| Entry |
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| Name |
progesterone monooxygenase;
progesterone hydroxylase
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
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| Sysname |
progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)
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| Reaction(IUBMB) |
progesterone + reduced acceptor + O2 = testosterone acetate + acceptor + H2O [RN: R02212]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Has a wide specificity. A single enzyme from ascomycete the Neonectria radicicola (EC 1.14.13.54 ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC 1.14.99.12 androst-4-ene-3,17-dione monooxygenase.
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| History |
EC 1.14.99.4 created 1972, modified 1999
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| Reference |
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| Authors |
Rahm MA, Sih CJ. |
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| Title |
Mechanisms of steroid oxidation by microorganisms. XI. Enzymatic cleavage of the pregnane side chain. |
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| Journal |
J Biol Chem 241:3615-23 (1966) |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.14.99.4 |
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