KEGG   ENZYME: 1.14.99.44
Entry
EC 1.14.99.44               Enzyme                                 

Name
diapolycopene oxygenase;
crtP (ambiguous)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
Sysname
4,4'-diapolycopene,AH2:oxygen oxidoreductase (4,4'-hydroxylating)
Reaction(IUBMB)
4,4'-diapolycopene + 4 reduced acceptor + 4 O2 = 4,4'-diapolycopenedial + 4 acceptor + 6 H2O [RN:R09671]
Reaction(KEGG)
R09671;
(other) R07654 R09727 R09728
Substrate
4,4'-diapolycopene [CPD:C19797];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
4,4'-diapolycopenedial [CPD:C19798];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Comment
Little activity with neurosporene or lycopene. Involved in the biosynthesis of C30 carotenoids such as staphyloxanthin. The enzyme oxidizes each methyl group to the hydroxymethyl and then a dihydroxymethyl group, followed by the spontaneous loss of water to give an aldehyde group.
History
EC 1.14.99.44 created 2011
Pathway
ec00906  Carotenoid biosynthesis
Orthology
K10210  diapolycopene oxygenase
Genes
MMT: Metme_3774
MDN: JT25_002365
MDH: AYM39_15930
MKO: MKLM6_3290
METL: U737_16970(crtI)
MPSY: CEK71_14805
KUS: B9G99_06335
KMA: B9H00_08720
DSF: UWK_02975
MEA: Mex_1p3665(ctrI)
MDI: METDI4240(ctrI)
MEX: Mext_3436
MCH: Mchl_3745
MPO: Mpop_3632
MET: M446_3156
MOR: MOC_5734
META: Y590_16875
MMES: MMSR116_03635(crtI)
GOH: B932_2266
GTI: FXF46_11910(crtI) FXF46_15790(crtI)
ABG: Asbog_01465(crtI)
RMUC: FOB66_05790(crtI)
NTN: D5366_08600(crtI)
AOZ: HUE56_02795(crtI)
BPU: BPUM_2690
BPUM: BW16_14510
BPUS: UP12_13760
BMH: BMWSH_3258(crtI)
BMEG: BG04_4322(crtP)
BACW: QR42_13585
BBEV: BBEV_0577(crtP-1) BBEV_1363(crtP-2)
BALT: CFN77_14445(crtI)
BPF: BpOF4_14565(crtP)
OIH: OB2459
AFL: Aflv_2195
PSYH: D0S48_20355(crtI)
POF: GS400_07995(crtI)
MEKU: HUW50_18265(crtI)
SAU: SA2351
SAV: SAV2564
SAW: SAHV_2548
SAM: MW2485
SAS: SAS2450
SAR: SAR2646
SAC: SACOL2579
SAE: NWMN_2464(crtI)
SAD: SAAV_2630
SUJ: SAA6159_02460(crtI)
SUK: SAA6008_02603(crtI)
SUC: ECTR2_2417(crtI)
SUQ: HMPREF0772_10625(crtI)
SUZ: MS7_2571(crtP)
SUG: SAPIG2615
SAUA: SAAG_00385
SAUS: SA40_2318
SAUU: SA957_2402
SAUG: SA268_2480
SAUV: SAI7S6_1019090(crtP)
SAUW: SAI5S5_1019030(crtP)
SAUX: SAI6T6_1019040(crtP)
SAUY: SAI8T7_1019070(crtP)
SAUF: X998_2547
SAB: SAB2437c
SAUB: C248_2622
SAUC: CA347_2640(crtP)
SAUR: SABB_01120(crtP)
SAUI: AZ30_13435
SAUD: CH52_06180
SAMS: NI36_12830
SHA: SH0488
SHH: ShL2_00389(crtI)
SXO: SXYL_00051(crtP)
SCAP: AYP1020_1735(crtP)
SARL: SAP2_00910(crtP)
LGZ: NCTC10812_02741(crtP)
ESI: Exig_0738
EAN: Eab7_0711
PSWU: SY83_16585
PBK: Back11_13210(crtP)
COHN: KCTCHS21_30250(crtP_1) KCTCHS21_30350(crtP_2)
SACA: FFV09_16680(crtI)
SIV: SSIL_3759
JEO: JMA_07510
KZO: NCTC404_02426(crtP)
SPOS: DV702_13350(crtI)
PANC: E2636_00235(crtI)
PLAY: DNR44_006400(crtI) DNR44_016995(crtI)
KPUL: GXN76_05120(crtI)
ECAS: ECBG_01335
EMU: EMQU_0489
CRN: CAR_c19220(crtP)
JDA: BW727_102018(crtP)
CAG: Cagg_2983
ROO: G5S37_15655(crtI)
PIR: VN12_20065(crtP)
RUL: UC8_21150(crtP)
PLM: Plim_2740
PEH: Spb1_35070(crtP)
PLS: VT03_32435(crtP)
PLH: VT85_17065(crtP)
GES: VT84_20055(carA2)
FTJ: FTUN_7583
IPA: Isop_0988
PBOR: BSF38_05169(crtP)
AGV: OJF2_67080(crtP)
PHM: PSMK_03760(crtI)
ACA: ACP_2301
ABAS: ACPOL_3674
BLQ: L21SP5_01096(crtP)
PGIN: FRZ67_12085(crtI)
SGN: SGRA_1067
SPIB: G8759_08155(crtI)
RUP: DTQ70_22340(crtI)
FAE: FAES_0082(crtI)
PSEZ: HME7025_02380(crtI)
NIB: GU926_12040(crtI)
ADD: HUW48_24355(crtI)
ASWU: HUW51_08650(crtI)
FLL: EI427_04945(crtI)
MARE: EJ994_07520(crtI)
NDO: DDD_2394
NOJ: EJ995_11890(crtI)
POM: MED152_02575(crtI1)
SPON: HME9304_02555(crtI)
AQB: D1818_13185(crtI)
AQA: D1815_18000(crtI)
OCI: FEZ18_11935(crtI)
CAGG: HYG79_01990(crtI)
IAL: IALB_0396(crtI)
CPRV: CYPRO_2658
 » show all
Reference
1  [PMID:15850982]
  Authors
Mijts BN, Lee PC, Schmidt-Dannert C
  Title
Identification of a carotenoid oxygenase synthesizing acyclic xanthophylls: combinatorial biosynthesis and directed evolution.
  Journal
Chem Biol 12:453-60 (2005)
DOI:10.1016/j.chembiol.2005.02.010
  Sequence
[sav:SAV2564]
Reference
2  [PMID:15933032]
  Authors
Tao L, Schenzle A, Odom JM, Cheng Q
  Title
Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde.
  Journal
Appl Environ Microbiol 71:3294-301 (2005)
DOI:10.1128/AEM.71.6.3294-3301.2005
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.44
IUBMB Enzyme Nomenclature: 1.14.99.44
ExPASy - ENZYME nomenclature database: 1.14.99.44
BRENDA, the Enzyme Database: 1.14.99.44

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