(dohh)
CVG107098435(dohh)
CTUL119772093(dohh)
GMU124874536(dohh)
NFU107387340(dohh)
KMR108246954(dohh)
ALIM106517324(dohh)
NWH119419324(dohh)
AOCE111564058(dohh)
CSEM103396847(dohh)
POV109625879(dohh)
SSEN122781298(dohh)
HHIP117760678(dohh)
LCF108900699(dohh)
SDU111240096(dohh)
SLAL111660179(dohh)
XGL120791264(dohh)
HCQ109516962(dohh)
BPEC110162806 110170221
MALB109972181(dohh)
SASA106584359 106613855
OTW112243972 112250951
OMY110521518 110524389
OGO123996996 124037735
ONE115108392 115144967
SALP111972168 111975365
SNH120051819 120054833
ELS105011648(dohh)
SFM108939549(dohh)
PKI111860193(dohh)
AANG118226184(dohh)
LOC102696410(dohh)
PSPA121300754 121301608(dohh)
ARUT117401250 117966329
LCM102349837(DOHH)
CMK103181911(dohh)
RTP109922563(dohh)
BFO118431904
BBEL109475292
CIN100180246
SCLV120330205
SPU582221
APLC110984371
SKO100373600 100373751 100377403 100377704 100377999 100378204 102800457 102801402 102808410
DMEDmel_CG2245(nero)
DER6554113
DSE6619522
DSIDsimw501_GD16326(Dsim_GD16326)
DYADyak_GE23304
DAN6505896
DSR110186640
DPODpse_GA15318
DPE6587973
DMN108154640
DWI6651712
DGR6569672
DMODmoj_GI10655
DAZ108621745
DNV108653781
DHE111596892
DVI6630945
CCAT101449077
BOD106619107
MDE101897972
SCAC106081053
LCQ111688401
AGAAgaP_AGAP002129
ACOZ120952654
AARA120897770
AAG5567528
AALB109413668
CQUCpipJ_CPIJ003558
CPII120414438
CNS116350722
AME410763
ACER107992729
ALAB122712196
BIM100744112
BBIF117206911
BVK117235200
BVAN117153673
BTER100647775
BPYO122569139
CCAL108632170
OBB114872291
MGEN117227045
NMEA116434706
CGIG122403717
SOC105199065
MPHA105835981
AEC105151414
ACEP105617358
PBAR105433719
VEM105563939
HST105185531
DQU106742705
CFO105251444
FEX115244827
LHU105677857
PGC109863023
OBO105283265
PCF106788882
PFUC122517669
VPS122637557
NVI116415676
CSOL105362197
TPRE106648371
MDL103570724
CGLO123265389
FAS105272828
DAM107036455
AGIF122859595 122859615
CCIN107275011
TCA659262
DPA109536937
SOY115881111
ATD109596705
CSET123316388
AGB108914360
LDC111512574
NVL108561238
APLN108737236
PPYR116166487
OTU111424648
BMOR100188970(Dohh)
BMAN114253258
MSEX115443630
DPLKGM_200312
BANY112048115
PMAC106718125
PPOT106106968
PXU106118750 106118827 106120414
PRAP110997348
ZCE119832615
HAW110379136
TNL113492078
OFU114353768
PXY105393841
API100161493(Dohh)
DNX107165433
AGS114127330
RMD113556604
BTAB109035624
DCI103504908 103504922
CLEC106667399
HHAL106684857
NLU111055242
PHUPhum_PHUM432000
FOC113213112
ZNE110836130
CSEC111862928
FCD110859186
DPXDAPPUDRAFT_196422
DMK116934454
PVM113820582
PJA122263316
PCHN125036879
HAME121857130
PCLA123759065
PTRU123513193
HAZT108676752
EAF111697169
DSV119450628
RSAN119383778
RMP119170686
VDE111244107
VJA111261404
TUT107359333
DPTE113793659 113796148
DFR124494224
CSCU111637747
PTEP107436786
SDM118202795
CELCELE_C14A4.1(dohh-1)
CBRCBG_25571(Cbr-dohh-1)
BMYBM_BM13744(Bma-dohh-1)
NAINECAME_06771
TSPTsp_00421
HROHELRODRAFT_186235
LGILOTGIDRAFT_189149
PCAN112573162
BGT106063681
GAE121375095
HRF124142864
HRJ124275299
CRG105337125
MYI110446923
PMAX117325281
MMER123524530
OBI106882333
OSN115215169 115230128
LAK106153717
SMMSmp_056370
OVIT265_09943
NVE5511624
EPA110241098
ATEN116288897
ADF107331466
AMIL114972626
PDAM113674376
SPIS111342163
DGT114525940
XEN124446191
HMG100198981 100208361
TADTRIADDRAFT_18390
AQU100633136
ATHAT3G58180
ALY9314261
CRB17886718
CSAT104712508 104730040 104744201 104781736 104792114 109124807
EUSEUTSA_v10006107mg
BRP103830147 103841712
BNA106353199 106368161 106368256 106437308
BOE106298346 106309707
RSZ108817939 108857454
THJ104802841
CPAP110815116
CIT102622276
CICCICLE_v10021217mg
PVY116120648
MINC123222671
TCC18613188
GRA105767611
GHI107936746 107955448
GAB108451839
DZI111305270
EGR104426600
GMX100815364
GSJ114406912
PVUPHAVU_001G159000g
VRA106757610
VAR108347998
VUN114191873
CCAJ109798159
APRC113863073
MTRMTR_7g096510
CAM101511485
LJALj1g3v4483390.1(Lj1g3v4483390.1)
ADU107457770 107488159
AIP107609800 107626410
AHF112702473 112720430 112765089 112784917
LANG109334722
FVE101303571
RCN112172621
PPER18768946
PMUM103334512
PAVI110757485
PDUL117636575
MDM114824918 114827692
PXB103946028
ZJU107425835
MNT21409036
CSV101220154
CMO103489734
BHJ120085296
MCHA111023477
CMAX111497653
CMOS111460813
CPEP111808421
RCU8274768
JCU105649873
HBR110632052 110644880
MESC110616369
POP7454337 7471983
PEU105126748 105128690
PALZ118049373 118062200
JRE108996054
QSU111987546 111995219 112033220
QLO115962154
TWL120007716 120010383
VVI100256697
VRI117917297
SLY101249195
SPEN107026805
SOT102590353
CANN107868535
NTA107784158 107797285 107816705
NSY104224664
NTO104106487
NAU109231302 109239609
INI109171906
ITR116024877
SIND105163395
OEU111372033 111379135 111411858
EGT105952422
SSPL121742581 121752109
HAN110884015
ECAD122607483
LSV111881252
CCAV112517829 112518667
DCR108211535 108214980
CSIN114274201
BVG104894634
SOE110784195
CQI110733148 110734383
NNU104600830 104610068
MING122066884
TSS122671217
PSOM113284623 113288404 113319457 113348673
NCOL116252672 116253053 116265620
OSA4351581 4352843
DOSAOs12t0163300-01(Os12g0163300) Os12t0626100-01(Os12g0626100)
OBR102712678
BDI100823998
ATS109737651 109757236
TDC119318573 119324826
TAES123129046 123139911 123146043 123146218
SBI8055325
ZMA100191312
SITA101757748
SVS117841608
PVIR120646930 120657649
PHAI112895073
PDA103705470
EGU105055595
MUS103973500
DCT110111583
PEQ110019592
AOF109850288
ATR18445675
SMOSELMODRAFT_123780 SELMODRAFT_269431
PPP112288669
CRECHLRE_10g435550v5
VCNVOLCADRAFT_102662(doh1)
MNGMNEG_5690
CSLCOCSUDRAFT_17554
CVRCHLNCDRAFT_36505
APROF751_1748
OLUOSTLU_18290
OTAOT_ostta16g00870
BPGBathy07g04230
MISMICPUN_60156
MPPMICPUCDRAFT_30818
CMECYME_CMT344C
GSLGasu_14920
CCPCHC_T00000296001
SCEYJR070C(LIA1)
AGOAGOS_AFR426C
ERCEcym_3146
KLAKLLA0_B14080g
KMXKLMA_30041(LIA1)
LTHKLTH0C02354g
VPOKpol_1054p54
ZROZYRO0G02090g
CGRCAGL0F00407g
NCSNCAS_0G03470(NCAS0G03470)
NDINDAI_0D01500(NDAI0D01500)
TPFTPHA_0F03590(TPHA0F03590)
TBLTBLA_0D03650(TBLA0D03650)
TDLTDEL_0F00400(TDEL0F00400)
TGBHG536_0G04650
KAFKAFR_0E00270(KAFR0E00270)
ZMKHG535_0G05430
PPAPAS_chr2-1_0553
DHADEHA2F23518g
PICPICST_79203(PPL1)
PGUPGUG_00437
SPAASPAPADRAFT_150589
LELLELG_02463
CALCAALFM_C207290WA(CaO19.2286)
CTPCTRG_01728
COTCORT_0C05820
CDUCD36_21560
CTENCANTEDRAFT_113656
YLIYALI0A08129g
CLUCLUG_04630
CLUSA9F13_11g01639
CAURCJI97_001471
SLBAWJ20_5315(LIA1)
PKZC5L36_0B04990
BNNFOA43_001903(LIA1)
BBRXBRETT_004604(LIA1)
NCRNCU05252
NTENEUTE1DRAFT80458(NEUTE1DRAFT_80458)
SMPSMAC_01736 SMAC_01737
PANPODANSg6292
TTTTHITE_2115568
MTMMYCTH_2299125
CTHRCTHT_0032300
MGRMGG_01725
SSCKSPSK_01832
FGRFGSG_09773
FPUFPSE_02301
FVRFVEG_06388
FOXFOXG_08287
NHENECHADRAFT_66463
TRETRIREDRAFT_120147
TRRM419DRAFT_23681
MAWMAC_01359
MAJMAA_06384
CMTCCM_07698
PLJVFPFJ_01138
VALVDBG_01089
VDAVDAG_00697
CFJCFIO01_03682
SAPOSAPIO_CDS8382
ELAUCREL1_11459
PFYPFICI_05148
SSLSS1G_08335
BFUBCIN_12g01940(Bclia1)
MBEMBM_00755
PSCOLY89DRAFT_692069
GLZGLAREA_05089
ANIAN7498.2
AFMAFUA_2G05490
ACTACLA_089210
NFINFIA_082210
AORAO090001000660
ANGANI_1_1172094(An11g09380)
AFVAFLA_012793
ALUCAKAW2_80795A(LIA1)
ACHEACHE_80334S(LIA1)
APUUAPUU_80543A(LIA1)
PCSPc22g09120
PDPPDIP_86700
TMFPMAA_071640
TRGTRUGW13939_06326
CIMCIMG_00751
CPWCPC735_055430
UREUREG_00729
PBLPAAG_02267
PBNPADG_05404
ABEARB_03888
TVETRV_06623
AJEHCAG_00971
BGHBDBG_08922
PNOSNOG_08746
PTEPTT_06531
BZECOCCADRAFT_90966
BSCCOCSADRAFT_32122
BORCOCMIDRAFT_32157
AALTCC77DRAFT_963513
ZTRMYCGRDRAFT_62164
PFJMYCFIDRAFT_30774
BCOMBAUCODRAFT_38836
NPAUCRNP2_1876
TMLGSTUM_00007940001
SPOSPAC30C2.02(mmd1)
CNECNL05340
CNBCNBI1470
CGICGB_D1680C
TMSTREMEDRAFT_35735
TASAA1Q1_02858
TVSTRAVEDRAFT_166724
DSQDICSQDRAFT_102948
PCOPHACADRAFT_262083
SHSSTEHIDRAFT_157556
HIRHETIRDRAFT_51265
PSQPUNSTDRAFT_97134
ADLAURDEDRAFT_121604
FMEFOMMEDRAFT_170743
GTRGLOTRDRAFT_61765
LBCLACBIDRAFT_292511
MPRMPER_05500
MRRMoror_12483
CCICC1G_02985
SCMSCHCODRAFT_48631(MFBC)
ABPAGABI1DRAFT120859(AGABI1DRAFT_120859)
ABVAGABI2DRAFT119601(AGABI2DRAFT_119601) AGABI2DRAFT186631(AGABI2DRAFT_186631)
CPUTCONPUDRAFT_123875
SLASERLADRAFT_470342
WSEWALSEDRAFT_53819
WICJ056_000053
UMAUMAG_00319
PFPPFL1_03665
MGLMGL_2350
MRTMRET_0162
MSYMMSY001_2052
PGRPGTG_03230
MLRMELLADRAFT_50851
ECUECU06_1490
EINEint_061460
EHEEHEL_061480
EROEROM_061480
MBRMONBRDRAFT_36356
SREPTSG_10762
DDIDDB_G0272634(dohh-1) DDB_G0274079(dohh-2)
DPPDICPUDRAFT_158856
DFADFA_11694(dohh-2)
ACANACA1_112960
PFAPF3D7_1302600
PFDPFDG_03639
PFHPFHG_04960
PREIPRSY57_1301600
PYOPY17X_1402700
PCBPCHAS_140300(PC000483.00.0)
PBEPBANKA_1401100
PVVPVVCY_1400280
PKNPKNH_1402800
PVXPVX_121970
PCYPCYB_141210
TANTA05925
TPVTP01_0705
TOTTOT_010000638
BEQBEWA_037590
BBOBBOV_IV009880(23.m06294)
BMICBMR1_03g00946
BBIGBBBOND_0107370
CPVcgd4_410
CHOChro.40055
TGOTGME49_290340
PTMGSPATT00036363001
FCYFRACYDRAFT_242381
TPSTHAPSDRAFT_31438
AAFAURANDRAFT_20061 AURANDRAFT_35297
PIFPITG_09484
PSOJPHYSODRAFT_514765
SPARSPRG_05701
EHXEMIHUDRAFT_64969 EMIHUDRAFT_76411
GTTGUITHDRAFT_150311 GUITHDRAFT_165660
TBRTb09.160.1240
TBGTbgDal_IX1120
TCR507615.70 508347.130
LMALMJF_26_1910
LIFLINJ_26_1920
LDOLDBPK_261920
LMILMXM_26_1910
LBZLBRM_26_1840
LPANLPMP_261880
NGRNAEGRDRAFT_58670
 » show all
Reference
1  [PMID:3949761]
  Authors
Abbruzzese A, Park MH, Folk JE.
  Title
Deoxyhypusine hydroxylase from rat testis. Partial purification and characterization.
  Journal
J Biol Chem 261:3085-9 (1986)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.29
IUBMB Enzyme Nomenclature: 1.14.99.29
ExPASy - ENZYME nomenclature database: 1.14.99.29
BRENDA, the Enzyme Database: 1.14.99.29
CAS: 101920-83-6

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