KEGG ENZYME: 1.14.99.46

ENZYME: 1.14.99.46

Entry

EC 1.14.99.46               Enzyme

Name

pyrimidine oxygenase;
rutA (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous

Sysname

uracil,FMNH2:oxygen oxidoreductase (uracil hydroxylating, ring-opening)

Reaction(IUBMB)

(1) uracil + FMNH2 + O2 + NADH = (Z)-3-ureidoacrylate + H2O + FMN + NAD+ + H+ (overall reaction) [RN:R12544];
(1a) FMNH2 + O2 = FMN-N5-peroxide [RN:R12756];
(1b) uracil + FMN-N5-peroxide = (Z)-3-ureidoacrylate + FMN-N5-oxide [RN:R12545];
(1c) FMN-N5-oxide + NADH = FMN + H2O + NAD+ + H+ (spontaneous) [RN:R12539];
(2) thymine + FMNH2 + O2 + NADH = (Z)-2-methylureidoacrylate + H2O + FMN + NAD+ + H+ (overall reaction) [RN:R12546];
(2a) FMNH2 + O2 = FMN-N5-peroxide;
(2b) thymine + FMN-N5-peroxide = (Z)-2-methylureidoacrylate + FMN-N5-oxide [RN:R12547];
(2c) FMN-N5-oxide + NADH = FMN + H2O + NAD+ + H+ (spontaneous)

Reaction(KEGG)

R12539 R12544 R12545 R12546 R12547 R12756;
(other) R09936 R09937

Substrate

uracil [CPD:C00106];
FMNH2 [CPD:C01847];
O2 [CPD:C00007];
NADH [CPD:C00004];
FMN-N5-peroxide [CPD:C22379];
FMN-N5-oxide [CPD:C22238];
thymine [CPD:C00178]

Product

(Z)-3-ureidoacrylate [CPD:C20254];
H2O [CPD:C00001];
FMN [CPD:C00061];
NAD+ [CPD:C00003];
H+ [CPD:C00080];
FMN-N5-peroxide [CPD:C22379];
FMN-N5-oxide [CPD:C22238];
(Z)-2-methylureidoacrylate [CPD:C20256]

Comment

The enzyme participates in the Rut pyrimidine catabolic pathway. The flavin-N5-oxide that is formed by the enzyme reacts spontaneously with NADH to give oxidized flavin, releasing a water molecule.

History

EC 1.14.99.46 created 2012, modified 2019

Pathway

ec00240

Pyrimidine metabolism

ec01100

Metabolic pathways

Orthology

K09018

pyrimidine oxygenase

Genes

ECO:	b1012(rutA)

ECJ:	JW0997(ycdM)

ECD:	ECDH10B_1084(rutA)

EBW:	BWG_0866(rutA)

ECOK:

ECMDS42_0857(ycdM)

ECOC:

C3026_06155

ECE:

Z1511

ECS:	ECs_1258(rutA)

ECF:	ECH74115_1249

ETW:

ECSP_1181

ELX:	CDCO157_1203

EOI:	ECO111_1201(ycdM)

EOJ:	ECO26_1250(ycdM)

EOH:	ECO103_1058(ycdM)

ECOO:

ECRM13514_1189(rutA)

ECOH:

ECRM13516_1118(rutA)

ESL:

O3K_15925

ESO:

O3O_09370

ESM:

O3M_15900

ECK:	EC55989_1123(rutA)

ECG:	E2348C_1063(rutA)

EOK:	G2583_1245(rutA)

ELR:	ECO55CA74_06090

ELH:

ETEC_1081

ECW:	EcE24377A_1130

EUN:	UMNK88_1167

ECP:

ECP_1011

ENA:	ECNA114_1083

ECOS:

EC958_1209(ycdM)

ECV:	APECO1_103(ycdM)

ECOA:

APECO78_09050

ECX:	EcHS_A1127

ECM:	EcSMS35_2113

ECY:

ECSE_1074

ECR:	ECIAI1_1057(rutA)

ECQ:	ECED1_1168(rutA)

EUM:	ECUMN_1195(rutA)

ECT:	ECIAI39_2143(rutA)

EOC:	CE10_1090(rutA)

EBR:	ECB_01015(ycdM)

ECOB:

C3029_09505

EBL:	ECD_01015(rutA)

EBE:	B21_01022(rutA)

EBD:

ECBD_2582

ECI:	UTI89_C1075(ycdM)

EIH:	ECOK1_1064

ECZ:	ECS88_1028(rutA)

ECC:

c1149

ELO:	EC042_1087(rutA)

ELN:	NRG857_04905

ESE:

ECSF_0918

ECL:	EcolC_2583

EKO:	EKO11_2818

EKF:	KO11_17660(rutA)

EAB:	ECABU_c10390(rutA)

EDH:	EcDH1_2630

EDJ:	ECDH1ME8569_0966(rutA)

ELU:	UM146_12550

ELW:	ECW_m1122(rutA)

ELL:	WFL_05475(rutA)

ELC:

i14_1049

ELD:

i02_1049

ELP:	P12B_c0997(ycdM)

ELF:	LF82_2049(rutA)

ECOL:

LY180_05300

ECOI:

ECOPMV1_01034(rutA)

ECOJ:

P423_05500

ESZ:	FEM44_19940(rutA)

SFL:

SF1015

SFX:

S1085

SFV:

SFV_1024

SFE:	SFxv_1101(rutA)

SFN:

SFy_1390

SFS:

SFyv_1433

SFT:	NCTC1_01054(rutA)

SBO:

SBO_2045

SBC:	SbBS512_E2306

SDY:

SDY_0987

SDZ:	Asd1617_01250

SHQ:	A0259_09190

ENC:	ECL_02622(rutA)

ENL:	A3UG_08165

ECLG:

EC036_15740

ECLE:

ECNIH2_08810

ECLN:

ECNIH4_14485

ECLI:

ECNIH5_07855

ECLX:

LI66_07890

ECLY:

LI62_08680

ECLZ:

LI64_08215

EHM:	AB284_17095

EXF:	BFV63_07825

ECLA:

ECNIH3_07870

ECLC:

ECR091_07845

EAU:	DI57_10690

EKB:	BFV64_08135

ENO:	ECENHK_08170

EEC:	EcWSU1_01610(rutA)

ELG:	BH714_04140

ERN:	BFV67_07755

ECLS:

LI67_009230

ECHG:

FY206_09415(rutA)

ESH:	C1N69_08300(rutA)

EPT:	HWQ17_04590(rutA)

ENT:	Ent638_1525

EAS:	Entas_1550

ENX:	NI40_007670

ENF:	AKI40_2539(rutA)

LNI:	CWR52_04065(rutA)

EBG:	FAI37_21405(rutA)

END:	A4308_12860

ENZ:	G0034_07985(rutA)

ENS:	HWQ15_16315(rutA)

ENK:	LOC22_18605(rutA)

EHU:	D5067_0014620(rutA)

EMOR:

L6Y89_07905(rutA)

ENB:	ELK40_08555(rutA)

EQU:	OM418_07885(rutA)

EPU:	QVH39_08310(rutA)

EDY:	F0320_07555(rutA)

ESA:

ESA_02361

CSK:	ES15_2461(rutA)

CSZ:	CSSP291_10995

CSJ:	CSK29544_03670

CCON:

AFK62_07355

CDM:	AFK67_07585

CSI:	P262_03590

CMJ:	AFK66_012350

CUI:	AFK65_07345

CMW:	AFK63_11270

CTU:	CTU_15930(rutA)

KPN:	KPN_01038(ycdM)

KPU:	KP1_2027(ycdM)

KPM:	KPHS_19140

KPP:

A79E_3194

KPH:	KPNIH24_18945

KPZ:	KPNIH27_09050

KPV:	KPNIH29_09575

KPW:	KPNIH30_10090

KPY:	KPNIH31_09465

KPG:	KPNIH32_09930

KPC:	KPNIH10_09580

KPQ:	KPR0928_09755

KPT:	VK055_1439(rutA)

KPO:	KPN2242_08260

KPR:	KPR_3485(rutA)

KPJ:

N559_3248

KPI:	D364_05395

KPA:	KPNJ1_03488

KPS:	KPNJ2_03477

KPX:	PMK1_03378(rutA)

KPB:	FH42_01045

KPNE:

KU54_016570

KPNU:

LI86_16880

KPNK:

BN49_2127(rutA)

KVA:

Kvar_3341

KPE:

KPK_3520

KPK:	A593_19690

KVD:	KR75_17360

KVQ:	SP68_23735

KOX:

KOX_17000

KOE:

A225_2250

KOY:	J415_20535

KOM:	HR38_15525

KOK:	KONIH1_11005

KOC:	AB185_25130

KQU:	AVR78_14230

EAE:

EAE_16035

EAR:

CCG30700

KQV:	B8P98_18060(rutA)

KLL:	BJF97_11280

KLW:	DA718_17555(rutA)

KAR:	LGL98_16035(rutA)

KGR:	JJJ10_17520(rutA)

KPAS:

LUW96_17625(rutA)

KLC:	K7H21_17235(rutA)

KLM:	BWI76_10780

REE:	electrica_03235(rutA)

ROR:	RORB6_09465

RON:	TE10_11095

RPLN:

B1209_17360

RAO:	DSD31_16095(rutA)

RTG:	NCTC13098_04743(rutA)

PGE:	LG71_19240

KOR:	AWR26_15860(rutA)

KRD:	A3780_08430

KOO:	O9K67_15450(rutA)

KOU:	C0557_08830(rutA)

LAX:	APT61_14385

LEI:	C2U54_13140(rutA)

LEH:	C3F35_03165(rutA)

LEE:	DVA44_15420(rutA)

LER:	GNG29_08310(rutA)

LEA:	GNG26_07930(rutA)

LPNU:

KQ929_12895(rutA)

LEY:	DVA43_09500(rutA)

LEF:	LJPFL01_1557

LEW:	DAI21_18780(rutA)

BUF:	D8682_07195(rutA)

BAGE:

BADSM9389_26670(rutA)

BFT:	MNO13_16125(rutA)

KIN:	AB182_16015

PDZ:	HHA33_18600(rutA)

METY:

MRY16398_36470(rutA)

IZH:	FEM41_12165(rutA)

EBC:	C2U52_26760(rutA)

EBU:	CUC76_06065(rutA)

PSTS:

E05_37920

YEN:	YE1950(ssuD)

YEW:	CH47_1382(rutA)

YEF:	FORC2_2482

YEE:	YE5303_22861(ssuD)

YAK:	ACZ76_00785

YMA:	DA391_09485(rutA)

SPE:

Spro_1823

SRR:	SerAS9_1768

SRL:	SOD_c16480(rutA)

SRY:	M621_09130

SPLY:

Q5A_009030(rutA)

SRS:	SerAS12_1768

SRA:	SerAS13_1769

SLQ:	M495_08455

SQU:	E4343_07070(rutA)

SFJ:	SAMEA4384070_1850(rutA)

SENP:

KHA73_09110(rutA)

SGRI:

SGBXF1_01754(rutA)

RAH:	Rahaq_3017

RACE:

JHW33_09275(rutA)

RAQ:	Rahaq2_3045

RAA:

Q7S_15215

ROX:	BV494_10020

RVC:	J9880_00925(rutA)

RBON:

QNM34_15500(rutA)

RIU:	I2123_09145(rutA)

GQU:	AWC35_20505

EAME:

GXP68_07350(rutA)

RBAD:

H2866_14920(rutA)

RCB:	O1V66_10845(rutA)

CARU:

P0E69_12675(rutA)

NIG:	C1N62_10495(rutA)

LPOP:

I6N93_14380

EBI:	EbC_11600 EbC_15660(rutA)

EPE:	CI789_10745(rutA)

ERWI:

GN242_13265(rutA)

ERP:	LJN55_07860(rutA)

EPI:	Q3V30_13680(rutA) Q3V30_19520

ETO:	RIN69_08605(rutA)

EGE:	EM595_1350(rutA)

PAM:	PANA_4033(ycdM)

PLF:	PANA5342_p10175(rutA3)

PAJ:	PAJ_p0253(ycdM)

PAQ:

PAGR_p120

PVA:	Pvag_0805(ycdM)

PAGG:

AL522_11305(rutA)

PAO:	Pat9b_1395

KLN:	LH22_15225

PANT:

PSNIH1_11545

PANP:

PSNIH2_10710

PAGC:

BEE12_13795

PSTW:

DSJ_25275

PALH:

B1H58_20130

PANS:

FCN45_07195(rutA)

PEY:	EE896_12565(rutA)

PDIS:

D8B20_06590(rutA)

PER:	LAC65_05790(rutA)

PJI:	KTJ90_12440(rutA)

PANO:

OJ965_14340(rutA)

KPIE:

N5580_11205(rutA)

PALF:

K6R05_11985(rutA)

PPHO:

CTZ24_07180(rutA)

PDIP:

KFZ74_12830(rutA)

PGZ:	C2E15_07960(rutA)

PCD:	C2E16_07865(rutA)

MHAN:

K6958_08150(rutA)

TCI:	A7K98_09280

PLU:

plu3815

PLUM:

A4R40_18980

PAY:

PAU_00991

PTT:	VY86_03085

PAKH:

B0X70_19005

PLUI:

CE143_19040

XBO:

XBJ1_1586

XBV:

XBW1_0887

XGR:	QL128_16455

VZI:	G5S32_21240(rutA)

VOS:	KNV97_09985(rutA)

PPSL:

BJP27_10350

PST:	PSPTO_1157

PSB:

Psyr_0999

PSYR:

N018_20685

PSP:	PSPPH_1048

PSAV:

PSA3335_08755

PAMG:

BKM19_007705(rutA)

PAVL:

BKM03_06650(rutA)

PVD:	CFBP1590__4358(rutA)

PCAB:

JGS08_05410(rutA)

PSYI:

MME58_04935(rutA)

PAST:

N015_05620(rutA)

PLUL:

FOB45_22260(rutA)

PRH:	LT40_19385

PSES:

PSCI_0304

PEZ:	HWQ56_15555(rutA)

PPAO:

K3169_19075(rutA)

PSKU:

KUIN1_10370(rutA)

PSA:

PST_3597

PSZ:	PSTAB_3567

PSR:	PSTAA_3692

PSC:	A458_03440

PSTT:

CH92_21415

PSTU:

UIB01_03255

PCHL:

LLJ08_03335(rutA)

PKG:	LW136_03325(rutA)

SDEG:

GOM96_02820

PZD:	KQ248_04940(rutA)

HPEG:

EAO82_01540(rutA)

HAES:

LO767_00615(rutA)

HARR:

HV822_10655(rutA)

MSR:	AU15_03000

MPQ:	ABA45_09600

ACC:	BDGL_002277(rutA)

ACAL:

BUM88_16245

ACI:

ACIAD0027

AEI:	AOY20_13225

AJO:	RZ95_09030

ACW:	A0J50_03130

ASOL:

BEN76_13385

ASJ:	AsACE_CH00966(rutA)

ARJ:	DOM24_07655(rutA)

ACUM:

C9E88_009225(rutA)

AGU:	AS4_29280(rutA)

AUG:

URS_1156

ALW:	FOB21_15240(rutA)

ABER:

BSR55_14115

ATN:	FM020_07950(rutA)

AWG:	GFH30_04570(rutA)

ASHA:

G8E00_05340(rutA)

AVB:	RYU24_20540(rutA)

ABOU:

ACBO_20440(rutA)

ATZ:	M5E07_07980(rutA)

ACIE:

KIP84_03340(rutA)

ACIG:

BS636_00095(rutA) BS636_15340(rutA)

MOS:	AXE82_11210

AMC:	MADE_000001022910

AMH:	I633_17760

AMAA:

amad1_17300

AMAL:

I607_16325

AMAE:

I876_16630

AMAO:

I634_16580

AMAD:

I636_16515

AMAI:

I635_17260

AMAG:

I533_16145

AMAC:

MASE_16140

AMG:	AMEC673_16435

AAL:	EP13_18370

AAUS:

EP12_19150

ALTM:

BM527_15985

GPS:

C427_0832

HAA:	A5892_14200

MME:	Marme_1361

CUH:	BJN34_36115

PGP:	CUJ91_33805

PTS:	CUJ90_27805

PLG:	NCTC10937_03397(rutA)

VAP:	Vapar_4838

VPD:	VAPA_1c50080(rutA)

VAM:	C4F17_21770(rutA)

VAZ:	H7F35_08850(rutA)

HGR:	DW355_05670(rutA)

RGU:	A4W93_25205

XYK:	GT347_11520(rutA)

XYG:	R9X41_21355(rutA)

MESO:

BSQ44_10080

PLA:

Plav_0991

ATU:	Atu2500(rutA)

ATA:	AWN88_17375

AGR:	AGROH133_08499(rutA)

ATF:	Ach5_23700(rutA)

AGC:	BSY240_839(rutA)

AGT:	EYD00_10560(rutA)

ALF:	CFBP5473_19085(rutA)

ARUI:

G6M88_16290(rutA) G6M88_19500(rutA)

AVQ:	HRR99_16120(rutA) HRR99_19305(rutA)

AVV:	RvVAT039_pl03440(rutA)

ASAL:

CFBP5507_11225(rutA)

RIR:	BN877_I2581(rutA)

RPUS:

CFBP5875_10895(rutA)

ACUC:

KZ699_10930(rutA)

ALEG:

CFBP4996_10875(rutA)

AGRC:

GSF67_12090(rutA)

AVI:

Avi_7126

RHV:	BA939_06935

ROY:	G3A56_13450(rutA)

RLS:	HB780_12135(rutA)

RROS:

D4A92_16410(rutA)

RRHO:

PR018_18905(rutA)

ARA:

Arad_7073

ARO:	B0909_00430(rutA)

NEN:	NCHU2750_47470(rutA)

BBT:	BBta_1128(ycdM)

TRB:	HB776_24815(rutA)

APRA:

G3A50_08470

MEA:	Mex_1p1664

MDI:

METDI2412

MEX:

Mext_1738

MCH:

Mchl_2057

MPO:

Mpop_1075

MZA:	B2G69_16360

MRD:	Mrad2831_1584

MOR:	MOC_1964(rutA)

META:

Y590_08280

MAQU:

Maq22A_c18500

MPHY:

MCBMB27_01224

MEE:	DA075_20040(rutA)

METX:

A3862_22955

METI:

DK427_02030(rutA)

MMES:

MMSR116_30935(rutA)

MIND:

mvi_25510(rutA)

MOG:	MMB17_22310(rutA)

MTAD:

M6G65_08160(rutA)

DEI:	C4375_16505(rutA) C4375_16510(rutA) C4375_16515(rutA) C4375_16520(rutA)

CCR:	CC_1169 CC_2798

CCS:	CCNA_01227 CCNA_02888

CAK:	Caul_1792 Caul_3982

CSE:	Cseg_1789 Cseg_1893 Cseg_2081

CHQ:	AQ619_03875 AQ619_04205

CFH:	C1707_01420(rutA) C1707_01770 C1707_03645

CAUF:

CSW63_09150 CSW63_19500(rutA)

CAUL:

KCG34_19140

BGOE:

IFJ75_12350(rutA)

KVL:	KVU_1293 KVU_1872(rutA)

KVU:

EIO_1827

KRO:	BVG79_02009(rutA)

CID:

P73_1975

YPAC:

CEW88_14425(rutA)

YAN:	AYJ57_05560 AYJ57_10120

LSAL:

KBK07_09960(rutA)

PLCG:

RVY76_16900(rutA)

LVS:	LOKVESSMR4R_02448(rutA)

HML:	HmaOT1_07750(rutA)

PSHQ:

F3W81_03045(rutA) F3W81_03050(rutA)

FAP:	GR316_12320(rutA)

HNE:

HNE_1252

HBA:

Hbal_2538

NPP:	PP1Y_AT10762

NPN:	JI59_06555

NRE:	BES08_16575 BES08_19315 BES08_19380

NOV:	TQ38_014325(rutA) TQ38_022325(rutA) TQ38_022440

NOG:	GKE62_04895

NDR:	HT578_04665 HT578_19540(rutA)

NHUM:

PQ457_16325(rutA)

NOL:	NSDW_04740(rutA) NSDW_10950

NCP:	U0041_08415

SPHQ:

BWQ93_13765

SWI:	Swit_1168 Swit_4216

SPHD:

HY78_20735

SPHI:

TS85_05045 TS85_06060

SSAN:

NX02_15970 NX02_23365

SPAN:

AWL63_12465

SPLM:

BXU08_06035

SPAP:

H3Z74_01520(rutA)

SPAI:

FPZ24_08920(rutA)

SARI:

H5J25_15430(rutA)

SNAP:

PQ455_17860(rutA)

SDON:

M9980_04355(rutA)

SPHR:

BSY17_3628(rutA)

SUFL:

FIL70_08440 FIL70_25155

SPAG:

sphantq_04077(rutA)

SFLA:

SPHFLASMR4Y_01888(rutA)

SPZR:

G5C33_08835(rutA)

AAY:	WYH_00064(rutA)

RGI:	RGI145_06135 RGI145_14655

ROS:	CTJ15_11265(rutA) CTJ15_21285(rutA)

RMUC:

FOB66_07945(rutA) FOB66_16700(rutA)

RMT:	IAI58_12850(rutA)

RFL:	Rmf_00330(rutA_1) Rmf_13210(rutA_2)

LCK:	HN018_01900

SRF:	LHU95_09130(rutA) LHU95_22010(rutA)

NAO:	Y958_23495

NCB:	C0V82_24835(rutA)

HOH:

Hoch_3938

TAP:	GZ22_02440

PBK:	Back11_38080

PLIG:

NAG76_03435 NAG76_22010

AACO:

K1I37_05850

MMAM:

K3U93_16435

MYW:	BVC93_11655

MTHN:

4412656_02908(rutA_4)

NNO:	NONO_c26560

RBY:	CEJ39_09950(rutA)

RAV:	AAT18_09645

RRZ:	CS378_24480(rutA)

RHQ:	IM25_13355

RRT:	4535765_00373(rutA_2)

RKO:	JWS14_38955

RHOU:

KZJ41_10775(rutA)

RHOW:

A4U64_15005

RHOJ:

JVH1_22150

GJI:	H1R19_08930

SLC:	SL103_22515

SCLF:

BB341_01515

SLS:	SLINC_2834 SLINC_6196

SGD:	ELQ87_01640

SQZ:	FQU76_31570(rutA)

SCYA:

EJ357_22520(rutA)

STSU:

B7R87_31380

SFEU:

IM697_01760(rutA)

SLF:	JEQ17_05090(rutA)

SCOA:

QU709_10425(rutA) QU709_29945

KBU:	Q4V64_15720 Q4V64_27055(rutA)

ABRY:

NYE86_22435

LEIF:

HF024_01940

LEIZ:

IT072_03905

MBIN:

LXM64_06920

MICE:

EHF32_06005

CUB:	BJK06_04380 BJK06_11565

AIL:	FLP10_11275

CART:

PA27867_1036 PA27867_2671

CPHY:

B5808_01655

SALC:

C2138_01880 C2138_11300

SALD:

FVA74_02570

HUM:	DVJ78_01010

HEA:	HL652_06285 HL652_16070

SUBA:

LQ955_13165

PUE:	FV140_02030

SKE:	Sked_02080

AEF:	GEV26_06470 GEV26_06495

NDA:

Ndas_4506

NEX:	NE857_02985

NAKE:

KGD83_02600

NCG:	KGD84_30170

SNAH:

OUQ99_29520

KRA:

Krad_3110

PDX:	Psed_6202 Psed_6730

PSEA:

WY02_01035

PSEE:

FRP1_17015

PSEQ:

AD006_24465

PECQ:

AD017_04055

PAUT:

Pdca_22210(rutA_1) Pdca_66760(rutA_2)

APRE:

CNX65_13320

AMI:

Amir_2625

ACTY:

OG774_11880(rutA)

ACTN:

L083_3836

DFU:	Dfulv_35240(rutA)

» show all

Reference

1 [PMID:20369853]

Authors

Mukherjee T, Zhang Y, Abdelwahed S, Ealick SE, Begley TP

Title

Catalysis of a flavoenzyme-mediated amide hydrolysis.

Journal

J Am Chem Soc 132:5550-1 (2010)
DOI:10.1021/ja9107676

Sequence

[eco:b1012]

Reference

2 [PMID:20400551]

Authors

Kim KS, Pelton JG, Inwood WB, Andersen U, Kustu S, Wemmer DE

Title

The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems.

Journal

J Bacteriol 192:4089-102 (2010)
DOI:10.1128/JB.00201-10

Sequence

[eco:b1012]

Reference

3 [PMID:28661684]

Authors

Adak S, Begley TP

Title

RutA-Catalyzed Oxidative Cleavage of the Uracil Amide Involves Formation of a Flavin-N5-oxide.

Journal

Biochemistry 56:3708-3709 (2017)
DOI:10.1021/acs.biochem.7b00493

Reference

4 [PMID:28784589]

Authors

Adak S, Begley TP

Title

Flavin-N5-oxide: A new, catalytic motif in flavoenzymology.

Journal

Arch Biochem Biophys 632:4-10 (2017)
DOI:10.1016/j.abb.2017.08.001

Reference

5 [PMID:32066967]

Authors

Matthews A, Saleem-Batcha R, Sanders JN, Stull F, Houk KN, Teufel R.

Title

Aminoperoxide adducts expand the catalytic repertoire of flavin monooxygenases.

Journal

Nat Chem Biol 16:556-563 (2020)
DOI:10.1038/s41589-020-0476-2

Other DBs

ExplorEnz - The Enzyme Database:

1.14.99.46

IUBMB Enzyme Nomenclature:

1.14.99.46

ExPASy - ENZYME nomenclature database:

1.14.99.46

BRENDA, the Enzyme Database:

1.14.99.46

DBGET integrated database retrieval system