Entry
Name
progesterone monooxygenase;
progesterone hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)
Reaction(IUBMB)
progesterone + reduced acceptor + O2 = testosterone acetate + acceptor + H2O [RN:
R02212 ]
Reaction(KEGG)
Substrate
Product
Comment
Has a wide specificity. A single enzyme from ascomycete the Neonectria radicicola (EC
1.14.13.54 ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC
1.14.99.12 androst-4-ene-3,17-dione monooxygenase.
History
EC 1.14.99.4 created 1972, modified 1999
Reference
Authors
Rahm MA, Sih CJ.
Title
Mechanisms of steroid oxidation by microorganisms. XI. Enzymatic cleavage of the pregnane side chain.
Journal
J Biol Chem 241:3615-23 (1966)
Other DBs
ExPASy - ENZYME nomenclature database: 1.14.99.4